首页 | 本学科首页   官方微博 | 高级检索  
相似文献
 共查询到20条相似文献,搜索用时 109 毫秒
1.
报告63例肝脏实质性占位病变的超声三维成像(3D)。原发性肝癌34例,肝转移癌20例,肝血管瘤9例。三维超声显示内部结构优于两维超声显像的占71%(45/63);三维超声显示肿块周邻与血管关系较清的占65%(41/63);三维超声显示肿块边界优于两维超声显像的占56%(35/63)。说明三维超声成像对肝脏实质性占位病变能较准确地提示肿瘤所占据的空间位置及内部结构和病变形态,为临床提供有意义的影像诊断学依据  相似文献   

2.
三维超声成像对肝脏实质性占位病变的探讨   总被引:8,自引:0,他引:8  
报告63例肝脏实质性占位病变的超声三维成像。原发性肝癌34例,肝转移癌2例、肝血管瘤9例。三维超声显示内部结构优于两维超声显像的占71%,三维超声显示肿块周邻与血管关系较清的占65%,三维超声显示肿块边界优于两维超声显像的占56%。说明三维超声成像对实质性占位病变能较准确地提示肿瘤所占据的空间位置及内部结构和病变形态,为临床提供有意义的影像诊断学依据。  相似文献   

3.
三维超声成像在附件实性及囊实混合性肿块中的应用   总被引:8,自引:1,他引:7  
目的:评价三维超声在附件实性及囊实混合性肿块中的临床应用价值。方法:98例附件区肿块患者在常规二维超声检查后进行三维超声检查,并与二维超声图像对比,确定是否三维超声成像要优于二维超声。结果:三维超声对瘤体内小突起的显示要优于二维超声;三维超声可正确判断病变位置,术前细致地评价肿瘤与周围脏器的空间位置关系;三维能量多普勒超声的应用为卵巢肿瘤的定性诊断提供了一个新的参考指标。结论:三维超声可直接显示盆腔解剖,在术前能够提供较二维超声更丰富的信息,对明确诊断及确定治疗方案有重要意义。  相似文献   

4.
利用最小回声透明成像对肝脏内部结构进行三维重建   总被引:10,自引:2,他引:8  
本研究对10例正常人及10例不同肝病患者的肝脏内部结构进行了三维重建。所用仪器为Voluson530D。三维容积探头用于采集二维组织灰阶图像,利用最小回声透明成像模式对肝脏内部结构进行三维重建。结果显示最小回声三维透明成像可显示肝脏内部结构:1)无回声血管结构:显示肝静脉,门静脉,各血管的空间位置关系,及其血管结构病变;2)扩张胆管:显示扩张胆管的立体形态,及其与有关病变(如结石和肿瘤)的空间位置关系;3)低回声肿瘤(如肝癌)和无回声囊性占位病变:显示有关病变的立体形态、大小及其与血管结构的空间位置关系。据此结论,最小回声三维透明成像能很好地显示肝脏内部结构的立体形态、为有关疾病的诊断或治疗提供更加丰富的信息。  相似文献   

5.
三维超声成像诊断甲状腺囊性肿块的价值   总被引:6,自引:1,他引:5  
目的:探讨三维超声成像在诊断甲状腺囊性肿块中的价值。方法:对检出的60例甲状腺囊性肿块进行三维重建,观察其内部结构及肿块边界。结果:三维超声诊断符合率98.3%(59/60),二维超声诊断符合率86.6%(52/60),两存在显性差异(P<0.05)。三维超声成像能清晰显示肿块的形态特征及其内部结构,特别是对小的乳头状结构的检出。所有病例均经手术及病理证实。结论:三维超声成像较二维超声能更直观、立体地反映肿块结构,提高诊断率。  相似文献   

6.
脉络膜黑色素瘤的三维与二维超声成像的比较   总被引:4,自引:0,他引:4  
目的 :通过三维与二维超声成像对脉络膜黑色素瘤的检查及比较 ,了解三维诊断技术的优越性。方法 :应用 OTI3Di- Scan眼科专用超声仪首先进行二维 B超检查 ,取肿瘤最清晰方位作三维检查 ,探头旋转 1 80度 ,连续取二维扫描图像 ,然后重建成三维图像。体积测定按需要设定病变的切割厚度 ,画出各切面的轮廓 ,由计算机算出体积。结果 :4例脉络膜黑色素瘤三维图像中 1例呈圆球形 ,3例为椭圆球形 ,并可观察任何切面的肿块内部结构。精确测定出肿块体积 ,其中最大 1例体积为 1 4 99.9mm3 。二维超声显像显示 1例圆形 ,3例为椭圆形。 4例都有挖空现象 ,3例有脉络膜凹陷及球后声影。测量肿块面积最大 1例为 1 1 .1 5mm× 1 7.66mm。结论 :诊断脉络膜黑色素瘤三维超声成像比二维超声成像更具有优越性。外部形态呈立体球形 ,与肿瘤实际形态接近 ,并可观察任意切面内部结构 ,能够精确测量肿瘤的体积  相似文献   

7.
三维超声不同成像方式在产科中的临床应用   总被引:2,自引:0,他引:2  
【目的】探讨三维超声不同成像方式在产科中的临床应用价值。【方法】利用三维超声表面成像技术、透明成像技术及三维彩色多普勒成像技术对79例胎儿进行三维重建。所用仪器为NAS2000,SONOG60S,Voluson730D三维超声成像系统,探头为凸阵容积探头,频率为3.5MHz。【结果】三维超声表面成像可显示含液体的病变或组织结构内部的细微特征,对被液体包绕的组织结构利用表面成像模式能显示感兴趣区域的外部结构特征;三维超声透明成像可立体地显示实质性脏器内部结构的空间位置关系,胎儿的脊柱、肋骨等结构可完整连续显示;三维超声彩色多普勒成像可清楚显示胎儿脐带的立体形态及空间关系。【结论】三维表面成像可以提供较二维超声更为丰富的灰阶信息,三维透明成像技术(最大回声模式、最小回声模式、混合模式)的出现丰富了三维超声的临床应用范围,三维彩色多普勒血流成像可提供较二维超声更多的血流信息,有重要的临床应用价值及前景。  相似文献   

8.
目的探讨三维超声断层成像技术(TUI)在腮腺局灶性病变鉴别诊断中的应用价值。方法对32例33个腮腺局灶性病变行二维超声检查及TUI检查,分析其对病灶部位、形态、回声、边缘及与周边结构的显示效果,诊断结果与手术病理结果比较。结果TUI通过在A、B、C三个平面上进行多方位断层成像,能更好地显示肿瘤的边缘、形态及与周边结构的关系。与病理诊断比较,TUI对腮腺恶性肿瘤诊断的阳性预测值为100%(6/6),阴性预测值为96.3%(26/27);二维超声成像的阳性预测值为100%(4/4),阴性预测值为89.7%(26/29)。结论三维超声TUI可为腮腺局灶性病变良恶性鉴别诊断提供更丰富的信息,有望得到更广泛的应用。  相似文献   

9.
目的:探讨三维超声重建在胰腺肿块中的应用价值。方法:对32例胰腺肿块进行三维超声重建并与二维进行对比,经手术及病理证实。结果:三维超声重建图像清晰、形态直观、立体感强,能够显示肿块内部结构特征,确定病变与相邻结构的空间关系。结论:三维超声成像从多切面、多角度获取更多的临床信息,在一定程度上弥补了二维超声的不足,为疾病的诊断和鉴别诊断提供了可靠的形态学依据。  相似文献   

10.
应用二维及三维超声诊断卵巢囊性肿瘤   总被引:4,自引:0,他引:4  
目的 :探讨三维超声在诊断卵巢囊性肿瘤诊断中的临床应用价值。方法 :采用二维及三维超声成像技术对 37例卵巢囊性肿瘤患者进行观察 ,获取肿瘤不同切面的二维及三维图像 ,并与术中及术后病理比较。结果 :三维超声所建图像清晰、直观、立体感强 ,能够描述内壁特征 ,显示内部结构如间隔、乳头状突起 ,确定病变与相邻结构的空间位置关系。结论 :三维超声成像从多切面、多角度对病变进行重建观察 ,获取更多的临床诊断信息 ,在一定程度上弥补了二维超声的不足 ,为疾病的诊断提供了可靠的形态学依据  相似文献   

11.
目的评估4种恶性风险指数(RMI)对鉴别卵巢肿瘤良恶性的诊断价值。 方法回顾性分析2017年10月至2018年10月在常州市第二人民医院接受治疗的200例卵巢肿瘤患者的术前癌抗原125(CA125)水平、绝经状态、超声分数、肿瘤大小以及术后病理等资料,采用不同的计算方法(RMI1、RMI2、RMI3、RMI4)计算卵巢肿瘤的RMI,并进行良恶性判定,结果与病理对照,评价在不同病理组织类型和临床分期的诊断价值,通过ROC曲线比较4种RMI与单项指标诊断效能的高低,以及各项的阳性预测值、阴性预测值、特异度和敏感度。采用Cochran's Q检验比较RMI1、RMI2、RMI3、RMI4四种方法的异同,Dunn's检验(经Bonferroni法校正)进行4种指数的两两比较。 结果RMI1、RMI2、RMI3、RMI4的ROC曲线下面积分别为0.859、0.872、0.866、0.878。根据ROC曲线分析,RMI1、RMI2、RMI3的界值为100,RMI4的界值为200时,其敏感度分别为77.5%、82.6%、80.0%、82.5%,特异度分别为94.4%、91.9%、93.1%、93.1%,阳性预测值分别为77.5%、71.7%、74.4%、75.0%,高于原始界值的阳性预测值。4种RMI诊断效能比较差异具有统计学意义(χ2=8.333,P=0.04),进行两两比较,发现RMI1与RMI2两种方法之间差异具有统计学意义(P=0.028)。RMI对卵巢恶性上皮性肿瘤的诊断率较高(71%、77%、71%、74%),其中RMI2的诊断率比其他3种RMI高;RMI对卵巢非上皮性肿瘤的诊断率较低(均为40%)。在卵巢恶性肿瘤中,对I期病变及交界性肿瘤的诊断率低。 结论4种RMI对卵巢肿瘤的良恶性诊断均有较高的特异度和阳性预测值,但对非上皮性肿瘤、交界性肿瘤、卵巢肿瘤早期患者敏感度较低,仍需进一步改良。  相似文献   

12.
OBJECTIVE: To determine whether subjective evaluation of the morphology of the vessel tree of ovarian tumors, as depicted by three-dimensional (3D) power Doppler ultrasound, can discriminate between benign and malignant ovarian tumors, and whether it improves characterization compared with using gray-scale ultrasound imaging alone. METHODS: A consecutive series of 104 women scheduled for surgical removal of an ovarian mass were examined with transvaginal two-dimensional (2D) gray-scale and 3D power Doppler ultrasound. Predetermined vessel characteristics, e.g. density of vessels, branching, caliber changes and tortuosity, were evaluated in 360 degrees rotating 3D images of the vessel tree of the tumor. Ultrasound results were compared with those of the histology of the surgical specimens. Univariate and multivariate logistic regression were used. RESULTS: There were 77 benign tumors, six borderline tumors and 21 invasive malignancies. All vascular features differed significantly between benign and malignant tumors. The areas under their receiver-operating characteristics (ROC) curves (AUCs) were in the range 0.61-0.83. The AUC of a logistic regression model containing three gray-scale ultrasound variables was 0.98. This model correctly classified all malignancies, with a false-positive rate of 10% (8/77). Adding branching of vessels in the whole tumor to the gray-scale model yielded an AUC of 0.99 and resulted in all malignancies and an additional four benign tumors being correctly classified. CONCLUSIONS: Subjective evaluation of the morphology of the vessel tree, as depicted by 3D power Doppler ultrasound, can be used to discriminate between benign and malignant ovarian tumors, but adds little to gray-scale ultrasound imaging in an ordinary population of tumors.  相似文献   

13.
目的 探讨HuR和环氧化酶(COX-2)与卵巢上皮性癌临床病理参数的关系及二者的相关性.方法 收集原发卵巢上皮性癌组织68例(卵巢上皮性癌组),交界性卵巢肿瘤10例(交界性卵巢肿瘤组),正常卵巢组织5例(正常卵巢组织组)行免疫组织化学染色SP法检测HuR与COX-2的表达及与临床病理参数的关系.结果 (1)HuR在卵巢上皮性癌胞核中阳性表达率为76.47%(52/68)明显高于交界性卵巢肿瘤胞核30.00%(3/10)和正常卵巢组织(正常卵巢组织无表达)(x2=18.873,P<0.05);HuR在交界性卵巢肿瘤的表达与正常卵巢组织比较差异无统计学意义(P>0.05).(2)HuR在卵巢上皮性癌和交界性卵巢肿瘤胞质中的阳性表达率分别为45.60%(31/68)、10.00%(1/10),正常卵巢组织无表达;胞质HuR在恶性卵巢肿瘤组织的表达与交界性卵巢肿瘤和正常卵巢组织比较差异有统计学意义(x2=7.999,P=0.018);胞质HuR在交界性卵巢肿瘤的表达与正常卵巢组织比较差异无统计学意义(P>0.05).(3)临床分期Ⅲ、Ⅳ期胞质HuR的阳性表达率为56.09%(23/41),显著高于Ⅰ、Ⅱ期的29.63%(8/27),差异有统计学意义(x2=4.598,P=0.032).在组织学分级高分化、中分化、低分化胞质HuR的阳性表达率分别为10.00%(1/10)、46.67%(14/30)、57.14%(16/28),差异有统计学意义(x2=6.627,P=0.036).(4)COX-2在卵巢上皮性癌(67.64%)和交界性卵巢肿瘤(60.00%)的表达明显高于正常卵巢组织(0),在卵巢上皮性癌的表达与交界性卵巢肿瘤比较差异无统计学意义(P>0.05);COX-2高表达与临床分期和淋巴结转移有关;(5)胞质HuR与COX-2在肿瘤中的表达呈正相关(x2=0.317,P=0.008).结论 HuR与COX-2在卵巢上皮性癌的表达明显增高,且胞质HuR的表达与COX-2的表达呈正相关,提示胞质HuR与COX-2的过表达可能与卵巢癌的发生发展密切相关.
Abstract:
Objective To detect the expressions of HuR and COX-2 in epithelial ovarian carcinoma,and investigate the correlation of HuR and COX-2 expression. In addition, we attempt to seek the pathway to prevent the occurrence and development of epithelial ovarian cancer by combined analysis of various clinicopathologic characteristics. Methods The expressions of HuR and COX-2 in 68 epithelial ovarian carcinoma, 10 borderline ovarian tumors and 5 normal ovarian tissues were examined by S-P immunohistochemical method. The relationship of HuR and COX-2 expressions with clinicopathologic parameterwere evaluated by correlation analysis. Results(1) The expression of HuR in epithelial ovarian cancer tissue (76. 47% ,52/68) was significantly higher than that in borderline epithelial ovarian tumor tissues (30. 00% ,3/10) and normal ovarian tissues (0, x2 = 18. 873, Ps < 0. 05), but there were no significant differences betweenthe expressions of HuR in borderline epithelial ovarian tumor and normal ovarian tissue(P > 0. 05).(2) The positive expression rate of cytoplasmic HuR in epithelial ovarian carcinoma and borderline epithelial ovarian tumor were 45.60% (31/68) and 10. 00% (1/10) respectively,but normal ovarian tissues showed no staining of HuR. We found no significant differences between the expression of cytoplasmic HuR in epithelial ovarian carcinoma and borderline epithelial ovarian tumor or normal ovarian tissue(x2 = 7. 999 ,P =0. 018).(3) The positive expression rate of cytoplasmic HuR in epithelial ovarian carcinoma of FIGO stage Ⅲ - Ⅳ was significantly higher than that of stage Ⅰ - Ⅱ(56. 09% vs. 29. 63%, x2 = 4. 598, P = 0. 032). The positive expression rates of cytoplasmic HuR in epithelial ovarian carcinoma of histological grade 1,2,3 were 10. 00%,46. 67% ,57. 14% respectively, which showed significant difference in the comparison among the three groups (x2 =6. 627 ,P =0. 036). (4) The positive expression rates of COX-2 in epithelial ovarian cancer (67. 64%)and borderline epithelial ovarian tumor tissues (60. 00%) were significantly higher than that in normal ovarian tissues (0, Ps < 0. 05), but we found no significant difference in the comparison between the expression of malignant and borderline ovarian tumors. Statistical analysis showed that the positive expression rate of COX-2 in epithelial ovarian carcinoma was correlated with FIGO stage and lymph node metastasis. (5)There was a significantly positive correlation between cytoplasmic HuR and COX-2 expressions in epithelial ovarian carcinoma. Conclusion The expressions of HuR and COX-2 increased in the epithelial ovarian carcinoma, and the cytoplasmic expression of HuR was significantly correlated with the expression of COX-2. These results suggested that increased cytoplasmic expression of HuR and COX-2 expression might play important roles in the initiation and development of epithelial ovarian carcinoma.  相似文献   

14.
目的:探讨上皮性卵巢肿瘤的三维彩色血管能量成像(three-dimensional color power angio,3D-CPA)特点及其血管病理学基础,评价3D-CPA鉴别卵巢肿瘤的临床应用价值。方法:对67例上皮性卵巢肿瘤患者(40例卵巢癌,27例良性上皮性卵巢肿瘤)术前应用3D-CPA检测肿瘤的血管分布类型并计算肿瘤血管指数(vascularity index,VI),术后分别应用抗血管内皮生长因子(VEGF)、抗CD34单克隆抗体对组织进行免疫组织化学染色,计数肿瘤的微血管密度(microvessel density,MVD)及VEGF染色强度。结果:卵巢癌的MVD及VEGF表达强度均显著高于良性上皮性卵巢肿瘤(P<0.05)。以3D-CPA血管指数>0.02条/cm^3诊断卵巢癌敏感性77.5%,特异性81.5%。卵巢癌的血管指数与MVD呈等级相关(rs= 0.503,P<0.01)。结论:3D-CPA可用于术前间接评价肿瘤的血管生成,为卵巢肿瘤的诊断及鉴别提供有价值的信息。  相似文献   

15.
目的探讨血清人附睾蛋白4(HE4)、糖类抗原125(CA125)以及癌胚抗原(CEA)3项肿瘤标志物联合检测在卵巢癌诊断及分期判断中的临床价值。方法选取该院2014年3月至2016年3月确诊的卵巢癌患者90例(卵巢癌组),良性卵巢疾病患者120例(良性组),以及60例健康女性(健康对照组),采用免疫化学发光法,检测3组人群的HE4、CA125和CEA水平,并进行比较分析。结果卵巢癌组3项指标显著高于良性组和健康对照组,差异具有统计学意义(P0.05),HE4、CA125、CEA联合检测卵巢癌Ⅰ~Ⅳ期的阳性率分别为81.2%、92.1%、97.4%和100.0%,且HE4、CA125、CEA联合检测在卵巢癌不同分期的阳性率要显著高于单一指标检测阳性率。结论采用HE4、CA125、CEA联合检测,对于卵巢癌诊断及分期判断的临床价值显著,值得进一步推广。  相似文献   

16.
目的探讨血清糖类抗原(CA)724、CA125检测联合ROMA值在卵巢癌诊断中的应用价值。方法采用回顾性分析,选取赣南医学院第一附属医院2017年10月至2018年7月,经术后病理确诊为卵巢恶性肿瘤的63例患者作为卵巢癌组,同期72例卵巢良性肿瘤患者作为卵巢良性肿瘤组,71例与卵巢无关其他原因入院患者为对照组。采用罗氏试剂化学发光免疫分析法测定患者血清CA724、人附睾蛋白4(HE4)及CA125水平,并计算ROMA值。结果卵巢癌组中血清CA724、CA125表达及ROMA值高于卵巢良性肿瘤组和对照组,差异有统计学意义(P<0.05);卵巢良性肿瘤组中血清CA125水平高于对照组,差异有统计学意义(P<0.001);血清CA724水平、ROMA值在卵巢良性肿瘤组与对照组比较,差异无统计学意义(P>0.05)。CA724、CA125检测联合ROMA值在卵巢癌组、卵巢良性肿瘤组及对照组比较,差异有统计学意义(P<0.001),灵敏度、特异度、准确度、假阴性率和假阳性率分别为89.06%、50.34%、71.5%、10.09%和49.65%。受试者工作特征曲线分析表明,以卵巢良性肿瘤组及对照组为参照,卵巢癌组CA125+CA724+ROMA值、CA125单独检测、CA724单独检测和ROMA值单独的曲线下面积分别为0.893、0.630、0.801、0.735。结论血清CA724、CA125水平及ROMA值的表达均与卵巢癌有密切关系,3项指标联合应用于卵巢癌的灵敏度高于各单项指标的使用,在卵巢癌检测中具有很高的临床价值,可以在早期更加准确地预测卵巢恶性肿瘤的风险。  相似文献   

17.
目的探讨血清人附睾蛋白4(HE4)、糖类抗原125(CA125)和细胞角蛋白19片段(CYFRA21-1)联合检测对卵巢癌诊断的临床价值。方法选择卵巢癌患者85例、卵巢良性肿瘤患者85例和健康妇女(正常对照组)85名,采用酶联免疫吸附试验(ELISA)检测血清HE4水平,采用化学发光法检测血清CA125、CYFRA21-l水平,比较各组3项指标的检测结果并计算阳性率及联合检测的阳性率。结果卵巢癌组血清HE4、CA125和CYFRA21-1水平明显高于卵巢良性肿瘤组和正常对照组(P0.01)。卵巢癌组HE4、CA125和CYFRA21-1的阳性率分别为88.24%、74.12%和77.65%,三者联合检测的阳性率为98.82%。结论 HE4、CA125和CYFRA21-1联合检测对卵巢癌具有良好的辅助诊断价值。  相似文献   

18.
Photodynamic therapy (PDT) is a promising alternative method for clinical cancer treatment. In the present study, cells from four breast carcinomas, seven ovarian carcinomas of various stages of differentiation, and ascites from a diffuse metastatic tumor were treated by PDT in vitro. Tetra(m-hydroxyphenyl)-chlorin (m-THPC) was used as the photosensitizer. Surviving cell rate was evaluated by the ATP-Cell-Viability-Assay (ATP-CVA), which measures light production as an interaction of intracellular ATP with the luciferin-luciferase complex. The most effective PDT of the tumor cells was achieved at an m-THPC concentration of 0.2 microgram/ml following incubation of the cells with photosensitizer for 24 hours. PDT toxicity resulted in a cell survival rate of 1% to 42% compared to untreated control cells (survival rate of control = 100%). The inhibitor concentration IC50 of m-THPC was determined both in the dark (dark toxicity) and in combination with laser irradiation. IC50 was defined as the concentration of photosensitizer which caused 50% of cell death. The IC50 values were heterogeneous in all tumor specimens examined. IC50 values for dark toxicity were on average 0.14 microgram m-THPC/ml for primary ovarian carcinoma, 2.16 micrograms m-THPC ml for refractory ovarian carcinoma and 0.3 microgram m-THPC/ml for breast carcinoma. After PDT, average IC50 value for refractory ovarian carcinoma was 0.04 microgram m-THPC/ml, for primary ovarian carcinoma 0.05 microgram m-THPC/ml and for breast carcinoma 0.03 microgram m-THPC/ml. These data might indicate that clinical PDT of gynecological carcinoma requires individual treatment conditions to achieve optimal results.  相似文献   

19.
目的 探讨原癌基因人类表皮生长因子受体-2(HER-2)和拓扑异构酶Ⅱ(TOPO-Ⅱα)在卵巢上皮癌组织中的表达及其相关性.方法 采用免疫组化SP方法检测经病理确诊的58例卵巢上皮癌、20例卵巢良性上皮肿瘤及10例正常卵巢组织标本中HER-2及TOPO-Ⅱα的表达情况,并结合临床病理特征进行分析.结果 HER-2在卵巢正常组织、卵巢良性上皮性肿瘤组织中的阳性表达率分别为10.0%(1/10)、15.0%(3/20),显著低于卵巢上皮癌组织[46.6%(27/58),x2值分别为4.705、6.225,P均<0.05];卵巢上皮癌组织中TOPO-Ⅱα的阳性表达率显著高于卵巢正常组织和卵巢良性上皮性肿瘤组织[53.4%(31/58)、10.0%(1/10)、15.0%(3/20),x2值分别为6.463、8.941,P均<0.05];而良性肿瘤组织和正常组织间比较差异均无统计学意义(P均>0.05).HER-2和TOPO-Ⅱα的表达与卵巢上皮癌临床分期(x2值分别为5.295、6.665)、细胞组织学分化(x2值分别为5.376、8.981)有显著相关性(P均<0.05),而与年龄、组织学类型无相关性(P均>0.05);卵巢上皮癌中HER-2和TOPO-Ⅱα蛋白的表达呈正相关(rs=0.324,P<0.05).结论 HER-2在卵巢上皮癌的发生发展中起重要作用,对临床诊断及预后评估具有一定的指导意义.
Abstract:
Objective To observe the expression of HER-2 and TOPO-Ⅱα in ovarian epithelial cancer,analyze the correlation between their expression and provide theoretical basis for clinical diagnosis,prognosis and treatment. Methods Expression levels of HER-2 and TOPO- Ⅱα in 10 normal ovarian tissues,20 benign tumors and 58 cases of ovarian epithelial cancers were detected by immunohistochemical method, and their correlations with pathological features were analyzed. Results The positive expression rate of HER-2 in normal ovarian and benign tumor tissues were significantly lower than ovarian epithelial cancers respectively ( 10. 0% , 15.0% VS 46. 6% ;P < 0. 05 ). The positive expression rate of TOPO- Ⅱα in ovarian epithelial cancers was significantly higher than normal and benign epithelial ovarian tumor tissue (53.4% vs 10. 0%, and 15.0%,Ps < 0. 05 ), but we did not find significant difference in the comparison between normal and benign epithelial ovarian tumor tissue ( Ps > 0. 05 ). The expression of HER-2 and TOPO- Ⅱα were significantly correlated with clinical stages, histological differentiation of tumor cells (Ps < 0. 05 ) ,but there were no correlations between the age or histological type. In ovarian cancer tissues, a positive correlation between the expression of HER-2 and TOPO- Ⅱα was observed ( r = 0. 324, P < 0. 05 ) . Conclusion The overexpression of HER-2 and TOPO- Ⅱαplay an important role in ovarian carcinogenesis and development. The expression of HER-2 is positively correlated with TOPO- Ⅱα in ovarian epithelial cancers. Coexpression of the two moleculars may be involved in the development and progression of ovarian epithelial cancer, which should be further studied.  相似文献   

20.
目的:探讨超声图像对卵巢恶性肿瘤诊断与鉴别诊断的价值与病理诊断符合率。方法:选择手术切除的卵巢恶性肿瘤患者185例,术前应用超声显像检测卵巢恶性肿瘤的声像图特征,并与术后病理诊断做对照。结果:本组185例患者共195个肿瘤,超声表现为囊性6个(6/195),占3%;囊实性141个(141/195),占72.3%;实性48个(48/195),占24.7%;血管分布特点为在肿瘤隔或实质成分的内部呈多血管弥漫分布,以束状、树枝状或彩球状血管网为主,实质中心部出现2~3级杂乱血流;与术后病理诊断符合率为95.7%。结论:超声图像对卵巢恶性肿瘤的诊断符合率较高,具有重要诊断价值,育龄妇女妇检时应常规进行卵巢超声检查。  相似文献   

设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号