Comparative study of the state of bone tissue during hormone replacement therapy and transplantation of human fetal tissues in oophorectomized women

The state of bone tissue is studied in 95 women with postoophorectomy syndrome. It is shown that fetal tissue therapy delayed the progression of the pathological process in bones and even increased bone density. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 120, N ^o 10, pp. 428–430, October, 1995     

Morphological characteristics of histions of developing and atresic human ovarian follicles

The morphology of tissue elements of human ovarian follicles was studied in the course of normal folliculogenesis and in some forms of its disorders. Signs of abnormal development of follicles were detected that are typical of different stages of their development under the conditions studied. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 120, N ^o 8, pp. 188–191, August, 1995     

Effect of low-intensity luminescence on reparative processes in skin wounds in the rat

Low-intensity noncoherent luminescent radiation stimulates reparative processes in soft tissue wounds of rats. The stimulation is dependent on the frequency of light pulsation and the luminescence spectrum. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 117, N ^o 6, pp. 665–667, June, 1994 Presented by B. A. Korolev, Member of the Russian Academy of Medical Sciences     

Morphological characteristics of lymphocyte-hepatocyte contacts in various periods of liver regeneration in mice

The histo-and ultrastructure of regenerating murine liver is studied after excision of 2/3 of its tissue. Counts of leukocytes and lymphocytes are found to be increased in the intertrabecular spaces after the operation. Lymphocytes come in close contact with hepatocytes and reticuloendotheliocytes forming microtunnels at the sites of contact. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 117, N ^o 2, pp. 176–179, February, 1994     

Oxyferriscorbone: Ulcerostatic effect and its possible mechanisms

It is found that oxyferriscorbone inhibits free-radical lipid peroxidation in blood plasma and gastric tissue. Interaction of the drug with modeled membranes is demonstrated. It is suggested that this effect underlies the mechanism of its ulcerostatic action. Translated fromByulleten Eksperimental'noi Biologii i Meditsiny, Vol. 117, N ^o 5, pp. 490–493, May, 1994     

Localization of serum immunoglobulins in tissue of rat autonomic ganglia

The distribution of immunoglobulins is studied on preparations of autonomic ganglia using an immunohistochemical technique. Perikarya of neurons are found to be highly accessible to serum macromolecules in tissue of the vagal caudal ganglion, while myenteric ganglion tissue is devoid of immunoglobulins. An individual pattern of serum immunoglobulin distribution is typical for other ganglia. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 120, N ^o 8, pp. 192–194, August, 1995 Presented by V. V. Kupriyanov, Member of the Russian Academy of Medical Sciences     

The role of the composition and gas-transporting function of the blood in the fluctuations of the electrical properties of the epidermis and subepidermal tissues

Changes in the composition and gas-transporting function of the blood contribute to the formation of the total electrical impedance of the epidermis, subepidermal connective tissue, and muscles. It is concluded that time fluctuations of the impedance result from the summated influence of the factors characterizing the modulations of the tissue oxygen consumption. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 121, N ^o 1, pp. 100–102, January, 1996 Presented by V. P. Kaznacheev, Member of the Russian Academy of Medical Sciences     

Effect of panangin on tissue repair in limb distraction

The effect of panangin on osteogenesis and on the state of the lymphoid and hemopoietic tissues is studied by distraction osteosynthesis with limb elongation in dogs. The drug eliminates the postoperative depression of immunity and erythropoiesis. Panangin is shown to stimulate repair in the bone tissue. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 120, N ^o 9, pp. 308–309, September, 1995 Presented by E. D. Gol'dberg, Member of the Russian Academy of Medical Sciences     

Specific features of the candidal infectious process under conditions of polychemotherapy

Foci of candidal pneumonia in the presence of iatrogenic immunodeficiency and dysbacteriosis caused by preinjection of cyclophosphamide and ampiox were examined by histoautoradiography and light and electron microscopy. Not only did the pathomorphogenesis ofCandida infection, type of manifestation of tissue defense reactions, and degree of manifestation of the pathogenic characteristics of the agent change under such conditions, but the mediation of the inflammation as well. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 120, N ^o 11, pp. 506–510, November, 1995     

Seasonal dynamics of serotonin in the duodenum of hibernating animals

A correlation is shown between the duodenal content of serotonin in the red-cheeked souslik and the period of hibernation. The serotonin concentration in the tissue is maximal at the beginning of the hypothermia period and minimal at the end of this period. During spontaneous awakening (winter normothermia) the necessary amount of amine is produced. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 118, N ^o 11, pp. 511–513, November, 1994 Presented by Yu. P. Borodin, Member of the Russian Academy of Medical Sciences     

Effects of chick embryo homogenate and cyclophosphamide on the growth and metastatic spread of pliss sarcoma in rats: A comparative study

A chick embryo homogenate inhibited the growth and metastatic spread of Pliss sarcoma in rats and prolonged their survival. The histological picture of extensive tumor tissue necrosis with a characteristic infiltration by leukocytes and macrophages suggests that the mechanism underlying the antineoplastic action of the embryonal homogenate is quite different from that of cyclophosphamide and involves the activation of cell-mediated immunity. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 120, N ^o 12, pp. 610–612, December, 1995     

Functional activity of blood mononuclear cells during regeneration of bone tissue

It is established that, during elongation of a segment of the extremity, normal regeneration of the bone tissue is attended by a slight decrease in monocyte adherence during the postoperative period and by an increase of the functional activity of lymphocytes during subsequent activation of osteogenesis. Suppression of the lymphoid apparatus is observed in the case of disturbed osteogenesis. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 1117, N ^o 1, pp. 104–105, January, 1994     

Detection of STLV-1 integration in DNA extracted from formalin-fixed and paraffin-embedded specimens ofM. Arctoides lymphomas using the polymerase chain reaction

The feasibility of using the polymerase chain reaction to analyze of DNA extracted by the conventional method from formalin-fixed and paraffin-embedded specimens of monkey lymphoid tissue was investigated. Using HTLV-1 primers that can amplify DNA fragments of various length (159 to 717 base pairs), we determined the size of formalin-destroyed DNA which appeared to be up to 500 base pairs in length. Analysis of four specimens ofM. arctoides lymphomas that had been stored since 1969 revealed integrated STLV-1 provirus. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 119, N ^o 3, pp. 314–316, March, 1995     

Biodegradation and restitution of the intercellular matrix in preserved fragments of dense fibrous connective tissue after their grafting into the recipient

Results are presented from a study in which the structural arrangement of the intercellular matrix was examined in preserved connective tissue fragments (allografts) after their implantation into rabbits to repair posttraumatic space-occupying defects in the capsular-ligamentous complex of the knee joint. Stages of biodegradation and restitution undergone by the interstitial substance of connective tissues after the implantation of allografts are identified. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 121, N ^o 1, pp. 20–23, January, 1996 Presented by G. N. Kryzhanovskii, Member of the Russian Academy of Medical Sciences     

Impact of 8-isoestrone analogs on estradiol binding in uterine tissue from ovariectomized rats

8-Isoanalogs of estrone were studied for their ability to influence estradiol binding in the cytosolic fraction of uterine tissue from ovariectomized rats and for their uterotropic activity 24 h after injection into such rats. Two groups of estrone 8-isoanalogs with opposite biological effects were identified: those increasing estradiol binding in the cytosolic fraction of uterine tissue and those decreasing this binding. Uterogenic activity was exhibited by all of the compounds tested, with the exception of compound I. No correlation was found between the uterogenic activity of the isoanalogs and hormone-receptor interactions. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 119, N ^o 2, pp. 165–167, February, 1995     

Immunocytotherapy. A new trend in fetal tissue transplantation

The clinical applications of theoretical immunology are not numerous. The authors demonstrate present-day immunocytotherapeutic approaches to fetal tissue transplantation widely used in medicine. Results of therapy by injections of lymphokine-activated killer cells in combination with interleukin-2, T-cell vaccines, and genetically transformed T cells are presented. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 117, N ^o 4, pp. 412–415, April, 1994     

Effect of incoherent red light on the proliferation and metabolic activity of the gastroduodenal epithelium

It is shown that incoherent red light exerts an antiulcer effect on the mucosa of the duodenum. Some regularities are found in the proliferative-metabolic reactions caused by local irradiation of the gastroduodenal epithelium. Intensified regenerative-plastic processes in the tissue underlie the biostimulating effect of radiation. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 118, N ^o 8, pp. 194–198, August, 1994 Presented by L. D. Sidorova, Member of the Russian Academy of Medical Sciences     

Adaptation to hypoxia stimulates the pancreatic islet apparatus in intact and diabetic rats

Using immunocytochemical and immunoradiometric assays, it is found that intermittent exposure to hypoxia stimulates insulin synthesis and secretion by pancreatic beta cells and activatesde novo formation of these cells in the acinar tissue of both intact rats and rats with streptozotocin-induced diabetes mellitus, as well as inhibiting the destruction of Langerhans islets in the latter animals. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 120, N ^o 12 pp. 565–567, December, 1995 Presented by G. N. Kryzhanovskii, Member of the Russian Academy of Medical Sciences     

Respiratory and circulatory disorders in experimental poisoning with an organophosphorus pesticide

Acute poisoning with Anthio is associated with a gradual drop of blood pressure in the greater circulation and the development of intensive metabolic acidosis, despite normoxia still observed in the arterial blood and a somewhat increased oxygen capacity of the blood, this indicating mitochondrial injury and disordered tissue respiration. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 117, N ^o 5, pp. 470–475, May, 1994 Presented by I.P. Ashmarin, Member of the Russian Academy of Medical Sciences     

Evaluation of the antipyretic effect of psychotropic agents and their influence on the fever-lowering effect of acupuncture

Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 115, N ⁰ 3, pp. 262–264, March, 1993