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1.
高压氧治疗对脑梗死患者血液流变学及LPO、SOD的影响   总被引:1,自引:0,他引:1  
【目的】研究高压氧治疗对脑梗死患者血液流变学及血清脂质过氧化物 (LPO)、超氧化物歧化酶(SOD)的影响。【方法】脑梗死患者 72例 ,随机分成高压氧组 (高压氧加药物治疗 )和对照组 (单纯药物治疗 )各 36例。治疗前及治疗后 2 0d检测血液流变学指标 ,LPO和SOD。【结果】高压氧组总有效率 91.7% ,对照组 6 6 .7% ,两组疗效差异有显著性意义 (P <0 .0 1) ;高压氧组血液流变学指标较治疗前明显改善 ,接近正常水平 ,对照组血液流变学亦有改善 ,但不如高压氧组明显 ;两组治疗前后相比差异有显著性 ;高压氧组LPO明显下降 ,SOD明显升高 ,治疗前后差异显著 (P <0 .0 1) ,而对照组无明显改善。【结论】高压氧治疗可明显改善脑梗死患者的血液流变学指标 ,提高SOD水平 ,降低LPO水平 ,并获得较好的临床治疗效果。  相似文献   

2.
前列腺素E_1治疗老年糖尿病足疗效观察   总被引:1,自引:0,他引:1  
目的 :观察脂化前列腺素E1对糖尿病足 (DF)的疗效。方法 :将 5 6例DF患者随机分为 2组 ,在基础治疗相同的情况下 ,治疗组 36例采用脂化前列腺素E1治疗 ,对照组 2 0例采用 6 5 4 2注射液治疗。观察脂化前列腺素E1对DF的下肢动脉血流动力学、肌电图、血液流变学、血脂的影响。结果 :治疗组总有效率为 83 .33 % ,对照组为 45 .0 0 % (P <0 .0 1) ,治疗组疗效优于对照组。在改善患者下肢动脉血流动力学、肌电图、血液流变学、血脂方面 ,治疗组亦优于对照组(P <0 .0 1~ 0 .0 5 )。结论 :脂化前列腺素E1治疗DF有较好疗效  相似文献   

3.
目的探讨高压氧(HBO)对糖尿病足的治疗效果。方法内分泌科收治的糖尿病足患者70例,随机分为2组:对照组35例采用常规治疗,观察组35例在对照组基础上加高压氧治疗,疗程30d。结合2组的临床表现、下肢动脉峰值血流速度和肌电图评价疗效。结果治疗后观察组总有效率(82.86%)较对照组(62.86%)增高,但差异无统计学意义(P>0.05);观察组下肢动脉峰值血流速度和神经传导速度均高于对照组(P均<0.05)。结论高压氧可以改善糖尿病足患者下肢的血流速度和周围神经传导速度,促进溃疡愈合,是治疗糖尿病足的有效方法。  相似文献   

4.
高压氧治疗糖尿病足的临床价值分析   总被引:3,自引:0,他引:3  
目的探讨高压氧对糖尿病足的治疗价值。方法糖尿病足患者58例,高压氧组(HBO)31例,药物治疗基础上加高压氧治疗1 h/d,共30 d;对照组27例,给予传统药物治疗。观察两组患者治疗前及治疗2个月后患者超敏C反应蛋白(hs-CRP)、纤维蛋白原(FIB)、下肢血流峰值的变化,并且判断两组治疗2个月后疗效。结果两组患者治疗前,超敏C反应蛋白、纤维蛋白原、下肢血流速度差异均无显著性(P>0.05);治疗2个月后,HBO组患者超敏C反应蛋白、纤维蛋白原均低于治疗前及对照组治疗后(P<0.01),下肢动脉血流速度高于治疗前及对照组治疗后(P<0.01)。治疗2个月后,对照组总有效率为70.37%(19/27),高压氧组总有效率为83.87%(26/31),两组比较差异有统计学意义(P<0.01)。结论高压氧组对糖尿病足的治疗效果明显优于单用药物治疗,是一种安全有效的治疗方法。  相似文献   

5.
目的观察综合康复疗法对糖尿病足的临床疗效。方法将98例糖尿病足患者分为常规治疗组50例,只给予内科常规治疗;综合康复组48例,在内科常规治疗基础上加用综合康复疗法。结果治疗1个月后,下肢动脉血管多普勒检测显示,综合康复组糖尿病足0级患者的血流参数改善更明显(P〈0.05);治疗2个月后,综合康复组患者疗效明显优于常规治疗组(P〈0.01)。结论综合康复疗法治疗糖尿病足疗效明显,有利于糖尿病足尽早康复。  相似文献   

6.
目的 探讨高压氧治疗高海拔地区糖尿病足的治疗作用.方法 将36例确诊为糖尿病足的患者按自愿原则分为两组,每组18例.对照组进行常规治疗,观察组在对照组的基础上行高压氧治疗,依据Wenger疗效标准进行效果评价.结果 观察组总有效率明显优于对照组(P<0.05),治愈时间明显缩短.结论 高压氧可以有效改善糖尿病足的血液循环,促进糖尿病足早期康复,对提高患者生活质量有积极作用.  相似文献   

7.
目的:评价下肢血管介入治疗糖尿病足的临床价值及预后情况.方法:将56例2型耱尿病伴糖尿病足并有外科截肢手术指征患者分为2组.观察组(21例)给予下肢动脉血管成形术+药物治疗+局部换药;对照组(35例)给予药物治疗+局部换药.分别在术后第5,30,60,90天观察并评价2组患者临床症状、下肢动脉血管内径及足部渍疡愈合情况、溃疡愈合时间、住院天数、截肢率.结果:观察组临床症状、下肢动脉血管内径、溃疡愈合情况、溃疡愈合时间、住院天数及截肢率明显优于对照组(P<0.05).结论:糖尿病足患者行下肢血管介入手术治疗效果满意,可以降低患者病残率.  相似文献   

8.
目的探讨高压氧联合西洛他唑治疗糖尿病足的临床价值。方法选取2014年6月至2016年7月该院确诊为糖尿病足患者90例,采用随机数字表法分为观察组和对照组,每组各45例。对照组在基础治疗基础上给予西洛他唑治疗,观察组在对照组基础上加用高压氧治疗。观察两组临床疗效,以及血液流变学、血液指标和血浆纤溶指标变化。结果观察组治疗总有效率(91.11%)明显高于对照组(71.11%),差异有统计学意义(P0.05);观察组治疗后全血黏度(高切、低切)、红细胞比容明显低于对照组(P0.05);观察组治疗后糖化血红蛋白(HbA1c)、同型半胱氨酸(Hcy)和超敏C反应蛋白(hs-CRP)水平明显低于对照组(P0.05);观察组治疗后纤维蛋白原、组织型纤溶酶原激活物水平明显优于对照组(P0.05)。结论高压氧联合西洛他唑能有效改善糖尿病足患者HbA1c、Hcy、hs-CRP水平,促进创面愈合,提高临床治疗效果。  相似文献   

9.
高压氧治疗不同年份阿片依赖康复期患者的疗效分析   总被引:2,自引:1,他引:1  
目的 探讨高压氧对阿片依赖康复期的疗效和预防复吸的作用。方法 不同年份的两组阿片依赖康复期患者 ,分为高压氧治疗组和对照组 ,观察两组间稽延性戒断症状和 2个月与 1年内的复吸情况。结果 同年份高压氧治疗组稽延性戒断症状低于对照组 (P <0 .0 5 )、近期复吸者低于对照组 (P <0 .0 5 )、远期复吸比较无显著性差异 (P >0 .0 5 ) ;不同年份高压氧治疗对稽延性戒断症状的疗效无显著性差异 (P >0 .0 5 )。结论 高压氧对消除阿片依赖康复期患者的稽延性戒断症状疗效肯定 ,并通过消除稽延性戒断症状降低近期复吸 ;对远期复吸的作用不肯定  相似文献   

10.
香丹注射液对脑梗死患者血液流变学的干预作用   总被引:1,自引:0,他引:1  
目的 :研究香丹注射液对脑梗死患者血液流变学的干预作用。方法 :5 0例脑梗死患者 ,按随机原则分为 2组 ,观察组应用香丹注射液治疗 ,对照组应用脑活素治疗 ,2周为 1个疗程并进行观察。结果 :观察组全血比粘度、血浆比粘度、红细胞电泳时间、纤维蛋白原、血小板粘附率等指标较治疗前有明显好转 (P <0 .0 5 ) ;对脑梗死患者红细胞变形性的影响 ,2组治疗后均较治疗前明显提高 (P <0 .0 1 ) ,但 2组间比较无明显差异 (P >0 .0 5 )。结论 :香丹注射液有改善中风患者血液流变学及红细胞变形性的作用 ,对脑梗死有确切的疗效。  相似文献   

11.
Hyperbaric oxygen in diabetic gangrene treatment   总被引:4,自引:0,他引:4  
We treated a group of 18 hospitalized adult diabetic patients (all with retinopathy, 17 with symptomatic neuropathy, and 6 with macroangiopathy) presenting with gangrenous lesions of the foot by a combined regime consisting of strict metabolic control, daily debridement of necrotic tissues, and daily hyperbaric oxygen (HBO) treatments given in a multiplace oxygen chamber. Another group of 10 adult subjects with comparable foot lesions (all with retinopathy, 9 with symptomatic neuropathy, and 4 with macroangiopathy) was treated in exactly the same way except for HBO. In the test treatment group, 16 patients were healed, and the remaining 2 showed no improvement and later underwent amputation. The number of HBO treatments required for healing was significantly related to the size of gangrenous lesions. In the non-HBO-treated group, only 1 patient improved, 5 of 10 showed no change, and 4 of 10 worsened until leg amputation was unavoidable. Comparison of the two groups by chi 2-test revealed a highly significant difference (P = .001). In practical terms, HBO treatment drastically reduced leg amputations in patients so treated in the last 3 yr compared with earlier and current figures for patients not receiving HBO treatment.  相似文献   

12.
OBJECTIVE: To study the effect of systemic hyperbaric oxygenation (HBO) therapy on the healing course of nonischemic chronic diabetic foot ulcers. RESEARCH DESIGN AND METHODS: From 1999 to 2000, 28 patients (average age 60.2 +/- 9.7 years, diabetes duration 18.2 +/- 6.6 years), of whom 87% had type 2 diabetes, demonstrating chronic Wagner grades I-III foot ulcers without clinical symptoms of arteriopathy, were studied. They were randomized to undergo HBO because their ulcers did not improve over 3 months of full standard treatment. All the patients demonstrated signs of neuropathy. HBO was applied twice a day, 5 days a week for 2 weeks; each session lasted 90 min at 2.5 ATA (absolute temperature air). The main parameter studied was the size of the foot ulcer measured on tracing graphs with a computer. It was evaluated before HBO and at day 15 and 30 after the baseline. RESULTS: HBO was well tolerated in all but one patient (barotraumatic otitis). The transcutaneous oxygen pressure (TcPO(2)) measured on the dorsum of the feet of the patients was 45.6 +/- 18.1 mmHg (room air). During HBO, the TcPO(2) measured around the ulcer increased significantly from 21.9 +/- 12.1 to 454.2 +/- 128.1 mmHg (P < 0.001). At day 15 (i.e., after completion of HBO), the size of ulcers decreased significantly in the HBO group (41.8 +/- 25.5 vs. 21.7 +/- 16.9% in the control group [P = 0.037]). Such a difference could no longer be observed at day 30 (48.1 +/- 30.3 vs. 41.7 +/- 27.3%). Four weeks later, complete healing was observed in two patients having undergone HBO and none in the control group. CONCLUSIONS: In addition to standard multidisciplinary management, HBO doubles the mean healing rate of nonischemic chronic foot ulcers in selected diabetic patients. The time dependence of the effect of HBO warrants further investigations.  相似文献   

13.
OBJECTIVE: To document peer-reviewed medical publications that have reported on hyperbaric oxygen (HBO) therapy as an adjunct to standard lower-extremity wound care, focusing on publications dealing with the diabetic foot. RESEARCH DESIGN AND METHODS: A review of the medical literature was conducted using MEDLINE. Research articles involving HBO treatment and the diabetic foot were critiqued to identify factors that may have been a source of bias. RESULTS: Of the published reports on human studies, seven involved diabetes-related foot pathology. Five of these studies, two of which were randomized, included a control group that did not receive HBO therapy The controlled diabetic foot studies included an average of 28 subjects in the HBO therapy group (range 10-62) and an average of 16.2 subjects in the non-HBO control group (range 5-33). Most of the published reports have several potential sources of bias, including, but not limited to, inadequate evaluation of comorbid conditions relevant to wound healing, small sample size, and poor documentation of wound size or severity. Four of the seven reports involving the diabetic foot were published by a group of researchers at the University of Milan between 1987 and 1996. CONCLUSIONS: Additional randomized placebo-controlled clinical trials in large diabetic populations would further lend credence to the presumption that HBO therapy improves clinical outcomes. Given the relatively high cost of this treatment modality, perhaps a more acute awareness of the medical literature would reduce the economic burden that HBO therapy imposes on care providers that are financially at risk.  相似文献   

14.
ObjectiveTo assess the efficacy and safety of hyperbaric oxygenation (HBO) therapy as adjunctive treatment for diabetic foot ulcers with a systematic review and meta-analysis of the literature.MethodsMEDLINE, EMBASE, and the Cochrane Library were searched to find relevant articles published up to April 20, 2012, without restriction as to language or publication status. All controlled trials that evaluated adjunctive treatment with HBO therapy compared with treatment without HBO for chronic diabetic foot ulcers were selected. A meta-analysis was performed to assess the efficacy and safety of hyperbaric oxygen in managing foot ulcers.ResultsThirteen trials (a total of 624 patients), including 7 prospective randomized trials, performed between January 1, 1966, and April 20, 2012, were identified as eligible for inclusion in the study. Pooling analysis revealed that, compared with treatment without HBO, adjunctive treatment with HBO resulted in a significantly higher proportion of healed diabetic ulcers (relative risk, 2.33; 95% CI, 1.51-3.60). The analysis also revealed that treatment with HBO was associated with a significant reduction in the risk of major amputations (relative risk, 0.29; 95% CI, 0.19-0.44); however, the rate of minor amputations was not affected (P=.30). Adverse events associated with HBO treatment were rare and reversible and not more frequent than those occurring without HBO treatment (P=.37).ConclusionsThis meta-analysis reveals that treatment with HBO improved the rate of healing and reduced the risk of major amputations in patients with diabetic foot ulcers. On the basis of these effects, we believe that quality of life could be improved in selected patients treated with HBO.  相似文献   

15.
Myocardial diastolic dysfunction is the relaxation abnormality of ventricles that limits the diastolic filling and generally precedes diastolic heart failure. Diastolic dysfunction is a common finding in diabetes. Diabetic patients receive hyperbaric oxygen (HBO) therapy for non-healing lower extremity ulcers, and exposure to HBO therapy is known to influence cardiovascular functions. This study was designed to evaluate the effect of HBO therapy on myocardial diastolic function in diabetic patients. Thirty diabetic patients (18 male and 12 female, 59.9 +/- 10 years old), who were planning to undergo HBO therapy, were consecutively enrolled. Myocardial diastolic function was evaluated by pulsed wave Doppler echocardiography and tissue Doppler echocardiography before the first HBO therapy and after the tenth HBO therapy session. HBO therapy improved the relaxation capability of left ventricular myocardium, which was reflected by reduction in E wave deceleration time of mitral valve inflow (286.1 +/- 65.8 msec vs 214.3 +/- 32.1 msec, p < 0.05). HBO therapy also affected favorably the diastolic filling dynamics of right ventricle, which was partially reflected by the changes in E wave peak velocity of tricuspid valve inflow (0.48 +/- 0.07 m/sec vs 0.46 +/- 0.09 m/sec, p < 0.05). Tissue Doppler parameters of mitral lateral annulus, which are better correlated with ventricular relaxation, tended to be improved after HBO therapy, but the degree of improvement was not statistically significant. In conclusion, we suggest that HBO therapy may improve the myocardial diastolic function of diabetic patients when applied repetitively.  相似文献   

16.
彩色多普勒超声评价糖尿病足患者下肢动脉病变   总被引:25,自引:0,他引:25  
目的 探讨下肢动脉病变与糖尿病足之间的关系。 方法 超声检查糖尿病足、糖尿病不合并糖尿病足息者和健康对照组各30例,将下肢动脉分为8个节段,二维超声评价管径、内一中膜厚度(IMT)和管径狭窄率,彩色多普勒显像观察血流充盈并测量流速。 结果 糖尿病足组息侧与对侧下肢动脉IMT及狭窄程度无明显差异(t检验,P〉0.05)。与对照组相比,糖尿病足组IMT厚,管径狭窄程度重(方差分析,P〉0.05)。 结论 糖尿病足患者下肢动脉硬化明显,患侧与对侧病变程度无显著差异。  相似文献   

17.
目的探讨硫辛酸注射液对糖尿病足患者氧化应激状态与局部微循环的影响。方法选取74例糖尿病足患者,随机分为2组。对照组进行常规的糖尿病足治疗,观察组则在对照组常规治疗的基础上加用硫辛酸注射液进行治疗。比较2组治疗前后的氧化应激状态与局部微循环指标。结果 2组治疗后的氧化应激状态与局部微循环指标均显著优于治疗前,且观察组显著优于对照组(P0.05)。结论硫辛酸注射液能改善糖尿病足患者的氧化应激状态与局部微循环状态。  相似文献   

18.
下肢动脉闭塞性病变对糖尿病足患者溃疡愈合的影响   总被引:2,自引:2,他引:0  
郭春兰 《护理学报》2008,15(4):43-45
目的 观察糖尿病患者下肢动脉闭塞性病变对糖尿病足溃疡疗效及预后的影响,为临床治疗糖尿病足溃疡提供参考。方法 75例糖尿病足溃疡患者用彩色多谱勒超声诊断仪检测下肢动脉血管情况。根据检测结果 分为两组:有下肢动脉闭塞性病变30例为观察组,无下肢动脉闭塞性病变45例为对照组。两组在相同病变程度和相同治疗手段的情况下,溃疡局部清创后,用敏感抗生素+普通胰岛素+生理盐水混合液换药。观察两组溃疡处肉芽组织生长时间,溃疡愈合时间及截肢率。结果 PAD组溃疡面肉芽组织生长时间和溃疡愈合时间明显长于对照组(P〈0.05),截肢率达16.6%;而对照组截肢率为0。结论 下肢动脉闭塞性病变不仅是糖尿病足溃疡的主要原因,而且也是影响疗效及预后的重要因素。提示在处理有下肢动脉闭塞性病变的糖尿病足溃疡时,可根据病变的严重程度,采取有效的治疗措施,改善下肢动脉血流及微循环,促进局部溃疡愈合。  相似文献   

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