湿润烧伤膏加云南白药对宫颈LEEP刀锥切术后创面修复疗效的观察

目的观察湿润烧伤膏联合云南白药对于宫颈LEEP刀锥切术后创面修复的疗效。方法将宫颈高级别内瘤样变（CINⅡ～Ⅲ）的患者随机分为两组,对照组155例LEEP刀术后宫颈创面不使用任何药物,观察组168例术后将湿润烧伤膏加云南白药混合后均匀涂抹于宫颈创面,观察4～8周。结果术后阴道排液量明显少于月经量患者观察组为150例（89.29%）,对照组为68例（43.87%）,差异有高度统计学意义（P〈0.01）。观察组创面停止流血时间平均为2.97周,对照组为5.80周,差异有高度统计学意义（P〈0.01）。且观察组宫颈创面渗血及完全上皮化时间明显缩短。结论湿润烧伤膏加云南白药对宫颈LEEP刀锥切术后创面修复有显著疗效。     

复方雌二醇乳剂联合宫颈LEEP刀治疗慢性宫颈炎的效果观察

目的：探讨复方雌二醇乳剂联合宫颈LEEP刀治疗慢性宫颈炎的效果分析。方法：选择2004年1月～2008年8月来本院门诊因慢性宫颈炎需行LEEP刀术的200例患者,将其随机分为观察组和对照组,其中观察组100例术后使用复方雌二醇乳剂宫颈创面上药,对照组100例行宫颈LEEP刀术后未使用任何药物,两组进行疗效分析。结果：观察组在宫颈LEEP刀术后阴道出血量,阴道出血持续时间,术后宫颈创面愈合时间均低于对照组,3个月后复查宫颈创面痊愈率明显高于对照组,差异有统计学意义（P〈0.05）。结论：复方雌二醇乳剂联合宫颈LEEP刀治疗慢性宫颈炎,可促进创面愈合,减少阴道出血,缩短出血时间,预防感染发生,值得推广使用。     

宫颈LEEP刀术配合云南白药术后创面的临床观察

目的观察宫颈LEEP刀术配合云南白药术后创面愈合疗效的临床观察。方法我院于2011~2012年共收治134例重度宫颈糜烂,随机分成A与B两组,A组为宫颈LEEP刀术术后配合云南白药(观察组),第一个月每5天换药一次,第二个月必要时换药。B组为宫颈LEEP刀术术后常规不用特殊药物治疗(对照组),除非宫颈创面有活动性出血时换药。两组患者均口服抗生素5d。结果 A组比B组宫颈术后创面出血的时间及排液时间明显缩短(P<0.05),治愈率均为100%。结论宫颈LEEP刀术术后配合云南白药治疗重度宫颈糜烂,可以缩短阴道排液及出血时间,提高手术治疗的效果,降低不良反应的发生,值得临床推广应用。     

云南白药粉配伍甲硝唑粉联合LEEP刀治疗宫颈病变的临床观察

目的观察LEEP刀治疗宫颈病变术后局部应用云南白药粉配伍甲硝唑粉的疗效观察。方法对我院2010年1月至2013年1月入院的400例宫颈病变患者行LEEP刀术后患者随机分为2组（实验组和对照组）,每组均为200例。实验组术后应用云南白药粉配伍甲硝唑粉局部喷撒,对照组只作常规处理。结果实验组术后创面出血少,阴道流血流液时间短,创面愈合快。结论云南白药加甲硝唑粉联合LEEP刀治疗宫颈病变能减少术后创面出血,阴道排液,感染,愈合不良的发生率,创面愈合快,缩短术后愈合时间,提高一次性治愈率,值得推广使用。     

壳聚糖宫颈抗菌膜在宫颈环形电切术后的应用研究

目的：观察壳聚糖宫颈抗菌膜在宫颈环形电切术（LEEP）治疗后,减少创面感染、促使创面愈合及预防术后出血的临床效果,寻求预防宫颈环切术后并发症的有效方法。方法选择进行LEEP术治疗的宫颈疾病患者200例,随机分成两组,LEEP术后采用壳聚糖宫颈抗菌膜创面上药者100例作为治疗组,LEEP术后自然修复100例作为对照组。对照组发生出血量多时用云南白药和甲硝唑药粉混合局部上药止血。结果观察组阴道出血量、流液量及流血持续时间少于对照组（P＜0.05）;观察组白带异常情况明显少于对照组（P＜0.05）;创面愈合总有效率两组差异无统计学意义,术后2个月和3个月观察痊愈率,观察组与对照组比较差异有统计学意义（P＜0.05）。结论壳聚糖宫颈抗菌膜具有局部抗菌、止血及促进术后创面愈合作用,使宫颈愈合时间缩短,减少创面感染、渗出、出血,以及LEEP术后并发症。     

宫颈CINⅡ～Ⅲ级LEEP刀术后应用α-2b凝胶与生物蛋白海绵的疗效对比

目的观察宫颈C1NⅡ～Ⅲ级LEEP刀后创面分别应用α-2b凝胶与生物蛋白海绵（创必复）的疗效。方法患者随机分为2组,每组40例。治疗组常规LEEP刀术后于创面贴上创必复,对照组常规LEEP刀术后于创面应用a-2b凝胶,分别于术后6、8、12周观察2组患者宫颈创面愈合时间及术后并发症情况。结果2组患者宫颈创面愈合时间、并发症发生情况比较差异无统计学意义（P〉0．05）。结论LEEP术后应用α-一2b凝胶与创必复,宫颈创面愈合时间,术后创面肉芽增生等并发症相比无显著性差异,但术后应用α-2b凝胶较繁琐,时间长,而创必复术后一次性应用,相对较简单,值得临床推广应用。     

LEEP刀术加宫颈黏膜诱导凝胶治疗慢性宫颈炎112例疗效的临床观察

目的观察LEEP刀术加宫颈黏膜诱导凝胶治疗慢性宫颈炎112例疗效的临床观察,以寻找预防LEEP刀术后并发症的有效方法。方法选择因宫颈病变需作LEEP刀的患者112例,随机分为两组,术后采用宫颈黏膜诱导凝胶局部用药者56例作为治疗组,术后自然修复的56例作为对照组。结果治疗组阴道出血、流液及持续时间少于对照组,创面愈合时间较对照组缩短。结论宫颈黏膜诱导凝胶具有明显促LEEP刀术后创面愈合的作用,使创面愈合时间缩短,减少创面感染、渗出、出血,具有止血作用,能有效减少LEEP刀术后并发症。     

云南白药联合肾上腺素局部应用对宫颈糜烂LEEP刀术后出血并发症的影响

目的：观察云南白药联合肾上腺素局部应用对宫颈糜烂LEEP刀术后出血并发症的影响。方法：将2011年1～12月期间就诊我院诊断为宫颈糜烂并行LEEP刀治疗的患者300例随机分为两组,治疗组在宫颈Leep刀术后创面上使用云南白药粉加肾上腺素。比较两组患者出血并发症情况。结果：治疗组阴道出血量及持续时间少于对照组（P〈0.05）,术后感染情况明显减少（P〈0.05）,治愈率显著升高（P〈0.05）。结论：云南白药联合肾上腺素局部应用于宫颈糜烂Leep刀术后创面,可有效减少阴道出血量及时间,减少术后感染情况,促进创面愈合。     

LEEP刀配合沙棘籽油栓治疗宫颈上皮内瘤样变临床观察

目的探讨高频电波刀电圈切除（LEEP）术配合复方沙棘籽油栓治疗宫颈上皮内瘤样变（CIN）的临床价值。方法 100例患者随机分为观察组52例和对照组48例,观察组采用LEEP术配合复方沙棘籽油栓治疗,对照组采用单纯LEEP术治疗。观察2组术后出血量、出血时间、术后排液时间、创面治愈时间、痊愈率（术后半年随访无CIN）、术后并发症发生率（宫颈管狭窄、宫颈外口粘连,术后半年随访）。结果观察组术后出血量、出血时间、排液时间、创面治愈时间显著少于对照组,差异有统计学意义（P〈0.05）。2组愈合率、术后并发症发生率比较差异无统计学意义（P〉0.05）。术后随访6个月,对照组有2例发现异常,再次行阴道镜、活检及第2次LEEP手术治疗,1例出现宫颈管狭窄,均无宫颈外口粘连等。结论 LEEP刀配合复方沙棘籽油栓治疗CIN可以防止创面感染,减少阴道出血量和阴道排液时间,缩短疗程,促进愈合,无不良反应,是LEEP治疗宫颈病变术后理想的辅助治疗药物。     

重度宫颈柱状上皮异位 LEEP 刀术后保妇康栓联合 bFGF 治疗促进创面愈合的疗效观察

目的：观察重度宫颈柱状上皮异位LEEP刀术后保妇康栓联合碱性成纤维细胞生长因子（ bFGF ）治疗创面愈合的临床效果。方法将226例重度宫颈柱状上皮异位LEEP刀术后患者随机分为观察组和对照组各113例。2组均行LEEP刀治疗。术后观察组给予保妇康栓联合bFGF治疗,对照组给予保妇康栓治疗。比较2组创面愈合情况和不良反应情况。结果观察组平均创面愈合时间短于对照组,第1、2、3个月的创面愈合情况优于对照组（P＜0．05）,平均排液时间短于对照组,阴道出血时间短于对照组（P均＜0．01）,阴道排液量和术后阴道出血量均少于对照组（P＜0．05）,不良反应发生率低于对照组（P＜0．05）。结论保妇康栓联合bFGF可有效促进宫颈柱状上皮异位LEEP刀术后患者的临床疗效,值得临床推广应用。     

Studies on wound healing

Factors affecting the rate of healing of experimental skin wounds in rats have been investigated. The effectiveness of healing was measured by determining the tensile strengths of the incised skin after various time intervals. When the skin histamine content was lowered by treatment with polymyxin B or with compound 48/80, retardation of the healing process was evident from the reduced tensile strengths. When the skin 5-hydroxytryptamine content was lowered by treatment with reserpine, retardation of healing was also found. Heparin increased the rate of healing and more rapid healing was obtained by giving histamine before each dose of heparin. On the other hand, some glucocorticoids markedly inhibited the healing process. Of the constituents of the tissue mast cells, heparin appears to be more important than histamine and 5-hydroxytryptamine in promoting the healing of experimental skin wounds in rats.     

聚氨酯创面敷料的研究进展

<正>近几十年来随着创面"湿润愈合"理论的提出和生物材料的发展,新型敷料特别是新型聚氨酯敷料不断出现[1]。传统创面敷料(如纱布、棉花)等有许多缺点:易滋生细菌,创面渗出液易与干燥真皮组织一起形成痂皮,妨碍上皮化;同时创     

鱼油伤口护理软膏的制备及其对皮肤切线伤的促愈合作用

鱼油中的多不饱和脂肪酸具有促进皮肤损伤修复的功能。以富含多不饱和脂肪酸的鱼油为原料，复配黄凡士林、液体石蜡，制备油性伤口护理软膏敷料。测试了该软膏敷料的细胞相容性、阻水性、阻菌性及其对Sprague Dawley（SD）大鼠切线伤的促愈合作用。结果表明，软膏浸提液培养的L929细胞相对存活率为（99.5 ± 2.2）%，具有优异的细胞相容性；软膏具有优异的阻水性和阻菌性；在切线伤护理中，所制备膏状敷料能够促进创面胶原的沉积与重排，减轻瘢痕的生成。鱼油伤口护理软膏在浅表性皮肤创面护理方面有着良好的应用前景。     

Effect of aged garlic extract on wound healing: A new frontier in wound management

Successful wound healing depends upon angiogenesis, and impaired angiogenesis is a hallmark of the chronic wounds encountered with diabetes and venous or arterial insufficiency. To intervene and improve wound closure, it is essential to investigate the effects of different natural remedies in wound healing. The chicken dorsum skin excisional wound assay was used to investigate the influence of different concentrations of aged garlic solution (AGS) on wound healing. Gross, histopathology, scanning electron microscopy (SEM) and computer-based three-dimensional (3D) image-probing techniques were utilized to determine the effects of AGS on wound closure, re-epithelialization, dermal matrix regeneration, and angiogenesis. Ninety chicks, aged 1 week and divided in 6 groups, were topically exposed to different concentrations of AGS for 6 days: control (group A), 1% (group B), 5% (group C), 10% (group D), 15% (group E), and skin lotion (group F). Different patterns, ranging from incomplete to almost complete wound closure, were observed among different groups with highly significant results (P?<?0.001) in group E. Histological investigations revealed a positive augment in the re-epithelialization of all AGS exposed wounds. An increase in the number of new loosely packed collagen and maturation of collagen bundles was observed in all treated wounds at days 4 and 6 post-wounding, respectively. Similar results were achieved through SEM of treated wounds. Histological investigations revealed the profuse dose-dependent neovascularization among AGS-treated wounds. Abbott curve, angular spectrum, and different parameters of 3D surface roughness of wounds were also measured for the precise quantification of angiogenesis. A very highly significant (P?<?0.001) increase in angiogenesis was observed among all treated groups. No significant change was observed among control and skin lotion–treated groups. These observations substantiate the beneficial use of AGS in the treatment of wounds. Additional studies are needed to study the specific wound-healing mechanisms of chemical, or group of chemicals, present in AGS.     

Effect of histamine on wound healing.

Using incision, excision and dead space wound models in rats, a study was conducted on the effect of histamine on wound healing. Exogenous histamine given either ip or locally was without any effect. Semicarbazide as (histamine synthesis inhibitor) suppressed healing process (breaking strength of skin incision wound), decreased breaking strength and hydroxyproline content of granulation tissue and delay in period of epithelization. On the other hand compound 48/80 (a promoter of histamine forming capacity) was found to promote wound healing. Exogenous histamine (topical) reversed the anti-healing effect of semicarbazide on incision and excision wounds.     

Role of phenytoin in wound healing--a wound pharmacology perspective

Topical agents used for the enhancement of wound healing are designed to act locally and, therefore, do not undergo classic systemic metabolic modification. This commentary reviews the potential role of a vulnerary agent, phenytoin, (PHT), from a wound pharmacology perspective. This agent may have the potential to alter the dynamics of wound healing, suggesting a therapeutic use for the stimulation of chronic wounds. Oral PHT therapy is used widely for the treatment of convulsive disorders, and about half the patients treated develop gingival overgrowth as a side-effect. This apparent stimulatory effect has prompted its assessment in wound healing. Investigations into the mechanisms of gingival overgrowth also provide clues to its action in wound healing, and important similarities and differences are discussed. It appears also that both gingiva and skin are important extrahepatic sites for xenobiotic metabolism, and analysis of the biochemical mechanisms should lead to the design of safer analogues for wound healing. On the other hand, differences between the pharmacokinetics of topical PHT in these tissue situations indicate that different formulations are required for gingival and cutaneous wound healing and during the changing course of wound healing itself.