Association of maternal chronic disease and negative birth outcomes in a non-Hispanic Black-White Mississippi birth cohort

OBJECTIVE: To investigate the impact of selected maternal chronic medical conditions, race, and age on preterm birth (PTB), low birth weight (LBW), and infant mortality among Mississippi mothers from 1999 to 2003. DESIGN: A retrospective cohort analysis of linked birth and death certificates. SAMPLE: The 1999-2003 Mississippi birth cohort comprising 202,931 singleton infants born to African American and White women. MEASUREMENTS: The relationship between maternal chronic conditions and the dependent variables of PTB, LBW, and infant mortality were investigated using logistic regression analysis. RESULTS: PTB, LBW, and infant mortality were more prevalent among African American women, very young women (< or =15 years), and women with certain chronic medical conditions. Among White mothers, maternal chronic hypertension was significantly associated with PTB and LBW, and maternal diabetes with PTB and infant mortality. Among African American mothers, maternal cardiac disease was significantly associated with PTB and LBW; maternal chronic hypertension was significantly associated with LBW and infant mortality; and maternal diabetes with PTB. CONCLUSIONS: Maternal chronic hypertension and diabetes were significantly associated with negative birth outcomes regardless of maternal race. Maternal cardiac disease was only significantly associated with PTB and LBW among African Americans.     

Diabetes in pregnancy and cesarean delivery.

OBJECTIVE: To evaluate the effect of diabetes during pregnancy on cesarean delivery and to determine whether the association between diabetes during pregnancy and cesarean delivery is mediated by birth weight. RESEARCH DESIGN AND METHODS: South Carolina 1993 birth certificates were matched through a unique identifier with infant and maternal hospital discharge records for the same year, yielding a total study population of 42,071 singleton births. Adjusted odds ratios (ORs) and 95% CIs were determined for the association between diabetes in pregnancy and cesarean delivery through multiple logistic regression, controlling for maternal age, race, education, number of prenatal care visits, length of gestation, birth weight, and a number of medical indications. RESULTS: Of the study population, 0.7% were pregnancies complicated by preexisting diabetes, 2.9% were pregnancies complicated by gestational diabetes, and 23.4% were cesarean deliveries. After controlling for confounders, including birth weight, cesarean delivery was strongly associated with both preexisting diabetes (OR [95% CI] 6.20 [4.47-8.61]) and gestational diabetes (1.71 [1.41-2.07]). The estimates remained essentially unchanged without birth weight in the model, and were substantially higher in analyses restricted to deliveries without common medical indications for cesarean delivery. CONCLUSIONS: Both preexisting and gestational diabetes increase the risk for cesarean delivery, independent of the effect of birth weight. The association is markedly greater among women without other medical indications for cesarean delivery. The increased risk of cesarean delivery for women with diabetes is mediated through other factors, which may include practice patterns and physician referrals to high-risk care.     

Differences in black and white infant birth weights: the role of maternal demographic factors and medical complications of pregnancy

In a retrospective study of 18,631 deliveries among women of low income, we examined the association of racial disparities in mean birth weight with population differences in maternal demographic characteristics and antepartum-intrapartum medical complications. The study population consisted of inborn, nonreferred, singleton, low-income patients delivered on the nonprivate service after at least five prenatal care visits. Repeat cesarean sections were not included. The mean birth weight for black infants was 214 g less than that for white infants. Black and white mothers differed significantly in marital status, age, and years of education. Black and white mothers also differed significantly in the incidence of chronic hypertension, preeclampsia-eclampsia, anemia, amnionitis, fever on admission, and sexually transmitted diseases. In this population, controlling for maternal demographic characteristics and medical complications of pregnancy produced a predicted mean birth weight for black infants that was 100 g less than that for white infants (53% of the observed racial difference in mean birth weight).     

Low birth weight and prenatal maternal conditions

This study was carried in the area covered by the Hospital Universitário of the University of S?o Paulo in order to verify the relationship between birth weight and maternal work and prenatal, nutritional (height, initial and final weight and weight gain during gestation) and socioeconomic-demographic (age, marital status, level of education, family income) conditions. It was based on a sample of 101 children. The occurrence of low birth weight (LBW) (5.1%) did not show association with maternal work nor with prenatal. On the other hand, LBW showed significant association with the following maternal variables: weight gain during the pregnancy under 7 kilograms, mother's age under 20 years old and marital status (single mothers). Despite the low occurrence of LBW, the results point out to the importance of taking measures to reduce LBW, in particular through the control of prenatal weight gain and prenatal among adolescents. Moreover, a policy of educating women, and in particular single women, about pregnancy, childbirth and nutrition seem an obvious necessity.     

Race, ethnicity, concentrated poverty, and low birth weight disparities

This study examines the extent to which the relationship between area socioeconomic position (SEP) and low birth weight (LBW) varies by race and ethnicity. A cross-sectional, secondary data analysis was performed with 1992-1994 Vital Statistics and 1990 U.S. Census data for selected metropolitan areas. Low birth weight (< 2500 grams) rates were calculated for non-Hispanic Black, Latino, and non-Hispanic White live singleton births. Concentrated poverty was defined as poor persons living in neighborhoods with 40% or more poverty in metropolitan areas. The results showed that the relationship between concentrated poverty and LBW varied by race and ethnicity. Concentrated poverty was significant for Latinos, even when controlling for maternal health and MSA-level factors. By contrast, maternal health characteristics, such as pre-term birth, teen birth and tobacco use, explained much of the variance in African-American and White LBW These findings extend the discussion about race, class, and health disparities to include Latinos and shows how the relationship between SEP and LBW can vary within an ethnic group.     

Antepartum bed rest: maternal weight change and infant birth weight

Despite lack of evidence for effectiveness, obstetricians in the United States prescribe antepartum bed rest for more than 700,000 women per year. However, in nonpregnant samples, bed rest treatment produces weight loss. This study assessed maternal weight change (gain) during antepartum hospitalization for bed rest treatment; compared appropriateness of infant birth weights for gestational age, race, and gender; and determined whether maternal weight change predicted infant birth weight. The convenience sample for this longitudinal study consisted of 141 women with high-risk pregnancies who were treated with hospital bed rest. Weekly rate of pregnancy weight change by body mass index was compared with Institute of Medicine recommendations for rate of pregnancy weight gain. Infant birth weight was compared with current US infant birth weights for matching gestational age, gender, and race. Weekly antepartum weight change was significantly lower than Institute of Medicine recommendations (P < 0.001). Infant birth weights were also significantly lower than the national mean when matched for each infant's gestational age, race, and gender (P < 0.001). Maternal weight change predicted infant birth weight (P = 0.05). Bed rest treatment is ineffective for improving pregnancy weight gain. Lower infant birth weights across all gestational ages suggest that maternal weight loss during bed rest may be associated with an increased risk of fetal growth restriction. A randomized trial comparing women with high-risk pregnancies who are ambulatory with those on bed rest is needed to determine whether bed rest treatment, underlying maternal-fetal disease, or both influence inadequate maternal weight gain and poor intrauterine growth.     

Maternal and infant outcomes at one year for a nurse-health advocate home visiting program serving African Americans and Mexican Americans

This article describes the outcomes at 1 year for a randomized clinical trial of Resources, Education and Care in the Home-Futures: a program to reduce infant mortality through home visits by a team of trained community residents led by a nurse. Low-income, inner-city pregnant women who self-identified as African American or Mexican American were recruited in two university prenatal clinics in Chicago. Because African Americans and Mexican Americans differed greatly at intake, we compared their outcomes at 12 months and then examined the effects of the intervention separately for these two groups. Participants were randomly assigned to the intervention or control group and were interviewed during the last trimester of pregnancy and at 2, 6, and 12 months after birth. The effects of the program varied by race/ethnicity. For African Americans, the program was associated with better maternal documentation of infant immunizations, more developmentally appropriate parenting expectations, and higher 12-month infant mental development scores. For Mexican Americans, the program had positive effects on maternal daily living skills and on the play materials subscale of the Home Observation for the Measurement of the Environment assessment. This study, along with previous research, suggests that home visits by a nurse-health advocate team can improve maternal and infant outcomes even for inner-city, low-income, minority families. Effective programs must be culturally sensitive, intensive, and adequately staffed and financed.     

Moving to mandatory Medicaid managed care in Ohio: impacts on pregnant women and infants

BACKGROUND: Understanding the impacts of Medicaid managed care on pregnant women is critical because Medicaid covers more than a third of all births nationally, many under managed care arrangements. OBJECTIVES: We sought to examine the impacts of mandatory Health Maintenance Organization (HMO) enrollment on prenatal care use, smoking, and birth weight for Medicaid-covered pregnant women in Ohio. RESEARCH DESIGN: Impact estimates are derived from a pre-post design with a comparison group, using Ohio birth certificate data linked to Medicaid enrollment files. Between April 1993 and April 1995 is the baseline period and October 1997 to June 1998 is the post-period. The treatment group consists of deliveries in 6 counties that implemented mandatory HMO enrollment in the mid 1990s; the comparison group consists of deliveries in 4 counties with voluntary HMO enrollment. SUBJECTS: Medicaid-covered deliveries to 24,799 non-Hispanic white women with no college education living in Ohio. MEASURES: Seven outcomes are analyzed: first trimester care; last trimester or no care; adequate prenatal care; inadequate prenatal care; smoking during pregnancy; and birth weight. RESULTS: Our findings indicate that mandatory HMO enrollment in Ohio's Medicaid program had positive effects on prenatal care and led to reductions in maternal smoking. No effects were found on birth weight. CONCLUSIONS: Even with the improvements related to Medicaid managed care, rates of inadequate prenatal care and maternal smoking remain relatively high. Addressing the underlying risk factors that are facing poor women and further expanding public programs may be critical to achieving further progress.     

Obstetrics and perinatal outcomes of Thai pregnant adolescents: a retrospective study

BACKGROUND: Adolescent pregnancy is considered a high risk pregnancy. OBJECTIVES: The purpose of this study was to compare pregnancy outcomes in adolescent females aged 19 and younger with those of adult women aged 20-34 years. DESIGN: A retrospective case control study was designed to address the purpose of the study. PARTICIPANTS: Participants of this study consisted of 401 randomly selected adolescent females and 815 adult mothers who gave birth at a regional hospital in Bangkok from 2001 to 2003. METHODS: Two domains of pregnancy outcomes; maternal and infant outcomes were collected from participants' medical and prenatal records by trained observers. RESULTS: The study revealed that, compared to the adult mothers, teenage mothers were less likely to make the first prenatal visit in their first trimester (16% and 38.9%, p<.001), to have adequate prenatal care (83% and 91%, p<.01), and cesarean sections (odds ratio (OR) 2.05, confidence interval (CI) 1.44, 2.92). They had higher rates of anemia (OR 0.44, CI 0.26, 0.75), preterm deliveries (OR 1.21, CI 1.01, 1.75), and lower mean birth weight babies (2931 g and 3077 g, p<.001). CONCLUSION: This study demonstrates that, while teenage pregnancy outcomes have improved in recent years due to medical accessibility, pregnant adolescents continue to be complicated requiring clinical interventions from the health care providers.     

Intrauterine growth retardation in full-term newborn infants with birth weights greater than 2,500 g

Intrauterine growth retardation (IUGR) is an overlooked problem in full-term infants with birth weights greater than 2,500 g. Birth weight less than the 10th percentile underestimates the presence of IUGR. The purpose of this study was to determine the prevalence of IUGR in full-term infants and to identify sociodemographic and maternal characteristics associated with IUGR. The Ohio Department of Health Vital Statistics database was used to obtain data related to sociodemographic and maternal characteristics. The fetal growth ratio (FGR) was used to determine the presence of IUGR. The sample consisted of 1,569 infants with normal ratios and 1,364 infants classified as IUGR. Infants with IUGR were more often male and African American or Asian American. Maternal characteristics associated with IUGR included history of smoking during pregnancy, lower pre-pregnancy weight, lower weight gain during pregnancy, and inadequate prenatal care. IUGR is present in a significant number of full-term infants with birth weights greater than 2,500 g. The long-term effects of IUGR in these infants remain to be determined.     

Cord blood lipids in infants born to HIV-1-infected women treated with combination antiretroviral therapy

BACKGROUND: To investigate the effect of exposure to protease inhibitor (PI) therapy in utero on cord blood lipids in infants born to mothers enrolled in AIDS Clinical Trials Group protocol 5084, a prospective, multicentre, observational study of antiretroviral therapy (ART) during pregnancy. METHODS: Clinical outcome was determined in 80 infants born to women treated with PIs and 73 infants born to women treated with other antiretrovirals during pregnancy. Cord blood serum from 117 of these infants was assayed for total, low-density lipoprotein (LDL) and high-density lipoprotein (HDL) cholesterol, triglyceride, apolipoprotein A1 (apoA1), apolipoprotein B100 (apoB) and lipoprotein (a). Covariates considered in the analysis included race/ethnicity, gestational age, infant gender, infant birth weight, mode of delivery, maternal tobacco and alcohol use, post-partum body mass index, and ART duration. RESULTS: Cord blood total and HDL cholesterol, triglyceride, apoA1, apoB, lipoprotein (a) and apoB/apoA1 ratio were not different between the two groups. Cord blood lipid levels in these HIV-exposed infants were similar to those reported in other neonatal cohorts. Controlling for race/ethnicity, infants born to women treated with PIs had higher LDL cholesterol than those born to women not treated with PIs (29 mg/dl versus 27 mg/dl, P = 0.006). CONCLUSION: Only LDL cholesterol was significantly higher in the cord blood of PI-exposed infants versus those not exposed to PIs in utero. As the difference between the two groups was small, the clinical relevance of the effect of maternal PI treatment on infant LDL cholesterol levels at birth is not clear.     

Prenatal risk factors among foreign-born Central American women: a comparative study

The purpose of this study was to compare the incidence of empirically established prenatal risk factors for low birthweight (LBW) outcomes among two groups of low-income mothers: foreign-born Central American women and nonimmigrant, non-Hispanic women. Two hundred ninety-six women who were part of a larger study of maternal role sufficiency were included in the present study: 127 Central American women and 169 nonimmigrant, non-Hispanic women who identified themselves as Black (n = 59) or White (n = 110). Data were collected by public health nurses (PHNs) during home visits and by research nurses in prenatal health department clinics. Comparisons were made between the two groups in areas of demographic characteristics, prenatal health behaviors, and prenatal stressful life-events. Foreign-born Central American mothers were found to be less educated, more likely to be living with their partners, less likely to engage in prenatal health risk behaviors, and less likely to identify stressors in their lives. The initiation of prenatal PHN services by the target group was similar to the comparison group. Their rate of LBW deliveries did not reflect the protective effect often attributed to foreign-born Hispanic mothers. Findings are discussed in light of the paradox of LBW and Hispanic heritage. Recommendations for practice, clinical research, and public policy are also addressed.     

Factors that Prevent Women of Low Socioeconomic Status from Seeking Prenatal Care

While there is an international trend toward lowering infant mortality, the United States ranks 19th among industrialized nations. In Arizona, as across the nation, a large and increasing number of low birth weight (LBW) infants are being delivered. This number is viewed with alarm as LBW is associated with infant mortality; however, LBW may be preventable in many cases if mothers receive adequate prenatal care. Despite recognition that absent or inadequate prenatal care is an important risk factor, a large number of women deliver without such care. In Arizona, the percentage of women delivering at a large metropolitan public hospital without prenatal care doubled in a 2-year period, reaching 14% (764 women). The majority of these women were of low socioeconomic status. The purpose of this study was to explore the reasons given by women delivering at this hospital for not seeking prenatal care. It was determined that a qualitative methodology was most appropriate; thus, an interview guide was developed with both demographic and open-ended probing questions. Fifteen respondents-5 Caucasian, 8 Latino (5 Spanish-speaking only), 1 Afro-American, and 1 Native American—participated in the interviews. The data were transcribed from taped interviews and studied using content analysis. Eleven barriers were identified and sorted into two categories: internal and external. Internal barriers identified by the women were attitudes associated with low motivation, knowledge deficits, fear, and fatigue. External barriers elicited were finances, transportation, system difficulties, lack of support, lack of child care, missed work, and insufficient time. These barriers are the same as those identified in other studies conducted over the past 10 years related to barriers to prenatal care. This study differs from prior ones in that it addresses programmatic and social issues related to these barriers.     

Community income, smoking, and birth weight disparities in Wisconsin.

This study examined the extent to which community-level income and smoking status were associated with birth-weight disparities in the state of Wisconsin. Data included 1998 and 1999 birth record files with appended census income data for African-American, Latino, and White single births in Wisconsin. Multinomial logistic regression analysis was performed where the dependent variable included low birth weight (LBW: < 2,500 grams) and very low birth weight (VLBW: < 1,500 grams) relative to normal birth weight. The independent variables included income levels categorized as poor (< $12,499), lower middle ($12,500-34,999), and upper middle to affluent ($35,000 or more) determined by zip code, and smoking status (yes/no). African-American and Latino mothers who lived in poor communities and smoked were almost three times more likely to have a low birth weight (LBW) infant than their more affluent, non-smoking counterparts. Community income and smoking status played significant roles in birth weight disparities.