结直肠癌术后化疗患者主观幸福感现状及其影响因素分析

目的：探讨结直肠癌术后化疗患者主观幸福感现状并分析其影响因素。方法：应用横断面研究方法,对215例结直肠癌术后化疗患者,使用一般资料调查表、总体幸福感量表、简易应对方式问卷、事件相关反刍性沉思问卷和Rosenberg自尊量表进行调查。结果：215例结直肠癌术后化疗患者主观幸福感总分为（69.72±13.67）分。多元逐步回归分析结果显示,积极应对、消极应对、自尊、侵入性沉思是结直肠癌术后化疗患者主观幸福感的主要影响因素（调整R²=0.761,P＜0.001）。结论：结直肠癌术后化疗患者主观幸福感水平亟待提高,临床工作中医护人员应正确引导患者积极应对疾病,帮助患者调节不良情绪,以提高其主观幸福感。     

全胸腹腔镜下食管癌根治术患者心理弹性及影响因素的研究

目的探讨全胸腹腔镜下食管癌根治术患者心理弹性及影响因素。方法回顾性分析2017年8月至2018年8月80例全胸腹腔镜下食管癌根治术患者的资料,采用一般资料调查问卷、心理弹性量表、自我感受负担、简易应对方式量表、社会支持评定量表进行问卷调查,应用Pearson相关分析自我感受负担、应对方式、社会支持与心理弹性的关系,采用多元回归方程分析影响全胸腹腔镜下食管癌根治术患者心理弹性的相关因素。结果全胸腹腔镜下食管癌根治术患者心理弹性总评分为(58. 36±4. 35)分。Pearson相关分析显示,患者心理弹性与客观支持、主观支持、支持利用度、社会支持总评分及积极应对呈正相关(P 0. 05),而与消极应对、身体负担、情感负担、经济负担及自我感受负担呈负相关(P 0. 05)。经多元回归方程分析显示,患者学历、身体负担、情感负担、消极应对方式是影响全胸腹腔镜下食管癌根治术患者心理弹性的重要因素,主观支持、支持利用度和积极应对方式是保护因素。结论全胸腹腔镜下食管癌根治术患者心理弹性水平较低,且受多种因素影响。术后给予患者社会支持有利于患者采取积极的态度面对疾病,减轻患者自我感受负担,提高患者心理弹性水平。     

脑卒中患者主观幸福感影响因素分析

目的探讨脑卒中患者主观幸福感水平并分析其影响因素。方法抽取491例住院脑卒中患者,应用一般资料问卷、纽芬兰纪念大学主观幸福感量表和家庭关怀度指数问卷进行调查,了解脑卒中患者主观幸福感状况及其影响因素。结果脑卒中患者主观幸福感得分为(23.15±13.96)分,属于中等偏低水平; 76.58%患者主观幸福感处于中等及以下水平;多元线性逐步回归分析显示:家庭关怀度、文化程度、家庭人均月收入是患者主观幸福感的主要影响因素。结论临床医护人员应根据脑卒中患者的具体情况采取针对性的干预措施,发挥患者家庭的社会支持功能,以减少患者的消极情绪体验,提高其主观幸福感水平。     

失代偿期肝硬化患者主观幸福感水平及影响因素分析

目的调查失代偿期肝硬化患者主观幸福感水平,分析其影响因素。方法采用一般资问卷,纽芬兰纪念大学幸福度量表、家庭关怀度指数问卷、正念注意觉知量表和自我感受负担量表对200例失代偿期肝硬化患者进行问卷调查。结果失代偿期肝硬化患者主观幸福感得分为(27.54±4.92)分,处于中等水平。多元线性回归分析显示,性别、治疗依从性、家庭关怀度、正念水平以及自我感受负是其主观幸福感水平的主要影响因素(P0.01或P0.05)。结论失代偿期肝硬化患者主观幸福感状况有待改善,护理人员应当及时开展个性化的干预措施,增强患者主观幸福感,提高其生存质量。     

慢性乙型肝炎患者主观幸福感状况及其影响因素分析

目的 探讨慢性乙型肝炎患者的主观幸福感水平及其影响因素.方法 采用便利抽样法抽取123例住院慢性乙型肝炎患者,运用纽芬兰纪念大学主观幸福感问卷、社会支持量表和医学应对问卷进行调查.结果 慢性乙型肝炎患者主观幸福感为中等水平[(21.92±2.65)分],不同婚姻状况、医疗费用支付方式的患者的主观幸福感得分差异均有统计学...     

食管癌术后患者自我效能及应对方式对希望水平的影响分析

目的调查食管癌术后患者希望水平及其相关因素,探讨食管癌术后患者自我效能及应对方式对希望水平的影响。方法采取便利抽样法选取某三级甲等医院食管癌手术后221例患者,使用一般资料调查表、Herth希望量表、癌症自我效能感量表、Jalowiec应对量表的问卷调查。采用阶层线性回归分析探讨自我效能和应对方式对希望水平的影响。结果食管癌术后患者希望水平处于中等水平。食管癌术后患者希望水平与自我效能及乐观应对呈正相关,与情感宣泄呈负相关。阶层回归分析显示,自我效能、乐观应对可以正向预测患者希望水平;情感宣泄的应对方式可以负向预测患者的希望水平。结论食管癌术后患者希望水平处于中等程度,自我效能和乐观应对可以作为食管癌术后患者的保护性因素。     

食管癌根治术后放疗患者自我感受负担现状分析及其影响因素研究

目的研究分析食管癌根治术后放疗患者自我感受负担现状及其影响因素。方法采用便利抽样法选取我院2014年6月-2017年6月收治的185例食管癌根治术后放疗患者及其照顾者作为研究对象,使用一般资料调查问卷表、自我感受负担量表(SPBS)、心理痛苦温度计(DT)、WHO生存质量评估简表(WHOQOL-BREF)和照顾者负担量表(ZBI)对其进行调查,采用多元线性回归分析探讨食管癌根治术后放疗患者自我感受负担及其影响因素。结果食管癌根治术后放疗患者自我感受负担总分为(36. 84±12. 75)分,处于中等水平。年龄、放疗疗程次数、合并慢性病数量、患者心理状况水平和生存质量水平、主要照顾者负担水平是食管癌根治术后放疗患者自我感受负担的主要影响因素。结论患者自我感受负担得分处于中等水平,应采取相应措施来降低自我感受负担以提高其生活质量及身心健康。     

维持性血液透析患者的主观幸福感现状调查及其影响因素研究

目的 调查维持性血液透析患者的主观幸福感现状,研究其影响因素.方法 选取本院2017年1月—2018年12月进行维持性血液透析治疗的82例患者作为研究对象,采用一般资料调查表、总体幸福感量表、家庭关怀指数量表、领悟社会支持量表进行调查.结果 维持性血液透析患者的总体幸福感总分为(75.12±15.14)分,家庭人均月收入、自评身体健康状况、心理健康状况、疾病支出占家庭收入比例、不同家庭功能的主观幸福感得分差异有统计学意义(P<0.05).多因素多元逐步回归分析结果显示:家庭人均月收入<2000元、自评身体健康差、心理健康高危、疾病支出占家庭收入比例>50％以及家庭功能障碍是影响患者主观幸福感的危险因素(P<0.05).结论 通过增强患者的家庭关怀疏导其不良情绪,减轻经济负担,提高患者的生活质量,有助于提高患者的主观幸福感.     

宫颈癌根治术后病人创伤后成长状况及其影响因素分析

[目的]调查宫颈癌根治术后病人创伤后成长水平并分析其影响因素。[方法]采用一般情况调查表、创伤后成长量表、社会支持评定量表和简易应对方式问卷对99例宫颈癌根治术后病人进行调查。[结果]宫颈癌根治术后病人创伤后成长总分为58.36分±6.81分,处于中等水平。多元逐步回归分析结果显示:术后时间、治疗方式、是否复发、积极应对、客观支持为宫颈癌病人术后创伤后成长的影响因素,可解释全部变异的60.3%。[结论]护理人员应针对不同的影响因素进行针对性护理,以提高宫颈癌根治术后病人创伤后成长水平。     

医养结合模式管理的老年患者总体幸福感及其影响因素分析

目的调查医养结合模式管理的老年患者总体幸福感并分析其影响因素。方法采用方便抽样法选取198例实施医养结合模式管理的老年患者为调查对象,采用一般资料调查表、总体幸福感量表和服务满意度问卷进行调查,通过单因素分析、多元线性回归分析探究医养结合模式管理的老年患者总体幸福感的影响因素。结果患者总体幸福感量表总分为(63.58±14.26)分,服务满意度问卷总分为(89.64±10.38)分;多元线性回归分析结果显示个人月收入、子女探视频率、生活自理程度、服务满意度是医养结合模式管理的老年患者总体幸福感的影响因素(P<0.05)。结论医养结合模式管理的老年患者总体幸福感处于较低水平,受多种因素影响。     

Domains of concern of intimate partners of sudden cardiac arrest survivors after ICD implantation

PURPOSE: There is limited research that describes the experiences of intimate partners of sudden cardiac arrest (SCA) survivors. The purposes of this article are to (1) describe the domains of concern of intimate partners of SCA survivors during the first year after internal cardioverter defibrillator (ICD) implantation and (2) outline strategies used by partners of SCA survivors in dealing with the concerns and demands of recovery in the first year after ICD implantation. METHODS: This is a secondary analysis of interview data collected for the primary study "Family Experiences Following Sudden Cardiac Arrest." A grounded theory method was used to identify experiences of SCA survivors and their family members from hospitalization through the first year after ICD implantation. Data were collected from the SCA survivor and one intimate partner at 5 times: hospital discharge, and at 1, 3, 6, and 12 months postdischarge. RESULTS: Eight Domains of Concern were identified for intimate partners following SCA and ICD implantation during the first year. These included (1) Care of the survivor, (2) My (partner) self-care, (3) Relationship, (4) ICD, (5) Money, (6) Uncertain future, (7) Health care providers, and (8) Family. Five categories of strategies to deal with the Domains of Concerns were identified (1) Care of the survivor, (2) My (partner) self-care, (3) Relationship, (4) Uncertain future, and (5) Controlling the environment. IMPLICATIONS: Nursing intervention programs should include the intimate partner of SCA survivors and contain education and support in the following areas: (1) information on the function of the ICD, (2) normal progression of physical and emotional recovery experiences, (3) safety and maintenance of the ICD, (4) activities of daily living after an ICD, (5) strategies to assist with the survivors care, and (6) strategies to assist with partner self care.     

Development of a high-affinity inhibitor of the prostaglandin transporter

Prostaglandin E(2) (PGE(2)) triggers a vast array of biological signals and physiological events. The prostaglandin transporter (PGT) controls PGE(2) influx and is rate-limiting for PGE(2) metabolism and signaling termination. PGT global knockout mice die on postnatal day 1 from patent ductus arteriosus. A high-affinity PGT inhibitor would thus be a powerful tool for studying PGT function in adult animals. Moreover, such an inhibitor could be potentially developed into a therapeutic drug targeting PGT. Based on structure-activity relationship studies that built on recently identified inhibitors of PGT, we obtained N-(2-(2-(2-azidoethoxy)ethoxy)ethyl)-4-((4-((2-(2-(2-benzamidoethoxy)ethoxy)ethyl)amino)-6-((4-hydroxyphenyl)amino)-1,3,5-triazin-2-yl)amino)benzamide (T26A), a competitive inhibitor of PGT, with a K(i) of 378 nM. T26A seems to be highly selective for PGT, because it neither interacts with a PGT homolog in the organic anion transporter family nor affects PGE(2) synthesis. In Madin-Darby canine kidney cells stably transfected with PGT, T26A blocked PGE(2) metabolism, resulting in retention of PGE(2) in the extracellular compartment and the negligible appearance of PGE(2) metabolites in the intracellular compartment. Compared with vehicle, T26A injected intravenously into rats effectively doubled the amount of endogenous PGE(2) in the circulation and reduced the level of circulating endogenous PGE(2) metabolites to 50%. Intravenous T26A was also able to slow the metabolism of exogenously injected PGE(2). These results confirm that PGT directly regulates PGE(2) metabolism and demonstrate that a high-affinity inhibitor of PGT can effectively prevent PGE(2) metabolism and prolong the half-life of circulating PGE(2).     

Characterization of substance P-induced contractions of guinea-pig trachea

In light of current interest in substance P as a bronchoconstrictor, several pharmacologic antagonists of known mediators of anaphylaxis were tested for possible activity against this neuropeptide. Concentration-dependent contractions of the isolated guinea-pig tracheal strips to substance P (10(-8) to 10(-5) M) were elicited. These contractions were inhibited by substance P receptor antagonists, D-Arg1-D-Trp7,9-Leu11 and D-Pro2-D-Trp7,9-substance P (10(-6) to 10(-4) M). Substance P-induced contractions were not inhibited by histamine, alpha and beta adrenergic receptor antagonists or by cyclooxygenase inhibition. However, atropine enhanced contractions to substance P. Both vasoactive intestinal polypeptide (10(-7), 10(-6) and 10(-4) M) and isoproterenol (10(-7) M) were able to reverse an ongoing substance P (10(-5) M)-induced contraction. Also, at a concentration of 10(-5) M, substance P increased cyclic GMP accumulation, but had no effect on the concentration of cyclic AMP. A 15-min pretreatment with either verapamil or nifedipine (10(-8) M) had no effect on substance P-induced contractions, whereas the purported intracellular Ca++ antagonist, 8-[N,N-diethylamino]-octyl 3,4,5-trimethoxybenzoate hydrochloride (10(-4) M) produced a rightward shift of a substance P concentration-response curve. A selective calmodulin inhibitor, N-(6-aminohexyl)-5-chloro-1-naphthalene-sulfonamide (10(-4) M) failed to affect the contraction produced by 10(-5) M substance P. When guinea-pig tracheal strips were washed and allowed to re-equilibrate in 0 Ca++ buffer, the initial maximum contractions to substance P (10(-5) M) were equal for both regular (1.8 mM) Ca++ and 0 Ca++ buffer.(ABSTRACT TRUNCATED AT 250 WORDS)     

Absence of spare autoreceptors regulating dopamine agonist inhibition of tyrosine hydroxylation in slices of rat striatum

Incubation of rat striatal slices with forskolin (0.05-10 microM) elicited a dose-dependent increase in the activity of tyrosine hydroxylase (TH) assayed in subsequently solubilized extracts of the enzyme. At low concentrations (33 microM) of the cofactor (6R)-5,6,7,8-tetrahydro-L-biopterin dihydrochloride TH activity was increased 2.5 to 3-fold. Kinetic analysis of TH activity as a function of (6R)-5,6,7,8-tetrahydro-L-biopterin dihydrochloride concentration indicated that the enzyme isolated from control slices was composed of multiple species with different Km's for cofactor. Treatment with forskolin (1.5-15 microM) converted the enzyme into a single species with a low Km (28 microM) for (6R)-5,6,7,8-tetrahydro-L-biopterin dihydrochloride. The dopamine (DA) agonist R-(-)-N-n-propylnorapomorphine (0.1 microM) reversed forskolin-induced activation of TH. Concentration-response curves were obtained for inhibition of forskolin-stimulated TH by R-(-)-N-n-propylnorapomorphine and the DA autoreceptor-selective agonists (+)- and (-)-3-(3-hydroxyphenyl)-N-n-propylpiperidine and 3-[4-(4-phenyl-1,2,3,6-tetrahydropyridyl-1)-butyl]indole. R-(-)-N-n-propylnorapomorphine maximally inhibited forskolin-stimulated activity 85%, as indicated by ALLFIT computer analysis of concentration-response curves. (+)-3-(3-hydroxyphenyl)-N-n-propylpiperidine and 3-[4-(4-phenyl-1,2,3,6-tetrahydropyridyl-1)-butyl]indole produced a lower degree of maximal inhibition (54 and 63%, respectively), whereas (-)-3-(3-hydroxyphenyl)-N-n-propylpiperidine was inactive. The D2 DA receptor blocker sulpiride (1 microM) competitively antagonised the effects of all the agonists.(ABSTRACT TRUNCATED AT 250 WORDS)     

Radioiodination of human intrinsic factor

Human intrinsic factor (IF) saturated with (60)Co-labeled cyanocobalamin ((60)CoB(12)) was purified and then iodinated with (125)I to yield (125)I-labeled IF-(60)CoB(12) preparations of high specific activity. Sephadex G200 and DEAE-cellulose chromatography of the iodinated IF-(60)CoB(12) complex showed coincidence of the major (125)I and the (60)Co radioactivity peaks. During starch-gel electrophoresis (60)Co radioactivity from noniodinated and iodinated complexes migrated to the same extent while (125)I radioactivity from the iodinated complex migrated slightly further anodally than did the (60)Co radioactivity. After the iodinated complex was mixed with antibody to the IF-B(12) complex (antibody II) the (125)I and (60)Co radioactivity were: (a) precipitated in similar amounts by antiglobulin serum. (b) eluted coincidentally in the 19S region on Sephadex G200, and (c) excluded to the same extent from starch gel during electrophoresis. After equilibrium exchange of IF "blocking" antibody (antibody I) for (60)Co-vitamin B(12) on (125)I-labeled IF. (125)I radioactivity from the IF-antibody I complex: (a) was precipitated by antiglobulin serum, (b) was eluated in the 19S region on Sephadex G200 gel filtration, and (c) migrated slowly towards the anode on starch-gel electrophoresis. Urinary excretion of (60)Co radioactivity in pernicious anemia patients after oral administration of (60)Co-vitamin B(12) bound to freshly prepared (125)I-labeled IF was similar to that obtained with noniodinated intrinsic factor.These results show that iodination of IF-(60)CoB(12) complex does not markedly alter the chromatographic, electrophoretic, antigenic, or absorption-promoting properties of IF.     

Inhibition by iodine of the release of thyroxine from the thyroid glands of patients with thyrotoxicosis

A method has been devised which is free of many of the shortcomings of serial epithyroid counting techniques as an index of the rate of thyroid hormone secretion. By means of this method, the effect of treatment with Lugol's iodine on the rate of thyroidal secretion of thyroxine (T(4)) has been assessed in eight patients with thyrotoxicosis due to diffuse or multinodular goiter. The technique involves administration of a tracer dose of inorganic (125)I followed several days later by an intravenous tracer dose of (131)I-labeled T(4). Serial observations of serum protein-bound (PB) (125)I and (131)I are accompanied by frequent measurements of endogenous serum T(4) (T(4)-(127)I) concentration. Regardless of whether or not its administration was anteceded and accompanied by the administration of large doses of methimazole, iodine induced a rapid decrease in serum T(4)-(127)I concentration which could not be explained by an increase in the peripheral turnover of T(4), as judged from the metabolism of the (131)I-labeled hormone. Hence, the decreased serum T(4) concentration could only have resulted from decreased secretion of the hormone by the gland. Analyses of specific activity relationships between PB(125)I or T(4)-(127)I and PB(131)I made possible estimations of the extent to which iodine had decreased the rate of secretion of T(4). From such analysis, and in view of other considerations, it is concluded that the rapid decrease in T(4) secretion induced by iodine is not the result of an acute, sustained inhibition of T(4) synthesis, but rather results from an abrupt decrease in the fractional rate of thyroidal T(4) release.     

不同类型炎症中生长因子水平差异及其意义

目的 研究感染性和自身免疫性两类炎症中血小板源生长因子(PDGF)、血管内皮生长因子(VEGF)的异常变化及变化持续时间方面的差异.方法 应用ELISA法于不同时间检测149例两类炎症患者血清各因子含量值共7次,比较各因子变化情况及变化持续时间.结果 PDGF:治疗前感染组(6.32±2.54)μg/ml,免疫组(2.57±1.65)μg/ml,差异有统计学意义(P<0.05).其组间、组内不同时间点及各组间对应时点差异均有统计学意义(P均<0.05).VEGF:治疗前感染组(179.5±53.30)ng/ml,免疫组(221.4±70.04)ng/ml,差异有统计学意义(P<0.05).其组间、组内不同时间点及各组间对应时点差异均有统计学意义(P均<0.05).2组生长因子水平达峰值时间[PDGF:感染组(2.6±1.1)d,免疫组(5.4±3.3)d;VEGF:感染组(2.4±0.7)d,免疫组(7.2±3.3)d],差异均有统计学意义(P<0.05).异常变化持续时间PDGF:感染组(6.7±3.1)d,免疫组(15.4±6.1)d.VEGF:感染组(8.1±3.4)d,免疫组(16.7±7.2)d,差异均有统计学意义(P均<0.05).结论 两类炎症中两种细胞因子异常变化水平及异常变化持续时间均有显著差异,这种差异与炎症的性质及结局可能有内在因果关系.     

Pharmacological analysis of autonomic innervation of the right atria of rats and guinea pigs: demonstration of nonadrenergic noncholinergic nerves

Transmural nerve stimulation (TNS) of the right atria in vitro produced positive and negative chronotropic responses in rats and guinea pigs. The negative component appeared only temporarily soon after the cessation of TNS and was usually masked by the positive component. The positive and negative chronotropic responses were accompanied by an increase and decrease in contractile force, respectively. Atenolol (3 X 10(-6) M) decreased and atropine (10(-6) M) potentiated the TNS-induced positive chronotropic response. In the presence of both atenolol and atropine, TNS accelerated the heart rate markedly in the right atria of guinea pigs and slightly in those of rats. TNS-induced acceleration of the heart rate was also observed in surgically sympathectomized or reserpine-pretreated (5 mg/kg/48 hr and 2.5 mg/kg/24 hr i.p.) right atrium, in which tyramine (up to 10(-4) M) exerted no appreciable effect. Inasmuch as tetrodotoxin (10(-6) M) almost abolished the TNS-induced chronotropic response, this atenolol- and atropine-resistant response is likely mediated by nonadrenergic noncholinergic (NANC) nerve(s). The NANC nerve-mediated positive chronotropic response was not affected by diphenhydramine (10(-6) M), cimetidine (10(-6) M), methysergide (10(-6) M) and hexamethonium (3 X 10(-6) M). The NANC nerve-mediated response was relatively slow at the onset yet long-lasting compared with adrenergic and cholinergic responses, suggesting that the neurotransmitter of the NANC nerve is a certain substance which may be inactivated more slowly than biogenic amines. Histochemical studies demonstrated the presence of vasoactive intestinal polypeptide-like and substance P-like immunoreactive nerves in the right atrium, as well as catecholamine-fluorescence and acetylcholinesterase-positive nerves.(ABSTRACT TRUNCATED AT 250 WORDS)     

Mechanistic study of inhibition of levofloxacin absorption by aluminum hydroxide.

The mechanisms of reduction in absorption of levofloxacin (LVFX) by coadministration of aluminum hydroxide were studied. The partition coefficient of LVFX (0.1 mM) between chloroform and phosphate buffer (pH 5.0) was reduced by 60 to 70% with the addition of metal ions such as Cu2+, Al3+, and Fe2+ (0.8 mM), which indicated the formation of LVFX-metal ion chelates. However, there was no significant difference in absorption from rat intestine between the synthetic LVFX-Al3+ (1:1) chelate (6.75 mM) and LVFX (6.75 mM) in an in situ recirculation experiment. On the other hand, Al(NO3)3 (1.5 mM) significantly inhibited the absorption of LVFX (1.5 mM) by 20% of the control in the in situ ligated loop experiment, in which partial precipitation of aluminum hydroxide was observed in the dosing solution. Data for adsorption of LVFX and ofloxacin (OFLX) from aqueous solution by aluminum hydroxide were shown to fit Langmuir plots, and the adsorptive capacities (rmax) and the K values were 7.0 mg/g and 1.77 x 10(4) M-1 for LVFX and 7.4 mg/g and 1.42 x 10(4) M-1 for OFLX, respectively. The rate of adsorption of several quinolones (50 microM) onto aluminum hydroxide (2.5 mg/ml) followed the order norfloxacin (NFLX) (72.0%) > enoxacin (ENX) (61.0%) > OFLX (47.2%) approximately LVFX (48.1%). The elution rate of adsorbed quinolones with water followed the rank order LVFX (17.9%) approximately OFLX (20.9%) approximately ENX (18.3%) > NFLX (11.9%). These results strongly suggest that adsorption of quinolones by aluminum hydroxide reprecipitated in the small intestine would play an important role in the reduced bioavailability of quinolones after coadministration with aluminum-containing antacids.     

不同型号SPECT肾动态显像GFR正常值的比较

目的 评价不同型号单光子发射型计算机断层成像(SPECT)肾动态显像测定的肾小球滤过率(GFR)正常值并比较其差异.方法 50名正常志愿者根据年龄(20～29岁,n=14;30～39岁,n=10;40～49岁,n=14;50岁以上,n=12)分为4组,均接受MPR型SPECT肾动态显像,分别测量其分肾GFR值及总肾GFR值,并计算其平均值,与采用GE Starcom 400AC/T型SPECT对33名正常志愿者(20～29岁,n=6;30～39岁,n=11;40～49岁,n=7;50岁以上,n=9)行肾动态显像的分肾GFR值及总肾GFR值进行比较.结果 MPR型单探头SPECT行肾动态显像的50名正常志愿者分组后所得的分肾GFR值分别为(51.03±11.12)ml、(48.44±11.13)ml、(47.79±7.71)ml、(46.54±12.28)ml,分肾总平均值为(48.51±10.50)ml,组内总肾GFR值分别为(102.13±18.33)ml、(96.62±19.90)ml、(95.54±13.04)ml、(92.85±22.83)ml,总肾GFR总平均值(97.04±18.16)ml;与Starcom400AC/T型SPECT所测定的相应组别分肾GFR值[(57.92±9.03)ml、(57.34±10.33)ml、(55.30±8.51)ml、(44.12±7.94)ml]、分肾总平均值[(52.92±10.61)ml],组内总肾GFR值[(115.86±16.51)ml、(113.14±17.71)ml、(110.54±11.13)ml、(88.12±14.41)ml],总肾GFR总平均值[(105.63±18.72)ml]进行比较,差异均有统计学意义(P<0.05).结论 不同型号的SPECT的GFR正常值不同,不同型号的SPECT应建立本机肾动态显像GFR正常参考值.