斑秃患者2000例中甲病变的临床分析

我们对2000例斑秃（alopecia areata,简称AA）患者甲病变的临床表现，发生率及病理改变，进行了观察，并以2130例普通人群作为对照，结果AA的甲病变明显高于普通人群，尤其是全秃和普秃型的患者，甲病变以凹点和白点为最多，病理改变以聚集大量的角化不全细胞为主，本文还分析了甲病变与AA的病程及病情的关系。     

丹参对斑秃患者甲皱微循环的影响

斑秃是皮肤科的常见病之一，其病因和发病机制尚不完全清楚。国内外有研究表明斑秃患者存在不同程度的微循环障碍，临床治疗效果不甚满意，笔者利用丹参治疗69例斑秃病人，观察丹参对甲皱微循环的影响。     

甲钴胺局部注射治疗斑秃疗效分析

我院从2005年2月—2007年2月,对斑秃患者的秃发区注射甲钴胺制剂,取得较满意治疗效果,现报告如下。1资料与方法临床资料:根椐临床皮损表现而确诊的斑秃患者共76例,其中男41例,女35例;年龄16～61岁,平均年龄32.4岁;     

斑秃患者甲改变的观察

本文观察了斑秃163例的甲片变化,其发生率为65.64%.但甲片变化与斑秃的严重程度、病程均无明显关系.甲片变化多为甲凹点.     

55例儿童斑秃临床分析

目的探讨儿童斑秃的临床特点、治疗经过及转归。方法回顾性分析55例儿童斑秃患者的一般资料、发病原因、临床表现、辅助检查、治疗方法及转归情况。结果 55例斑秃儿童中,14例有斑秃家族史,2例其父或母患Ⅰ型糖尿病,26例合并过敏性疾病,8例先后患白癜风,3例经检查发现甲状腺功能异常,2例有明显惊吓史。伴指趾甲改变者37例,外周血微量元素2项以上降低者12例,血嗜酸性粒细胞升高者20人。治疗采用外用2%米诺地尔酊溶液,中药水煎剂洗头,辅以氦氖激光治疗,斑秃严重及局部治疗不佳者予口服中药,系统应用糖皮质激素治疗。49例患者1年内治愈,5例患者1年内好转但再发,1例患者无效。结论儿童斑秃常有家族史,易伴发过敏性疾病和免疫性疾病,甲损害常见。轻型斑秃采用局部药物和理疗疗效佳,较重型及较顽固型斑秃采用内服外用等联合疗法治疗可显效,但仍有小部分再发。     

白癜风患者100例甲病变发生率分析

目的了解白癜风患者甲病变的发生概率、类型等。方法收集2015年1月-2019年1月本院经治白癜风患者100例(观察组),另招募性别、年龄匹配的健康志愿者100例(对照组)。对比分析两组甲病变发生率和白癜风不同分型、分期间甲病变发生率。结果观察组甲病变总体发生率高于对照组,差异具有统计学意义(P<0.05)。观察组甲纵脊发生率高于对照组,差异具有统计学意义(P<0.05)。进展期白癜风甲病变发生率高于稳定期,差异具有统计学意义(P<0.05)。不同临床分型间甲病变发生率差异无统计学意义(P>0.05)。甲病变发生与发病年龄、病程间均无相关性(P均>0.05)。结论白癜风可见甲病变,以进展期白癜风多见,并常表现为甲纵脊。其发生无临床分型差异,且与发病年龄、病程均无相关性。     

壮医药线点灸对不同中医证型斑秃患者的影响

<正>斑秃为累及毛发的突发性、非瘢痕性、慢性炎症性疾病,是中青年较常见的一种损容性疾病,笔者采用壮医药线点灸治疗,结果报道如下。1资料与方法1.1临床资料1.1入选标准50例斑秃患者均为本院皮肤科门诊病人,其中男22例,女28例,平均年龄33.7岁;病程7 d～1.5年;     

斑秃病人甲皱和头部皮肤微循环观察与研究

斑秃病人甲皱和头部皮肤微循环观察与研究倪剑①孙益年②近年来微循环的研究已取得了较大的进展。采用微循环显微镜对斑秃病人甲皱和头部斑秃区皮肤进行微循环的研究，国内目前报道不多。因微循环在各种伤病情况下反映快，一些典型的病理过程中都可引起微循环的改变。因此...     

斑秃655例伴发疾病分析

目的探讨斑秃发病的临床特点及伴发疾病分析。方法收集本科门诊2006年1月-2008年5月确诊的斑秃患者,以调查表的形式收集患者临床资料及伴发疾病情况,包括斑秃发病年龄、病程、严重程度、家族史和复发情况等,用SPSS13.0软件分析。结果 655例斑秃患者,男320例,女335例,平均年龄(38.4±12.4)岁,平均病程(14.8±35.7)个月,88例(13.44%)为全秃/普秃,84例(12.82%)家族史阳性,195例(29.77%)斑秃反复发作。655例患者中,190例(29.01%)除斑秃外,还伴发至少1种过敏性疾病或自身免疫性疾病,仅伴过敏性疾病者123例(18.78%)。未发现伴发疾病与性别、发病年龄、病程、斑秃类型、既往史及家族史相关联(P>0.05)。全秃/普秃更易伴发过敏性疾病,包括湿疹、荨麻疹、哮喘和药物过敏(P=0.004),与无伴发过敏性疾病的斑秃患者相比,伴发者发病更早(P=0.033)。结论斑秃与伴发的其他疾病可能有着相同的遗传学、免疫学基础,不同的伴发疾病可能对斑秃的发生、发展和预后产生不同的影响。     

斑秃患者临床特征分析研究

目的调查斑秃患者的临床特征,分析影响斑秃病情轻重的相关因素,为临床诊治和预后判定提供依据。方法制作斑秃患者临床及流行病学调查表,通过对患者问诊填写相关项目,总结分析斑秃的临床特征,评价斑秃病情轻重的相关因素。结果283例斑秃患者入组,男性135例(47.70%),女性148例(52.30%),男女比例1︰1.10。发病年龄为9个月～74岁,中位数为29岁。29例S3～S4型斑秃、19例全秃、13例普秃定义为重型斑秃。重型斑秃患者较轻型斑秃患者发病年龄小、首发病情重、复发率高、多伴有家族史(P<0.01)。结论发病年龄小、首发病情严重、有斑秃家族史是重型斑秃的重要临床特征,可作为斑秃预后的评价指针之一。     

76例重型斑秃的临床分析

目的 :探讨重型斑秃的临床特征。方法 :回顾分析了近 4年诊治的 76例重型斑秃病例。结果 :重型斑秃中女性患者的病程比男性患者长 (P <0 0 5 ) ,与重型斑秃中的斑秃相比 ,甲异常改变更多见于全秃和普秃患者 (P <0 0 5 ) ,有家族斑秃史患者与无家族斑秃史患者比较 ,两者的初次发病年龄有显著性差异 (P <0 0 5 ) ,发病前伴有精神神经因素诱发者比无伴有精神神经因素诱发者病程要短 (P <0 0 5 )。结论 :女性重型斑秃患者可能病程更容易持续延绵、迁移反复 ,重型斑秃中有家族斑秃史者 ,它的发病年龄更早 ,甲异常改变不但多见于病程较长、病情顽固、反复的患者 ,而且也多见于病情较重的患者 ,全秃和普秃患者甲异常改变更多见 ,重型斑秃的治疗应注意精神因素的影响及强调综合治疗。     

46例斑秃患者经络生物共振检测结果病因分析

目的斑秃病因未明,利用经络生物共振检测技术开展大范围斑秃患者病因检测与分析。方法采用德国MORA-Supe经络生物共振仪,通过人体体表经络穴位广泛开展人体内不耐受物质和器官检测。结果环境化学物质作为首要病因39例(84.78%)、植物类26例(56.52%)、电磁辐射19例(41.30%)、动物蛋白15例(32.61%)、寄生虫12例(26.09%)、动物脂肪6例(13.04%)、微生物7例(15.22%)、酒类4例(8.70%)、精神因素3例(6.52%)、食用真菌2例(0.04%)。结论斑秃病因检测结果,以环境化学物质因素(87.78%)远远高于其他因素,需要引起注意。     

斑秃患者血浆内皮素及血清一氧化氮水平测定及其意义

目的 :探讨血浆内皮素 (ET)和血清一氧化氮 (NO)在斑秃发病中的作用。方法 :应用放射免疫法和Greiss法测定 2 3例斑秃活动期患者、1 1例斑秃稳定期患者以及 2 5例正常人血浆ET和血清NO值。结果 :斑秃活动期患者ET水平和ET/NO比值显著高于正常人 (P <0 0 5 ) ,但其NO水平与正常人无显著性差异 (P >0 0 5 ) ;斑秃稳定期ET和NO水平以及ET/NO比值与正常人无显著性差异(P >0 0 5 )。结论 :斑秃活动期患者ET水平和ET/NO比值可能与斑秃的活动性有关     

斑秃家族患病调查及其研讨

报道原发性斑秃1210例,发现有家族史者75例(6.2%),其家族中共有患者163例,患病率为14.91%.家族患者之间亲缘关系分属于:Ⅰ级亲属142例(87.12%),Ⅱ级17例,Ⅲ级4例,患者发病在同一个世代者33户,70例;发于两世代40户,87例;三世代2户,6例.有4例单合子双胎,今尚未见其孪生者同发斑秃.对遗传因素与斑秃发病之关系进行了分析研讨.     

Alopecia areata: Clinical presentation, diagnosis, and unusual cases

Alopecia areata (AA) is a nonscarring hair loss disorder with a 2% lifetime risk. Most patients are below 30 years old. Clinical types include patchy AA, AA reticularis, diffuse AA, AA ophiasis, AA sisiapho, and perinevoid AA. Besides scalp and body hair, the eyebrows, eyelashes, and nails can be affected. The disorder may be circumscribed, total (scalp hair loss), and universal (loss of all hairs). Atopy, autoimmune thyroid disease, and vitiligo are more commonly associated. The course of the disease is unpredictable. However, early, long‐lasting, and severe cases have a less favorable prognosis. The clinical diagnosis is made by the aspect of hairless patches with a normal skin and preserved follicular ostia. Exclamations mark hairs and a positive pull test signal activity. Dermoscopy may reveal yellow dots. White hairs may be spared; initial regrowth may also be nonpigmented. The differential diagnosis includes trichotillomania, scarring alopecia, and other nonscarring hair loss disorders such as tinea capitis and syphilis.     

斑秃患者中医体质分型和心理评估研究及关系分析

目的 探讨斑秃的中医体质类型与心理特征间的关系,为斑秃的治疗提供依据及新的思路.方法 应用《中医体质分类判定标准》及《艾森克个性调查表》测试对113例斑秃患者进行体质类型及性格调查,采用SPSS16.0统计软件分析.结果 与正常对照组比较,斑秃患者的E、N、P量表（E：Extrovision-Introvision,外向和内向;N：Neuroticism,神经质;P：Psychological）均显著高于正常对照组.与性格内外向（E）、神经质（N）、精神质（P）差异有统计学意义;2组中医体质类型比较,差异有统计学意义（x2=51.256,P＜0.01）,病例组多见偏颇体质（占93.81％）,对照组多见平和体质（47.20％）,斑秃病例组中医体质类型依次为阴虚质、瘀血质、气虚质、特禀质、气郁质、平和质、阳虚质、湿热质、痰湿质,斑秃患者平和质与阴虚质人群比较,阴虚质人群E、N分数差异有显著统计意义,具有内向、情绪不稳定的个性特点.结论 斑秃患者大部分表现为内向、神经质和精神质,3个都是突出表现在焦虑、抑郁方面.而他们在中医体质类型中以阴虚内热为主,故个性急躁、易急.本研究从体质及性格分析的角度出发,为预防和中医辨证治疗本病提供了理论依据,但斑秃与其他心身疾病一样,真正的病因和确切的发病机制有待阐明.     

Tale of Two Alopecias: Alopecia Areata and Central Centrifugal Cicatricial Alopecia Occurring in the Same Patient

Introduction: Scarring and non-scarring alopecias have rarely been described to occur together in the same patient. Distinguishing these two different types of alopecia is important as treatment and prognosis can be different.Case presentation: Here, we report the first case of simultaneous alopecia areata (AA) and central centrifugal cicatricial alopecia (CCCA) in a 35-year-old woman. New alopecic patches were noted on her frontal and vertex scalp. Biopsy of the frontal scalp revealed miniaturi...     

The role of the National Alopecia Areata Foundation in the management of alopecia areata

Like a mysterious thief in the night, alopecia areata (AA) suddenly appears without warning—seemingly without rhyme or reason—randomly robbing the hair and subsequently the self-esteem of those affected. Very persuasive scientific evidence now suggests that AA is a T-lymphocyte-mediated autoimmune disease directed against an as yet unidentified hair follicle autoantigen in genetically susceptible individuals. The severity of the clinical phenotypes seen in AA run the gamut from patchy hair loss localized in one or more areas, to total scalp hair loss [alopecia totalis (AT)], to complete body hair loss [alopecia universalis (AU)]. Although not life threatening, AA is most certainly life altering, and its sudden onset, recurrent episodes, and highly unpredictable course have a profound psychological impact on the lives of those with the disease. There are a limited number of therapeutic agents available to treat AA. Responses vary widely and the hard fact remains that any treatment, no matter how successful, does not alter the ultimate course of this capricious and recalcitrant disease. Founded in 1981 to meet the challenges of AA and mollify the deep emotional pain inflicted by this disease, the National Alopecia Areata Foundation (NAAF) now serves as the world center of information and hope for those with AA. The foundation plays a crucial role in the management of AA by encouraging and funding medical research for better treatment and an ultimate cure, by providing support and resources for those with the condition, and by raising public awareness of the disease.     

Impact of Pediatric Alopecia Areata on Quality of Life of Patients and Their Family Members: A Nationwide Multicenter Questionnaire Study

BackgroundPediatric alopecia areata (AA) can affect the quality of life (QoL) of patients and their family members. Research on the QoL and burden on family members in pediatric AA is limited.ObjectiveThis nationwide multicenter questionnaire study described the QoL and burden of the family members of patients with pediatric AA.MethodsThis nationwide multicenter questionnaire study enrolled AA patients between the ages of 5 and 18 years from March 1, 2017 to February 28, 2018. Enrolled patients and their parents completed the modified Children’s Dermatology Life Quality Index (CDLQI) and the modified Dermatitis Family Impact (mDFI). The disease severity was measured using the Severity of Alopecia Tool (SALT) survey scores.ResultsA total of 268 patients with AA from 22 hospitals participated in this study. Our study found that the efficacy and satisfaction of previous treatments of AA decreased as the severity of the disease increased. The use of home-based therapies and traditional medicines increased with the increasing severity of the disease, but the efficacy felt by patients was limited. CDLQI and mDFI scores were higher in patients with extensive AA than those with mild to moderate AA. The economic and time burden of the family members also increased as the severity of the disease increased.ConclusionThe severity of the AA is indirectly proportional to the QoL of patients and their family members and directly proportional to the burden. Physicians need to understand these characteristics of pediatric AA and provide appropriate intervention to patients and their family members.