苯扎贝特致巨大胆囊结石1例

1　病例报告患者 ,男 ,5 2岁 ,因患高血压病 (Ⅰ期 ) ,混合型高脂血症 10年。血甘油三酯 (ＴＧ )最高达 11.2ｍｍｏｌ/Ｌ ,胆固醇及低密度脂蛋白轻度升高。无胆结石史 ,近期Ｂ超检查未发现胆、肾结石。在服用尼群地平、卡托普利降压药的基础上 ,先后服用了降甘油三酯为主的调脂药 ,如γ 月苋草丸、多烯康胶丸 ,且均按常规剂量服用 ,服用数月后血脂 ,特别是甘油三酯下降不理想。最后服用苯扎贝特 (商品名 :必降脂 ) 2 0 0ｍｇ ,ｔｉｄ ,服用 1月后血脂下降 ,甘油三酯下降至 3 .46ｍｍｏｌ/Ｌ ,胆固醇及低密度脂蛋白正常 ,但出现上腹部疼痛伴…     

苯扎贝特对中老年高血压代谢综合征患者的影响

目的 探讨苯扎贝特对中老年高血压代谢综合征患者各代谢因素的影响。方法 将55例中老年高血压代谢综合征患者分为2组：苯扎贝特组28例给予缓释硝苯地平、苯扎贝特并饮食控制；对照组27例给予缓释硝苯地平、安慰剂并饮食控制。观察治疗前后血压、体质指数、血脂、空腹血糖、胰岛素、胰岛素抵抗指数及尿酸水平等变化。结果 2组血压水平均有明显下降，苯扎贝特组治疗后舒张压降低较对照组显著（P〈0．05）；苯扎贝特组血甘油三酯、总胆固醇、低密度脂蛋白胆固醇水平明显降低（P〈0．05或0．001），高密度脂蛋白胆固醇显著升高（P〈0．05）。空腹血糖及胰岛素浓度降低（P〈0．05），胰岛素敏感性升高（P〈0．05）。血尿酸水平明显下降（P〈0．01）。结论 苯扎贝特有可能改善中老年高血压代谢综合征患者的多种代谢异常因素。     

普伐他汀和苯扎贝特在体外对血小板功能影响的比较

近年的研究发现，降脂药物的疗效除降脂外，还有其它有益作用［‘］。我们观察了普保他汀（pravastatin）和来扎贝特（bezafibrate）在体外对28例高胆固醇血症（HC）患者和10名正常人血小板的作用，现报道如下。材料和方法1血标本与分组1．IHC组：28例（男11例，女17例）均为本院门诊患者，平均年龄57岁。两次血清总胆固醇水平（TC－C）＞6．24mmol／L和（或）低密度脂蛋白胆固醇（LDL－C）＞4．16mmol／L，临床上排除继发性HC。至少1个月内未用过降脂药、抗血小板药和钙桔抗剂。1．2正常组：10名（男5名，女5名），均为本院健康体检…     

苯扎贝特和辛伐他汀治疗重度高脂血症一例报告

1 临床资料 患者，男，44岁，因头昏、乏力伴四肢麻木1个月，于2007年9月13日人本院。患者9月12日门诊查：血清甘油三酯（TG）30．05mmol／L（正常值O～2．3mmol／1．），总胆固醇（TC）14．58mmol／L（正常值0～5．7nmol／L），高密度脂蛋白（HDL）0．9mmol／I，（正常值1．04～1．66mmol／L），谷丙转氨酶（ALT）81．1U／L（止常值0～54U／L），谷草转氨酶（GOT）72u／L（正常值0～45U／L）；B超示：中度脂肪肝；甲型肝炎、乙型肝炎、丙型肝炎的血清标记物均阴性。查体：T36．6℃、R19次／min、P62次／min、BP120／80mmHg（1mmHg-0．133kPa），一般情况好，神清，步入病房，慢性病容，皮肤黏膜无黄染，浅表淋巴结无肿大，巩膜无脂质沉着环，口唇无紫绀，颈软，双肺未闻及干、湿性哕音，     

苯扎贝特与菸酸肌醇脂对原发性高脂血症疗效观察

目的　观察苯扎贝特与菸酸肌醇脂的降脂疗效。方法　原发性高脂血症６６ 例,其中３４ 例（ 男性２０ 例,女性１４ 例,年龄５４ ±１２ 岁） 用苯扎贝特２００ｍｇ ．Ｐｏ．ｔｉｄ共治疗８ 周。另同病患者３２ 例（ 男性２２ 例,女性１０ 例,年龄５３ ±９ 岁） 用菸酸肌醇脂４００ｍｇ ．Ｐｏ ．ｔｉｄ 共治疗８ 周做为对照。结果　苯扎贝特组ＴＣ、ＴＧ、ＬＤＬ—ｃｈ 、ＡｐｏＢ、ＬＰ（ａ） 治疗２ 周后就有明显下降（ Ｐ ＜ ０ ．０１） ,ＨＤＬ—ｃｈ 、ＡｐｏＡ 明显上升（ Ｐ ＜ ０ ．０１） ,苯扎贝特药效明显强于菸酸肌醇脂,疗效随用药时间延长而提高,未见明显副作用。结论　苯扎贝特是一个安全有效的降脂药物,特别适用于多项脂质异常患者。     

苯扎贝特短期内引起血肌酸激酶显著升高1例

1 病例摘要 患者,女性,85岁.因高血压、冠心病、房颤、高脂血症入院.入院查体：体温（T）36.5℃、脉搏（P）70次/分、呼吸（R）20次/分、血压（BP）165/90mmHg,神志清,精神佳,两肺呼吸音清,未闻及啰音,心率78次/分,心律绝对不齐,心音强弱不等,未闻及病理性杂音,腹软,无压痛及反跳痛,下肢无水肿.     

苯扎贝特片联合氨氯地平片治疗高血压合并血脂代谢紊乱的疗效及不良反应

目的 探讨苯扎贝特片联合氨氯地平片治疗高血压合并血脂代谢紊乱的疗效及不良反应.方法 选取2018年1月至2019年12月郑州市中医院收治的80例高血压合并血脂代谢紊乱患者的临床资料,按照随机数字表法分为对照组与观察组,每组40例.对照组应用氨氯地平片口服治疗,5 mg/次,1次/d;观察组在对照组基础上加用苯扎贝特片口...     

苯扎贝特致横纹肌溶解症、急性肾衰竭、心肌损伤1例

患者女,56岁.因全身水肿伴腰痛、腰酸、乏力8日于2007-05-13入院.患者8日前无明显诱因出现全身水肿伴腰痛、腰酸、乏力.既往有卵巢肿瘤切除术22年,子宫肌瘤切除术10年,高血压5年,平时未监测血压.否认糖尿病及药物过敏史.体格检查:体温37.0℃,脉搏88次/分,呼吸20次/分,血压140/80 mmHg(10 mmHg=1.33 kPa).     

非诺贝特对冠心病患者血管内皮依赖性舒张功能及血清NO浓度的影响

【目的】探讨冠心病患者血管内皮功能及血清NO浓度的变化及非诺贝特干预的影响。【方法】用高分辨超声技术检测各组对象的肱动脉内皮依赖性舒张功能,并测定血清NO浓度,药物非诺贝特干预8周后复测上述指标。【结果】与正常对照组比较,冠心病患者肱动脉内皮依赖性血管舒张功能明显减退(P<0.01),血清NO浓度降低(P<0.01)。非诺贝特可改善内皮血管依赖性舒张功能[(8.09±4.30)%vs(2.51±1.30)%,P<0.01],升高血清NO浓度[(66.43±17.87)μmol/Lvs(49.12±17.81)μmol/L,P<0.01],并且血管内皮依赖性舒张功能与血清NO浓度正相关(r=0.741,P<0.001)。【结论】冠心病患者肱动脉内皮依赖性血管舒张功能明显减退,血清NO浓度降低。非诺贝特通过增加血清NO浓度改善冠心病患者的血管内皮功能,该作用可能是贝特类调脂药防治冠心病的机制之一。     

血清对氧磷酶-1水平变化与慢性心力衰竭的相关性分析

目的探讨血清对氧磷酶-1（PON-1）和氧化应激指标与慢性心力衰竭（chronic heart failure,CHF）的关系。方法选择我院2008年6月～2009年6月收治的CHF101例（CHF组）并按心功能进行分级,同期行健康体检者21例作为对照组。测定两组PON-1、过氧化脂质（LPO）及总抗氧化物（TAS）。结果 CHF组血清PON-1、TAS水平与对照组比较明显下降,LPO显著升高,差异有统计学意义（P〈0.01）;CHF组随着心功能级别的加大,血清PON-1、TAS水平下降,LPO升高,不同级别间比较差异有统计学意义（P〈0.01）;相关分析显示,血清PON-1和TAS与LPO均呈负相关（r=-0.917,r=-0.910）,而PON-1与TAS呈明显正相关（r=0.879）。结论 PON-1和机体的氧化应激水平变化参与了CHF的发生、发展,故PON-1可以作为预测病情严重程度的指标。     

Effect of Delayed Treatment with Sodium Polystyrene Sulfonate on Serum Lithium Concentrations in Mice

Objectives: To determine the efficacy of sodium polystyrene sulfonate (SPS) in lowering serum lithium (Li) concentrations. Specifically, to determine the effects of both different doses of SPS and different times to treatment with SPS on serum Li levels.
Methods: The study was a controlled, single-dose murine trial of SPS on serum Li levels. Male CD-I mice ( n = 525) were given orogastric LiCl and then divided into three main treatment groups: group SPS received a single orogastric administration of SPS in a dose of 5 gm/kg body weight at either 0, 15, 30, 45, or 90 minutes after LiCl; group half-SPS received a single orogastric administration of SPS in a dose of 2.5 gm/kg body weight at times equivalent to those of group SPS; and the control group received orogastric deionized water in a volume equivalent to that of group SPS at 0, 15, 30, 45, or 90 minutes after LiCl. Subgroups of seven to ten mice in each of the four treatment groups were sacrificed at one, two, four, and eight hours after administration of LiCl, and their blood was analyzed for Li concentration.
Results: 1) Single doses of SPS significantly lowered serum Li concentrations; 2) this effect was dose-related; 3) the delays in administration of SPS used in this study did not significantly reduce its ability to lower serum Li concentrations; and 4) even when administered after peak serum Li concentrations had been achieved, a single dose of SPS was effective in lowering serum Li levels.
Conclusions: SPS may be efficacious in the treatment for Li toxicity under certain circumstances, even when there is delay to treatment. Additional study is warranted to further characterize the ability of SPS to alter Li kinetics.     

细胞周期抑制剂SNS-032对小鼠造血干细胞生物活性的影响研究

本研究旨在探讨SNS-032（C17H24N4O2S2）对小鼠骨髓造血干细胞（hematopoietic stem cells,HSC）细胞周期、凋亡、分化及自我更新的影响及其可能的相关机制。利用极限稀释实验检测SNS-032作用前后HSC自我更新的变化,用流式细胞术检测SNS-032作用前后小鼠骨髓细胞Lin-c-kit＋Sca-1＋及Lin-c-kit＋Sca-1-表型细胞的细胞周期及凋亡的变化,用实时定量PCR检测SNS-032作用前后细胞周期相关基因、凋亡相关基因及HSC自我更新相关基因mRNA表达量的水平。结果显示,SNS-032处理后,小鼠骨髓细胞中HSC的自我更新能力没有明显变化;加SNS-032处理后,小鼠骨髓细胞Lin-c-kit＋Sca-1＋表型细胞的细胞周期无统计学意义的变化（P〉0.05）,小鼠骨髓Lin-c-kit＋Sca-1-表型细胞的G1期细胞增多（P〈0.05）;小鼠骨髓细胞Lin-c-kit＋Sca-1＋表型细胞和Lin-c-kit＋Sca-1-表型细胞的细胞凋亡增多,与对照相比均无显著性差异（P〉0.05）。小鼠骨髓细胞经SNS-032处理后,HSC周期相关基因CDK1、CDK2、CDK7、p27的表达量均明显降低（P〈0.05）,而CDK4,CDK6,p21,p18,p19,p16的表达与对照组相比没有明显变化（P〉0.05）。凋亡相关基因Bcl-2、Bax、Puma和p53表达量与对照组相比没有明显区别（P〉0.05）,与干细胞自我更新相关的基因中Bim,Sall4,Notch1表达量升高,但与对照组相比没有显著性差异（P〉0.05）。结论：SNS-032没有明显的抑制正常造血干细胞自我更新、分化作用,而且SNS-032没有明显的诱导正常造血干、祖细胞的凋亡作用。     

Effect of Tilorone Treatment on Intracellular Microbial Infections in Specific-Pathogen-Free Mice

Specific-pathogen-free CD-1 mice were treated orally with the drug tilorone (2,7-bis[2-diethylaminoethoxy]fluoren-9-one hydrochloride) at dosages of 10 or 100 mg per kg of body weight. Drug was given 24 h before challenge and then every other day for up to 15 days. Growth of sublethal doses of Listeria monocytogenes, Mycobacterium bovis (BCG Montreal), M. tuberculosis H37Rv, and Salmonella enteritidis in the livers and spleens of intravenously challenged mice was significantly increased compared with that in control animals receiving distilled water orally. Tilorone given every other day at a dosage of 10 mg/kg reduced (but did not completely ablate) the tuberculin response to the mycobacterial infections. Both tuberculin hypersensitivity and anti-mycobacterial resistance returned to normal values within days of stopping the drug treatment. Tilorone treatment at the 100-mg/kg dose level increased the growth of S. enteritidis in both intravenously and intragastrically challenged mice; this effect seemed to be due to the reduced ability of the host to express the normal granulomatous response to the microbial infection within the liver and spleen.     

Effect of Experimental Hypertriglyceridaemia on Tissue and Serum Lipoprotein Lipase Activity

Abstract Hypertriglyceridaemia was produced in rats by the intravenous infusion of Intralipid emulsion or of very low density (d < 1.006) rabbit or human lipoproteins (VLDL). Lipoprotein lipase activity was assayed, in tissues removed at the end of infusion, on serum-activated mono- and triolein emulsions at pH 8.6. Hypertriglyceridaemia resulted in a marked decrease in epididymal adipose tissue lipoprotein lipase activity and in an increase in heart enzyme activity. These changes were evident with both mono- and triolein substrates. The effects on adipose tissue enzyme activity seemed roughly dependent on the triglyceride (TG) level and, relative to TG elevation, were most pronounced in the case of VLDL infusion. Serum lipoprotein lipase activity, measured in the absence of heparin, was considerably increased suggesting that the TG-rich material "leached" the adipose tissue enzyme into the circulation. Leaching of lipoprotein lipase from adipose tissue by Intralipid emulsion or VLDL was also demonstrated in an in vitro system devoid of heparin. Contact with the TG-poor, 1.006 < d < 1.063, lipoprotein induced only a small loss in adipose tissue lipoprotein lipase activity, either in vitro or in vivo.
Intracellular lipolytic activity toward mono- and triolein, measured in adipose tissue and heart homogenates at pH 7.2 in the absence of serum, was not significantly affected by TG elevation. Thus, the observed changes in lipoprotein lipase activity seem unrelated to the intracellular lipolytic activity.
It is suggested that the low adipose tissue lipoprotein lipase activity and the retarded TG removal observed in certain hypertriglyceridaemic conditions may be secondary to the increased supply of TG-rich lipoproteins.     

Antagonistic Effect of Calcium in Serum on the Activity of Tobramycin Against Pseudomonas

Physiological concentrations of calcium in serum antagonize the activities of colistin, polymyxin B, and gentamicin against Pseudomonas aeruginosa. Studies were carried out to determine whether tobramycin, a new aminoglycoside antibiotic, is also antagonized by calcium. The activity of tobramycin in vitro was shown to be antagonized by human serum and by physiological concentrations of calcium. The addition of human serum in broth-dilution tests produced a fourfold rise in the minimal inhibitory concentrations of tobramycin for five strains of Pseudomonas. In disc diffusion tests, the addition of calcium to the agar significantly decreased the size of inhibition zones, and the addition of a chelating agent to the agar increased the zone sizes. In a limited comparative study, tobramycin and gentamicin were tested against both light and heavy bacterial inocula of two strains of Pseudomonas. Tobramycin appeared to be antagonized less by serum than was gentamicin at equal antibiotic concentrations.     

高压氧对小鼠血清皮质醇,脾T淋巴细胞及其亚群的影响

正常小鼠（Ｃ（５７）ＢＬ／６）在０．２５ＭＰａ吸９９．２％氧情况下，血清皮质醇含量明显高于对照组；脾淋巴细胞Ｔｈｙ－１、Ｌ３Ｔ４、Ｌｙｔ－２阳性细胞百分率及Ｔｈ／Ｔｓ比值均明显低于对照组。提示高压氧可降低细胞免疫功能，其机理与肾上腺皮质功能增强有关。     

磁处理水对小白鼠脑胆硷酯酶和单胺氧化酶活性的影响

研究饮用磁处理水对小白鼠全脑胆硷酯酶和单胺氧化酶活性的影响。结果表明，小白鼠饮用磁处理水４０天，脑内的胆硷酯酶活性明显升高，但单胺氧化酶的活性无有意义的改变。由于脑的胆硷酯酶是乙酰胆硷的标识物，故可证明饮用磁处理水可提高脑内的局酰胆硷水平。     

血清对氧磷酯酶1活性监测在肝移植术中的意义

目的 探讨血清对氧磷酯酶1(paraoxonase 1,PON1)活性的测定在肝移植术中的意义。方法 对17例肝移植患者术前、术中及术后2d内血清各生化指标进行监测,分析血清PON1在肝移植术中的变化规律及与其他生化指标的关系。结果 正常人血清PON1活性呈正态分布,参考值为45.5-265.8 U/ml。17例肝移植受者术前血清PON1活性比对照组低(P<0.001)。在门静脉开放后5min始升高,开放后90 min[(47.1±2.4)U/ml]较术前明显增高(P<0.05),术后第1、2 d继续升高。丙氨酸氨基转移酶(ALT)及天冬氨酸氨基转移酶(AST)水平在开放后较术前明显升高,术后第2 d还较正常值高。结论 血清PON1活性可作为判断植入肝脏存活的生化指标之一,协同其他生化指标用来监测肝移植患者的肝脏功能。