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1.
目的观察醒脑开窍针刺加头针法治疗对急性脑梗死的临床疗效。方法将310例脑梗死患者随机分成常规针刺组和醒脑开窍加头针组,比较其0、7、14 d美国国立卫生研究院卒中量表(NIHSS)、改良的Rankin量表(MRS)评分,分析其临床疗效。结果醒脑开窍加头针组治疗后7、14 d NIHSS评分和MRS评分与常规针刺组相比较均有明显改善,差异均有统计学意义(P均<0.01)。结论醒脑开窍加头针法可改善急性脑梗死神经功能缺损,有较好疗效。  相似文献   

2.
目的观察醒脑开窍针刺加头针法治疗对急性脑梗死的临床疗效及血清超敏C-反应蛋白(hs-CRP)水平的影响。方法 330例脑梗死患者随机分成常规针刺组162例和醒脑开窍加头针组168例,比较两组患者治疗0、7、14 d时美国国立卫生研究院卒中量表(NIHSS)评分、改良的Rankin量表(MRS)评分及血清hs-CRP水平变化。结果醒脑开窍加头针组治疗后7、14 d卒中量表(NIHSS)评分和改良的Rink量表(MRS)评分与常规针刺组相比较均有明显改善,差异有统计学意义(P<0.01)。治疗后两组血清hs-CRP水平均有所下降,醒脑开窍加头针组7、14 d hs-CRP水平低于常规针刺组(P<0.01)。结论醒脑开窍加头针可改善急性脑梗死患者神经功能缺损,降低其血清hs-CRP水平。  相似文献   

3.
目的观察醒脑开窍针刺加头针法治疗对急性脑梗死的临床疗效及对血清超敏C反应蛋白(hs-CRP)水平的影响。方法90例脑梗死患者随机分成单纯药物组30例,常规针刺组30例,醒脑开窍加头针组30例,比较其0、7d、14d美国国立卫生研究院卒中量表(NIHSS)、改良的Rankin量表(MRS)评分及hs-CRP水平。结果常规针刺可改善急性脑梗死患者的神经功能缺损,与单纯药物组无显著性差异;醒脑开窍加头针组神经功能缺损评分优于常规针刺组及单纯药物组(P〈0.05)。治疗前3组血清hs-CRP水平均高于正常对照值(P〈0.01),治疗后3组血清hs-CRP水平均有所下降,醒脑开窍加头针组7、14d hs-CRP水平低于常规针刺组及单纯药物组(P〈0.05)。结论醒脑开窍加头针可降低急性脑梗死血清hs-CRP水平,改善急性脑梗死神经功能缺损。  相似文献   

4.
目的探讨醒脑开窍针刺法对脑梗死恢复期患者神经功能及脑血流动力学的影响。方法选择我院2017年6月至2019年2月收治的70例脑梗死恢复期患者,随机将其分为对照组(n=35)与针灸组(n=35)。两组患者均采用常规西药治疗,针灸组在此基础上施加醒脑开窍针刺法。比较两组的临床疗效、神经功能、日常生活能力、脑血流动力学指标及预后情况。结果针灸组的治疗总有效率为94.29%,高于对照组的77.14%(P<0.05)。治疗15、30 d时,两组患者的NIHSS评分均低于治疗前,BI评分均高于治疗前,且针灸组优于对照组(P<0.05)。治疗15、30 d时,两组患者大脑中动脉Vs、Vd、Vm均较治疗前显著升高,PI、RI均较治疗前显著降低,且针灸组优于对照组(P<0.05)。治疗60 d后,针灸组的预后良好率为65.71%,高于对照组的40.00%(P<0.05)。结论醒脑开窍针刺法治疗脑梗死恢复期患者效果显著,能显著改善患者的神经功能、日常活动能力、脑血流动力学指标及预后。  相似文献   

5.
"醒脑开窍"针法治疗脑梗死疗效观察   总被引:13,自引:1,他引:12  
目的:观察“醒脑开窍”针刺疗法治疗脑梗死的临床疗效。方法:63例脑梗死患者按随机原则分为“醒脑开窍”针法组(治疗组,32例)和传统疗法组(对照组,31例)。两组均采用常规药物治疗,包括脱水、降颅压、营养神经及对症支持治疗。治疗组在常规药物治疗的基础上加用“醒脑开窍”针刺疗法,主穴:内关、人中、三阴交,副穴:极泉、尺泽、委中、风池、印堂、上星透百会,并随症状不同加减穴位;对照组在常规药物治疗的基础上加用传统针刺疗法,上肢取肩井、曲池、外关、合谷,下肢取足三里、阳陵泉、环跳、丰隆、昆仑等穴。两组均每日针刺2次,共15 d。治疗前后测定血液流变性,血脂,血、尿、粪及生化常规,外周血白细胞变化以及神经功能缺损程度评分(NDS);治疗后观察两组临床疗效。结果:治疗后治疗组和对照组总有效率分别为93.75%和67.74%,差异有显著性(2χ=4.85,P<0.01);两组在血液流变性、血脂、外周血白细胞计数及NDS评分均有明显改善,且治疗组更为显著(P<0.05或P<0.01)。结论:“醒脑开窍”针法在治疗脑梗死的临床疗效方面明显优于传统疗法。  相似文献   

6.
目的研究醒脑开窍针联合常规方法治疗脑梗死的疗效及对脑梗死患者炎症因子、神经功能缺损程度的影响。方法选取2017年4月至2019年4月该院收治的124例脑梗死患者为研究对象,采用随机数字表法将其分为对照组(常规药物治疗)和观察组(在对照组的基础上联合醒脑开窍针治疗),每组各62例。比较两组治疗有效率;比较两组治疗前后卒中量表(NIHSS)评分和改良Rankin量表(mRS)评分;比较两组治疗前后血流介导的血管扩张功能(FDM)、同型半胱氨酸(Hcy)、超敏C反应蛋白(hs-CRP)、白细胞介素(IL)-6及肿瘤坏死因子α(TNF-α)水平。结果观察组患者治疗有效率为90.32%,高于对照组的72.58%(P<0.05);观察组患者治疗后NIHSS和mRS评分均低于对照组(P<0.05),FDM水平高于对照组(P<0.05),Hcy、hs-CRP、IL-6、TNF-α水平均低于对照组(P<0.05)。结论醒脑开窍针联合常规方法治疗脑梗死疗效确切,可减轻患者的神经功能缺损程度,降低患者体内的炎性反应水平,改善血管内皮功能及预后,值得在临床推广使用。  相似文献   

7.
目的:观察温阳化瘀汤联合醒脑开窍针刺疗法对脑梗死恢复期患者NIHSS评分及生活质量的影响。方法:选取2017年1月~2018年6月在我院治疗的104例脑梗死恢复期患者作为研究对象,随机分为A组和B组,每组52例。A组在常规治疗的基础上加服温阳化瘀汤,B组在A组的治疗基础上加用醒脑开窍针刺疗法。比较两组患者治疗前后的美国国立卫生研究院卒中量表(National Institute of Health Stroke Scale,NIHSS)评分、ADL(Activities of Daily Living)评分、世界卫生组织生存质量测定简表(WHOQOL-BREF)评分和治疗总有效率。结果 :治疗后,B组的NIHSS评分低于A组,而ADL和WHOQOL-BREF评分高于A组,差异均有统计学意义,P<0.05;B组的治疗总有效率为96.15%,高于A组的84.62%,差异有统计学意义,P<0.05。结论:温阳化瘀汤联合醒脑开窍针刺疗法可有效提高脑梗死恢复期患者神经功能和生活质量。  相似文献   

8.
目的研究黄芪九物汤加减联合醒脑开窍针法对中风后偏瘫患者神经功能缺损(NIHSS)评分及生活质量的影响。方法选择2013年1月~2018年1月我院收治的130例中风后偏瘫患者作为研究对象,随机数字表法分为对照组和研究组各65例。给予对照组常规西药治疗及康复训练,研究组于对照组基础上加用黄芪九物汤加减及醒脑开窍针法。对比两组治疗效果、治疗前后NIHSS评分、运动功能(FMA评分)、生活质量(SS-QOL评分)。结果治疗结束后,两组NIHSS、FMA及SS-QOL分值均较治疗前改善,且研究组NIHSS分值低于对照组,FMA及SS-QOL分值均高于对照组(P0.05);研究组治疗总有效率为92.31%,高于对照组的75.38%(P0.05)。结论黄芪九物汤加减联合醒脑开窍针法治疗中风后偏瘫患者,能显著降低患者神经功能缺损程度,增强运动功能,改善生活质量,有效提高治疗效果。  相似文献   

9.
目的:探究醒脑开窍针法联合重复经颅磁刺激(rTMS)治疗脑梗死后血管性痴呆患者的疗效及对认知功能、血清指标及日常生活能力的影响.方法:将项城市中医院脑病科2017年10月至2019年10月期间109例符合纳入标准的脑梗死后血管性痴呆患者作为研究对象,随机分为2组,对照组54例给予rTMS治疗,观察组55例在对照组基础上加用醒脑开窍针法治疗,6周后观察2组患者的临床疗效、血清指标以及认知功能和日常生活能力.结果:观察组总有效率94.55%(52/55)比对照组79.63%(43/54)高(P<0.05);观察组MMP-2和MMP-9水平比对照组低,TIMP-1水平比对照组高(P<0.05);观察组ADL评分和MMSE评分比对照组高(P<0.05).结论:醒脑开窍针法联合rTMS治疗脑梗死后血管性痴呆患者效果确切,能够发挥通络益气和补血固本等作用,通过兴奋大脑皮层,增加脑部血氧供应和修复神经功能损伤等机制改善临床疗效,平衡血清中MMP-2、MMP-9和TIMP-1水平以及改善认知功能障碍,提高日常生活能力,值得临床推广使用.  相似文献   

10.
目的:探讨醒脑开窍针刺法在卒中后偏瘫患者治疗中的应用价值。方法:选取我院2016年11月~2018年8月收治的卒中后偏瘫患者102例,随机数字表法分为研究组和对照组各51例。对照组在常规治疗基础上接受康复训练,研究组于对照组基础上采取醒脑开窍针刺法治疗,两组均持续治疗4周。观察两组临床疗效,比较两组治疗前后神经功能、日常生活能力与肢体运动能力评分。结果:研究组治疗总有效率明显高于对照组(P0.05);治疗前,两组NIHSS、BI与FMA评分比较无显著性差异(P0.05);治疗后,研究组BI与FMA评分高于对照组,NIHSS评分低于对照组(P0.05)。结论:醒脑开窍针刺法在卒中后偏瘫患者治疗中的应用价值较高,可有效改善患者日常生活能力及肢体运动能力,恢复神经功能,提高疾病整体疗效。  相似文献   

11.
An open study in the Netherlands have investigated the efficacy of combination therapy with methylprednisolone(mPSL) and high-dose immunoglobulin (IVIg) for Guillain-Barré syndrome (GBS) patients. The study suggested that the combination therapy is more effective than treatment with IVIg alone. Following the study, randomized trial of the combination therapy for the GBS patients was performed by the Dutch GBS study group in 2004. The randomized trial revealed that it was associated with a slightly, but not significantly, higher percentage of patients who recovered by more than grade 1 in the disability score. In addition, the long-term outcome (52 weeks) of the combination did not significantly differ from that of non-combination therapy; however, the median time to independent ambulation tended to be shorter in patients undergoing the combination therapy. We have summarized the recent advances in our understanding of the therapy for the patients with GBS. GBS consists of at least two subtypes of acute peripheral neuropathy, such as acute motor axonal neuropathy (AMAN) and acute inflammatory demyelinating polyneuropathy (AIDP). It has been reported that the subtype of AMAN is morecommon in Japan, as compared with the Western countries. Further studies are needed to clarify the effectiveness of the combination therapy, because of the difference of the subtype between Japan and the Western countries.  相似文献   

12.
Elevated plasma levels of lipoprotein(a), Lp(a), represent a major, inherited risk factor for coronary heart disease, although the mechanism of its action remains unknown. Lp(a) is distinguished from the related LDL particle by the addition of apolipoprotein(a), apo(a). The presence of this large glycoprotein is likely to affect the binding of the particle to the LDL receptor and/or other receptors which may contribute to the atherogenic potential of Lp(a). Here we demonstrate the binding to macrophages of Lp(a) and pure recombinant apo(a) protein, via a specific, high-affinity receptor. This binding could lead to foam cell formation and the localization of Lp(a) to atherosclerotic plaques.  相似文献   

13.
Numerical and structural chromosomal abnormalities are common in hematological malignancies. Near-triploidy (58-80 chromosomes) is a numerical abnormality observed in 3% of adult cases of acute lymphoblastic leukemia. Near-triploidy is rare in myeloid lineage hematologic malignancies and compared to near-triploidy in lymphoid malignancies, near-triploidy in myeloid malignancies is associated with poor outcomes. Few studies on near-triploidy in myelodysplastic syndrome (MDS) have been reported, and the clinicopathologic significance of this condition is still unclear. Here, we report a novel case of MDS with near-triploidy and multiple structural chromosomal abnormalities: del(5q) combined with del(1p) and del(13q). These abnormalities were detected by cytogenetic analysis with array comparative genomic hybridization (CGH). Our results suggest that array CGH can be a useful tool for detecting chromosomal abnormalities in patients with MDS.  相似文献   

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The diagnosis of Lyme borreliosis is based on the recognition of typical clinical signs and is assisted by laboratory confirmation of borrelial infection. The aim of the present study was to assess the value of an immunofluorescence test (IFT) and an immuno (western) blot (WB) test for the detection of Borrelia burgdorferi sensu lato antibodies in patients with erythema migrans residing in Slovenia. We determined specific IgM and IgG antibodies in 117 patients with erythema migrans and 96 healthy persons using an IFT (in-house test) and a commercial WB test. Skin biopsies of erythema migrans lesions were cultured, and isolated strains were identified with PFGE. There were 66/117 (56.4%) culture-positive and 51/117 (43.6%) culture-negative patients. B. afzelii was found in 52/62 (84%) and B. garinii in 10/62 (16%) biopsies. IFT-IgM antibodies were established in 2/117 (1.7%) erythema migrans patients and in none of the control group, while WB-IgM antibodies were present in 56/117 (48%) patients with erythema migrans and 21/96 (22%) members of the control group (p = 0.002). IFT-IgG antibodies were demonstrated in 3/117 (2.2%) erythema migrans patients and 2/96 (4%) persons of the control group, while corresponding values for WB-IgG were 36/117 (31%) and 26/96 (27%), respectively (non-significant differences). IgM antibodies directed against p41 and OspC, and IgG antibodies directed against p41, p18 and OspC were frequently found in both erythema migrans patients and the control group. The only significant difference between erythema migrans patients and the control group in the WB test was in the reaction of IgM antibodies with OspC antigen, which was found in 54/117 (46%) erythema migrans patients and 18/96 (18.8%) healthy persons (p < 0.0001). The immune response in patients with erythema migrans was very similar to that of the control group determined with either the IFT or WB test.  相似文献   

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Thirty patients suffering from systemic lupus erythematosus (SLE) were treated with daily 20 mgs of piroxicam (Hotemin). The patients were in a mildly active stage of the disease, taking maintenance doses of corticosteroids. The duration of piroxicam therapy was 3 months. Allergy was observed in one case, intolerance (gastrointestinal symptoms, nausea, vomiting) in two; these resulted in the cessation of therapy. Twenty seven patients were on piroxicam therapy for 3 months. Signs of clinical activity diminished, corticosteroid requirement decreased, subjective complaints were reduced. The drug was tolerated. In 3 cases, due to mild water retention, diuretics were given. Gastrointestinal symptoms, transaminase elevation, changes in blood cell counts were not observed during the 3 months period.  相似文献   

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Nursing- and healthcare-associated pneumonia (NHCAP) has been proposed by the Japanese Respiratory Society as a new category of pneumonia considering the characteristics of the Japanese medical care environment. It is necessary to ascertain the epidemiology and clinical outcomes of NHCAP. A prospective study was conducted of patients with pneumonia who were hospitalized at our hospital from August 2011 to July 2012. We compared 192 cases of NHCAP with 114 cases of community-acquired pneumonia (CAP). Compared with CAP, NHCAP had a higher disease severity, higher 30-day mortality rate (10.9 vs. 3.5 %, P = 0.022), and longer length of hospital stay (median, 12 vs. 8 days, P < 0.001). Streptococcus pneumoniae was the most frequent causative pathogen in both NHCAP and CAP (33.9 vs. 34.8 %, P = 0.896). The incidence of atypical pathogens in NHCAP was low (1.7 %). Multidrug-resistant (MDR) pathogens were isolated more frequently in NHCAP than in CAP, but there was no significant difference (11.0 vs. 4.5 %, P = 0.135). Among 192 NHCAP patients, 122 (63.5 %) were aspiration pneumonia. Aspiration pneumonia was associated with poor outcomes and was considered a major characteristic of NHCAP. Our study suggested that many patients with NHCAP do not need broad-spectrum antibiotic therapy targeting MDR pathogens. Excess mortality in NHCAP patients is the result of patient backgrounds or disease severity rather than the presence of MDR pathogens.  相似文献   

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