首页 | 本学科首页   官方微博 | 高级检索  
相似文献
 共查询到20条相似文献,搜索用时 109 毫秒
1.
头面部血管肉瘤1例   总被引:1,自引:1,他引:0  
患者男,76岁。头面部红斑2月余。皮肤组织病理示:真皮内可见形状不规则裂隙状血管腔,部分血管内皮细胞有异型性。免疫组化:CD31(+)、CD34(+)、von Willebrand因子(+)、CollagenIV血管壁(+),Ki-67阳性率8%。临床及组织病理确诊为血管肉瘤。  相似文献   

2.
患者男,61岁。左上肢多发性结节2年。皮损组织病理示:瘤组织位于真皮层,呈结节状,结节中心坏死,坏死周边肿瘤细胞呈上皮样或梭形,核分裂相易见。免疫组化染色示:CK(2+),EMA(2+),Vim(+),CD34(3+),CD31(+)。诊断:上皮样肉瘤。  相似文献   

3.
报告1例浅表性血管黏液瘤。患者男,75岁。左侧乳头结节状赘生物5年,间有疼痛,逐渐增大。皮损(左侧乳头)组织病理检查示:乳头状增生,表皮变薄,表皮突下延,真皮小血管增生,慢性炎性细胞浸润,间质黏液变。阿新蓝染色(+),免疫组化:波形蛋白(Vim)(+)、CD31(+)、CD34(+),S-100蛋白(-)。考虑浅表性血管黏液瘤。  相似文献   

4.
患者女,17岁。全身反复起丘疹、水疱、坏死、凹陷状瘢痕伴瘙痒、发热15年,四肢起肿块2年。血清抗EBV-IgM(-),抗EBV-IgG(+)。肿块处皮损组织病理示真皮中下层和皮下组织见弥漫性致密的瘤细胞浸润,细胞核呈间变性;免疫组化示CD3(+),浸润的大细胞CD30(+),CD43(+),80%浸润细胞Ki-67(+)。水疱处皮损组织病理示表皮网状变性及多个水疱,真皮和皮下组织可见血管和附属器周围以淋巴细胞为主的、伴少量嗜酸粒细胞浸润,部分浸润细胞呈明显异形性;免疫组化示CD3(+),CD30(-),CD43(+),Ki-67(+)。诊断:种痘样水疱病样T细胞淋巴瘤伴发原发性皮肤CD30阳性大细胞淋巴瘤。确诊后建议患者转肿瘤科化疗,随访中。  相似文献   

5.
报告1例色素性隆突性皮肤纤维肉瘤患者.患者男,30岁.左上臂蓝色斑块半年就诊.皮肤科检查:左上臂三角肌处一蓝红色斑块,表面轻微萎缩凹陷.皮损组织病理检查:真皮内有一瘤细胞团块,细胞核呈梭形,核大、深染,无明显异形,排列成车辐状或条索状,含黑素的树突状细胞不规则分布于瘤细胞之间.免疫组化染色示CD34(+),波形蛋白(vimentin)(+).诊断为色素性隆突性皮肤纤维肉瘤.  相似文献   

6.
患者男,64岁。右侧头部红斑渗液伴痒半个月。门诊初诊为"脂溢性皮炎"。皮损组织病理示:表皮角化过度伴角化不全,棘层增生肥厚,表皮突延长增宽,病变一侧表皮缺失,表面见坏死组织;肿瘤位于真皮及皮下脂肪,境界不清,由大量大小不等、交织吻合的血管组成,浸润性生长,内皮细胞单层或多层,有异型性。免疫组化示:CD31(+),D2-40(+),ERG(+),Ki-67约30%阳性。诊断:老年人头面部血管肉瘤。  相似文献   

7.
患者男,66岁。右侧头面、眼部青色结节4个月。皮损组织病理检查示:真皮全层血管网状血管瘤样增生;血管内皮细胞增生、肥大、明显异型;网状纤维染色示:网状纤维包绕肿瘤细胞。免疫组化染色示:CD31,CD34,Vimentin,LCA,Sm A和S-100全部(+),CD99(±),CD30,CEA和CK全部(-)。患者头颅MRI、全身骨扫描及胸腹部CT均提示颅骨、肋骨、纵膈和脾脏均有肿瘤转移可能。诊断:血管肉瘤并全身多处转移。  相似文献   

8.
患者男,40岁,汉族。下颌部红褐色结节2个月,无特殊自觉症状。外院曾诊断为"疖"欲行切开引流;门诊拟诊"下颌结节待查,不除外Kaposi肉瘤"。皮损组织病理示:表皮大致正常,真皮内大量的梭形细胞增生,其间呈血管样裂隙,裂隙内可见红细胞;免疫组化标记CD31(+),CD34(+)。诊断:Kaposi肉瘤。  相似文献   

9.
患者男,60岁,藏族。全身斑块、结节及肿块6月,肿块破溃伴疼痛2月。皮损病理组织示:表皮变薄,基底层液化变性,瘤细胞在真皮及皮下脂肪层呈弥漫性浸润,瘤细胞形态不一,核深染,可见血管中心性浸润及凝固性坏死。免疫组化标记瘤细胞CD3,CD3ε,CD56,TIA-1,粒酶B均为(+),CD30约10%(+),CD8(-),CD79a(-),EBER1/2原位杂交(+)。TCR-γ重排未见明确克隆性重排条带。诊断:皮肤结外鼻型NK/T细胞淋巴瘤。  相似文献   

10.
患者男,29岁。四肢、臀部起蓝色结节1年余。皮损约数十个,蓝色或蓝黑色,质软可压缩,部分有触痛。组织病理示:真皮下部及皮下组织见大量纡曲扩张血管腔,管壁内衬一层血管内皮细胞,其外有一层至数层血管球细胞。免疫组化:平滑肌肌动蛋白(+),波形蛋白(+),CD31(-)。结合临床表现、组织病理改变及免疫组化染色结果诊断:播散性多发性血管球瘤。  相似文献   

11.
BACKGROUND: Cutaneous epithelioid angiosarcoma is a type of cutaneous angiosarcoma and usually arise both on the head or neck of the elderly. CASE REPORT: An 86-year-old male with an epithelioid angiosarcoma of the scalp that mimicked malignant melanoma. RESULTS: A large irregular dark grey-blue plaque with an adjacent speckled tan nodule was suggestive of a primary cutaneous malignant melanoma with adjacent in-transit metastasis. Both had a well-circumscribed growth pattern and were composed of numerous large epithelioid cells with scattered severe atypia and mitoses. The tumor was positive for S-100 protein and vimentin and negative for low- and high-molecular weight cytokeratins. However, at high power, the epithelioid cells with severe atypia were negative for S-100 protein, and abundant large epithelioid macrophages were responsible for the S-100 protein positivity. The malignant tumor cells were negative for HMB-45, positive for CD31 and Factor VIII-related antigen, and focally positive for CD34. A focus of infiltrative, classical angiosarcoma with irregular vascular channels lined with plump, anaplastic endothelial cells was then found deep to the epithelioid tumor. CONCLUSIONS: Macrophage-rich epithelioid angiosarcoma demonstrates abundant S-100 protein-positive epithelioid macrophages. This subset of epithelioid angiosarcoma may mimic malignant melanoma and may present as a pitfall in diagnosis.  相似文献   

12.
We report a case of cutaneous postradiation angiosarcoma of the breast exhibiting pseudoepidermotropism that resembled metastatic adenocarcinoma on hematoxylin and eosin. The patient is a 74-year-old woman with history of breast carcinoma treated with mastectomy, chemotherapy, and radiotherapy who complained of an erythematous "rash" along the central portion of the mastectomy scar. Radiography showed widespread osseous metastasis. Biopsy revealed an infiltrative tumor with single file growth and tumor cells obscuring the dermal--epidermal junction in multiple foci, imparting an appearance of epidermotropism. The tumor cells were positive for CD31, CD34, and D2-40 and negative for Cam 5.2. This novel case of pseudoepidermotropic angiosarcoma highlights a potential pitfall in the histomorphologic assessment of poorly differentiated angiosarcoma.  相似文献   

13.
The majority of cutaneous angiosarcomas display typical architectural features of irregular anastomosing vascular channels in the dermis and subcutis. Nuclei are usually hyperchromatic and pleomorphic but die volume of cytoplasm of the neoplastic cells is often small. Diagnosis can be made readily on an adequate biopsy. We recently experienced difficulty diagnosing an angiosarcoma composed predominantly of cells with abundant granular cytoplasm. We were able to compare the present case with sections obtained from the only other reported example. The architectural expression of an anastomosing vascular pattern in areas of tumor, combined with the positive staining for Factor VIII-related antigen (FVIIIRAg) and Ulex europaeus agglutinin-1 (UEA1) enabled us to make a diagnosis of angiosarcoma. The tumor failed to stain for the other endothelial markers (CD31 and CD34) which were positive in the original case. A marker for lysosomes (CD68) stained the granules in both cases. The granular cell variant of cutaneous angiosarcoma is very rare. Diagnosis is possible by recognizing the typical anastomosing neoplastic vascular channels at the periphery of the lesion, and by use of a combination of lectin (UEA1) and immunohistochemical (FVIIIRAg, CD34 and CD31) endothelial markers.  相似文献   

14.
We report an 80-year-old woman, suffering from a recurrence of a multilocalized lymphedema-associated angiosarcoma of the right arm. The tumor consisted of solid tumor cell formations and "classical" spongiform tumor complexes. In the tumor periphery, pathological endothelial cell proliferates on pre-existing dilated lymphatic capillaries were detectable, which, together with immunohistology (CD 31+/Desmoplakin-1-2.17+/CD 34-), supported the diagnosis of lymphangiosarcoma. Complete remission was achieved under radioimmunotherapy (54 Gy/Interferon beta). A further recurrence 3 months later outside the primary therapy fields was successfully treated with radiotherapy alone. During a follow-up observation period of 3 years, there was neither local recurrence nor metastasis. This case demonstrates for the first time the long-lasting efficacy of photon radiation in a case of histologically-defined lymphangiosarcoma. Further studies should elucidate the suitability of radio monotherapy as first-line therapy in lymphedema-associated angiosarcoma with lymphatic endothelium-like immunohistology.  相似文献   

15.
Cardiac epithelioid angiosarcoma presenting as cutaneous metastases   总被引:4,自引:0,他引:4  
BACKGROUND: Cardiac angiosarcoma is a rare tumor that has a predilection for middle-aged males and a marked predominance in the right atrium. The tumor may present abruptly with a fulminant clinical course. Initial presentation with metastatic disease is rare. Only one case has been reported of a patient who presented with cutaneous metastases. METHODS AND RESULTS: We here report the case of a 51-year-old man who initially presented with cutaneous metastases in the absence of cardiac symptoms. The skin biopsy was diagnosed as metastatic undifferentiated sarcoma. The patient died 26 days later with widely disseminated disease. At autopsy a tumor arising in the wall of the left atrium and in the interatrial septum was found. After an immunohistochemical study including CD31 and CD34 stains the diagnosis of cardiac pure epithelioid angiosarcoma was made. To the best of our knowledge this tumor variant has not been documented in the heart until now. CONCLUSION: Although cardiac angiosarcoma is a rare neoplasm, its presence should be suspected in patients with cutaneous metastatic angiosarcoma without an evident source of the tumor, even in absence of cardiac symptoms.  相似文献   

16.
BACKGROUND: Angiosarcomas arise in the scalp and face in the elderly, in association with chronic lymphedema (Stewart-Treves syndrome), and in irradiated areas. Rarely in these settings, angiosarcomas exhibit pure spindle cell phenotype. METHODS: Herein, the clinicopathologic features of a 72-year-old-woman with spindle cell angiosarcoma are described. RESULTS: A 72-year-old woman presented with numerous nodules and diffuse induration from the lower abdomen to the right buttock, corresponding to the area exposed to 60Co-irradiation during treatment for cervical carcinoma 10 years earlier. Histopathological examination revealed inflitrative, atypical, spindle cells that labeled with antibodies to CD31, CD34, and factor VIII-related antigen. Ultrastructurally, these malignant spindle cells contained Weibel-Palade bodies. No features suggesting radiation dermatitis (sclerosis or bizarre, large fibroblasts) were identified, but lymphangiectases and widely spaced collagen bundles(lymphedema) were prominent in the skin surrounding the angiosarcoma. Computed tomographic scan of the abdomen highlighted this histologic finding by demonstrating tumor masses limited to areas of lymphedema. Treatment with intravenous and local injections of recombinant interleukin 2 (rIL 2) followed by electron beam irradiation were initially effective with tumor remission for 2 months. However, the recurrent tumor did not respond to a second course of one-shot injection of rIL 2 through the abdominal aorta and the patient succumbed to her angiosarcoma 19 months after diagnosis. CONCLUSIONS: Radiation-induced lymphedema may be a factor in angiosarcoma associated with radiotherapy.  相似文献   

17.
患者男,53岁。头部丘疹1年,肿块5个月。组织病理:真皮内可见内含红细胞的不规则管腔相互融合,浸润生长,管腔衬附细胞大小不一,核大深染,胞浆丰富,核分裂易见,异型性明显。免疫组化:CD31,CD34阳性;S-100,SMA,Des阴性。诊断:血管肉瘤。经重组人血管内皮抑制素注射液及紫杉醇方案化疗10周期后皮损缩小,因无手术切除指征,遂予局部放疗。4个月前患者右小腿出现一包块,术后病理证实为血管肉瘤。1个月前PET/CT示右小腿肌组织、左侧腮腺、盆腔、右侧腹股沟至腘窝淋巴结、右侧肱骨头均考虑恶性病变。行长春瑞滨、顺铂及重组人血管内皮抑制素注射液化疗。  相似文献   

18.
Pseudolymphomatous cutaneous angiosarcoma represents a rare, relatively new variant of cutaneous angiosarcoma exhibiting a prominent inflammatory lymphoid infiltrate that can mask the underlying vascular malignant proliferation and mimic a lymphomatous or pseudolymphomatous process. We describe the clinicopathologic characteristics of two new cases of pseudolymphomatous cutaneous angiosarcoma whose originality lies in the unusual setting from which they have arisen. In fact, the first case was an exceedingly lymphocyte‐rich recurrence of a typical epithelioid cutaneous angiosarcoma whose primary lesion that was almost devoid of inflammatory infiltrate underwent surgical excision and radiotherapy while the second one was an unexpected histopathological finding associated with a basal cell carcinoma. Immunohistochemically, most of the lymphocytes expressed immunoreactivity for T‐cell markers, while the neoplastic endothelial lymphatic cells expressed CD31 and CD34. D2‐40 immunoreactivity was observed lining some channels and some neoplastic cells. In the first case a possible relationship between radiotherapy and the pseudolymphomatous reactive pattern is discussed while the second case has been considered as a rare example of collision tumor.  相似文献   

19.
以皮肤水疱为主要表现的血管肉瘤1例   总被引:1,自引:1,他引:0  
报告1例以皮肤水疱为主要表现的血管肉瘤。患者男,78岁,面部、额部、头皮紫红色肿物、水疱5月余,经组织病理学检查确诊为血管肉瘤,免疫组化检查显示CD31( )、CD34(血管 )。  相似文献   

20.
A case of cutaneous epithelioid angiosarcoma with anomalous CD30 expression, occurring after breast-conserving surgery and adjuvant irradiation, is reported. This seems to be the first such case reported. The differential diagnosis of CD30 epithelioid angiosarcoma is discussed.  相似文献   

设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号