72例老年脂肪肝的血脂和血液流变学特征分析

[目的]探讨老年脂肪肝的血液流变学及血脂异常特征及临床意义.[方法]检测老年脂肪肝患者72例和正常对照63例全血比粘度、血浆比粘度、血沉、血沉K值、压积和纤维蛋白原及甘油三脂,胆固醇等指标,计算红细胞聚集指数.[结果]脂肪肝患者的全血比粘度、血浆比粘度、压积、红细胞聚集指数和纤维蛋白原及血脂指标较正常对照组显著升高( P <0.01).血沉和血沉K值较正常对照组低( P <0.01;0.02).[结论]脂肪肝患者血液流变性及血脂明显异常,高血脂及血液粘度增加可能促使脂肪肝的形成.     

2型糖尿病患者的血脂、血液流变学的临床观察

目的探讨2型糖尿病患者血脂水平与血液流变学对糖尿病的影响。方法检测65例2型糖尿病患者甘油三酯(TG)、胆固醇(CH)、及血液流变学各项指标。结果2型糖尿病组的甘油三酯、胆固醇、全血粘度、血浆粘度、纤维蛋白原等指标明显高于对照组。结论2型糖尿病患者存在明显的血脂、血液流变学指标的异常,临床治疗上应重视降脂、扩容降低血粘度改善微循环的治疗。     

茶色素治疗脂肪肝病人血液流变性改变分析

本文应用茶色素治疗１０００例脂肪肝病人，总有效率为９１．９％，分析脂肪肝病的血液流变学特点，１．脂肪肝病人多伴有血脂升高；２．血液粘滞度增高；３．血液流变学异常，经茶色素１－２疗程。血脂、血液粘度降至正常血液流变学明显改善，治疗前后各项指标比较有显著性差异（Ｐ〈０．０５，Ｐ〈０．０１）。提示茶色素可作为治疗脂肪矸的良药。     

脂肪肝患者血液流变学指标检测分析

目的探讨脂肪肝患者血液流变学指标检测的相关性分析。方法使用LG-R-80A血液流变仪对210例脂肪肝患者进行血液流变学检测。结果脂肪肝患者平均全血比粘度、血浆比粘虚、红细胞聚集指数明显高于正常组（P〈0．01）。结论脂肪肝息者血液流变学的变化，可使微循环发生变化，引起微循环障碍。是心脑血管疾病发生率增高又一重要危险因素。     

高脂血症患者血液流变学变化的初步探讨

本文通过对３１９例高脂血症患者７项血液流变学指标测定，并与２０４例血脂正常者进行比较，结果表明，高脂血症患者全血低切粘度，全血高切粘度，红细胞压积，血浆粘度，血沉，纤维蛋白原，红细胞聚集指数７项血液流变学指标显著高于血脂正常者（Ｐ＜０．０５或Ｐ＜０．０１），提示高脂血症患者的血液粘滞度明显高于血脂正常者．     

血液流变学指标在代谢综合征中的临床应用价值

目的 调查研究69例胰岛素抵抗指数高值组和69例低值对照组的血液流变学指标水平，探讨在代谢综合征中血液流变学检测的临床意义。方法应用普利生N6A＋全血粘度仪及LBY-NW1血浆粘度汁检测血液流变学指标，并结合血压、血糖、血脂、胰岛素等相关指标进行研究。结果胰岛素抵抗指数高值组和低值对照组血流变指标有显著差异。结论血液流变学检测在胰岛素抵抗综合征形成过程中有显著升高，进行血流变指标检测在该疾病的早防早治中具有重要意义。     

Ⅱ型糖尿病患者血脂、血液流变学变化分析

目的 分析Ⅱ型糖尿病患者血脂与血液流变学指标变化和糖尿病患者血脂与血浆黏度的相关性.方法 检测187例Ⅱ型糖尿病患者和200名健康体检者血脂和血液流变学指标,并进行统计学分析;对糖尿病患者血脂含量与血浆黏度作相关性分析.结果 Ⅱ型糖尿病患者血脂及血液流变学多数指标存在明显的异常改变,与对照组相比有显著性差异(P＜0.05);Ⅱ型糖尿病患者血脂与血浆粘度呈正相关.结论 Ⅱ型糖尿病患者常常合并存在血脂、血液流变学的改变,表现为高脂血症和高黏血症.对糖尿病患者及时做血脂、血液流变学检测和及早纠正高脂血症、高黏血症,是改善糖尿病的预后和延缓糖尿病慢性并发症的重要措施.     

高脂血症患者血液流变学实验观察

目的观察血脂增高对血液流变学指标的影响.方法测定44例三型高脂血症患者和43例正常对照者血液流变学和血脂指标,并对结果进行统计学分析.结果除女性高甘油三脂血症组(高TG组)外,三型高脂血症患者的全血表现粘度、还原粘度大多有不同程度的改变(P<0.05),其中,高胆固醇血症组、混合型高脂血症组比高TG组改变明显,三型高脂血症患者的红细胞聚集指数(女性高TG组除外)与对照组比较有显著性差异(P<0.05),红细胞刚性指数、血浆粘度与对照组比较无显著性差异(P>0.05).结论高脂血症可引起血液流变学指标的异常改变,其中胆固醇增高的影响尤为显著.     

慢性盆腔炎患者血液流变学指标的变化

目的 观察慢性盆腔炎患者血液流变学指标的改变。方法 对70例慢性盆腔炎患者及40例正常对照组进行血液流变学指标检测。结果 慢性盆腔炎患者的全血粘度、血浆粘度、血沉、全血还原粘度、血沉方程K值、红细胞聚集指数及刚性指数与正常对照组比较，均有显著性差异（P＜0．01）。结论 慢性盆腔炎患者血液流变学指标的改变，可引起机体代谢和功能失调。     

通心络治疗高脂血症疗效及血液流变学指标观察

本文采用自身对照法用通心络胶囊治疗７６例高脂血症，合并血液粘 度异常患者，观察用药用后患者的血脂水平改变和血液流变学８项指标改变，结果 说明通心络可以明显改善血脂异常，血液流变学８项指标均有明显降低（Ｐ＜０． ０５），是一种较好的降低血脂水平和改善血液粘度的药物。     

LEUCOPROTEASE AND ANTI-LEUCOPROTEASE OF MAMMALS AND OF BIRDS

The inhibiting action of the blood serum upon the enzyme of the polynuclear leucocytes, leucoprotease, is exerted by the albumin fraction of the serum. The albumin fraction contains no proteolytic enzymes. The globulin fraction of the serum contains no anti-enzyme for leucoprotease; it contains, on the contrary, an enzyme which digests proteids in a neutral or alkaline medium. This enzyme resembles leucoprotease which is present in the polynuclear leucocytes of an inflammatory exudate and in the bone marrow from which these cells are derived, and is doubtless identical with the similar enzyme occurring in smaller quantity in the spleen. This enzyme which is present in the blood serum is held in check by its anti-enzyme, but the latter is in such excess that the serum as a whole is capable of checking the action of leucoprotease when added in considerable quantity. Leucoprotease of one mammalian species is inhibited by sera of other mammalian species, but the anti-enzymotic activity of various sera differs; the anti-enzyme of the rabbit''s serum is stronger than that of dog''s serum, when tested either with dog''s or with rabbit''s leucoprotease. The co-existence in the rabbit of leucoprotease with feeble strength and anti-body of great activity may explain the absence in these animals of typical suppuration with liquefaction of tissues. The serum of birds which have been tested, namely, pigeon and hen, almost completely fails to inhibit mammalian leucoprotease (of dog). The polynuclear leucocytes, the bone marrow and the spleen of the hen do not contain an enzyme resembling leucoprotease of mammals. The absence of anti-enzyme in the serum is associated with absence of a corresponding enzyme in the leucocytes.     

环胞霉素A、亲合素和钙调磷酸酶复合物的结构特性与免疫抑制及其毒理作用机理

钙调磷酸酶（calcineurin，CN）是亲免素（immunophilin）-免疫抑制药物（immunosuppressant）复合物-环胞霉素A（cyclosporin A，CsA）、环胞霉素A亲合素（cyclophilin，CyP）和FK506结合蛋白（FK506-bindingprotein，FK BP-506）、FK506的共同靶目标。这些药物蛋白的复合物都能特异地抑制CN的生物活性，但是两种结构完全不同的亲免素-免疫抑制药物复合物为何能够作用同一靶目标目前仍不清楚。     

Fraxiparin对巨核细胞－血小板系统刺激增生作用的研究

Ｆｒａｘｉｐａｒｉｎ是一种小分子量肝素。研究结果表明，Ｆｒａｘｉｐａｒｉｎ可刺激鼠巨核细胞－血小板系统增生。在体外试验，Ｆｒａｘｉｐａｒｉｎ可刺激鼠巨核系祖细胞的增生和巨核细胞的成熟，其刺激增生作用与其中和血小板第４因子的作用有关。鼠的体内研究结果进一步证实Ｆｒａｘｉｐａｒｉｎ对巨核细胞有刺激增生作用。小剂量Ｆｒａｘｉｐａｒｉｎ也有刺激作用，但其刺激增生作用持续时间较短。Ｆｒａｘｉｐａｒｉｎ注射后５天，血小板计数较对照组略有升高，但无统计学意义。无论体内或体外，Ｆｒａｘｉｐａｒｉｎ对ＣＦＵ－ＧＭ均无刺激作用。     

旅店业卧具污染及清洗消毒效果调查

通过对宾馆和小型招待所卧具(被罩、床单、枕套)抽样检测,了解细菌污染程度及其消毒效果。结果,使用过的卧具细菌总数超标率为50％,大肠菌群检出率为28.8％,以招待所床单污染最严重,细菌总数超标率达到72％。宾馆卧具污染程度较小型招待所轻,两者有显著差异。清洗消毒后的卧具(备用品)细菌总数超标率为5％,大肠菌群检出率为2.5％,说明清洗消毒效果显著。为此提示,对旅店业卧具的监督管理重点是小型招待所,主要是抓好卧具的清洗消毒,以保障卧具安全卫生。     

思瑞康和维思通治疗精神分裂症的临床研究

目的　以维思通为对照组 ,探讨思瑞康治疗精神分裂症的疗效和副作用。方法　将 65例符合CCMD 3的精神分裂症患者随机分为两组 ,分别给予思瑞康和维思通治疗 8周。采用阳性症状和阴性症状量表 (PANSS)评定临床疗效 ,副反应量表 (TESS)评定副反应。结果　治疗 8周后的疗效相当 (P >0 .0 5 ) ;思瑞康组和维思通组的显效率差异无显著性 (P >0 . 0 5 ) ;思瑞康组的副反应发生率低于维思通组 ,但差异无显著性 (P >0 . 0 5 ) ;维思通组锥体外系副反应和内分泌改变的发生率均明显高于思瑞康组 (P <0. 0 5 ) ,但两药引起的副反应一般为轻度或中度 ,患者耐受性较好。结论　思瑞康和维思通对精神分裂症的疗效相当 ,但副作用有所不同。     

DETECTION OF THE VIRUS OF POLIOMYELITIS IN THE NOSE AND THROAT AND GASTRO-INTESTINAL TRACT OF HUMAN BEINGS AND MONKEYS

Five strains of virus were recovered from nasal washings and feces. Four strains were of human origin, the fifth strain came from a monkey sacrificed at the height of the disease. Of the four human strains the first was isolated from the feces of a 14 year old child 7 days after the onset of illness. The second strain was from the nasal washings of a 6½ year old child, 5 days after the onset of illness. The third and fourth strains were recovered from the same patient, a 2½ year old child, 9 days after the onset of illness. One of these strains was obtained from nasopharyngeal washings and the other from the feces. The single monkey strain was isolated from the upper intestinal segment and appears to be the only instance of its isolation from this source in the literature. We believe that the detection of the virus in the nasal washings of two additional patients during convalescence lends further support to the belief that the virus of poliomyelitis is spread by human contact. Furthermore, the recovery of the virus from the gastro-intestinal tract with as great or greater frequency as from the upper respiratory tract, need not, it appears to us, alter our concept of the mode of entrance of the virus into the body, namely, by way of the upper respiratory tract. If the presence of the virus is conceded, then a consideration of the physiologic passage of nasal and oral secretions into the gastro-intestinal tract by reflex swallowing would serve to explain adequately the presence of the virus in those organs. It might even be further predicated that since the gastro-intestinal tract functions as a temporary reservoir for secretions from the upper respiratory tract, the gut should, after a time, contain the virus in higher concentration than any single sample of secretion obtained from the upper respiratory tract by nasal washing. It appears to us that failures to detect the virus in the gastro-intestinal tract are perhaps more indicative of inadequate procedures for its detection than of its absence. The recovery of the virus from the feces 7 and 9 days after the onset of illness takes on added significance. It indicates first, that the virus withstands the gastric acidity which under normal physiological conditions tends to keep gastric contents relatively free of bacteria. It further suggests that improper disposal of feces from patients with poliomyelitis may have serious public health consequences, particularly in smaller communities where inadequate sewage disposal may result in contamination of surrounding beaches or even local water systems.     

《疼痛知信行调查问卷》的研制及信效度检验

目的:编制适合全髋关节置换术患者疼痛知识、疼痛信念、疼痛控制行为问卷,检测其信效度。方法:采用知信行理论为问卷构架,在文献阅读、专家咨询、专题小组讨论的基础上初步编制疼痛知信行问卷。采取方便抽样法抽取盐城某三甲医院骨科75名拟行全髋关节置换术的患者,并进行问卷调查。采用Cronbach'α系数、分半信度进行信度检测,选用内容效度、探索因子分析检验问卷效度。结果:本问卷编制了36个条目,包括疼痛知识、疼痛信念、疼痛控制行为三个子问卷。问卷总的内部一致性信度为0.853,子问卷的内部一致性信度分别为0.817、0.814、0.919,子问卷的内容效度系数分别为0.837、0.946、0.902。对子问卷进行因子分析,累积贡献率分别为53.33%、61.26%、71.33%,每个项目的共性方差均超过0.4。结论:编制的《疼痛知信行调查问卷》具有良好的信效度,可以作为评鉴全髋关节置换术患者疼痛认知、疼痛信念、疼痛控制行为现状以及调查影响因素的可靠工具。     

急慢性疼痛病人电针感觉阈和痛阈的调查分析

目的:了解急性和慢性疼痛病人的电针感觉阈和痛阈的特点,以便选用适宜的电针参数进行镇痛治疗。方法:测定正常人、急性疼痛病人和慢性疼痛病人三组人群的感觉阈和痛阈,并进行相互比较。结果:急性疼痛病人的感觉阈和痛阈均低于正常人(均P<0. 01),明显低于慢性疼痛病人(均P<0. 01)。结论:急、慢性疼痛病人有不同的电针感觉阈和痛阈基础,急性疼痛病人相对较低,慢性疼痛病人相对较高。电针镇痛治疗时,电针强度的运用应因人而异。     

ENHANCEMENT OF ANTIBIOTIC ACTIVITY OF COLICINE K AND ALTERATION OF SEROLOGICAL PROPERTIES OF COLICINE K AND ENDOTOXINS

Hemoglobin, its chains, and myoglobin enhance the antibiotic activity of colicine K. These proteins also interact with colicine K and other O antigens to alter their serological activity. The hemoglobin proteins did not alter the serological activities of three Pneumococcus polysaccharides or T4 bacteriophage DNA antigens but did alter the antigenic activity of fetuin. Interaction of hemoglobin and colicine K resulted in a retardation of colicine K antibiotic moiety as measured by gel filtration but did not affect the gel filtration properties of the lipopolysaccharide moiety.