伴有脂肪化生的多形性腺瘤1例

伴有脂肪化生的多形性腺瘤是一种罕见的多形性腺瘤.本文报道1例伴有脂肪化生的多形性腺瘤,该患者为28岁女性,发现左耳前肿物2年余,伴有疼痛.CT及B超检查提示为多形性腺瘤可能.手术治疗后病理结果为伴有脂肪化生的多形性腺瘤,脂肪成分占肿瘤的60％.结合文献,本文讨论了该类疾病的命名,总结了其影像学表现、临床病理特征、鉴别诊...     

舌下腺多形性腺瘤1例

临床资料 男性,45岁,无意中发现左舌下无痛性肿物2年,渐增大。2009年4月在外院活检,病理诊断为舌下腺多形性腺瘤。     

舌下腺癌在多形性腺瘤中1例

发生于舌下腺的癌在多形性腺瘤中极为罕见。本文报道 1例发生于舌下腺的腺样囊性癌在多形性腺瘤的病例。     

多形性腺瘤基因1与唾液腺肿瘤

近年来学者发现,多形性腺瘤基因1的激活和表达与多形性腺瘤及其他唾液液肿瘤的发生密切相关。多形性腺瘤基因1具有转录因子活性,通过对下游靶基因的表达调控而发挥生物学功能。对多形性腺瘤基因1及其相关基因的功能以及其在多形性腺瘤发病机制中的作用研究,在口腔颌面肿瘤领域具普遍指导意义。     

颌下腺转移性多形性腺瘤1例

本文报道1例罕见的转移性多形性腺瘤,患者女性,30岁,左颌下腺及右锁骨上包块术后病检结果与患者8年前左颌下腺肿块切除后病检结果一致,病理形态均表现为良性多形性腺瘤。并结合文献报道,对转移性多形性腺瘤的临床病理特征、发病机制及防治方法等进行讨论。     

舌根多形性腺瘤恶性变1例

恶性多形性腺瘤为常见的涎腺恶性肿瘤,约占涎腺恶性肿瘤的15%～20%,好发于腮腺及颌下腺。小涎腺好发于腭腺,发生于舌根者较为罕见,现将1例报道如下。患者,女性,18岁,2004年6月收治入院。入院前1周因口内出血发现舌根部一肿物,无疼痛及其他不适。查体:舌根部见一肿物约4 cm×3 c     

颌下腺鳞癌在多形性腺瘤中1例报告

癌在多形性腺瘤中又称恶性混合瘤，其发病部位以腮腺最常见，癌变组织类型以腺癌、未分化癌，粘液表皮样癌多见，癌变成分为鳞癌较少见，我科收治一例颌下腺鳞癌在多形性腺瘤中病人，报告如下：     

腮腺区复发性多形性腺瘤恶变侵犯颧骨1例报告

腮腺区复发性多形性腺瘤（recurrent pleomorphic adenoma,RPA）存在一定的恶变几率,但检索国内外文献未见侵犯颧骨的报道。本文报告1例腮腺区复发性多形性腺瘤恶变侵犯颧骨病例,并结合相关文献分析其临床、影像及病理特点,以进一步提高对该病的认识,减少误诊误治。     

舌根多形性腺瘤1例

患者,女,27岁,主因舌根肿物发现一周入院。患者入院前一周偶然发现舌根正中有一肿物,枣样大小,无痛,不影响进食和语言。入院后检查见肿物位于舌根舌盲孔部位,突出于舌背表面,约2cm×2cm×2.5cm,表面光滑,为球形,表面粘膜完整并可见怒张的毛细血管,质中等硬度,其基底有轻度浸润,界限尚清楚,肿物无压痛。ECT显示未见典型异位甲状腺征象。MRI提示舌根部含脂肪良性病变。治疗:全麻下完整切除肿物及四周部分舌组织,见肿物包膜完整,结节状,有分叶,上部2cm×2cm×2cm,下部蒂1cm×0.8cm×0.8cm,中等硬度。剖面为实性,有少量粘液。病理报告:舌后腺…     

涎腺多形性腺瘤恶变机制的研究进展

涎腺多形性腺瘤是最常见的涎腺上皮性肿瘤,多次复发或病程长者可恶变为恶性多形性腺瘤.涎腺多形性腺瘤的恶变是多因素、多基因变异的综合病变过程.研究发现,细胞遗传学改变、癌基因、抑癌基因、黏附分子及细胞外基质蛋白在涎腺多形性腺瘤的恶变过程中均有一定的作用.本文就多形性腺瘤恶变机制的研究进展作一综述.     

Pleomorphic adenoma with extensive squamous metaplasia and keratin cyst formations in minor salivary gland: a case report

Pleomorphic adenoma (PA), the most common salivary gland tumor, accounts for 54 to 65% of all salivary gland neoplasias and 80% of the benign salivary gland tumors. It most frequently affects the parotid gland, followed by the submandibular and the minor salivary glands. Microscopically, mucous, sebaceous, oncocytic and squamous metaplasia, sometimes with the formation of keratin pearls, may be present, but the latter rarely results in the formation of extensive keratin-filled cysts lined by squamous epithelium. Extensive squamous metaplasia can be mistaken for malignancy, including mucoepidermoid carcinoma and squamous cell carcinoma. Here, we present an unusual case of PA with extensive squamous metaplasia and keratin cyst formations in a minor salivary gland, and discuss its microscopic features, including the immunohistochemical characteristics, and differential diagnosis of this uncommon presentation.     

Pleomorphic adenoma with extensive necrosis: report of two cases

Pleomorphic adenoma (PA) is the most common neoplasm for both the major and minor salivary glands. While PA is occasionally associated with cystic change or hemorrhage necrosis, spontaneous infarction appears to be very uncommon. We report two unusual cases of extensive necrosis of PA; one occurred in the palate with the necrotic tumor mass slipping into the oral cavity. This phenomenon, possibly associated with incision biopsy, has never been described previously. A second case, arising in the parotid with spontaneous tumor necrosis, poses some dilemma in differential diagnosis.     

Pleomorphic adenoma of the lacrimal gland: case report

Lacrimal gland tumours are rare. We present a case of a lacrimal gland pleomorphic adenoma in a 19-year-old man. The tumour was removed and he has made an uncomplicated recovery, with no sign of recurrence after nine months of follow-up. We will keep him under long-term review.