Changes in sialic acid content in the intestinal tissues of animals vaccinated with living poliomyelitis vaccine

A single oral administration of living poliomyelitis vaccine of immunologic type II (Sabin strain) to albino mice weighing 12–14 g is followed by an increase in the free sialic acid content from the 5th to the 20th days and in the bound sialic acid content from the 20th to the 45th day from the beginning of immunization in the small intestine of the vaccinated animals.Laboratory of Immunopathology, D. I. Ivanovskii Institute of Virology, Academy of Medical Sciences of the USSR, Moscow. (Presented by Academician of the Academy of Medical Sciences of the USSR V. M. Zhdanov.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 81, No. 3, pp. 298–299, March, 1976.     

Permeability of the placenta in rats after massive bleeding

Intravenous injection of physiological saline, sigetin, and Premarin into rats on the 16th day of pregnancy had a marked effect on permeability of the placenta after blood loss.Laboratory of Normal and Pathological Physiology, Institute of Obstetrics and Gynecology, Academy of Medical Sciences of the USSR, Leningrad. (Presented by Academician of the Academy of Medical Sciences of the USSR O. V. Baroyan.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 84, No. 8, pp. 164–165, August, 1977.     

Oxidative phosphorylation in liver mitochondria in the toxic form of experimental influenza

All-Union Influenza Research Institute, Ministry of Health of the USSR. I. M. Sechenov Institute of Experimental Physiology and Biochemistry, Academy of Sciences of the USSR. I. P. Pavlov Institute of Physiology, Academy of Sciences of the USSR, Leningrad. (Presented by Academician of the Academy of Medical Sciences of the USSR A. N. Klimov.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 112, No. 12, pp. 617–619, December, 1991.     

Some aspects of structural disturbances in the DNP complex when damaged by N-nitroso-N-methylurea

The effect of solubilization of deoxyribonucleoproteins (DNP) in a medium of near-physiological ionic strength after treatment with the mutagen N-nitroso-N-methylurea (NMU) is highly dependent on the NMU concentration. To convert DNP into a soluble state, the critical number of groups in the DNA and protein must evidently be modified. On the basis of data obtained by the circular dichroism method and by viscosimetry it is concluded that after treatment with NMU the DNP complex becomes soluble in solvents with near-physiological ionic strength largely as a result of labilization and dissociation of the DNA-protein bonds.Laboratory of Biophysics, Institute of Medical Genetics, Academy of Medical Sciences of the USSR. Sector of Kinetics of Chemical and Biological Processes, Institute of Chemical Physics, Academy of Sciences of the USSR. Laboratory of Physical Methods of Investigation, D. I. Ivanovskii Institute of Virology, Academy of Medical Sciences of the USSR, Moscow. (Presented by Academician of the Academy of Medical Sciences of the USSR S. S Debov.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 81, No. 6, pp. 674–677, June, 1976.     

Changes in organization of the intermediate filament system in human fibroblasts in lysosomal storage diseases and their experimental models

Institute of Biological and Medical Chemistry, Academy of Medical Sciences of the USSR. Institute of Carcinogenesis, All-Union Oncologic Scientific Center, Academy of Medical Sciences of the USSR, Moscow. (Presented by Academician of the Academy of Medical Sciences of the USSR A. I. Archakov.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 113, No. 3, pp. 263–268, March, 1992.     

Biological activity of follicle-stimulating hormone in the human fetal pituitary

Changes in the follicle-stimulating hormone (FSH) level in the human fetal pituitary were studied by biological methods. FSH was detected in the fetal pituitary throughout the period of investigation: from the 8th to the 34th week. From the 17th to the 34th week of intrauterine development considerable sex differences were found both in the total and the relative content of the hormone in the gland.Laboratory of Development of the Nervous System and Laboratory of Endocrinology, Institute of Human Morphology, Academy of Medical Sciences of the USSR, Moscow. (Presented by Academician of the Academy of Medical Sciences of the USSR A. P. Avtsyn.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 85, No. 3, pp. 359–362, March, 1978.     

Chemotactic function of skin fibroblasts in patients with amyloidosis

Department of Internal Medicine and Occupational Diseases, and Problem Laboratory for Nephrology, Central Research Department, I. M. Sechenov First Moscow Medical Institute. Institute of Medical Genetics, Academy of Medical Sciences of the USSR. Institute of Crystallography, Academy of Sciences of the USSR, Moscow. (Presented by Academician of the Academy of Medical Sciences of the USSR N. P. Bochkov.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 109, No. 6, pp. 578–580, June, 1990.     

Structural and functional changes in peripheral nerves after application of certain drugs

Institute of Experimental Medicine, Academy of Medical Sciences of the USSR. I. P. Pavlov Institute of Physiology, Academy of Sciences of the USSR. A. L. Polenov Leningrad Neurosurgical Research Institute. (Presented by Academician of the Academy of Medical Sciences of the USSR N. P. Bekhtereva.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 112, No. 8, pp. 158–160, August, 1991.     

Elevation of calcium-dependent phospholipase C activity in the myocardium during adaptation to short-term stress

Research Institute of General Pathology and Pathological Physiology, Academy of Medical Sciences of the USSR. Research Institute of Experimental Cardiology, All-Union Cardiologic Scientific Center, Academy of Medical Sciences of the USSR, Moscow. (Presented by Academician of the Academy of Medical Sciences of the USSR G. N. Kryzhanovskii.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 113, No. 2, pp. 130–132, February, 1992.     

Selective depression of the primary humoral immune response in mice by a combination of deoxycytidine with cytosar

Injection of cytosine-arabinoside in a lethal dose into female C57BL/6j mice immunized with sheep's red blood cells, under protection of deoxycytidine, leads to a decrease in the serum hemagglutinin level on the 5th day without the development of toxicosis. Simultaneous injections of the metabolite and antimetabolite is optimal.Oncologic Scientific Center, Academy of Medical Sciences of the USSR, Moscow. (Presented by Academician of the Academy of Medical Sciences of the USSR L. M. Shabad.) Translated by Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 87, No. 6, pp. 569–571, June, 1979.     

Detection of antibodies to cross-reacting bacterial antigens in cancer patients

Institute of Clinical and Experimental Medicine, Siberian Branch, Academy of Medical Sciences of the USSR, Novosibirsk. R. E. Kavetskii Institute for Problems in Oncology, Academy of Sciences of the Ukrainian SSR, Kiev. (Presented by Academician of the Academy of Medical Sciences of the USSR V. P. Kaznacheev). Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 111, No. 5, pp. 525–528, May, 1991.     

Endocrine-metabolic relations in rats with inherited stress-induced arterial hypertension

Laboratory of Endocrinology, Institute of Clinical and Experimental Medicine, Siberian Branch, Academy of Medical Sciences of the USSR. Laboratory of Genetic Bases of Neuroendocrine Regulation, Institute of Cytology and Genetics, Siberian Branch, Academy of Sciences of the USSR, Novosibirsk. (Presented by Academician of the Academy of Medical Sciences of the USSR V. P. Kaznacheev.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 109, No. 6, pp. 575–576, June, 1990.     

Extracellular pH, [K+], and synaptic transmission in the dorsal horn of the spinal cord of hypercapnic rats

P. K. Anokhin Research Institute of Normal Physiology, Academy of Medical Sciences of the USSR, Moscow. Research Institute of General Pathology and Pathological Physiology, Academy of Medical Sciences of the USSR, Moscow. (Presented by Academician of the Academy of Medical Sciences of the USSR K. V. Sudakov.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 113, No. 1, pp. 8–10, January, 1992.     

Rhythm of ornithine decarboxylase activity in rat parotid gland slices

In rat parotid gland slices incubated in vitro ornithine decarboxylase activity and the rate of protein synthesis were determined. A circahoralian rhythm of enzyme activity preceding inphase fluctuations in the range of protein synthesis was found. These results indicate a role of ornithine decarboxylase in maintenance of the circahoralian rhythm of the rate of protein synthesis in parotid gland cells.Laboratory of Cytology, Institute of Developmental Biology, Academy of Sciences of the USSR. Department of Biochemistry, Central Research Laboratory, Attached to the 4th Main Board, Ministry of Health of the USSR, Moscow. (Presented by Academician of the Academy of Medical Sciences of the USSR S. E. Severin.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 86, No. 12, pp. 726–728, December, 1978.     

Mechanisms of effect of orotic acid on growth and development of young rats

Chronic administration of potassium orotate to young rats in a dose of 75 mg/kg body weight from the 5th to the 14th day and 150 mg/kg from the 15th to the 30th day of life sharply accelerates growth and functional maturation of the animals. The rate of growth of the experimental animals between the 5th and 14th days and the 21st and 30th days was much greater than in the control rats, but between the 14th and 21st days there was no significant difference. The acceleration of growth from the 5th to the 14th day is accounted for by the greater activity of the autonomic systems (increased oxygen consumption, respiration rate, and heart rate at rest) than in the control. Between the 21st and 30th days the acceleration of growth in the experimental rats was connected with an earlier decrease in activity of the autonomic systems and sympathicoadrenal control mechanisms, as shown by a decrease in the catecholamine concentration in the adrenals and brain.Laboratory of Age Physiology and Pathology, Institute of Normal and Pathological Physiology, Academy of Medical Sciences of the USSR, Moscow. (Presented by Academician of the Academy of Medical Sciences of the USSR N. A. Fedorov.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 79, No. 3, pp. 18–21, March, 1975.     

Adrenergic receptors in the liver parenchyma of children with chronic hepatitis

Research Center for Molecular Diagnosis, Ministry of Health of the USSR, Moscow Research Institute of Pediatrics, Academy of Medical Sciences of the USSR, Moscow. (Presented by Academician of the Academy of Medical Sciences of the USSR M. Ya. Studenikin.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 113, No. 2, pp. 127–129, February, 1992.     

Mycoplasma hominis as an agent of diseases of the respiratory tract

The respiratory organs of newborn rats infected intranasally with a broth culture ofMycoplasma hominis were studied by histological, histochemical, and immunofluorescence methods. Tracheitis and, suppurative and interstitial pneumonia with a hemorrhagic component were observed 24 h after infection and lasted until the 7th day of the experiment. During the same period, specific fluorescence ofM. hominis antigen was detected by the immunofluorescence method. The morphological picture found demonstrates the pathogenicity ofM. hominis for the respiratory tract of newborn rats.Institute of Human Morphology, Academy of Medical Sciences of the USSR. N. F. Gamaleya Institute of Epidemiology and Microbiology, Academy of Medical Sciences of the USSR, Moscow. (Presented by Academician of the Academy of Medical Sciences of the USSR A. P. Avtsyn.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 84, No. 9, pp. 372–375, September, 1977.     

Adaptation to stress increases the resistance of heart cell nuclei to the damaging action of single-stranded exogenous DNA

Research Institute of General Pathology and Pathophysiology, Academy of Medical Sciences of the USSR, Moscow. Leningrad Institute of Nuclear Physics, Academy of Sciences of the USSR, Leningrad. (Presented by Academician of the Academy of Medical Sciences of the USSR S. S. Debov.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 111, No. 5, pp. 460–462, May, 1991.     

Effect of ethyrazole and parmidine on the development of experimental atherosclerosis in rabbits

In rabbits receiving cholesterol with the diet for 3–4 months the accumulation of total cholesterol in the aorta and the degree of severity of atherosclerosis of the aorta were reduced by administration of ethyrazole and parmidine. These substances had no substantial effect on the blood cholesterol, triglyceride, and phospholipid levels of these animals.Laboratory of Experimental Pharmacotherapy, N. N. Anichkov Department of Atherosclerosis, Institute of Experimental Medicine, Academy of Medical Sciences of the USSR, Leningrad. (Presented by Academician of the Academy of Medical Sciences of the USSR S. V. Anichkov.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 81, No. 5, pp. 558–559, May, 1976.     

Biogenic monoamines in mouse oocytes and preimplantation embryos

N. K. Kol'tsov Institute of Developmental Biology, Academy of Sciences of the USSR, Moscow. Institute of Experimental Biology, Academy of Sciences of the Kazakh SSR, Alma-Ata. (Presented by Academician of the Academy of Medical Sciences of the USSR A. P. Avtsyn.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 109, No. 6, pp. 577–578, June, 1990.