首页 | 本学科首页   官方微博 | 高级检索  
相似文献
 共查询到20条相似文献,搜索用时 62 毫秒
1.
对65例急性脑血管病(ACVD)患者血清与脑脊液(CSF)中三碘甲状腺原氨酸(T3)、甲状腺素(T4)及促甲状腺激素(TSH)的含量进行了测定,发现脑出血组与脑梗塞组血清与CSF中T3、T4明显低于正常对照组(P均<0.01),TSH则明显高于对照组(P<0.05);且脑出血组T3、T4明显低于脑梗塞组,TSH则高于脑梗塞组;病情轻重与甲状腺激素的变化明显相关(P<0.05);治疗前后甲状腺激素水平明显不同,治疗后T3、T4明显升高(P均<0.05),以T3升高最明显(P<0.01)。作者并就其改变机制及临床意义进行了初步讨论。  相似文献   

2.
目的:探讨肿瘤坏死因子(TNF)与急性脑血管病(ACVD)的关系。方法:采用酶联免疫吸附法检测了60例ACVD患者血与脑脊液(CSF)中TNF水平。结果:ACVD组血及CSF中TNF水平分别为(2.391±0.519)μg/L和(3.294±1.418)μg/L,对照组血及CSF中TNF水平分别为(1.769±0.272)μg/L和(1.236±0.399)μg/L,ACVD组血及CSF中TNF含量均显著高于对照组(P<0.01,P<0.001)。轻、中、重型ACVD组患者血TNF水平分别为(2.113±0.412)μg/L、(2.417±0.310)μg/L和(2.946±0.434)μg/L,CSF中TNF水平分别为(2.763±1.108)μg/L、(3.417±0.942)μg/L和(4.219±1.253)μg/L,轻、重型组分别与中型组比较,血和CSF中TNF含量均有显著性差异(P<0.05,P<0.01)。结论:TNF参与了ACVD的炎性反应过程,抑制TNF产生及抗炎性反应的治疗可能具有潜在的临床价值。  相似文献   

3.
川芎嗪治疗特发性肺纤维化临床观察   总被引:14,自引:0,他引:14  
目的:观察川芎嗪治疗肺间质纤维化(IPF)临床疗效。方法:IPF38例,随机分为川芎嗪治疗组20例(静滴川芎嗪800mg/d)和糖皮质激素治疗组18例(强的松1mg.kg^-1.d^-1)疗程2月。采用临床,X线,生理综合观察法判定疗效,结果,川芎嗪可明显改善IPF患者的呼吸困难(P〈0.01),X线表现(P〈0.05),提高动脉血氧分压(P〈0.01)和VC,FVC(P〈0.05,0.01)且优  相似文献   

4.
目的:比较九龙丹和日本心丹治疗无痛性心肌缺血(SMI)的疗效。方法:将35例SMI患者分为①九龙丹组(A组,18例):口服九龙丹1粒,每日3次,连服27日;②日本心丹组(B组,17例):口服日本心丹1粒,每日3次,连服27日。治疗前后检测:①心率、血压乘积(RPP);②心电图ST段压低总导联数(NST)、心电图ST段压低总和(ΣST);③每搏输出量(SV)、每分输出量(CO)、射血分数(EF);④血浆载脂蛋白(apoA1、apoB);⑤全血粘度(ηb)、血浆粘度(ηp)、纤维蛋白原(Fi)。结果:2组患者治疗后NST、ΣST、RPP均降低(P<0.05或P<0.01),SV、CO、EF均升高(P<0.05或P<0.01),其中A组ΣST、RPP降低和SV、EF升高均较B组明显(P均<0.05);2组患者apoA1、apoA1/apoB升高(P均<0.05),apoB、ηb、ηp和Fi均显著降低(P<0.05或P<0.01),其中A组ηp较B组明显降低(P<0.05)。结论:口服九龙丹治疗SMI在改善心肌血供,缓解心肌缺血和降低心肌耗氧方面具有较好的疗效。  相似文献   

5.
目的:观察川芎嗪联合参麦注射液治疗肺原性心脏病(肺心病)心力衰竭(心衰)的疗效方法。方法:应用川芎嗪联合参麦注射液治疗肺心病心衰42例(治疗组),与应用常规西药强心利尿方法治疗的40例(对照组)作对比。结果:治疗组显效率为54.76%,总有效率为92.86%;对照组显效率为32.50%,总有效率为77.50%。2组疗效比较有显著性差异(P<0.05)。治疗组治疗前后全血比粘度、血浆比粘度及红细胞电泳时间均有显著性差异(P均<0.05)。2组治疗后PaO2和PaCO2均得到改善(P<0.05~0.01),且治疗组明显优于对照组。治疗组治疗后1秒率(FEV1%)和最大换气量(MVV)均明显改善(P均<0.01)。结论:本疗法明显优于西药组,具有改善血液流变性、提高PaO2、FEV1%、MVV,降低PaCO2等作用(P<0.05~0.01),有救治率高、起效快、副作用小等特点。  相似文献   

6.
抵克力得治疗非瓣膜病性心房颤动的临床观察   总被引:1,自引:0,他引:1  
TP治疗NVAF80例,并与ASA组78例作对照。结果:TP组近期(1年)及远期(3~5年)脑栓塞、TIA、外周血管栓塞、心梗、心衰等的发生率明显低于ASA组(P均<0.01~0.005),且LVEF明显高于ASA组(P<0.01),STI明显低于ASA组(P<0.01),尤其是远期观察中,TP组脑栓塞年发生率(1.5%)明显低于ASA组(6.5%),P<0.005,心脑性病死率明显低于ASA组(P<0.01)。TP疗效肯定、副作用轻微,可作为NVAF长期治疗、预防脑栓塞和降低心脑血管事件病死率的二级预防药物。  相似文献   

7.
在高频喷射通气(HFJV)治疗犬实验性急性呼吸窘迫综合征(ARDS)时,采用连续HFJV基础上间歇叠加深吸气(HFJV+DI)的新通气方法,以期为ARDS的治疗寻找一种新途径。用油酸复制犬ARDS模型,并随机分为3组。HFJV+DI组(n=10):在连续HFJV基础上每隔10分钟加入1次深吸气;常规机械通气组(CMV,n=10),给予0.785kPa(1kPa=10.20cmH2O)呼气末正压(PEEP)治疗;对照组(n=10),未予通气治疗。每隔1小时测定1次氧合及血流动力学指标,共观察5小时。注射油酸后,动脉氧分压(PaO2)由12.400kPa(1kPa=7.5mmHg)降至6.560kPa(P<0.01),动脉二氧化碳分压(Pa-CO2)未见明显变化。通气治疗后,CMV和HFJV+DI均使PaO2明显升高,PaCO2无明显变化(P>0.05),HFJV+DI的氧释放指数(DO2I)明显高于CMV组(P>0.05),心脏指数(CI)在CMV组及HFJV+DI组均明显减低(P<0.05)。提示:HFJV+DI时PaO2的提高大于CI下降所致的不利影响,在改善组织缺氧方面明显优于CMV时加用PEEP  相似文献   

8.
用咔玛琪染料结合法对24例高原慢性肺心病患者及28例健康人作了红细胞镁(MgRC)和血浆镁(MgPL)浓度及其与心肺检查关系的研究。结果:①肺心病组MgRC(2.57±0.58mmol/L)及MgPL(0.80±0.15mmol/L)明显低于健康组(分别为3.41±0.49mmol/L、0.96±0.11mmol/L),P均<0.01。MgRC与MgPL之间无相关。②MgRC与FEV1.0%明显相关(r=0.676,P<0.001),MgPL与PEV1.0%无相关。③右室肥厚组与右室肥厚伴心律失常组之间MgRC差异明显(P<0.05),MgPL无差异。④MgRC与右室内径(RVIDd)相关明显(r=0.451,P<0.05),与右室流出道(RVOTd)及平均肺动脉压(MPAP)相关极明显(r分别=0.525、0.553,P均<0.01),MgPL与RVIDd、RVOTD和MPAP无相关。提示,MgRC浓度与心肺功能损害有一定关系  相似文献   

9.
目的:观察联用黄芪注射液和硫酸镁注射液治疗重度支气管哮喘的疗效。方法:重度支气管哮喘急性发作患者57例,随机分成2组。对照组24例予西医常规治疗,治疗组33例在对照组治疗基础上加用黄芪注射液20~30ml/d,25%硫酸镁注射液10~20ml/d(均静滴)。观察2组疗效及治疗前后用力肺活量(FVC)、1秒种用力呼气量(FEV1)和肺活量(VC)的变化。结果:2组总有效率分别为93.9%和79.2%,治疗组疗效优于对照组(χ2=6.79,P<0.01)。治疗组治疗后肺功能明显改善,治疗前后比较VC分别为(1.86±0.42)L和(2.98±0.63)L,P<0.05;FVC分别为(1.68±0.48)L和(2.16±0.64)L,P<0.05;FEV1分别为(0.98±0.72)L和(1.42±0.37)L,P<0.05。对照组治疗后肺功能改善不明显(P均>0.05)。结论:联用黄芪注射液和硫酸镁注射液治疗重度支气管哮喘安全有效。  相似文献   

10.
对30例冠心病患者口服硫氮卓酮缓释剂(合心爽90SR)90mg,一日2次,进行为期4周的治疗观察。结果显示:VE/VA由0.82±0.32至1.03±0.41(p<0.01),PFR由1.51±0.68至1.83±0.52(p<0.01),1/3FR由0.86±0.28至1.15±0.61(p<0.05)舒张功能明显改善。LAD/AOD由1.24±0.2s至0.23±0.23(p>0.05),EDC由3.51±1.68至3.12±1.24(p>0.05)均无明显变化。代表收缩功能的EF,PER及FS均无明显变化(p>0.05)。  相似文献   

11.
Objective: To identify patterns of nonfatal and fatal penetrating trauma among children and adults in New Mexico using ED and medical examiner data.
Methods: The authors retrospectively sampled in 5-year intervals all victims of penetrating trauma who presented to either the state Level-1 trauma center or the state medical examiner from a 16-year period (1978–1993). Rates of nonfatal and fatal firearm and stabbing injury were compared for children and adults.
Results: Rates of nonfatal injury were similar (firearm, 34.3 per 100,000 person-years; stabbing, 35.1). However, rates of fatal injury were significantly different (firearm, 21.9; stabbing, 2.7; relative risk: 8.2; 95% confidence interval: 5.4, 12.5). From 1978 to 1993, nonfatal injury rates increased for children (p = 0.0043) and adults (p < 0.0001), while fatal penetrating injury remained constant. The increase in nonfatal injury in children resulted from increased firearm injury rates. In adults, both stabbing and firearm nonfatal injury rates increased.
Conclusions: Nonfatal injury data suggest that nonfatal violence has increased; fatal injury data suggest that violent death rates have remained constant. Injury patterns vary by age, mechanism of trauma, and data source. These results suggest that ED and medical examiner data differ and that both are needed to guide injury prevention programs.  相似文献   

12.
Three supplementary perspectives are presented arguing that interprofessional collaboration is both necessary and desirable. Nonetheless, there are often too many serious intra-professional barriers and obstacles to interprofessional collaboration to make it successful. Some of these barriers, it is argued and illustrated, are found in the multiple ways in which professional identity is tacitly acquired and embodied in the practitioners' habitual, everyday practice. The paper then explores ways in which reflection, especially Second order reflection, can help to elucidate and overcome these obstacles, as well as increasing professional adaptability and competence.  相似文献   

13.
This is a new method for the determination of creatine kinase isoenzyme MB activity in serum. The method uses direct activity measurement of creatine kinase B subunit activity after blocking of CK-M subunit activity by inhibiting antibodies. The test takes no longer than 15 min. The method yields an intra-serial C.V. of 2.0-12.9%, and a C.V. from day to day of 5.5%. The detection limit is 3.4 U/l creatine kinase MB. In the 95 cases with proven myocardial infarction several types of creatine kinase MB activity kinetics could be determined. The percentage of creatine kinase MB of peak CK-total is 6-25%, with a mean of 11.1%. The amount of creatine kinase MB with respect to total CK activity after reinfarction is higher than the amount after initial infarction.  相似文献   

14.
ABSTRACT

The Cochrane Library of Systematic Reviews is published quarterly as a DVD and monthly online. The January 2011 issue (first quarterly DVD for 2011) contains 4515 complete reviews, 1985 protocols for reviews in production, and 13,521 one-page summaries of systematic reviews published in the general medical literature. In addition, there are citations of 641,000 randomized controlled trials, and 14,018 cited papers in the Cochrane methodology register. The health technology assessment database contains over 9300 citations. One hundred and seven new reviews have been published in the last 3 months, of which five have potential relevance for practitioners in pain and palliative medicine.  相似文献   

15.
目的 探讨手转胎头术失败的原因与分娩结局.方法 选择2008年1月至2010年12月于我院住院分娩的持续性枕横位、枕后位产妇198例,根据行手转胎头术后结果分为成功组126例、失败组72例.比较两组分娩结局,对比分析失败原因.结果 失败组胎儿体质量≥3500 g的发生率[76.4%(55/72)]明显高于成功组[31.7%(40/126)],差异有统计学意义(x2=30.177,P=0.001)、失败组宫缩乏力发生率[58.3%(42/72)]高于成功组[38.1% (48/126)],差异有统计学意义(x2=7.569,P=0.006)、失败组骨盆临界或轻度狭窄发生率[38.9% (28/72)]高于成功组[23.8%(30/126)],差异有统计学意义(x2 =5.030,P=0.002)、失败组手转胎头时机不当(宫口开大<6 cm、胎头位于坐骨棘上及宫口开大8~10 cm、胎头位于坐骨棘下≥2 cm)发生率[61.1%(44/72)]高于成功组[38.9%(49/126)],差异有统计学意义(x2=9.084,P=0.003).失败组母儿并发症(产后出血、产褥病率、胎儿窘迫、新生儿窒息)发生率高于成功组(x2 =9.586,P=0.002、x2=9.334,P=0.002、x2=5.910,P=0.015、x2=5.240,P=0.022)、失败组剖宫产发生率[72.2%(52/72)]明显高于成功组[34.1 %(43/126),x2=26.641,P=0.001)].结论 手转胎头术能使难产变顺产,降低剖宫产率,减少母儿并发症,但须积极预防、处理导致手转胎头术失败的原因,对矫正失败后继续矫正及试产应慎重.  相似文献   

16.
The Department of Veterans Affairs (VA) in the USA operates a network of 172 medical centres which all utilize a hospital information system (HIS) which has been developed and is currently maintained by the VA. During the past several years, an image management and communication module has been developed, installed and clinically utilized at the Washington DC and Maryland VA Medical Centres. This image management and communication system, referred to as the decentralized hospital computer program (DHCP) imaging system, is fully integrated with a commercial picture archiving and communication system (PACS). The system is utilized to capture, archive, and display all images generated within the hospital including radiology, nuclear medicine, pathology, endoscopy, bronchoscopy, and dermatology, intraoperative photographs, ECG data, and a limited number of paper documents. The ultimate goal of the project is to have all patient text and image data available at any clinical workstation to any authorized user anywhere within the network of medical centres. Clinical requirements for an imaging workstation include ease of use, rapid and reliable access to the complete set of patient information, and images which are of acceptable quality to meet the requirements of the user and the subspecialty. Patient confidentiality and data security must be safeguarded at all times. Integration of the images with the remainder of the patient's database was found to be critical to the success of the project. The experience at the Washington and Maryland facilities suggests that an imaging system that is successfully integrated with a hospital information system can provide substantial clinical and economic benefits both within and among medical centres. Clinical acceptance and utilization of the system has been excellent, particularly in diagnostic radiology where DHCP Imaging has been interfaced to a commercial PAC system. Based upon this initial experience, the VA has begun to deploy the system throughout its large network of medical centres.  相似文献   

17.
18.
目的 探讨俯卧位通气对高海拔地区肺复张术(RM)治疗无效急性呼吸窘迫综合征(ARDS)患者的治疗作用.方法 从海拔2260m的地区医院筛选RM治疗无效的41例ARDS患者[平均氧合指数( PaO2/FiO2)较RM前升高<20%视为RM无效],依不同病因分为肺内源性ARDS组(ARDSp组)和肺外源性ARDS组(ARDSexp组),每组再按信封法随机分为俯卧位组和仰卧位组,即ARDSp俯卧位组(11例)、ARDSp仰卧位组(9例)、ARDSexp俯卧位组(10例)、ARDSexp仰卧位组(11例).在通气前及通气1、2、3、4h监测动脉血氧分压( PaO2)、PaO2/FiO2、静态顺应性(Cst)、气道阻力(Raw)的变化.结果 通气lh时,ARDSexp俯卧位组PaO2/FiO2( mm Hg,l mm Hg=0.133 kPa)即较通气前显著升高(157.4±40.6比129.3±48.7,P<0.05),并随通气时间延长呈持续增高趋势,4h达峰值(219.1 ±41.1);且ARDSexp俯卧位组通气3h内PaO2/FiO2较其他3组显著增高,另3组间则差异无统计学意义.ARDSp俯卧位组、ARDSexp俯卧位组通气4h时PaO2/FiO2均较相应仰卧位组显著增高(208.8±39.7比127.4±47.1,219.1±41.1比124.9±50.8,均P<0.05).4组通气前后Cst无显著改变,各组间差异也无统计学意义.ARDSp俯卧位组通气4h时Raw(cmH2O·L-1·s-1)较通气前显著降低(6.8±1.7比10.7±1.8,P<0.05),且明显低于其他3组;其他3组各时间点Raw组内及组间比较差异均无统计学意义.结论 俯卧位通气作为ARDS机械通气重要策略之一,可以改善RM无效高原ARDS患者的氧合,为抢救患者赢得宝贵的时间.  相似文献   

19.
Ranganath C  Heller AS  Wilding EL 《NeuroImage》2007,35(4):1663-1673
Although substantial evidence suggests that the prefrontal cortex (PFC) implements processes that are critical for accurate episodic memory judgments, the specific roles of different PFC subregions remain unclear. Here, we used event-related functional magnetic resonance imaging to distinguish between prefrontal activity related to operations that (1) influence processing of retrieval cues based on current task demands, or (2) are involved in monitoring the outputs of retrieval. Fourteen participants studied auditory words spoken by a male or female speaker and completed memory tests in which the stimuli were unstudied foil words and studied words spoken by either the same speaker at study, or the alternate speaker. On "general" test trials, participants were to determine whether each word was studied, regardless of the voice of the speaker, whereas on "specific" test trials, participants were to additionally distinguish between studied words that were spoken in the same voice or a different voice at study. Thus, on specific test trials, participants were explicitly required to attend to voice information in order to evaluate each test item. Anterior (right BA 10), dorsolateral prefrontal (right BA 46), and inferior frontal (bilateral BA 47/12) regions were more active during specific than during general trials. Activation in anterior and dorsolateral PFC was enhanced during specific test trials even in response to unstudied items, suggesting that activation in these regions was related to the differential processing of retrieval cues in the two tasks. In contrast, differences between specific and general test trials in inferior frontal regions (bilateral BA 47/12) were seen only for studied items, suggesting a role for these regions in post-retrieval monitoring processes. Results from this study are consistent with the idea that different PFC subregions implement distinct, but complementary processes that collectively support accurate episodic memory judgments.  相似文献   

20.
Myocardial elastography is a novel method for noninvasively assessing regional myocardial function, with the advantages of high spatial and temporal resolution and high signal-to-noise ratio (SNR). In this paper, in-vivo experiments were performed in anesthetized normal and infarcted mice (one day after left anterior descending coronary artery [LAD] ligation) using a high-resolution (30 MHz) ultrasound system (Vevo 770, VisualSonics Inc., Toronto, ON, Canada). Radiofrequency (RF) signals of the left ventricle (LV) in longitudinal (long-axis) view and the associated electrocardiogram (ECG) were simultaneously acquired. Using a retrospective ECG gating technique, 2-D full field-of-view RF frames were acquired at an extremely high frame rate (8 kHz) that resulted in high-quality incremental displacement and strain estimation of the myocardium. The incremental results were further accumulated to obtain the cumulative displacements and strains. Two-dimensional and M-mode displacement images and strain images (elastograms), as well as displacement and strain profiles as a function of time, were compared between normal and infarcted mice. Incremental results clearly depicted cardiac events including LV contraction, LV relaxation and isovolumetric phases in both normal and infarcted mice, and also evidently indicated reduced motion and deformation in the infarcted myocardium. The elastograms indicated that the infarcted regions underwent thinning during systole rather than thickening, as in the normal case. The cumulative elastograms were found to have higher elastographic SNR (SNR(e)) than the incremental elastograms (e.g., 10.6 vs. 4.7 in a normal myocardium, and 6.0 vs. 2.4 in an infarcted myocardium). Finally, preliminary statistical results from nine normal (m = 9) and seven infarcted (n = 7) mice indicated the capability of the cumulative strain in differentiating infracted from normal myocardia. In conclusion, myocardial elastography could provide regional strain information at simultaneously high temporal (>/=0.125 ms) and spatial ( approximately 55 microm) resolution as well as high precision ( approximately 0.05 microm displacement). This technique was thus capable of accurately characterizing normal myocardial function throughout an entire cardiac cycle, at the same high resolution, and detecting and localizing myocardial infarction in vivo.  相似文献   

设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号