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1.
初中生成就动机与自尊的相关研究   总被引:4,自引:0,他引:4  
目的 探讨初中生成就动机和自尊之间的关系.方法 采用自尊量表和成就动机量表对莱初中的学生进行测查.结果 初中生的自尊和成就动机不存在性别差异;渴望成功和避免失败动机的差异非常显著,自尊是影响初中生成就动机的重要因素.结论 初中生的自尊和成就动机存在明显关联.  相似文献   

2.
大学生完美主义研究   总被引:1,自引:0,他引:1  
目的 研究大学生完美主义的现状.方法 采用FMPS完美主义问卷对620名大学生进行了调查.结果 ①大学生的完美主义可以聚类为健康型、障碍型和非完美型.②大学生完美主义存在显著的性别、独生、文理、年级和城乡差异.③学业成绩不同的学生在完美主义上存在差异.结论 大学生的完美主义状况整体上良好.  相似文献   

3.
生理实验报告书写存在的问题与对策   总被引:2,自引:0,他引:2  
南瑛  相里伟 《医学信息》2008,21(7):1094-1095
通过分析学生在书写生理学实验报告中所存在的常见问题及成因,结合教学实践提出相应对策,旨在提高学生书写能力和整体素质,进一步适应系统化生理学理论知识学习.  相似文献   

4.
<正>一天,有家公司的老板叮嘱全体员工:"谁也不要走进六楼那个没挂门牌的房间。"但他没解释为什么。员工们尽管有所好奇,但都无一例外地选择了服从。数月后,公司新招聘了一批员工,老板对新员工再次交待不准进那个房间。这时有个年轻人小声嘀咕了一句:"为什么?"老  相似文献   

5.
脐形态学调查及其意义   总被引:2,自引:0,他引:2  
目的:为临床脐整形美容术提供形态学依据。方法:随机观测男女性脐形态557例,男性269例,女性288例。对脐外形结构进行观察和统计。结果:脐外形男性以圆形、卵圆形居多,分别为42.4%和30.9%;女性卵圆形者、纵形者居多,分别为32.6%和31.9%;脐檐男性有者占54.3%,女性占23.6%;脐窝突起数1个或以上者男性占68.8%,女性占48.3%。结论:脐形态各型分布存在性别差异,有临床参考意义。  相似文献   

6.
目的 了解综合医院青少年咨客心理咨询的特点,为其心理健康教育提供依据.方法 选取2003年5月~2004年11月门诊心理咨询163人的资料进行分析.结果 该年龄段中主动求询意识占据明显优势有140人(85.9%);医学问题以神经症77人(47.2%),精神分裂11人(6.7%)列前2位;非医学问题则是厌学13人(8.0%),人际交往障碍10人(6.1%)为主要求询问题;性别与求询问题间亦有一定相关性.结论 综合医院青少年心理咨询以医学问题为主,非医学问题并存,应注意社会支持系统的完善.  相似文献   

7.
急诊内科自杀未遂病人的临床特点   总被引:4,自引:0,他引:4  
目的 收集和分析急诊内科自杀未遂病人的临床特点.方法 用自制的《自杀病人情况调查表》对2002年1月~2005年12月在我院急诊内科就诊自杀病人进行登记.结果 急诊内科自杀病人自杀方式以服药为主,服用安定者预后比较好,年龄越小越倾向于采取激烈的自杀方式;自杀者女多于男,男性服农药和灭鼠药的多,女性服安定的多.自杀者的平均年龄为35岁,男性大于女性.结论 急诊内科自杀未遂病人有其特定的临床特点.  相似文献   

8.
范立华 《校园心理》2008,6(5):56-58
<正>6月25日晴格尔木——沱沱河420公里今天就要踏上青藏线了,心里很兴奋。很早就醒了,在床上先喝了药,看了一会儿早间新闻,喝了两袋麦片,吃了一小块饼干和熟肉,很慢很仔细地穿好衣服,整理好行李,下楼发动车很顺利,声音也不错,安排  相似文献   

9.
目的 探讨病毒性肝炎在漾濞县的发病特点及流行趋势,为更好地制定有针对性地控制措施提供依据.方法 利用办公软件Excel2000对漾濞县2000~2007年病毒性肝炎疫情资料和监测资料进行分析整理.结果 漾濞县2000~2007年年平均发病率为96.81/10万.男女性别比为1.21:1,发病分布以青壮年为主,职业发病以农民最高.顺次为学生、干部职员、工人、民工.一年四季均可发病.监测显示甲型肝炎所占比重下降,乙型肝炎所占比重上升.结论 漾濞县肝炎防制工作在继续巩固甲肝低发病率的同时.重点应加强乙肝防制工作.  相似文献   

10.
医院HIS系统网络常见故障与维护   总被引:2,自引:0,他引:2  
王鹤飞 《医学信息》2008,21(7):1036-1037
医院HIS系统的应用极大的满足了部队信息化建设和平战时医疗卫生信息化建设的需要,HIS系统网络在医院各部门的应用较为普遍,涉及到医院的方方面面,其重要性就不言而喻了,网络的稳定是十分重要的,但网络故障也十分繁杂.如果把网络故障的常见故障进行归类查找,那么无疑能够迅速而准确的查找故障根源,解决网络故障.文章主要就网络常见故障的分类诊断和如何维护进行了阐述.  相似文献   

11.
Protein arginine methyltransferases (PRMT) 5, a member of type II arginine methyltransferases, catalyzes the symmetrical dimethylation of arginine residues on histone and non‐histone substrates. Although the overexpression of PRMT5 has been reported in various cancers, its role in oral squamous cell carcinoma (OSCC) has not been elucidated. In the present study, we immunohistochemically examined the expression of PRMT5 in surgically resected oral epithelial dysplasia (OED, n = 8), oral intraepithelial neoplasia (OIN)/carcinoma in situ (CIS) (n = 11) and OSCC (n = 52) with or without contiguous OED lesions. In the normal epithelium, PRMT5 was weakly expressed in the cytoplasm of basal layer cells. In OED, OIN/CIS, and OSCC, its expression consistently and uniformly increased in the cytoplasm of dysplastic and cancer cells. Moreover, nuclear and cytoplasmic localization was detected in the invasive front of cancer cells, particularly in cases showing poor differentiation or aggressive invasion patterns. The concomitant nuclear and cytoplasmic expression of PRMT5 correlated with the loss of E‐cadherin and cytokeratin 17, and the upregulation of vimentin, features that are both indicative of epithelial‐to‐mesenchymal transition. PRMT5 may play a role from early oncogenesis through to the progression of OSCC, particularly in the aggressive mode of stromal invasion.  相似文献   

12.
Methylation of arginine residues is a widespread post-translational modification of proteins catalyzed by a family of protein arginine methyltransferases (PRMT), of which PRMT1 is the predominant member in human cells. We have previously described the localization and mobility of PRMT1 in live cells, and found that it shuttles between the nucleus and the cytoplasm depending on the methylation status of substrate proteins. Recently, amino-terminal splicing isoforms of PRMT1 were shown to differ significantly in intracellular localization, the most interesting being splice variant 2 that carries a nuclear export signal in its amino terminus, and is expressed in increased levels in breast cancer cells. We show here that enzymatic activity is required for nucleo-cytoplasmic shuttling of PRMT1v2, as a catalytically inactive mutant highly accumulates in the nucleus and displays altered intranuclear mobility as determined by fluorescence recovery after photobleaching experiments. Our results indicate that nuclear export of PRMT1v2 is dominant over activity-independent nuclear import, but can only occur after activity-dependent release of the enzyme from substrates, suggesting that shuttling of the enzyme provides a dynamic mechanism for the regulation of substrate methylation.  相似文献   

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PRMT7 encodes for an arginine methyltransferase that methylates arginine residues on various protein substrates and has been shown to play a role in various developmental processes. Mutations in PRMT7 have been recently shown to be implicated in a phenotype with intellectual disability, short stature and brachydactyly, and considered to be a phenocopy of pseudohypoparathyroidism. We report a patient with short stature, psychomotor delay, hearing loss and brachydactyly, for whom whole exome sequencing detected two mutations in PRMT7 and parental segregation studies detected biallelic mutation inheritance. Few patients with biallelic PRMT7 mutations have been reported so far in the literature. We report a new patient and review all reported cases to date to delineate the clinical manifestations that may help in diagnosis this disorder, known as Short Stature, Brachydactyly, Intellectual Developmental Disability, and Seizures syndrome, allowing appropriate management and genetic counselling.  相似文献   

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Protein arginine methyltransferase‐5 (PRMT5), a major type II arginine methyltransferase, is an important epigenetic modifier with oncogene‐like properties because of its ability to repress the expression of tumor suppressor genes. We determined the correlations between PRMT5 expression or its cellular localization and malignant progression, with special reference to invasiveness, in colorectal adenomas and early colorectal carcinomas (CRCs). We performed immunohistochemical detection of PRMT5 in 108 endoscopically resected tissue samples (6 adenomas with low‐grade dysplasia, 34 adenomas with high‐grade dysplasia, 30 intramucosal carcinomas, and 38 submucosal invasive carcinomas). Early CRC (55 of 68, 80.9%) showed more frequent nuclear expression of PRMT5 than adenoma (15 of 40, 37.5%) (P < 0.001). Furthermore, high (strong staining in ≥ 50% of nuclei) nuclear expression of PRMT5 was more common in submucosal invasive carcinoma (21 of 38, 55.3%) than in intramucosal carcinoma (9 of 30, 30.0%) (P = 0.037). In conclusion, our data suggests that high nuclear expression of PRMT5 is a potentially useful marker for estimating submucosal invasion of early CRC in endoscopically resected specimens.  相似文献   

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Neurite outgrowth is one of the crucial events in the formation of neural circuits. The majority of studies on neurite outgrowth have focused on signal transduction processes based on phosphorylation and acetylation; a few studies have suggested the involvement of other molecular mechanisms. Recent progress in understanding the nature of protein arginine N-methyltransferases (PRMTs) raises the possibility of the involvement of protein methylation accompanied by cell shape changes during neuronal differentiation. Here, we show that PRMT1 play a pivotal role in the neurite outgrowth of Neuro2a cells. Our results revealed that PRMT1 depletion specifically affected neurite outgrowth but not the physiological processes involved in cell growth and differentiation. Furthermore, we demonstrated that Btg2, one of the PRMT1 binding partner, depletion down-regulated arginine methylation in the nucleus and inhibited neurite outgrowth. These results indicate that protein arginine methylation by PRMT1 in the nucleus is an important step in neuritogenesis.  相似文献   

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