HIV/AIDS人员心理卫生状况与心理社会影响因素

目的 :研究HIV/AIDS (艾滋病毒感染者 /艾滋病患者 )人群的心理卫生状态与心理社会因素的影响。方法 :采用病例对照研究方法。病例组与对照组两组对象均接受一般情况问卷、症状自评量表(Symptomchecklist 90 ,SCL -90 )、生活事件量表 (LifeEventScale ,LES)、生活质量综合评定问卷 (GenericQualityofLifeInventory -74,GQOLI -74)、自我接纳问卷 (Self -AcceptanceQuestionnaire ,SAQ )五个量表的测查。结果 :(1)病例组的SCL -90各个因子分高于对照组 (P <0 0 0 1) ;(2 )病例组总生活事件和负性生活事件得分高于对照组 (P =0 0 0 1) ;(3 )病例组自我接纳得分低于对照组 (P =0 0 0 1) ;(4 )病例组生活质量综合评定得分低于对照组 (P <0 0 0 1) ;(5 )多因素逐步回归分析 ,SCL -90总因子分相关因素主要为躯体症状严重程度 (负向评分 )、负性生活事件和自我接纳因子 ,躯体症状严重程度与SCL -90总因子分呈负相关 ,负性生活事件得分与SCL -90总因子分呈正相关 ,自我接纳得分与SCL -90总因子分呈负相关。结论 :HIV/AIDS组较对照组心理健康状态有明显差异 ,有较多的负性生活事件 ;自我接纳得分低于对照组 ;生活质量低于对照组。     

生活事件对大学生心理状况的影响

即将毕业的医科大学生面临着考试和就业分配双重压力。本文对173名毕业生进行症状自评量表（SCL－90）和生活事件量表测试．并作相关分析,结果发现,社交及其它问题与多项心理症状有关。1对象和方法对象：采取整群抽样,调查我校第一临床学院五年级大学生173名,男113名、女60名;年龄20～24岁。方法：采用精神症状自评量表（SCL－90）和生活事件量表[1]进行集体测验,给予统一指导语,受试者独自完成量表。SCL－90表中每题按1～5分计,资料分析在PC－486计算机上运用SYS－TAT统计软件进行统计学处理。2结果生活事件与心理症状相关…     

中学生生活应激评定量表的初步编制

目的 :编制中学生生活应激评定量表并制定常模。方法 :参考了国内外同类量表 ,采用问卷调查拟定条目 ,并进行信效度检验 ,用困扰症状量表、SCL - 90、特质焦虑量表和中国青少年生活事件检查表作为效标。结果 :新编的量表有较好的信度 ,α系数为 0 86 ,重测信度为 0 90 ;有较好的效度 ( 0 6 0～0 71 )。结论 :该量表具有较满意的心理测量指标。     

生活事件因素与中国少数民族大学生心理健康状况的相关和多元回归分析

本研究采用 SCL—90和生活事件影响因素调查表,对中央民族学院44个民族902名大学生的心理健康水平与生活事件关系进了分析,结果表明,约10%的少数民族大学生有心理健康问题。在各类生活事件因素中,人际关系问题、学习挫折和生活习惯改变是重要的影响因素。     

紧张性生活事件与恶性肿瘤关系探讨

应用紧张性生活事件评定表（SLERS），对118例确诊的恶性肿瘤患者及其对照者进行了调查，以探讨紧张性生活事件与恶性肿瘤的关系。结果表明，恶性肿瘤患者的环境问题计分和心理紧张总值均高于对照组（P＜0．01）；一定强度的紧张负性生活事件与恶性肿瘤发病的危险性问有明星联系（OR＝2．91，95％Cl1．51—5．50）。逐步回归分析结果亦显示，一些紧张性生活事件（如学习问题、环境问题和婚恋问题）与恶性肿瘤的发病呈正相关。据此，作者认为某些紧张性负性生活事件在恶性肿瘤发病过程中发挥了一定促进作用。     

527名大学生心理健康状况及相关因素调查

目的 :了解大学生心理健康状况与负性生活事件、应对方式、社会支持等各种因素之间的关系。方法 :用SCL - 90、青少年生活事件量表 (ASLEC)、简易应对方式问卷、社会支持评定量表 (SSRS)等工具对 5 2 7名大学生进行调查。结果 :(1)影响大学生心理健康的因素依次是 :负性生活事件、消极应对方式、丧失因子、受惩罚因子、对支持的利用度。 (2 )负性生活事件与SCL - 90总分间有显著正相关 ;消极应对与SCL - 90总分间相关极其显著 ;社会支持总分及其各因子与SCL - 90总分间呈显著负相关。结论 :负性生活事件、消极应对等是影响大学生心理健康状况的重要因素     

中小学教师抑郁症状影响因素研究

作者运用CES－D进行抑郁症状调查，并与SCL－90、生活事件量表及EPQ进行相关分析，结果表明中小学教师抑郁症状发生率为15.38％（中学教师为18.15％，小学教师为11．95％）．较文献报道的居民、工人、大学生的抑郁症状发生率低。相关分析表明，CES—D与SCL－90、生活事件总值、负性生活事件值、EPQ的N量表和P量表呈正相关。提示抑郁症状发生率不是单一因素的孤立作用。     

中学生心理危机源的调查与分析

心理危机是伴随着危机事件的发生而出现的一种心理失衡状态。本文以上海市嘉定区530名中学生为研究对象，采用《中学生生活事件量表》，对中学生的心理危机源进行调查分析。研究结果表明：中学生心理危机源主要有学习、丧失、关系、师生、意外、暴力和家庭，中学生心理危机事件存在年级差异。     

职业驾驶员心理应激及其相关变量分析

目的 :了解职业驾驶员心理应激状况及相关因素 ,为减少事故的发生提供资料。方法 :采用LES、应对、成人内外控制、SSRS、EPQ、SCL -90等量表对 2 40名职业驾驶员进行测试。结果 :①驾驶员的主要应激源是工作学习问题、家庭有关问题 ;应对方式上 ,更趋向于积极应对 ;社会支持上 ,主观支持分明显高于客观支持分 ;在心理控制感上 ,明显趋于外控 ;EPQ得分与普通人群相比 ,E分较高 ,N分较低 ;SCL -90各因子分均值与全国常模相比 ,除躯体化、强迫、焦虑等项因子均值较高外 ,其他无显著差异。②事故组与安全组驾驶员在生活事件、相关变量、应激反应上 ,均存在显著差异。③行车事故与应激性生活事件呈正相关 (P <0 0 1)、与EPQ -N ,SCL -90诸因子呈负相关 (P <0 0 1)。结论 :生活事件引起的情绪应激 ,与驾驶操作、交通违章和事故发生有一定相关关系。     

肿瘤病人病前个性及生活事件的特点

为探讨个性、生活事件因素与肿瘤发生的关系及住院期间肿瘤病人的精神症状,采用艾森克个性问卷、生活事件量表及症状自评量表(SCL—90)对食道癌、淋巴癌、乳腺癌、肝癌、肺癌、鼻咽癌6种肿瘤病人300名及100名内科同期住院病人进行病前个性和生活事件回顾性调查以及住院期间的     

Studien zur humoralen Regulation des erythropoetischen Proliferationsspeichers beim Menschen

Zusammenfassung Die Beeinflussung der Erythroblasten-Proliferation durch das Mikromilieu wurde in vitro mittels Auswertung durch Differential- und Mitosezählungen und Signifikanzberechnung vieler Versuchsreihen auch unter verschiedenen pathologischen Bedingungen getestet.Sowohl die Mitosehäufigkeit wie die Ausreifung waren positiv mit dem Erythropoetingehalt des Medium korreliert. Der Effekt wurde durch Folsäure, Ätiocholanolon und cAMP verstärkt. Cobalt stimulierte ebenso wie Testosteron und Methenolon in vitro unabhängig von der Erythropoetinkonzentration im Medium die Erythroblastenproliferation. Ein vermindertes Eisenangebot störte die endgültige Ausreifung der Erythroblasten zu Retikulozyten und bewirkte dadurch eine Ineffektivität der Erythorpoese. Anhaltspunkte für ein Erythrozyten-Chalon oder einen Erythropoetinhemmkörper ließen sich aus unserem Versuchsansatz nicht gewinnen, weil er die Transformation der pluripotenten in die erythropoetin-sensible Stammzelle nicht einschließt. Als Nebenbefund ergab sich eine Stimulation des granulozytopoetischen Proliferationsspeichers durch Serumzusatz zum Medium von Patienten nach akutem Blutverlust und bei Polycythämia vera.Unterstützt durch die Deutsche Forschungsgemeinschaft     

HLA study in Amerindian Bolivia La Paz Aymaras

Aymara people has been a relatively homogeneous group since Spanish Conquest by 1,532 CE, even if previously represented a group of various cultural defined populations who gave rise to them. They were and are established in Andean Altiplano around Titikaka Lake (Bolivia, Peru), Argentina and Chile neighborhood, speak Aymara language and have been maintained after Europeans arrival at a lower social status than Quechua (Inca) speaking people. However, both Aymara and Quechua populations acknowledge Titikaka Lake as center of their origins; both languages are also related. Specific high frequencies of HLA-A*02, -A*24 and -A*68, HLA-B*35, -B*39 and -B*48, HLA-DRB1*08:02, -DRB1*09:01, and -DRB1*14:02, and HLA-DQB1*04:02, -DQB1*03:02 and -DQB1*03:01 alleles are found in Aymaras and HLA class II haplotypes common to Andean Amerindians (DRB1*08:02-DQB1*04:02 and DRB1*04:03-DQB1*03:02), like Quechua, Aymara, Uros, Lamas and Mapuche are also found in Easter and other Pacific Islands. Giant human head stone statues at Tiwanaku (Titikaka Lake, Bolivia) are also found at Easter Island. Thus, it is possible a gene and cultural flow between Andean Amerindians and Easter and other Pacific Islands, as it was demonstrated by Thor Heyerdahl in his Kon-Tiki expedition which reached Pacific Islands sailing from El Callao Harbour (Lima, Peru).     

Lipid composition of metacestodes of Taenia taeniaeformis and lipid changes during growth

A lipid analysis was performed on developing metacestodes of Taenia taeniaeformis removed from the livers of rats at times varying from 3 to 35 weeks post infection. Lipid accounted for 7–21% of the dry weight of the parasites. The highest proportions were found at the earlier stages. The distribution was as follows; neutral lipid 27–45%; glycolipid 5–11%; and phospholipid 50–61%. The major neutral lipid was cholesterol, and minor neutral lipids were sterol esters, triglycerides, diglycerides and monoglycerides. Hydrocarbons were present throughout development, but in the highest amounts at the earlier stages. Five different glycolipids were found, all of which were identified as glycosphingolipids. An increase in the proportion of more complex glycolipids was noted as parasites grew older. Ten different phospholipids were identified, with the major components being phosphatidylcholine, phosphatidylethanolamine, and phosphatidylserine. Other phospholipids were: lysophosphatides, phosphatidylinositol, phosphatidic acid, diphosphatidylglycerol, sphingomyelin, and an unknown phospholipid component. Changes in the relative amounts of the two major phospholipids were found when the early and late stages were compared. Two lipids found throughout development were identified as glycosylated dolichol phosphates, and they comprised between 1 and 3% of the total phospholipid fraction. Nineteen fatty acids were detected, and the fatty acid distribution for each lipid class at each stage was determined. Seven major fatty acids were common to each. These were: hexadecanoic, octadecanoic, oleic, linoleic, arachidonic, docosanoic, and docosahexaenoic.     

Simple Serological Assays for Detecting Rice Tungro Viruses

An attempt was made to produce sensitive and specific polyclonal antisera against the viruses causing rice tungro disease, and to assess their potential for use in simple diagnostic tests. Using a multiple, sequential injection procedure, seven batches of polyclonal antisera against rice tungro bacilliform virus (RTBV) and rice tungro spherical virus (RTSV) were produced. These were characterized for their sensitivity and specificity using ring-interface precipitin test and double antibody sandwich (DAS) ELISA. Thirty-one weeks after the first immunization, antiserum batch B6b for RTBV showed the highest ring interface titer (DEP = 1:1920). For RTSV, batches S3, S4b and S5b all had similar titres (DEP = 1:640). In DAS-ELISA, however, significant differences among purified antisera (IgG) batches were observed only at IgG dilution of 10^-3. At that dilution, IgGB4b showed the greatest sensitivity, while IgGS3 showed greatest sensitivity for RTSV. When all IgG batches were tested against 11 tungro field isolates (dual RTBV-RTSV infections) at sample dilution of 1:10, IgGB4b and IgGB6b for RTBV and IgGS3 and IgGS6b for RTSV performed equally well. However, after cross adsorption with healthy plant extracts in a specially prepared healthy plant-Sepharose affinity column, only IgGB6b could be used specifically to detect RTBV in a simple tissue-print assay.     

Is it worthy to take full-course immunotherapy for allergic rhinitis? About efficacy biomarker of allergen immunotherapy

Nowadays, people pay more attention to biomarkers that can predict clinical efficacy of immunotherapy for allergic rhinitis. As the only recognized aetiological treatment, the efficacy of allergen immunotherapy (AIT) has been proved by many studies. However, treatment success depends on compliance and persistence greatly, which can be impaired by the lengthy duration of AIT and socioeconomic status of patients. Besides, ineffectiveness is another factor that accounts for non-adherence. If the clinical efficacy can be predicted in the early stage of immunotherapy, it can help patients choose appropriate treatment plans, increase patient compliance and optimize the allocation of medical resources. This paper mainly focuses on five candidate biomarkers, the sIgE/tIgE ratio before treatment, serum inhibitory activity for IgE, decreased basophil activation, upregulation of Tregs and tolerogenic DCs, reviews the time when potential biomarkers can predict or monitor the efficacy of AIT, discusses the reason why these indicators could serve as efficacy biomarkers and interactions among potential biomarkers.     

Neurotransmitter signaling pathways required for normal development in Xenopus laevis embryos: a pharmacological survey screen

Neurotransmitters are not only involved in brain function but are also important signaling molecules for many diverse cell types. Neurotransmitters are widely conserved, from evolutionarily ancient organisms lacking nervous systems through man. Here, results are reported from a loss‐ and gain‐of‐function survey, using pharmacological modulators of several neurotransmitter pathways to examine possible roles for these pathways in normal embryogenesis. Applying reagents targeting the glutamatergic, adrenergic and dopaminergic pathways to embryos of Xenopus laevis from gastrulation to organogenesis stages, we observed and quantified numerous malformations, including craniofacial defects, hyperpigmentation, muscle mispatterning and miscoiling of the gut. These data implicate several key neurotransmitters in new embryonic patterning roles, reveal novel earlier stages for processes involved in eye development, suggest new targets for subsequent molecular‐genetic investigation, and highlight the necessity for in‐depth toxicology studies of psychoactive compounds to which human embryos might be exposed during pregnancy.     

Uncombable Hair (cheveux incoiffables, pili trianguli et canaliculi) Syndrome: Brief Review and Role of Scanning Electron Microscopy in Diagnosis

Uncombable hair syndrome was first described some 3 decades ago as "cheveux incoiffables" and is also known as spun-glass hair and pili trianguli et canaliculi. Both inherited (autosomal dominant and recessive with variable levels of penetrance) and sporadic forms of uncombable hair syndrome have been described, both being characterized by scalp hair that is impossible to comb due to the haphazard arrangement of the hair bundles. A characteristic morphologic feature of hair in this syndrome is a triangular to reniform to heart shape on cross-sections, and a groove, canal or flattening along the entire length of the hair in at least 50%of hairs examined by scanning electron microscopy. Most individuals are affected early in childhood and the hair takeson a spun-glassappearance with the hair becoming dry, curly, glossy, lighter in color, and progressively uncombable. Only the scalp hair is affected. Several conditions are associated with uncombable hair, such as ectodermal dysplasia, retinal dysplasia/ pigmentary dystrophy, juvenile cataract, digit abnormalities, tooth enamel anomalies, oligodontia, and phalangoepiphyseal dysplasia. Other syndromes with hair abnormalities may also mimic uncombable hair syndrome clinically and these include, Rapp-Hodgkin ectodermal dysplasia; loose anagen hair syndrome; ectodermal dysplasia, ectrodatyly, cleft lip/ palate (EEC) syndrome; and familial tricho-odonto-onchyial ectodermal dysplasia with syndactyly. Unlike other conditions with an uncombable hair component, uncombable hair syndrome alone (cheveux incoiffables, pili trianguli etcanaliculi) is not associated with physical, neurologic, or mental abnormalities. In most cases of uncombable hair syndrome, the hair is grossly abnormal in infancy and early childhood, but may have improved manageability later in life. Scanning electron microscopy of hair samples provides definitive evidence for diagnosis of clinically suspected uncombable hair syndrome and eliminates other hair abnormalities from the differential diagnosis.     

A comparative study of cholinergic systems of the neocortex and hippocampus in rats with low and high resistance to hypoxia

Synaptic structures in the neocortex and hippocampus of the intact brain were compared between rats with low and high resistance to hypobaric hypoxia. Activities of choline acetyltransferase, acetylcholinesterase, Na,K-ATPase, and the portion of protein in the light and heavy synaptosome fractions and subfractions were measured. A discrepancy in cholinergic metabolism molecular mechanisms between high and low resistance animals have been found in the heavy somatosoma fraction from the neocortex. Activities of choline acetyltransferase, acetylcholinesterase, and Na,K-ATPase in the synaptolemmal subfraction of low resistant rats were much lower than in high resistant rats. This implies a less effective synaptic transmission in proper cholinergic neurons in the low resistance animals and, therefore, specifically changed neuron functioning in the circulation control. No differences in the cholinergic components of either neocortical light synaptosome fraction or hippocampal light and heavy synaptosome fractions were found between low and high resistance rats. Translated fromByulleten' Eksperimental'noi Biologii I Meditsiny, Vol. 125, No. 5, pp. 521–525, May, 1998     

BSACI guideline for the diagnosis and management of cow's milk allergy

This guideline advises on the management of patients with cow's milk allergy. Cow's milk allergy presents in the first year of life with estimated population prevalence between 2% and 3%. The clinical manifestations of cow's milk allergy are very variable in type and severity making it the most difficult food allergy to diagnose. A careful age‐ and disease‐specific history with relevant allergy tests including detection of milk‐specific IgE (by skin prick test or serum assay), diagnostic elimination diet, and oral challenge will aid in diagnosis in most cases. Treatment is advice on cow's milk avoidance and suitable substitute milks. Cow's milk allergy often resolves. Reintroduction can be achieved by the graded exposure, either at home or supervised in hospital depending on severity, using a milk ladder. Where cow's milk allergy persists, novel treatment options may include oral tolerance induction, although most authors do not currently recommend it for routine clinical practice. Cow's milk allergy must be distinguished from primary lactose intolerance. This guideline was prepared by the Standards of Care Committee (SOCC) of the British Society for Allergy and Clinical Immunology (BSACI) and is intended for clinicians in secondary and tertiary care. The recommendations are evidence based, but where evidence is lacking the panel of experts in the committee reached consensus. Grades of recommendation are shown throughout. The document encompasses epidemiology, natural history, clinical presentations, diagnosis, and treatment.