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1.
湿疹及皮炎     
20023622 CTLA4-lg对变应性接触性皮炎小鼠模型的治疗作用/周倩(北大一院皮肤科)…∥中华皮肤科杂志.-2002,35(4).-256-259建立小鼠DNFB变应性接触性皮炎模型,静脉注  相似文献   

2.
银屑病的动态发病模式   总被引:1,自引:0,他引:1  
本文阐述CD4+T细胞、抗原提呈细胞、CD8+T细胞三类细胞相继作用而形成的银屑病动态病模式,强调了B7/CD28非抗原依赖共刺激信号在CD8+T细胞活化、银屑病发病中的重要作用,并提出通过CTLA4Ig阻断共刺激信号而抑制CD8+T细胞活化,为治疗银屑病提供了新的思路。  相似文献   

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复方木尼孜其颗粒对变应性接触性皮炎小鼠模型的影响   总被引:1,自引:0,他引:1  
目的研究复方木尼孜其颗粒对变应性接触性皮炎(ACD)小鼠模型的影响。方法建立小鼠变应性接触性皮炎反应模型,观察使用不同浓度复方木尼孜其颗粒后的效果。结果复方木尼孜其颗粒高剂量组能明显抑制ACD小鼠的耳厚度、耳肿胀度,真皮中多形核细胞及单一核细胞数,以及ACD小鼠外周血γ干扰素(IFN)含量。结论复方木尼孜其颗粒能明显抑制二硝基氟苯(DNFB)诱导的变应性接触性皮炎。  相似文献   

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B7分子与CD28/CTLA4结合后产生的共刺激信号是T细胞活化和自身抗体产生的必要条件。系统性红斑狼疮患者体内抗原递呈细胞表达B7分子异常,并与系统性红斑狼疮发病机制有关。阻断B7/CD28信号通路在系统性红斑狼疮动物模型上取得了良好的疗效,因而可能具有潜在的临床应用价值。  相似文献   

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以B7-CD28/CTLA-4分子为主的共刺激通路是T细胞活化增殖的必要条件。银屑病是一种T细胞介导的炎症性自身免疫性疾病,患者体内存在着免疫学异常,皮损中亦有T淋巴细胞的浸润及活化。近年来的研究表明,B7-CD28/CTLA-4共刺激通路在银屑病的发病中可能起重要的作用,利用CTLA-4Ig、抗CD80单抗治疗银屑病取得了较好疗效。  相似文献   

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目的:评价苦豆子总碱(TASA)对小鼠变应性接触性皮炎的抗炎效果.方法:用2,4-二硝基氟苯(2, 4-DNFB)对BALB/c小鼠进行皮肤致敏和激发,制成小鼠接触性皮炎模型,其中3组分别外用0.05%、0.1%和0.2%TASA治疗,连续3天,以非治疗组和哈西奈德溶液治疗组作对照,24 h后对小鼠耳肿胀度和质量进行测定,并对皮损行组织病理检查.结果:0.1%和0.2%治疗组小鼠的耳肿胀度及质量均显著下降;HE染色显示外用0.1%和0.2%治疗组皮肤组织的炎症程度明显减轻.结论:外用0.1%和0.2%的TASA对DNFB所致的小鼠变应性接触性皮炎具有抑制作用.  相似文献   

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探讨苦豆子总碱(totalalkaloids from Sophora alopecuroides,TASA)对小鼠变应性接触性皮炎模型肥大细胞及TNF—α表达的影响。用1%浓度的2,4-二硝基氟苯(2,4-DNFB)对BALB/c小鼠进行皮肤刺激制成小鼠刺激性接触性皮炎模型,将小鼠分为四组,G1组未作任何处理,G2组单纯外用0.9%生理盐水,G3组外用0.1%哈西奈德溶液,G4组外用0.1%的TASA治疗,均在刺激后30min搽药。5h后进行肥大细胞染色及对皮肤组织采用ELISA检测前炎症因子肿瘤坏死因子(TNF—α)表达水平。G4组与G1组及G2组小鼠比较,皮肤组织的肥大细胞数量明显减少,皮损ELISA检测示TNF—α明显降低。外用0.1%的TASA对DNFB所致的小鼠刺激性接触性皮炎具有抑制作用。  相似文献   

8.
湿疹及皮炎     
961581 雷公藤内酯酮对小鼠变应性接触性皮炎的抑制作用及其机制探讨/周平…//首都医科大学学报。-1996,17(1).-52~54 研究了雷公藤内酯酮对小鼠变应性接触性皮炎T和B淋巴细胞增殖反应及脾细胞分泌白细胞介素2(IL-2)活性的影响。发现雷公藤内酯酮1、2、5mg/kg腹腔注射(ip、qd×5d)能显著抑制二硝基氟苯(DNFB)诱导的变应性接触性皮炎,而对脾细胞IL-2分泌活性无显著影响。体外试验表明,0.02、0.10、0.50mg/L浓度的雷公藤内酯酮能显著抑制刀豆素A(Con A)及脂多糖(LPS)诱导的T、B琳巴细胞增殖反应。表2参4  相似文献   

9.
为研究咪唑斯汀对小鼠变应性接触性皮炎(ACD)的疗效,分析咪唑斯汀与血清白三烯的相关性。建立小鼠ACD疾病模型,观察咪唑斯汀在不同时间点对小鼠ACD炎症性肿胀的治疗作用;同时使用酶联免疫法检测血清白三烯C4(LTC4)水平并进行相关分析。咪唑斯汀对小鼠ACD的炎症性肿胀具有显著迅速地抑制作用;而且其皮肤肿胀度与血清LTC4水平呈正相关。咪唑斯汀对小鼠变应性接触性皮炎有很好的治疗作用,其机制可能是抑制5-脂氧合酶的活性,继而阻止白三烯的产生而发挥其抗炎活性。  相似文献   

10.
中药黄柏、茯苓及栀子抗迟发型超敏反应作用的实验研究   总被引:15,自引:0,他引:15  
本研究以小鼠 2、4 -二硝基氟苯 ( DNFB)变应性接触性皮炎 ( ACD)为迟发型超敏反应 ( DHR)的实验模型 ,分别以黄柏、茯苓及栀子的高、中、低剂量于致敏期及诱发期给药 ,观察鼠耳肿胀、耳部组织块重量。结果显示黄柏、茯苓及栀子均能明显抑制 ACD,且呈现一定量效关系 ,这对临床应用中药治疗以 DHR为主要发病机理的疾病具有指导作用  相似文献   

11.
It is generally believed that ablative laser therapies result in prolonged healing and greater adverse events when compared with nonablative lasers for skin resurfacing. To evaluate the efficacy of ablative laser use for skin resurfacing and adverse events as a consequence of treatment in comparison to other modalities, a PRISMA‐compliant systematic review (Systematic Review Registration Number: 204016) of twelve electronic databases was conducted for the terms “ablative laser” and “skin resurfacing” from March 2002 until July 2020. Studies included meta‐analyses, randomized control trials, cohort studies, and case reports to facilitate evaluation of the data. All articles were evaluated for bias. The search strategy produced 34 studies. Of 1093 patients included in the studies of interest, adverse events were reported in a total of 106 patients (9.7%). Higher rates of adverse events were described in nonablative therapies (12.2% ± 2.19%, 31 events) when compared with ablative therapy (8.28% ± 2.46%, 81 events). 147 patients (13.4%) reported no side effects, 68 (6.22%) reported expected, transient self‐resolving events, and five (0.046%) presented with hypertrophic scarring. Excluding transient events, ablative lasers had fewer complications overall when compared with nonablative lasers (2.56% ± 2.19% vs 7.48% ± 3.29%). This systematic review suggests ablative laser use for skin resurfacing is a safe and effective modality to treat a range of pathologies from photodamage and acne scars to hidradenitis suppurativa and posttraumatic scarring from basal cell carcinoma excision. Further studies are needed, but these results suggest that ablative lasers are a superior, safe, and effective modality to treat damaged skin.  相似文献   

12.
ABSTRACT:  Two new collagen-based lidocaine-containing dermal fillers, ArteSense™/ArteFill™ (Artes Medical, San Diego, CA) and Evolence® (Colbar LifeScience Ltd., Herzliya, Israel), have proved to be of particular interest to men, many of whom seek a long-lasting or permanent correction. ArteFill™ has been available in the United States since 2006, and it is expected that Evolence® will reach the American market in 2008. The properties of the two products will be described, and experience based on the administration of many hundreds of syringes of both products by a Canadian dermatologist will be detailed here, with tips and precautions to optimize patient outcomes.  相似文献   

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12 cases of occupational allergic contact dermatitis caused by decorative plants were diagnosed in a 14-year period. The patients were middle-aged, and their average exposure time was 13 years. The plant families and plants causing occupational contact dermatitis were Compositae (5 patients: chrysanthemum, elecampane, gerbera, feverfew), Alstroemeriaceae (5 patients, Alstroemeria ), Liliaceae (4 patients; tulip, hyacinth). Amaryllidaceae (2 patients: narcissus) and Caryophyllaceae (2 patients; carnation, cauzeflower). The known chemical allergens causing dermatitis were tuliposide-A and sesquiterepene lactones, such as alantolactones and parthenolide, in the Liliaceae and Compositae families. 7 of the 12 patients were able to continue their work; 5 were not because of severe relapses of skin symptoms. The plant allergen and extract series currently available are of great help in the diagnosis.  相似文献   

17.
Studies integrating clinicopathological and genetic features have revealed distinct patterns of genomic aberrations in Melanoma. Distributions of BRAF or NRAS mutations and gains of several oncogenes differ among melanoma subgroups, while 9p21 deletions are found in all melanoma subtypes. In the study, status of genes involved in cell cycle progression and apoptosis was evaluated in a panel of 17 frozen primary acral melanomas. NRAS mutations were found in 17% of the tumors. In contrast, BRAF mutations were not found. Gains of AURKA gene (20q13.3) were detected in 37.5% of samples, gains of CCND1 gene (11q13) or TERT gene (5p15.33) in 31.2% and gains of NRAS gene (1p13.2) in 25%. Alterations in 9p21 were identified in 69% of tumors. Gains of 11q13 and 20q13 were mutually exclusive, and 1p13.2 gain was associated with 5p15.33. Our findings showed that alterations in RAS‐related pathways are present in 87.5% of acral lentiginous melanomas.  相似文献   

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Psoriasis is a chronic inflammatory skin disorder resulting from a complex network of cytokines and chemokines produced by various immune cell types and tissue cells. Emerging evidence suggests a central role of IL-17 and IL-23/T17 axis in the pathogenesis of psoriasis, giving a rationale for using IL-17-blocking agents as therapeutics.Three agents targeting IL-17 signaling are being studied in Phase III clinical trials: secukinumab and ixekizumab (IL-17 neutralizing agents), and brodalumab (IL-17 receptor antagonist). Preliminary results are highly promising for all anti-IL17 agents, creating fair expectations on this class of agents as the new effective therapeutic approach for the treatment of psoriasis.  相似文献   

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