埃兹蛋白在皮肤鳞癌、基底细胞癌中的表达及相关研究

目的 探讨埃兹（Ezrin）蛋白在皮肤基底细胞癌（BCC）和鳞状细胞癌（SCC）中的表达及在肿瘤侵袭转移过程中的作用.方法 采用免疫组化SP法检测Ezrin蛋白在皮肤BCC（30例）、SCC（32例）及正常皮肤对照组（10例）中的表达情况.结果 Ezrin蛋白在BCC、SCC及正常皮肤对照组中阳性表达率分别为60.0％、84.4％和10％.Ezrin蛋白在各组之间表达差异有统计学意义（P＜0.05）.Ezrin蛋白阳性表达与SCC的分化程度和淋巴结转移密切相关,各组间表达差异有统计学意义（P＜0.05）.结论 Ezrin蛋白的检测可能成为预测皮肤恶性肿瘤转移和预后的一项指标.     

不同皮肤病生活质量的比较研究

目的　探讨不同皮肤病对患者生活质量的影响。方法　采用DLQI调查问卷 ,选取门诊患者 2 14例 ,包括慢性荨麻疹、慢性湿疹、瘙痒症、银屑病等 ,完成问卷的填写 ,然后进行统计分析。结果　慢性荨麻疹、湿疹、瘙痒症、银屑病等对于患者生活质量的影响比寻常疣、色素痣、脂溢性角化等的影响大。结论　上述疾病严重影响了患者的生活质量 ,不同的疾病对于生活质量不同方面的影响不同。     

鳞状细胞癌抗原在几种皮肤病中的检测

目的了解常见皮肤病患者的血清鳞状细胞癌抗原(SCC-Ag,简称SCCA)表达并探讨其在皮肤病诊疗中的意义。方法收集179例患者的临床资料,对42种皮肤科常见疾病患者血清SCCA的测定值进行分析。结果银屑病与红皮病患者的SCCA值高于正常水平者为100%。此外,存在SCCA血清水平增高的疾病还包括天疱疮(12/16)、大疱型类天疱疮(14/23)、湿疹(18/28)、药疹(2/5)、皮肤鳞状细胞癌(2/7)、嗜酸细胞增多性皮病(3/4)等。皮肤表皮受累面积越广、表皮角化、表皮剥脱越严重的疾病SCCA值相对越高。随着病情的好转,患者的SCCA值降低。结论血清SCCA测定值可以作为皮肤病临床诊疗过程中皮损受累程度和治疗效果评价的一项参考指标。     

Dermatoscopia del carcinoma basocelular: revisión actualizada

Dermoscopy is a noninvasive technique that has been demonstrated to improve diagnostic accuracy in basal cell carcinoma (BCC). The first dermoscopic model for the diagnosis of BCC, based mainly on the identification of pigmented structures, was described by Menzies et al., and since then dermoscopy has generated an abundance of literature useful to routine clinical practice. From a practical perspective, dermoscopic structures associated with BCC can be classified as pigmented, vascular, or nonpigmented/nonvascular. One of the most recent applications of dermoscopy in BCC is as an aid to predicting histologic subtype and essentially differentiating between superficial and nonsuperficial BCC. It can also, however, help raise suspicion of more aggressive variants with a higher risk of recurrence. A thorough dermoscopic examination during follow-up of patients with actinic damage or a history of multiple BCCs can facilitate the detection of very incipient lesions and significantly impact treatment and prognosis.     

An overview of Mohs micrographic surgery for the treatment of basal cell carcinoma

This article reviews Mohs micrographic surgery for basal cell carcinoma. Its evolution to the present day technique, indications, and limitations are discussed, along with future expectations for the procedure.     

Evaluación de indicadores de estructura en la atención al paciente con cáncer de piel en los servicios de dermatología

Introduction and objectivesA series of quality indicators for melanoma and nonmelanoma skin cancer were recently approved within a project promoted by the Healthy Skin Foundation of the Spanish AEDV. The aim of this study was to evaluate adherence to these indicators.Material and methodsIn November 2016, an anonymous questionnaire consisting of 32 items was sent to the heads of Spanish dermatology and venereology departments listed in the AEDV's database. The questions referred to the above-mentioned quality of care indicators.ResultsThe questionnaire was completed by 104 of the 150 people contacted (response rate, 69.3%). The lowest response rate for any given question was 56% (84 respondents). Over 85% of respondents answered 29 questions or more (91%). The most widely used indicators were those related to the use of computed tomography or magnetic resonance imaging for squamous cell carcinoma (98%), followed by the availability of a standardized melanoma pathology report (90%). The least widely used indicators were related to availability of electrochemotherapy (25%) and other invasive therapies for locoregionally advanced melanoma (20%).ConclusionsAdherence to quality of cancer care criteria at the different hospitals evaluated varied. Our findings could be useful for identifying areas for improvement at different hospitals. Future studies should focus on measuring both process and outcome indicators.     

Management of Skin Cancer in Solid-organ Transplant Recipients: A Multidisciplinary Approach

Solid-organ transplant recipients are at increased risk for the development of skin cancers. A promising strategy for managing these complex patients involves a multidisciplinary approach that incorporates clinicians from various specialties, which provides the optimal milieu for patient education, treatment, and follow-up. The multidisciplinary clinic also facilitates communication between dermatologists and transplant physicians regarding such crucial concerns as revision of immunosuppression. This article reviews the problem of skin cancer in solid-organ transplant recipients, outlines preventive measures, discusses therapeutic modalities, and reinforces the advantage of a multidisciplinary approach in the management of this population.     

CD44V6在表皮肿瘤及恶性黑素瘤的表达

目的　研究CD44V6在鳞状细胞癌、基底细胞癌和恶性黑素瘤的表达。方法　免疫组织化学对石蜡包埋组织标本进行检测。结果　 1 0例鳞状细胞癌CD44V6膜表达阳性 ,且随癌细胞分化程度降低CD44V6表达下调。 1 0例基底细胞癌和 8例恶性黑素瘤不表达CD44V6。结论　CD44V6的表达与皮肤肿瘤的类型有关     

Immunohistochemical localization of proliferating cell nuclear antigen/cyclin in human skin

Summary Expression of proliferating cell nuclear antigen/cyclin (PCNA/cyclin) in skin tissue specimens and cultured keratinocytes was studied using a monospecific antibody, obtained from a patient with systemic lupus erythematosus, and a monoclonal antibody. Indirect immunofluorescent staining revealed that cultured keratinocytes obtained from human foreskins expressed PCNA/cyclin as variable nuclear patterns in 15–30% of the cells. In normal human skin tissue specimens, PCNA/cyclin was demonstrated in only a few basal cells. Interestingly, PCNA/cyclin was expressed strongly in almost all the cells of the lowest layer of the epidermis adjacent to squamous cell carcinomas, whereas the tumor aggregates themselves had no positive staining. In contrast, no such characteristic staining was demonstrated in specimens of basal cell carcinoma. The staining pattern of PCNA/cyclin was different from that of Ki-67 in the skin tissue specimens. Our results suggest that PCNA/cyclin could be a useful marker of cell proliferation.