磁共振T1ρ和T2 mapping成像对骨性关节炎早期软骨损伤的定量研究

目的 探讨磁共振T1ρ和T2 mapping生理成像对骨性关节炎早期软骨损伤的价值。方法 100例志愿者行膝关节软骨磁共振成像,包括快速自旋回波T1/T2加权序列（FSE T1WI/ T2WI）、自旋锁定T1ρ和T2 mapping成像。分别测量股骨软骨平均T1ρ和T2值,用SPSS18.0统计学软件比较各组间的差异。结果 ①共有86个膝关节516个观察面纳入研究,其中65例、143个关节面出现不同程度的软骨损伤,软骨损伤主要位于股骨内侧髁后部。T1ρ的敏感度和特异度均高于T2 mapping和T2WI。②重度OA、轻度OA、对照组平均T1ρ/T2值分别为：48.37?.80ms/48.67?.05ms、44.26?.16ms/45.78?.85ms、40.34?.10ms/42.62?.15ms,各组间T1ρ值有统计学差异（P值<0.05）,正常组与轻度OA组、轻度OA组与重度OA组T2值没有统计学意义。③ OA发病率与年龄呈中度正相关,T1ρ观察更明显（R2=57.9%,P值=0.000）。结论 T1ρ和T2 mapping成像能够发现早期软骨损伤,T1ρ敏感度和特异度更高,可进一步应用于骨性关节炎的早期诊断。     

T_(1p) MRI对膝关节软骨退行性变的临床应用价值

目的探讨T1p对膝关节软骨退行性变的临床应用价值。方法 20例OA患者的患侧膝关节行T1p、T2 mapping序列扫描,以T2 mapping序列作为对比,测量髌骨、股骨软骨的T1p、T2值,与20例正常组比较;同时计算各部分软骨的T1p、T2值Z-score的置信区间、Z-score的相关性(Pearson相关)及了解其分布情况。结果 OA组髌骨、股骨软骨T1P值分别为(50.01±4.23)ms、(53.80±4.38)ms,较正常组(45.12±0.92)ma、(45.42±0.84)ms高,两组间比较差异有统计学意义(t=5.077,P0.001;t=8.446,P0.001)。OA组与正常组软骨的T_1 p、T_2值之间具有相关性[OA组相关系数为0.548±0.170,置信区问为(0.396,0.812),正常组相关系数为(0.455±0.163),置信区间为(0.246,0.789)]。结论 OA患者中关节软骨T1p值升高,且T1p与T2值两者的变化具有一定的相关性。T1p与T2 mapping能互补的诊断关节软骨早期退变,两技术可作为临床诊断的检查方法。     

MRT2弛豫时间定量测定在研究关节软骨生物组织构成中的价值

目的探讨MRT2弛豫时间定量测定在研究关节软骨生物组织构成中的价值。方法20名健康成年男性志愿者和19名骨性关节炎（Osteoarthritis,OA）患者行膝关节矢状位TSE序列8回波扫描,在获得的图像上进行关节软骨B值的测量,分析志愿者软骨浅深层T2值、志愿者与OA患者的T2值之间差异。结果志愿者胫骨面关节软骨浅层的平均B值为（48．8±6．3）ms,深层的平均T2值为（44．3±5．7）ms;股骨面则为（52．1±5．7）ms和（47．7±5．3）ms,差异有统计学意义。（t=3．148和t=3．384,P〈0．01）,相应的T2图显示了B值的这种空间分布趋势。OA患者胫骨关节软骨的平均T2值为（56．0±9．1）ms,较健康志愿者膝关节胫骨关节软骨浅层的平均T2值要高,差异有统计学意义（t=3．446,P〈0．01）。结论应用MRT2弛豫时间定量测定可研究关节软骨生物组织构成及其变化,具有临床应用价值。     

软骨延迟增强磁共振成像诊断膝关节软骨早期退行性变

目的 探讨dGEMRIC用于诊断膝关节软骨早期退变的可行性和价值.方法 OA组30例退变膝关节患者经肘静脉注射马根维显后步行10 min使对比剂尽量弥散至关节软骨内,注射后2 h接受dGEMRIC扫描;对照组27个正常膝关节.于T1时间图中选取感兴趣区(ROI)测量T1值,对照组同时测量软骨浅深层的T1值.对照组与OA组、对照组浅层与深层的T1值行独立样本t检验.结果 OA组的T1值为(359.10±41.64)ms,对照组为(426.42±39.81)ms,差异有统计学意义 (t=-6.223, P<0.05);对照组髌骨软骨浅层T1值为(411.39±41.50)ms,深层为(468.40±45.05)ms,差异有统计学意义 (t=-4.838, P<0.05).另于OA组5例患者的软骨T1时间图中发现低信号区.结论 dGEMRIC通过定量分析关节软骨中GAG含量的变化来判断关节软骨是否有组织成分的丢失,是可用于诊断关节软骨早期退变的有潜力的方法 .     

T1ρMRI对膝关节软骨退行性变的临床应用价值

目的：探讨T1ρ对膝关节软骨退行性变的临床应用价值。方法20例OA患者的患侧膝关节行T1ρ、T2 mapping序列扫描,以T2 mapping序列作为对比,测量髌骨、股骨软骨的T1ρ、T2值,与20例正常组比较;同时计算各部分软骨的T1ρ、T2值Z-score 的置信区间、Z-score的相关性（Pearson相关）及了解其分布情况。结果 OA组髌骨、股骨软骨T1ρ值分别为（50.01±4.23）ms、（53.80±4.38）ms,较正常组（45.12±0.92）ms、（45.42±0.84）ms高,两组间比较差异有统计学意义（t＝5.077,P＜0.001;t＝8.446,P＜0.001）。OA组与正常组软骨的T1ρ、T2值之间具有相关性[OA组相关系数为0.548±0.170,置信区间为（0.396,0.812）,正常组相关系数为（0.455±0.163）,置信区间为（0.246,0.789）]。结论 OA患者中关节软骨T1ρ值升高,且T1ρ与T2值两者的变化具有一定的相关性。T1ρ与T2 mapping能互补的诊断关节软骨早期退变,两技术可作为临床诊断的检查方法。     

定量T2-mapping评价半月板退变与膝关节骨性关节炎的相关性

目的利用定量T2-mapping评价半月板退变与膝关节骨性关节炎(OA)之间的关系。方法收集85例OA患者患者(114个膝关节)行常规MR扫描、多回波自旋回波序列T2-mapping及膝站立位DR检查。对半月板损伤进行定性分级后,将患者分为病例组(半月板退变组,58例)和对照组(非半月板退变组,27例),分析两组关节软骨T2值的差异性,并验证半月板退变与软骨T2值的相关性。结果①病例组的软骨T2值(51.42±4.13)ms高于对照组(43.27±3.85)ms(P<0.05);②两组OA患者中内侧软骨单元的T2值均高于外侧软骨单元(P=0.009);③68.29%(84/123)的半月板损伤发生于内侧半月板的前角或后角;④半月板损伤级别与软骨T2值呈正相关(r=0.34);⑤病例组中30.08%(37/123)半月板退变处所对应的软骨单元T2值高于未发生退变处的软骨单元T2值。结论 T2-mapping评价半月板退变与OA之间呈正相关。     

T~2*-mapping成像用于骶髂关节软骨成像的初步研究

目的:采用T2*-mapping成像定量分析正常骶髂关节(SIJ)软骨T2*弛豫时间值,探讨磁共振T2*-mapping成像用于青年健康志愿者SIJ软骨研究的可行性。材料与方法:利用T2*-mapping成像对30名青年健康志愿者行5回波GRE序列双侧SIJ斜冠状面扫描,运用T2*图测量30例骶侧软骨平均T2*弛豫时间值,并进行统计学分析。结果:30名青年健康志愿者骶侧软骨T2*弛豫时间值平均为17.15±3.26 ms。30名正常青年健康志愿者中,15名男性和15名女性骶侧软骨T2*弛豫时间值分别约为18.66±3.17 ms和15.65±2.62 ms,差异有统计学意义(t=4.005,P0.05)。30名正常青年健康志愿者中,左侧和右侧骶侧软骨T2*弛豫时间值分别约为17.26±3.51 ms和17.05±3.04 ms,差异没有统计学意义(t=0.516,P0.05)。结论:T2*-mapping成像可用于测量正常青年人SIJ骶侧软骨的T2*值,可为临床骶髂关节炎(SIS)疾病的诊断和研究提供参考。由于SIJ髂侧面软骨太薄,T2*-mapping成像应用于SIJ髂侧面软骨研究仍面临挑战。     

磁共振T1ρ和T2mapping成像定量评价早期骨性关节炎

目的 探讨磁共振T1ρ和T2mapping成像评价骨性关节炎（OA）早期软骨损伤的价值。方法 对78例OA患者（轻度OA组50例,重度OA组28例）和23名正常人（正常组）行膝关节软骨MR扫描,包括FSET1W/T2W、自旋锁定T1ρ和T2mapping成像。分别测量股骨软骨平均T1ρ和T2值,采用SPSS18.0统计学软件比较各组间的差异。结果 共86个膝关节516个观察面纳入研究,其中正常组20名,轻度OA组41例,重度OA组25例。65例（143个关节面）出现不同程度软骨损伤,主要位于股骨内侧髁后部。重度OA、轻度OA及正常组平均T1ρ和T2值分别为（48.37±5.80）ms和（48.67±6.05）ms、（44.26±4.16）ms和（45.78±5.85）ms、（40.34±2.10）ms和（42.62±4.15）ms,各组间T1ρ值和T2值差异均有统计学差异（P<0.05）,重度OA组与正常组T2值差异有统计学差异（P<0.05）。结论 T1ρ和T2mapping成像可发现早期软骨损伤,T1ρ敏感度更高,可用于早期诊断骨性关节炎。     

MR T1ρ成像技术早期诊断膝骨性关节炎早期软骨损伤

目的 探讨MR T1ρ技术诊断早期骨性关节炎(OA)软骨损伤的临床应用价值。方法 纳入经临床和MRI确诊的OA患者75例及健康志愿者23名(对照组),进行常规MR及MR T1ρ成像。根据常规MRI表现,按Noyes分级将OA患者分为轻度OA组和重度OA组,比较不同OA组与对照组患者T1ρ值差异,分析年龄与T1ρ值的相关性。结果 膝关节T1ρ伪彩图对照组呈均一蓝色,轻度OA组呈斑片状绿色增高影,重度OA组色阶信号混杂。对照组、轻度OA组和重度OA组膝关节软骨平均T1ρ值为(39.18±2.05)ms、(44.00±3.33)ms和(47.57±3.57)ms,两两比较差异均有统计学意义(P均<0.05)。T1ρ值与年龄呈正相关(r=0.62,P<0.05)。结论 T1ρ成像可显示膝关节OA患者早期软骨损伤,有助于早期诊断OA。     

骨关节炎患者血清1,25(OH)_2D_3、IL-17和IL-10水平的变化及临床意义

目的探讨骨关节炎(OA)患者血清1,25-羟基维生素D3[1,25(OH)_2D_3]、白细胞介素(IL)17及IL-10水平变化及临床意义。方法采用酶联免疫吸附试验(ELISA)检测91例OA患者(OA组)及80名体检健康者(正常对照组)血清1,25(OH)_2D_3、 IL-17和IL-10水平,同时采用电化学发光法检测血清25-羟基维生素D3[25(OH)D3]水平。采用视觉模拟评分法(VAS)对OA患者的疼痛程度进行评分。采用Spearman相关分析评价各指标之间的相关性。结果与正常对照组比较,OA组血清1,25(OH)_2D_3、25(OH)D3、IL-10水平明显降低(P0.05),IL-17水平明显升高(P0.05)。按25(OH)D3水平将患者分为维生素D缺乏、不足和充足3组,维生素D缺乏组VAS评分明显高于维生素D不足组和维生素D充足组(P0.05),而维生素D不足组与维生素D充足组之间VAS评分差异无统计学意义(P0.05)。按VAS评分将患者分为轻度疼痛组、中度疼痛组和重度疼痛组。重度疼痛组和中度疼痛组血清1,25(OH)_2D_3水平均明显低于轻度疼痛组(P0.05);而重度疼痛组与中度疼痛组之间差异无统计学意义(P0.05)。Spearman相关分析显示,1, 2 5 (O H)_2D_3与IL-10呈正相关(r=0.778、P=0.002),与VAS和IL-17呈负相关(r值分别为-0.691、-?0.735,P值分别为0.01、0.007);VAS评分与IL-10呈负相关(r=-0.725,P=0.008),与IL-17呈正相关(r=0.699、P=0.010)。OA患者治疗后血清1,25(OH)_2D_3和IL-10水平明显高于治疗前(P0.05),但仍低于正常对照组(P0.05);血清IL-17水平明显低于治疗前(P0.05),但仍高于正常对照组(P0.05)。结论 1,25(OH)_2D_3可能与OA的发生及严重程度有一定关系。     

T2 mapping成像评价健康成年人腕关节三角纤维软骨复合体差异

目的 探讨MR T2 mapping成像评价正常成年人腕关节三角纤维软骨复合体（TFCC）差异的可行性。方法 对81名健康志愿者行腕关节MR T2 mapping成像，其中30名行双侧腕关节扫描，分为利手组和非利手组。经后处理获得T2 mapping伪彩图，测量桡侧软骨、三角纤维软骨盘（TFC）、纤维血管、类半月板及TFC尺侧附着处T2值。比较不同性别之间、利手组与非利手组之间腕关节软骨不同区域T2值差异。结果 腕关节软骨不同区域T2值差异有统计学意义（F=32.235，P<0.01）。纤维血管组织[（34.22±6.85）ms]与TFC尺侧附着处[（32.57±7.23）ms]、桡侧软骨[（41.37±7.04）ms]与类半月板[（39.26±8.88）ms]T2值差异无统计学意义（P均>0.05），其余软骨各区域间T2值两两比较差异均有统计学意义（P均<0.05）。不同性别间、利手组与非利手组间腕关节不同区域T2值差异均无统计学意义（P均>0.05）。结论 T2 mapping成像可直观显示腕关节TFCC形态，定量分析TFCC不同区域T2值变化，不受性别及是否利手的影响。     

Feasibility and safety of high-dose adenosine perfusion cardiovascular magnetic resonance

Background

Although previous studies have helped define the natural history of Duchenne Muscular Dystrophy (DMD)-associated cardiomyopathy, the myocardial pathobiology associated with functional impairment in DMD is not yet known. The objective of this study was to assess the distribution of transverse relaxation time (T2) in the left ventricle (LV) of DMD patients, and to determine the association of myocardial T2 heterogeneity to the severity of cardiac dysfunction. DMD patients (n = 26) and normal control subjects (n = 13) were studied by Cardiovascular Magnetic Resonance (CMR). DMD subject data was stratified based on subject age and LV Ejection Fraction (EF) into the following groups: A (<12 years old, n = 12); B (≥12 years old, EF ≤ 55%, n = 8) and C (≥12 years old, EF = 55%, n = 6). Controls were also stratified by age into Groups N1 (<12 years, n = 6) and N2 (>12 years, n = 5). LV mid-slice circumferential myocardial strain (ε_cc) was calculated using tagged CMR imaging. T2 maps of the LV were generated for all subjects using a black blood dual spin echo method at two echo times. The Full Width at Half Maximum (FWHM) was calculated from a histogram of LV T2 distribution constructed for each subject.

Results

In DMD subject groups, FWHM of the T2 histogram rose progressively with age and decreasing EF (Group A FWHM= 25.3 ± 3.8 ms; Group B FWHM= 30.9 ± 5.3 ms; Group C FWHM= 33.0 ± 6.4 ms). Further, FWHM was significantly higher in those with reduced circumferential strain (|ε_cc| ≤ 12%) (Group B, and C) than those with |ε_cc| > 12% (Group A). Group A FWHM was not different from the two normal groups (N1 FWHM = 25.3 ± 3.5 ms; N2 FWHM= 24.0 ± 7.3 ms).

Conclusion

Reduced EF and ε_cc correlates well with increased T2 heterogeneity quantified by FWHM, indicating that subclinical functional impairments could be associated with pre-existing abnormalities in tissue structure in young DMD patients.     

精囊的磁共振扩散成像初步研究

目的评价磁共振扩散成像对精囊病变的鉴别诊断价值.方法 75例患者行MR扩散成像检查,使用回波平面扩散张量成像序列检查,b值为0和1 000.测量其精囊、膀胱、盆底脂肪和直肠内气体的ADC值.40例获最终诊断结果,其中10例为前列腺癌侵犯精囊,9例为前列腺癌内分泌治疗后改变,9例为良性前列腺增生患者,12例为无前列腺和精囊症状的健康志愿者.结果 40例患者中36例(90%)获得精囊的ADC值.前列腺癌侵犯精囊的ADC值为[0.30±0.08(均值±标准差)]×10-3 mm2/s (n=8),较前列腺癌内分泌治疗后精囊的ADC值低(P<0.05).前列腺癌内分泌治疗后精囊的ADC值为(0.46±0.17)×10-3 mm2/s (n=8),较前列腺增生患者的精囊ADC值低(P<0.05).前列腺增生患者的精囊ADC值为(0.96±0.10)×10-3mm2/s (n=8),健康志愿者的精囊ADC值为(0.97±0.33)×10-3mm2/s (n=12),二者无显著性差异(P>0.05).各组间膀胱、盆底脂肪和直肠内气体的ADC值无显著性差异(P>0.05).结论 ADC值可用于精囊病变的鉴别诊断.     

QRS duration predicts outcomes in cardiac arrest survivors undergoing therapeutic hypothermia

BackgroundWhether the electrocardiography (ECG) serial changes predict outcomes in cardiac arrest survivors undergoing therapeutic hypothermia remains unclear.Methods and resultsThis retrospective observational study enrolled 366 adult nontraumatic cardiac arrest survivors who underwent therapeutic hypothermia in a tertiary transfer center during 2006–2018. The ECG at return of spontaneous circulation (ROSC), during hypothermia and after rewarming were analyzed. 295 cardiac arrest survivors were included. Compared with the survivors, the non-survivors had longer QRS durations at the ROSC (118.33 ± 32.47 ms vs 106.88 ± 29.78 ms, p < 0.001) and after rewarming (99.26 ± 25.07 ms vs 93.03 ± 19.09 ms, p = 0.008). The enrolled patients were classified into 4 groups based on QRS duration at the ROSC and after rewarming, namely (1) narrow–narrow (narrow QRS at ROSC and narrow QRS after rewarming, n = 156), (2) narrow–wide (n = 29), (3) wide–narrow (n = 87), and (4) wide–wide (n = 23) group. The wide–wide group had the worst survival rates [odds ratio (OR) = 0.141, p = 0.001], followed by the narrow–wide group (OR 0.223, p = 0.003) and the wide–narrow group (OR 0.389, p = 0.003).ConclusionsIn cardiac arrest survivors given therapeutic hypothermia, QRS durations at the ROSC, after rewarming and their changes may predict survival to hospital discharge.     

T2 mapping定量分析健康青年人肩关节软骨T2值

目的 探讨T2 mapping成像评价青年健康志愿者肩关节软骨构成成分的可行性,并定量分析肩关节软骨T2值。方法 对16名青年健康志愿者行双侧肩关节斜冠状位8回波T2 mapping成像,并经后处理获得伪彩图,将肩关节软骨三等分为外带、中带、内带,测量其T2值。比较外带、中带、内带间T2值的差异及不同性别间、左右侧间T2值差异。结果 肩关节软骨外带、中带、内带T2值分别为（38.67±2.82）ms、（38.41±2.52）ms、（36.49±1.80）ms,总体差异有统计学意义（F=7.789,P=0.001）,肩关节外带、中带软骨T2值均大于内带（P均<0.05）。肩关节软骨外带、中带及内带的左侧与右侧T2值、不同性别间肩关节软骨外带、内带T2值差异均无统计学意义（P均>0.05）。不同性别间肩关节软骨中带T2值差异有统计学意义（P<0.05）。结论 T2 mapping成像可用于评价肩关节软骨构成成分变化。     

Ferumoxytol Is Not Retained in Kidney Allografts in Patients Undergoing Acute Rejection

Purpose

To evaluate whether ultrasmall superparamagnetic iron oxide nanoparticle (USPIO)-enhanced magnetic resonance imaging (MRI) can detect allograft rejection in pediatric kidney transplant patients.

Procedures

The USPIO ferumoxytol has a long blood half-life and is phagocytosed by macrophages. In an IRB-approved single-center prospective clinical trial, 26 pediatric patients and adolescents (age 10–26 years) with acute allograft rejection (n = 5), non-rejecting allografts (n = 13), and normal native kidneys (n = 8) underwent multi-echo T2* fast spoiled gradient-echo (FSPGR) MRI after intravenous injection (p.i.) of 5 mg Fe/kg ferumoxytol. T2* relaxation times at 4 h p.i. (perfusion phase) and more than 20 h p.i. (macrophage phase) were compared with biopsy results. The presence of rejection was assessed using the Banff criteria, and the prevalence of macrophages on CD163 immunostains was determined based on a semi-quantitative scoring system. MRI and histology data were compared among patient groups using t tests, analysis of variance, and regression analyses with a significance threshold of p < 0.05.

Results

At 4 h p.i., mean T2* values were 6.6 ± 1.5 ms for native kidneys and 3.9 ms for one allograft undergoing acute immune rejection. Surprisingly, at 20–24 h p.i., one rejecting allograft showed significantly prolonged T2* relaxation times (37.0 ms) compared to native kidneys (6.3 ± 1.7 ms) and non-rejecting allografts (7.6 ± 0.1 ms). Likewise, three additional rejecting allografts showed significantly prolonged T2* relaxation times compared to non-rejecting allografts at later post-contrast time points, 25–97 h p.i. (p = 0.008). Histological analysis revealed edema and compressed microvessels in biopsies of rejecting allografts. Allografts with and without rejection showed insignificant differences in macrophage content on histopathology (p = 0.44).

Conclusion

After ferumoxytol administration, renal allografts undergoing acute rejection show prolonged T2* values compared to non-rejecting allografts. Since histology revealed no significant differences in macrophage content, the increasing T2* value is likely due to the combined effect of reduced perfusion and increased edema in rejecting allografts.

     

MRI和DTI评价犬急性脊髓损伤后的形态及功能改变

目的观察犬急性脊髓损伤后的形态和功能改变.方法制作犬T13脊髓左半横断损伤模型.分别于损伤前、损伤后1周行MRI和DTI(SSFSE序列扫描,b=500 s/mm2,扩散敏感梯度方向=13)检查,测量手术侧和非手术侧的ADC值及FA值,并对结果进行统计学分析.结果正常犬脊髓左、右侧的ADC值为(1.00±0.15)×103mm2/s和(1.01±0.17)×10-3mm2/s,FA值为0.59±0.11和0.60±0.08,左右两侧无明显差异.脊髓损伤后手术侧ADC值升高为(1.65±0.45)×10-3mm2/s(t=4.366,P=0.001)、FA值降低为0.30±0.17(t=-3.749,P=0.003);非手术侧无明显变化.结论DTI能对实验性脊髓损伤后的观察提供有价值的信息.     

Enzyme-linked immunosorbent assay (ELISAs) for metalloproteinase derived type II collagen neoepitope, CIIM--increased serum CIIM in subjects with severe radiographic osteoarthritis

ObjectivesIn joint degenerative diseases, the collagens are degraded by matrix metalloproteinases and protein fragments are released to serum as potential biomarkers.MethodsA collagen type II specific neoepitope, CIIM, was identified (…RDGAAG¹⁰⁵³) by mass spectrometry. Two ELISAs against the neoepitope were developed. CIIM was measured in cartilage explants in the presence or absence of protease inhibitors. CIIM was measured in OA synovial fluid (n = 51) and serum (n = 156). Knee OA was graded by standard Kellgren–Lawrence (KL) score.ResultsThe ELISAs showed good technical performance; CV%, < 13%. CIIM release from cartilage explants was blocked by the MMP inhibitor. CIIM was detected in synovial fluid. Furthermore, serum CIIM levels were significantly higher (P < 0.05) in those individuals with mild or severe OA than in those with no OA.ConclusionWe developed a new biomarker for joint degenerative diseases, which we demonstrated was derived from MMP-degraded type II collagen.     

MRI诊断女子排球运动员髌腱腱病

目的 探讨女子排球运动员髌腱腱病(PT)的MRI表现。方法 回顾性分析34名中国国家女子排球队运动员60个膝关节的MRI资料。结果 60个膝关节中,41个(26例)有PT(PT组),患病率76.47%,其中信号增强2级以上占82.93%(34/41)。13名19个膝关节阴性为对照组。PT组髌腱近端、中点、下止点前后径分别为(9.21±2.31)mm、(5.39±1.01)mm、(6.53±1.32)mm,与对照组相比差异有统计学意义(P<0.01)。PT组髌腱近端前后径与分级相关(r=0.334,P<0.01)。PT急性期髌腱近端增粗,T1WI低信号,T2WI中、高信号,FS-PDWI高信号;慢性期髌腱近端呈"V"形增粗增厚,T1WI低信号,T2WI中、低信号,FS-PDWI中等信号。髌腱近端后缘紊乱不清晰、髌腱中部和下止点信号增强以及髌骨下极增生等在两组间差异均有统计学意义(P<0.05)。所有患膝可见髌骨下极不规则片状、大小不一的信号增强。结论 女子排球运动员PT患病率较高。MRI有助于明确诊断、分期分级,鉴别髌骨下极损伤,监控康复效果以及评估运动能力。