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1.
我们用4,4'-二苯基甲烷二异氰酸酯(MDI),扩链剂1,4-丁二醇(BDO)为硬段,聚乙二醇(PEG)与聚四氢呋喃醚二元醇(PTMG)为混合软段,在不同PEG、PTMG配比下,采用二步法,合成了一系列聚醚聚氨酯(PU)。对所合成的材料进行了傅立叶变换红外光谱、力学性能测试、水接触角、吸水率、溶血试验和静态血小板粘附试验。结果表明,本研究成功合成了机械强度高、亲水性好、血液相容性良好的新型混合软段的聚氨酯,是一种有着巨大应用前景的生物医用材料。  相似文献   

2.
目的 制备和评价碳纳米管/聚氨酯复合材料的生物相容性。方法 通过溶胶-凝胶方法制备碳纳米管/聚氨酯复合材料,对其力学性能进行测试;根据ISO10993指南,选取溶血实验、动态凝血实验、血小板黏附实验、血小板活化实验、细胞毒性实验和材料局部植入方法对复合材料的生物相容性进行评价。结果 复合材料无明显细胞毒性,并表现出比聚氨酯材料更好的抗溶血性能、动态凝血性能、抑制血小板黏附性能以及组织相容性。结论 碳纳米管-聚氨酯复合材料具有优良的生物相容性,可以作为制备组织工程细胞生长支架、人工血管、药物载体的基础材料。  相似文献   

3.
医用壳聚糖膜的制备与性能研究   总被引:4,自引:0,他引:4  
作者以天然高分子壳聚成膜材料,制备了医用壳聚糖膜。经性能测试和体外降解实验表明:该膜具有较好的力学性能和可降解性,可用于外科手术以防止术后粘连。  相似文献   

4.
一种LDL选择性吸附剂的制备及其血液相容性研究   总被引:1,自引:0,他引:1  
目的制备一种对低密度脂蛋白(LDL)的选择性吸附效率高且血液相容性良好的LDL选择性医用吸附材料.方法以聚阴离子物质肝素为配基,并将之共价固定到载体聚乙烯醇的表面上制得一种低密度脂蛋白LDL选择性医用吸附材料.在体外循环实验中,1份该吸附材料与4份人高脂混合血浆(2份人高脂血浆 2份弱碱性缓冲稀释液相混合而得)动/静态接触半小时以上后,测定其对LDL的吸附率.此外对该吸附材料进行了溶血性能、凝血性能及血小板黏附性能考察.结果在体外循环实验中测得该材料对LDL的选择性吸附效率达到60%左右,具有较高的选择吸附性能,且本吸附材料溶血率<5%,对血小板几乎无粘附,表明本吸附材料具有良好的血液相容性.结论该材料对LDL具有良好的特异性吸附性能且血液相容性良好,可望开发为一种低密度脂蛋白的血液净化医用吸附材料.  相似文献   

5.
聚氨酯具有良好的生物相容性和机械强度并且易于加工成型,是最具价值的生物医学合成材料之一,可分为惰性聚氨酯和降解性聚氨醋两类.医用惰性聚氨酯材料稳定、耐磨、力学性能好,广泛用于医用装置及人工器官.文中从采用新型抗氧剂,减少醚键,与硅烷嵌段共聚改性以提高其生物稳定性、生物相容性及抗菌性等三个方面,综述了惰性聚氨酯材料的研究重点;医用降解性聚氨酯材料有利于人体健康和环保、安全、便捷,可作为人体修复材料和智能药物缓释材料,文中从提高降解性及力学性能两个方面,讨论了降解性聚氨酯材料的研究热点.解决医用惰性聚氨酯材料环境污染问题,降低医用降解性聚氨酯材料降解产物毒性,研发聚氨酯复合材料,加强临床试验将成为新的课题.  相似文献   

6.
两种新型聚氨酯涂层材料的血液相容性研究   总被引:4,自引:0,他引:4  
以十八烷基聚氧乙烯 (SPEO )与 4 ,4 '-二苯甲撑二异氰酸酯 (MDI)的偶联物 SPEO- MDI- SPEO(MSPEO)作为改性材料 ,并分别与聚醚氨酯 (PEU)、壳聚糖 (Chi)两种成膜剂共混得到 MSPEO- PEU、MSPEO- Chi两种改性涂层 ,改性 PEU基膜得到两种改性膜 MSPEO- PEU/PEU(膜 )、MSPEO- Chi/PEU(膜 )。通过血小板黏附实验 ,复钙化时间和凝血酶原时间的测定 ,对比了膜 和膜 的抗凝血性能。结果发现两种改性涂层均可显著提高聚氨酯材料的抗凝血效果 ,并不引发溶血反应 ,是极具潜力的两种新型医用聚氨酯涂层材料。其中 ,膜 对血小板的吸附较多 ,但对延长复钙化时间效果较好 ,膜 则能较好的延长凝血酶原时间  相似文献   

7.
背景:体外构建组织工程化心肌是当今医学领域的研究热点,支架材料的选择和设计是心肌组织工程的关键环节,但目前仍未找到理想的心肌支架材料。目的:对新型可降解材料聚氨酯进行体外评价,初步探讨其作为心肌组织工程支架的可行性。方法:以赖氨酸基二异氰酸酯为硬段,以赖氨酸为扩展链合成新型聚氨酯(PU-Lys)。在拉力机上测试材料的缝合强度和拉伸强度;在37℃,pH=7.4的磷酸盐缓冲溶液中检测聚氨酯的降解性能;采用细胞培养MTT法、细胞形态学观察方法,分析该聚氨酯的细胞毒性。结果与结论:力学性能检测得出该聚氨酯的拉伸强度为(8.1±0.1)MPa,缝合强度为(12.2±0.8)N;体外降解8周后质量损失为(13.1±0.3)%;MTT比色法结果显示细胞毒性为0~1级;细胞形态学观察显示L929细胞在聚氨酯材料浸提液中呈梭形或三角形,贴壁良好。提示此种新型解聚氨酯具有良好的力学性能和降解性,细胞相容性良好,符合组织工程心肌支架材料的应用要求。  相似文献   

8.
研究新型可降解高分子材料己内酯(CL)/碳酸亚乙酯(EC)共聚物的力学性能和生物相容性。利用Nd(DBMP)3催化合成可降解共聚物Poly(CL-co-EC),对不同CL/EC共聚比例的Poly(CL-co-EC)进行力学性能和表面特征的测试;并对Poly(CL-co-EC)薄膜和浸提液进行生物相容性测试:细胞粘附试验、细胞增殖实验、溶血试验、乳酸脱氢酶(LDH)释放实验、四唑氮盐(MTS)细胞毒性试验和肌肉植入试验。结果表明随不同的CL/EC共聚比例可调控Poly(CL-co-EC)力学性能;细胞粘附试验,L929细胞在Poly(CL-co-EC)薄膜粘附较聚苯乙烯慢;MTS细胞毒性试验,共聚物组吸光度较阴性对照组无明显升高(P〈0.05);LDH释放试验,各实验组LDH相对释放率〈10%;溶血反应,共聚物浸提液溶血率〈6%;肌肉植入试验,Poly(CL-co-EC)柱状物周围组织炎症反应轻微。Poly(CL-co-EC)共聚物具有可调控的力学性能和熔点,并具有良好的生物相容性,可作为医用材料和组织工程材料。  相似文献   

9.
聚醚砜中空纤维透析膜血浆分离器的血液相容性评价   总被引:7,自引:0,他引:7  
本研究通过溶血试验、动态凝血时间试验、体外动脉血栓形成试验及血小板粘附试验,综合评价了聚醚砜中空纤维透析膜血浆分离器的血液相容性,结果显示该材料具有较好的血液相容性。  相似文献   

10.
医用聚氨酯材料具有良好的生物相容性及机械性能,因而已被用于制作人工器官。本文综述了近年来在改进医用聚氨酯血液相容性方面的研究进展,包括新型聚氨酯材料的合成、聚氨酯材料的化学改性、在聚氨酯材料上固定具有抗凝血活性的物质。作者认为,目前医用聚氨酯材料还存在一定缺陷,今后应在阐明材料结构与血液相容性的关系的基础上,进一步开发力学性能和长期抗凝血性好的聚氨酯材料。  相似文献   

11.
目的通过对可降解材料聚丁二酸丁二醇酯(PBS)刺激和迟发超敏反应及血液相容性的研究,进一步评价PBS材料的生物安全性。方法选用新西兰白兔,通过单次接触实验法,研究原发刺激指数,以确定材料的刺激性。在实验用豚鼠上,采用最大剂量法,判定材料的迟发超敏反应性。采取新鲜兔血,通过溶血实验和血小板黏附实验,研究材料的血液相容性。结果 PBS局部刺激反应极轻微,无迟发超敏反应,材料的溶血率小于5.0%,血小板黏附性与聚乳酸材料相当。结论 PBS材料生物安全性良好,与皮肤接触无不良反应,溶血率低,血小板黏附性与聚乳酸材料相当。  相似文献   

12.
Citric acid (CA) and chitosan (CS) were covalently immobilized on polyurethane (PU) materials to improve the biocompatibility and antibacterial property. The polyurethane pre-polymer with isocyanate group was synthesized by one pot method, and then grafted with citric acid, followed by blending with polyethersulfone (PES) to prepare the blend membrane by phase-inversion method so that chitosan can be grafted from the membrane via esterification and acylation reactions eventually. The native and modified membranes were characterized by attenuated total reflectance-Fourier transform infrared spectroscope, X-ray photoelectron spectroscopy, scanning electron microscopy, water contact angle measurement, and tensile strength test. Protein adsorption, platelet adhesion, hemolysis assay, activated partial thromboplastin time, prothrombin time, thrombin time, and adsorption of Ca2+ were executed to evaluate the blood compatibility of the membranes decorated by CA and CS. Particularly, the antibacterial activities on the modified membranes were evaluated based on a vitro antibacterial test. It could be concluded that the modified membrane had good anticoagulant property and antibacterial property.  相似文献   

13.
目的通过聚氨酯发泡制备出能应用于负压封闭引流技术的聚氨酯敷料。方法通过正交实验设计聚氨酯泡沫一步法发泡工艺,并对制备的聚氨酯泡沫进行物理机械性能测试和表面形态观察,从中选取出一组综合性能最佳的聚氨酯泡沫配方,并对其进行优化设计。对优化配方制备的聚氨酯泡沫进行细胞毒性和溶血实验生物学评价。结果制备的聚氨酯泡沫的表观密度为20~35 kg/m3,拉伸强度为16~21 N。细胞体外毒性测试所得细胞相对增殖率为90.1%,符合国家细胞毒性安全标准。聚氨酯泡沫溶血率为2.53%,低于5%的国家标准。一步法发泡所制备的聚氨酯泡沫具有良好的物理机械性能和生物相容性。结论聚氨酯泡沫作为医用负压引流材料具有良好的应用前景,但还需对负压引流效果及其他生物相容性进行进一步的测试。  相似文献   

14.
A new haemocompatible phospholipid polyurethane based on hydrogenated poly(isoprene) glycol (HPIP) and 4,4'-methylenediphenyl diisocyanate (MDI) was synthesized using 2-[bis(2-hydroxyethyl)methylammonio]ethylstearylphosphate (BESP) and 1,4-butanediol (BD) as chain extender. The bulk and surface characteristics of this material was investigated by differential scanning calorimetry (DSC), dynamic viscoelasticity and tensile property measurements, attenuated total reflectance-Fourier transform infrared spectroscopy (ATR-FTIR), and contact angle measurement. This polymer possessed a hydrophobic surface revealed by contact angle measurement. The haemocompatibility of this polyurethane was evaluated by platelet rich plasma (PRP) contacting studies and scanning electron microscopy (SEM) observation using medical grade poly(vinyl chloride) (PVC) as the reference.The results show that this new polyurethane had relatively lower platelet adhesion and limited shape change for the attached platelets compared to PVC. The clotting time of the materials in contact with platelet poor plasma (PPP) was 99, 75, and 62 s and in contact with PRP was more than 240, 100, and 86 s for new polyurethane, PVC, and glass, respectively. This new phospholipid polyurethane is expected to have wide applications as coating or structural material for blood-contacting medical equipment due to its outstanding haemocompatibility and excellent mechanical strength.  相似文献   

15.
新型聚氨酯材料的血液相容性及毒理学研究   总被引:1,自引:0,他引:1  
目的 通过对新型聚氨酯材料的血液相容性及毒理性研究,评价新型聚氨酯作为人工心脏辅助泵体材料的可行性。方法 实验包括溶血实验、刺激试验及全身急性毒性试验,观察72h组织及动物反应情况。结果新型聚氨酯材料溶血指数小于5%,血液相容性良好,无明显毒性。结论此种新型聚氨酯符合人工心脏辅助泵体材料的要求。  相似文献   

16.
Physicochemical and mechanical properties, in vitro cytotoxicity, cytocompatibility, and platelet adhesion were investigated on a shape-memory polyether-based polyurethane (MM-5520 SMPu) using the polyether-based Pellethane 2363-80AE (Pell-2363 SPU) as reference. MM-5520 SMPu and Pell-2363 SPU showed similar average molecular weights and different surface properties, with a higher hydrophilicity and roughness for the SMPu. By tensile tests and dynamic mechanical analysis, the peculiar characteristics of the MM-5520 SMPu were evidenced: strong temperature-dependent behavior for SMPu compared with SPU, and a high shape recovery. MM-5520 SMPu did not show any cytotoxic effect on the adhesion and proliferation of human skin fibroblasts and gingival fibroblasts, and a good cytocompatibility was observed with both cell types, as demonstrated by cell counting and scanning electron microscopy observations. SMPu compared with SPU showed higher adsorption of extracellular matrix proteins such as fibronectin, fibrinogen, and collagens. Proteins adsorbed onto SMPu significantly enhanced the adhesion and proliferation of human fibroblasts. The interaction of SMPu with platelets was studied with platelet rich plasma. Fewer platelets adhered to the SMPu, with minor morphological variations than onto the SPU. The cytocompatibility and hemocompatibility of MM-5520 SMPu combined with its unique properties such as change in shape or in stiffness, depending on practical requirements, make this shape-memory material potentially advantageous for biomedical applications.  相似文献   

17.
我们以牛跟腱和酸性成纤维细胞生长因子(acidic fibroblast growth factor,aFGF)为原料,研制了一种新型的创伤敷料--aFGF/胶原蛋白复合海绵,并检测了其物理性能和组织相容性,特别是在血液相容性方面,研究其作为医用生物材料的安全性.结果显示:制备的高剂量和低剂量aFGF/胶原蛋白复合海绵的急性毒性试验、刺激性试验结果均为阴性;复钙试验表明aFGF/胶原蛋白复合海绵复钙时间较长,具有较好的抗凝特性;溶血试验表明复合海绵对红细胞的破坏很小,符合生物材料的溶血性要求;血小板黏附试验表明aFGF/胶原蛋白复合海绵的血小板黏附量较少且未被激活,对血小板没有明显的破坏作用.结果表明,aFGF/胶原蛋白复合海绵具有较好的组织相容性,具备临床应用的可能性.  相似文献   

18.
Microelectromechanical systems (MEMS) create an opportunity for the development of smaller, cheaper, and more precise biomedical instrumentation and devices. Little is known, however, about the hemocompatibility of the materials used to fabricate these devices. Because of the potentially harmful consequences of thrombus formation, a better understanding of blood interactions with bioMEMS materials is desirable. This study is an in vitro assessment of the hemocompatibility of silicon (Si), silicon dioxide (SiO2), silicon nitride (Si3N4), low-stress silicon nitride (Si(1.0)N(1.1)), SU-8 photoresist, and parylene thin films. A polycarbonate-based polyurethane, was used as a reference material. Experiments were carried out to detect differences in platelet adhesion or morphology after contact with these materials under static conditions. Platelet adhesion on Si, Si3N4, Si(1.0)N(1.1,) and SU-8 photoresist was significantly greater (P < 0.05) than platelet adhesion on polyurethane. Adhesion on parylene and SiO(2) was not significantly different from on polyurethane (P < 0.05). The median platelet area and circularity were higher on polyurethane than all other materials. Materials that showed higher levels of platelet adhesion tended to have platelets that showed less spreading, except for SiO2, where platelets exhibited relatively low adhesion and spreading. This data suggests that Si, Si3N4, Si(1.0)N(1.1), and SU-8 photoresist may be more reactive to platelets and therefore more thrombogenic than parylene, SiO2, and polyurethane. These results may be helpful in guiding the selection of materials for use in the development of blood-contacting microelectromechanical systems.  相似文献   

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