101例偏头痛和95例紧张型头痛患者伴发焦虑和/或抑郁临床分析

目的:分析就诊于神经内科门诊的偏头痛和紧张型头痛患者中焦虑抑郁的发生率及特点,旨在提高偏头痛和紧张型头痛患者的诊疗水平。方法:对2009年6月~2010年2月来我院神经内科就诊101例偏头痛和95例紧张型头痛患者,采用汉密顿焦虑和抑郁量表进行焦虑抑郁测定,并同时对性别、年龄、职业、收入状况、病程、头痛程度、发作频率进行分析。结果:44.6%偏头痛患者和55.8%紧张型头痛患者伴发情绪障碍,两者比较无统计学差异(P>0.05)。慢性紧张性头痛患者有情绪障碍的概率较发作性紧张性头痛患者、无先兆偏头痛患者、有先兆偏头痛患者无统计学差异(P>0.05)。有焦虑症状的头痛患者出现抑郁症状显著高于无焦虑症状的患者,反之亦然。女性头痛患者伴发焦虑抑郁显著高于男性(P<0.05)。年龄<40岁患者伴发焦虑抑郁明显高于年龄>40岁患者(P<0.05)。收入<1500(元/月)的头痛患者伴发焦虑抑郁显著高于收入≥1500(元/月)。中、重度头痛患者伴发焦虑抑郁显著高于轻度头痛(P<0.05)。头痛病程>1年患者伴发焦虑抑郁显著高于病程<1年(P<0.05)。结论:偏头痛和紧张型头痛患者经常伴有焦虑抑郁。在头痛患者的诊治中,应加强对偏头痛及紧张型头痛共患焦虑抑郁的认识,提高诊治水平。     

头痛专病门诊患者抑郁焦虑患病特点分析

目的:评估头痛门诊原发性头痛患者的抑郁焦虑共病情况。方法:使用9条目患者健康问卷(patient health questionnaire-9,PHQ-9)和7条目广泛性焦虑量表(generalized anxiety disorder-7,GAD-7)对2012年10月8日至2012年12月29日就诊于解放军总医院头痛门诊的原发性头痛患者进行评估。结果:在225例头痛患者中,偏头痛为58例(25.8%),紧张型头痛为97例(43.1%),丛集性头痛为14例(6.2%),慢性每日头痛为56例(24.9%);头痛患者的抑郁和广泛性焦虑的检出率分别为37.8%和34.2%。慢性每日头痛出现抑郁和广泛性焦虑共病的比例明显高于其他类型头痛(P<0.01,P=0.03)。结论:头痛专病门诊中原发性头痛的抑郁和广泛性焦虑患病比例高,和其他类型头痛相比,慢性每日头痛更容易出现抑郁焦虑共病。     

文拉法辛与帕罗西汀治疗共患焦虑或抑郁状态的紧张型头痛临床研究

目的:评价文拉法辛与帕罗西汀治疗紧张型头痛共患焦虑或抑郁的疗效及不良反应.方法:将符合ICHD-II诊断标准的35例共患焦虑或抑郁状态的紧张型头痛门诊患者随机分为两组,分别给予文拉法辛(n=18)75mg和帕罗西汀(n=17)20mg,疗程8周.用视觉模拟量表(VAS)、汉密尔顿抑郁量表(HAMD)、汉密尔顿焦虑量表(HAMA)评定疗效并观察两组的不良反应.结果:文拉法辛组1例服药后头痛加重停药,帕罗西汀组1例头痛加重停药、1例不能忍受副反应改服其它药物.治疗后2、4、8周两组VAS、HAMD、HAMA评分无统计学意义,但治疗前后以上指标两组均有显著差异.结论:文拉法辛和帕罗西汀在治疗紧张型头痛共患焦虑、抑郁时安全有效,不良反应少.     

260例非器质性头痛患者头痛相关因素分析

目的:分析260例非器质性头痛患者头痛的相关因素,为临床上非器质性头痛的诊断和治疗提供科学依据。方法 :用表格对2009年6月~2010年2月在郑州大学第一附属医院神经内科门诊就诊的非器质性头痛患者的资料进行收集,总结患者的一般情况和头痛的相关因素。结果 :260例非器质性头痛患者中,女性多于男性(男:女=1:1.17)。随着收入的增高非器质性头痛的发病人数逐渐降低。发病率较高的职业是农民和学生。所有非器质性头痛患者有50.78%合并焦虑抑郁状态。紧张和压力是诱发头痛加重的最主要因素。其中有9例患者在病程中出现了头痛特点的转换。结论:非器质性头痛患者与性别、年龄、职业、收入等均存在相关性,在临床中要特别关注合并焦虑抑郁状态的非器质性头痛以及头痛特点转换。     

探讨头痛门诊慢性紧张型头痛患者睡眠质量及影响因素

目的:分析头痛门诊收治慢性紧张型头痛患者的睡眠质量情况,探究影响睡眠质量的相关因素。方法:选取2018年1月至2018年12月间贵州省六盘水市人民医院神经内科收治的偏头痛患者200例作为研究对象,应用匹兹堡睡眠质量指数、疼痛视觉模拟评分量表、焦虑抑郁评分量表分析患者睡眠质量、头痛程度及负性情绪情况,分析睡眠质量的相关因素。结果:慢性紧张型头痛患者伴焦虑抑郁、头痛病程与患者PSQI指数得分相关(P 0. 05);伴焦虑、抑郁症状慢性紧张型头痛患者PSQI指数得分相比不伴焦虑抑郁患者增高(P 0. 05);慢性紧张型头痛伴睡眠障碍、焦虑、抑郁症状患者的PSQI总分、主观睡眠质量、睡眠效率、睡眠障碍相关因素对比非慢性紧张型头痛伴睡眠障碍、焦虑、抑郁症状存在显著差异(P 0. 05)。结论:对于慢性紧张型头痛患者,临床上应结合患者的共患病予以规范治疗,通过降低头痛症状的发作频率,调控患者的焦虑、抑郁症状以改善慢性紧张型头痛患者睡眠障碍症状。     

门诊原发性头痛患者就诊类型研究

目的 应用ICHD-Ⅱ诊断标准分析原发性头痛患者门诊就诊类型。 方法 从2011年7月－2013年3月，对以头痛为主诉的473例患者进行详细的问诊。为排除继发性头痛及其他颅内病变对患者的影响，所有问诊患者均为行CT或MRI扫描并排除颅内有明确病变者。 结果 473例患者平均40.4岁，男女比为1︰2.61。其中，偏头痛者214例（45.2%），紧张型头痛者230例（48.6%），丛集性头痛者1例（0.2%），其他原发性头痛者28例（5.9%）。473例患者中，有29例（6.1%）患者伴有药物过度使用性头痛。 结论 西部地区就诊于头痛门诊的原发性头痛患者以偏头痛和紧张型头痛最多，其中无先兆的偏头痛为最常见的就诊类型。部分患者已存在药物过度使用性头痛，应引起足够的重视。     

原发性头痛与抑郁焦虑障碍共病的临床研究

目的:分析原发性头痛与抑郁焦虑障碍共病的临床特点及疗效评估.方法:纳入符合标准的105例门诊原发性头痛患者,分为共病组和非共病组,予以药物治疗并完成8周随访.分别于治疗前及治疗后4周、8周应用SF-12健康调查问卷及HIT-6量表评估患者生活质量,并记录头痛持续时间、频率、疼痛程度.结果:抑郁焦虑障碍在高、低频率头痛发作组中的OR值为3.277,95%置信区间(1.48,7.27).治疗前共病组的精神健康部分评分(MCS-12)较非共病组低(P<0.01),HIT-6评分比非共病组高(P<0.01);治疗后两组的生活质量和临床症状都较前明显改善(P<0.01),且治疗后2周共病组的头痛发作频率下降较非共病组慢(P<0.05).结论:原发性头痛患者其头痛频率的增加与抑郁焦虑障碍共病密切相关.合并有抑郁焦虑使头痛患者生活质量差,症状缓解慢,治疗疗程长.     

慢性偏头痛伴发焦虑抑郁障碍的调查分析

[目的]了解慢性偏头痛病人伴发焦虑或抑郁障碍的发生情况.[方法]采用焦虑自评量表（SAS）及抑郁自评量表（SDS）对本院门诊221例偏头痛患者的焦虑和抑郁程度进行评价.[结果]221例偏头痛患者中伴有焦虑者占72.4%,抑郁者65.6%,同时患焦虑抑郁者49.3%;另外伴有失眠者32.6%,乏力者21.2%,健忘者10.4%.[结论]慢性偏头痛患者多伴有焦虑抑郁情绪,了解偏头痛与焦虑抑郁的相互关系或相互影响,有助于提高偏头痛治疗的有效率.     

乌灵胶囊联合尼莫地平片治疗紧张型头痛疗效观察

目的:观察乌灵胶囊联合尼莫地平片治疗紧张型头痛的临床疗效。方法:将2011年2月至2013年8月收治的紧张型头痛患者68例随机分为治疗组和对照组各34例,对照组仅应用尼莫地平片治疗,治疗组在对照组治疗的基础上加用乌灵胶囊3粒/次,3次/d,疗程4周。两组根据临床相关症状(头痛程度、发作频率、持续时间)改善情况进行疗效评价,并于治疗前后行汉密尔顿焦虑量表(HAMA)和抑郁量表(HAMD)评分。结果:治疗组治愈11例,显效14例,好转6例,无效3例,总有效率91.17%;对照组治愈6例,显效11例,好转9例,无效8例。总有效率76.4%,治疗后治疗组的总有效率明显高于对照组(P0.01)。两组治疗后的焦虑和抑郁评分均优于治疗前,但治疗组明显优于对照组(P0.01)。结论:在尼莫地平治疗紧张型头痛的基础上,联合乌灵胶囊可提高疗效。建议临床推广应用。     

帕罗西汀治疗慢性紧张型头痛的疗效对照观察

慢性紧张型头痛(CTTH)是神经内科的常见病,由于发病率高,往往还伴有抑郁、焦虑等精神症状[1],如果得不到及时治疗,将会明显影响患者的工作效率及生活质量。本文总结本院2006年2月~2008年2月82例慢性紧张型头痛患者的治疗,报道如下。1资料与方法门诊和住院患者共82例,男29例,女5     

Airplane headache: a further case report of a young man

Headache with normal examinations and imaging, occurring during an airplane flight has been rarely reported. We present a young patient with a new type of headache that appeared during flights: take-off and landing of a plane and was not associated with other conditions. This airplane headache is rather rare in population and the pathophysiology of this type is not clear. Secondary causes must be ruled out before the diagnosis of a primary headache is made.     

Cluster headache prevalence. Vågå study of headache epidemiology

In the V?g? study of headache epidemiology, a search was made also for cluster headache. Of the available 18-65-year-old dalesmen, 1838 (88.6%) could be examined personally (O.S.) - 51.3% females and 48.7% males. Based on current International Headache Society criteria, cluster headache seemed to be present in seven dalesmen, one female and six males (corresponding to a total prevalence of 381 per 100 000; 95% confidence interval (CI) 153-783 per 100 000). Except for the female gender, the female case was fairly typical. In one case, there were short-lasting bouts ('minibouts'). It was felt that this also was a genuine case of cluster headache. If one excluded the latter case, there would be one female and five males [a prevalence of 106 per 100 000 for females, and 558 per 100 000 for males, giving a prevalence in the total population of 326 per 100 000 (95% CI 120-709 per 100 000)]. The confidence interval was considerable. This study therefore does not give a clear indication as to prevalence.     

An interregional comparative study of headache clinic populations

We present a comparative study between headache clinic populations from 2 inherently different regions of the United States. Using standardized methods, 1 of us (JFR) prospectively evaluated 578 new patients attending the headache clinic at the University of California in San Diego. In a similar manner, we subsequently evaluated 115 new patients presenting to the headache clinic at the University of South Alabama in Mobile, Alabama. We found few differences between the 2 populations. These differences more likely reflect regional variations in healthcare delivery or methodologic artifact than intrinsic dissimilarities.     

Clues in the Differential Diagnosis of Primary vs Secondary Cough,Exercise, and Sexual Headaches

Activity‐related headaches can be provoked by Valsalva maneuvers (“cough headache”), prolonged exercise (“exertional headache”) and sexual excitation (“sexual headache”). These entities are a challenging diagnostic problem as can be primary or secondary and the etiologies for secondary cases differ depending on the headache type. In this paper we review the clinical clues which help us in the differential diagnosis of patients consulting due to activity‐related headaches. Cough headache is the most common in terms of consultation. Primary cough headache should be suspected in patients older than 50 years, if pain does not predominate in the occipital area, if pain lasts seconds, when there are no other symptoms/signs and if indomethacin relieves the headache attacks. Almost half of cough headaches are secondary, usually to a Chiari type I malformation. Secondary cough headache should be suspected in young people, when pain is occipital and lasts longer than one minute, and especially if there are other symptoms/signs and if there is no response to indomethacin. Every patient with cough headache needs cranio‐cervical MRI. Primary exercise/sexual headaches are more common than secondary, which should be suspected in women especially with one episode, when there are other symptoms/signs, in people older than 40 and if the headache lasts longer than 24 hours. These patients must have quickly a CT and then brain MRI with MRA or an angioCT to exclude space‐occupying lesions or subarachnoid hemorrhage.     

Hydrogen sulphide headache and other rare, global headaches: Vågå study

One aim of the V?g? study of headache epidemiology was to depict the total panorama of headaches in a small-sized, Norwegian community at the end of the 20th century. In the present part of the study, a search was made for the rare, global headaches. Various, relatively unknown headache categories were observed, such as hydrogen sulphide intoxication (n = 2) after exposure to H(2)S ambient air concentrations of >or=100 p.p.m. In V?g?, nitroglycerine headache ('dynamite headache') proved to be a relatively frequent disorder (n = 13). This represents approximately 0.7% of the study group. A main reason for this, in all probability unusually high frequency is that there previously have been soapstone mines within the precincts of the parish. Another relatively frequently occurring headache followed exposure to wind (n = 7; 0.38%). Ice-cream headache was rare (n = 3; 0.16%), when only the general question was asked: 'other headaches?'. Approximately 7 years later, an ad hoc procedure was adopted: 50 parishioners who did not answer positively concerning ice-cream headache on the first examination were asked specific questions concerning ice-cream headache. Four had had such an experience, i.e. prevalence of 8%, which is 50 times higher than the original result, but still a rather low prevalence when compared with the mean prevalence from other studies: 39%. This demonstrates that the result as regards prevalence, even for a headache such as ice-cream headache, to a large degree depends upon the interview technique used.     

Epidemiology of fixed unilateral headaches

A fixed location unilateral headache suggests involvement of a precise nervous structure, and neuroimaging investigations are essential to seek to identify it. Nevertheless, side-locked primary headaches also occur, although they are rare. Side-locked primary headaches are more frequently found in the group of the short-lasting (≤ 4 hours) headaches but long-lasting headache forms may also present with the pain always on the same side, including migraine, tension-type headache, new daily persistent headache and cervicogenic headache. Future studies should address the issue whether patients with side-locked headache form differ from those with non-side-locked form both in terms of natural history and biological markers.
Among 63 consecutive chronic cluster headache patients seen by us from 1999 to 2007, 32 (51%) had side shift. We also found that the duration of the chronic condition was significantly longer in those with side shift than those without. The high frequency of side shift in chronic cluster headache should be considered when proposing surgical treatment for severe intractable forms of the disease.     

The clinical characteristics of new daily persistent headache

New daily persistent headache (NDPH) is a subtype of chronic daily headache. The literature on NDPH is scant and its true aetiology is unknown. A retrospective chart review was carried out from a computerized database at the Jefferson Headache Centre from August 1997 to May 2000 to identify patients with NDPH using the Silberstein et al. criteria. Forty women and 16 men were identified. Age of onset ranged from 12 to 78 years. The peak age of onset was the second and third decade in women and the fifth decade in men. Eighty-two per cent of patients were able to pinpoint the exact day their headache started. Onset occurred in relation to an infection or flu-like illness in 30%. A prior headache history was found in 38% of patients. A family history of headache was documented in 29%. The duration of daily headache ranged from 1.5 h to 24 h; 79% were continuous. Nausea occurred in 68% of patients, photophobia in 66%, phonophobia in 61%, and lightheadedness in 55%. Laboratory testing and neuroimaging in all patients was normal except for Epstein-Barr virus antibody titres, which were positive in 71% of seven patients tested, representing past infection. NDPH appears to be a female-predominant disorder, marked by a continuous daily headache with associated migrainous symptoms. Over 80% of patients could state the exact date their headache began. One-third of patients developed NDPH with a flu-like illness.