血浆CysC、Hcy、D-D及hs-CRP检测在急性脑梗死早期诊治中的临床应用

目的探析血浆胱抑素C(CysC)、同型半胱氨酸(Hcy)、超敏C反应蛋白(hs-CRP)、D-二聚体(D-D)检测在急性脑梗死早期诊治中的临床价值。方法选择70例急性脑梗死患者作为观察组,根据急性脑梗死面积不同分为大梗死组(20例)、中梗死组(22例)、小梗死组(28例);同时选择70例健康体检者作为对照组。应用自动化分析仪对两组血浆CysC、Hcy、D-D及hs-CRP进行检测。比较观察组和对照组入院24 h内CysC、Hcy、D-D及hs-CRP水平;比较大梗死组、中梗死组、小梗死组患者入院24 h内、治疗1周后CysC、Hcy、D-D及hs-CRP水平。结果入院24 h内,观察组血浆CysC(1.25±0.44)mg/L、Hcy(22.20±5.71)μmol/L、D-D(2.39±0.54)mg/L、hs-CRP(19.34±2.45)mg/L均高于对照组的(0.81±0.15)mg/L、(10.42±3.85)μmol/L、(0.82±0.38)mg/L、(2.20±1.53)mg/L,差异具有统计学意义(P<0.05)。入院24 h内,大梗死组患者血浆CysC、Hcy、D-D及hs-CRP水平高于中梗死组、小梗死组,中梗死组高于小梗死组,差异具有统计学意义(P<0.05)。治疗1周后,三组患者血浆CysC、Hcy、D-D及hs-CRP水平均低于本组入院24 h内,差异具有统计学意义(P<0.05)。结论在急性脑梗死早期诊治中,通过检测血浆CysC、Hcy、D-D及hs-CRP水平可以对病情进行早期诊断,为临床医生制定治疗方案提供依据,有助于提高患者治疗效果及安全性。     

急性脑梗死患者血浆ADMA与同型半胱氨酸水平相关性研究

目的探讨急性脑梗死患者血浆不对称性二甲基精氨酸(ADMA)与同型半胱氨酸(Hcy)水平的相关性及其与急性脑梗死的关系。方法分别采用高效液相色谱法检测64例急性脑梗死患者血浆ADMA含量,以荧光偏正免疫分析法测定血浆Hcy水平。结果急性脑梗死组血浆ADMA水平(4.32±0.27μmol/L)明显高于对照组(1.02±0.10μmol/L)(P相似文献   

急性脑梗死患者hs-CRP、Hcy、FIB表达与颈动脉狭窄相关性分析

目的 分析急性脑梗死(ACI)患者血清高敏C反应蛋白(hs-CRP)、同型半胱氨酸(Hcy)、纤维蛋白原(FIB)与颈动脉狭窄的相关性。方法 选取我院收治的符合条件的急性脑梗死患者80例,收集患者疾病相关临床资料,所有患者均行计算机体层血管成像技术(CTA)检测明确颈动脉狭窄程度,所有患者就诊时均采集静脉血检测血清hs-CRP、Hcy、FIB水平。对上述数据进行分析。结果 80例ACI患者颈动脉狭窄程度中轻度狭窄29例,中度狭窄38例,重度狭窄13例。hs-CRP、Hcy、FIB水平分别为：(18.19±2.25)mg/L、(20.37±2.41)μmol/L、(3.12±0.46)g/L;不同TC、TG、HDL-C、LDL-C、PT、TT、梗死灶面积、NIHSS评分患者颈动脉狭窄分级构成及hs-CRP、Hcy、FIB水平差异均有统计学意义(P<0.05);相关性分析显示,ACI患者颈动脉狭窄程度与hs-CRP、Hcy、FIB呈正相关(r=0.516、0.489、0.527,P﹤0.01)。结论 ACI患者血清hs-CRP、Hcy、FIB与颈动脉狭窄程度呈现较高的相关性,患者就诊...     

帕金森病患者血浆同型半胱氨酸水平与其临床特征的关系

目的探讨帕金森病(PD)患者血浆同型半胱氨酸(Hcy)水平与临床特征的关系。方法检测PD患者(PD组,52例)和健康体检者(对照组,62例)血浆Hcy浓度,分析PD患者血浆Hcy水平与性别、年龄的关系。结果 PD组血浆Hcy高于对照组[(16.24±6.70)μmol/L vs.(13.83±5.40)μmol/L](P<0.05)。PD组男性Hcy水平高于女性[(18.34±6.63)μmol/L vs.(14.44±6.32)μmol/L](P<0.05)。结论血浆Hcy升高可能是帕金森病的危险因素之一,其水平与PD患者性别、年龄有关。     

血清同型半胱氨酸及高敏C反应蛋白与冠心病相关性分析

目的：探讨血清同型半胱氨酸（ Hcy ）、高敏 C 反应蛋白（ hs-CRP ）与冠心病的相关性。方法测定111例冠心病患者组（冠心病组）及77例健康志愿者（健康对照组） Hcy、hs-CRP水平,分析其与冠心病的关系。应用循环酶法检测Hcy,应用免疫比浊法检测hs-CRP。冠心病组患者根据病情不同分为稳定型心绞痛（ SAP）组、不稳定型心绞痛（ UAP）组、急性心肌梗死（ AMI）组,分析各亚组Hcy、hs-CRP水平差异性。结果冠心病组患者血清Hcy、hs-CRP水平明显高于健康对照组[（21±9）μmol/L比（9±6）μmol/L,（15．1±1．4）mg/L比（1．0±0．9）mg/L]（P＜0．05）。冠心病各亚组比较：AMI组患者血清Hcy、hs-CRP水平明显高于SAP组及UAP组[（24±8）μmol/L比（16±5）、（19±6）μmol/L,（23．7±5．9）mg/L比（4．0±3．0）、（15．4±3．2）mg/L]（P＜0．05）。 UAP组患者血清Hcy水平、血清hs-CRP水平明显高于SAP组[（19±6）μmol/L 比（16±5）μmol/L,（15．4±3．2） mg/L 比（4．0±3．0） mg/L]（P ＜0．05）。结论血清Hcy及hs-CRP水平与冠心病病情相一致,检测血清Hcy及hs-CRP水平可以判断冠心病病情,对于指导治疗有积极的意义。     

急性脑梗死与血清同型半胱氨酸、C反应蛋白、白介素-6的关系探讨

目的 探讨急性脑梗死与血中同型半胱氨酸（Hcy）、C反应蛋白（CRP）、白介素-6（IL-6）的关系.方法 急性脑梗死患者90例,于入院次日清晨抽血检测Hcy、CRP、IL-6的含量.同时选择性别和年龄相似的健康体检者50例作为对照组.比较不同梗死面积的急性脑梗死患者各30例血液中Hcy、CRP、IL-6水平（大梗死灶、小梗死灶和腔隙性梗死分别为〉3 cm、1.5～3.0 cm、〈1.5 cm）.结果 （1）急性脑梗死组Hcy、CRP、IL-6水平与对照组差异有统计学意义（P〈0.01）.（2）不同梗死面积的急性脑梗死患者组间Hcy、CRP、IL-6水平呈现大梗死灶〉小梗死灶〉腔隙性梗死的趋势（P〈0.05）.结论 急性脑梗死的发生发展与血液中Hcy、CRP、IL-6水平关系密切,Hcy、CRP、IL-6水平越高提示梗死面积越大,病情严重.     

急性脑梗死患者血清脂联素和同型半胱氨酸与高敏C反应蛋白的临床研究

目的 探讨急性脑梗死(ACI)患者血清脂联素、同型半胱氨酸(Hcy)和高敏C反应蛋白(hs-CRP)水平的变化及临床意义.方法 选择ACI患者100例,按脑梗死体积及神经功能缺损程度分别分为3个亚组,选择同期健康体检者35例作为正常对照组.用酶联免疫吸附法检测血清脂联素和Hcy水平,应用免疫比浊法测定血清hs-CRP水平,并对结果进行比较.结果 ACI组血清脂联素水平(6.4±1.5)mg/L明显低于正常对照组的(12.5±2.3)mg/L,差异有统计学意义(P＜0.05);小梗死组(28例)、中梗死组(42例)、大梗死组(30例)患者血清脂联素水平[(8.8±1.9)、(5.6±1.3)、(2.7±0.8)mg/L]逐渐降低,轻型组(27例)、中型组(42例)、重型组(31例)患者[(8.5±1.7)、(5.4±1.1)、(2.5±0.7)mg/L]亦逐渐降低,差异均有统计学意义(均P＜0.05).ACI组血清Hcy和hs-CRP水平明显高于正常对照组,差异均有统计学意义(均P＜0.05);小梗死组、中梗死组、大梗死组患者血清Hcy和hs-CRP水平逐渐升高,轻型组、中型组、重型组患者亦逐渐升高,差异均有统计学意义(均P＜0.05).结论 血清脂联素、Hcy及hs-CRP参与了ACI的发病;并且它们的水平与脑梗死体积及神经功能缺损程度密切相关,检测这3个指标有助于对ACI患者病情及预后做出正确的判断.

Abstract：

Objective To investigate the clinical significance of serum levels of adiponectin (APN),homocysteine(Hcy) and high-sensitive C-reaction protein (hs-CRP) in patients with acute cerebral infarction(ACI).Methods One hundred patients with ACI were selected and divided into different groups according to the size of infarction and clinical neurologic impairment degree score. 35 healthy people were used as control group. APN and Hcy concentrations were detected by enzyme-linked immunosorbent assay (ELISA). The serum hs-CRP level was detected by immunoturbidimetry. Results The serum APN levels in the patients with ACI were significantly lower than those in the healthy subjects(P＜0.05). The serum levels of APN decreased steply with the volume of infarction;the serum levels of APN decreased steply with the clinical neurologic impairment degree score,the differences of APN levels between the groups were significant (all P＜0.05). The serum Hcy and hs-CRP levels in the patients with ACI were significantly higher than those in the healthy subjects(12.5 ± 2.3)mg/L(P＜0.05). The serum levels of Hcy and hs-CRP increased steply with the volume of infarction [(8.8 ± 1.9) mg/L,(5.6 ± 1.3) mg/L,(2.7 ±0.8)mg/L];the serum levels of Hcy and hs-CRP increased steply with the clinical neurologic impairment degree score [(8.5±1.7)mg/L,(5.4±1.1)mg/L,(2.5±0.7)mg/L],the differences of levels of Hcy and hsCRP between two groups were significant (all P＜0.05). Conclusions The APN,Hcy and hs-CRP may play an important role in the pathogenesis of ACI. The serum level of APN,Hcy and hs-CRP is closely correlated with the volume of infarction and the clinical neurologic impairment degree score,which may be of great value in predicting acute cerebral infarction and the severity of cerebral infarction.     

急性脑梗死患者血清同型半胱氨酸与高敏C反应蛋白及肿瘤坏死因子α水平检测的临床意义

目的 探讨急性脑梗死(ACI)患者血清同型半胱氨酸(Hcy)、高敏C反应蛋白(hs-CRP)和肿瘤坏死因子α(TNF-α)水平的变化及临床意义.方法 选择ACI患者100例,按梗死体积及神经功能缺损程度分组,用ELISA法检测血清Hcy和TNF-α水平,应用免疫比浊法测定血清hs-CRP水平,并与同期在我院进行体格检查的30名正常人(对照组)比较.结果 ACI组Hcy、hs-CRP及TNF-α水平明显高于对照组[ACI组Hcy、hs-CRP及TNF-α分别为(35.4±10.9)mg/L、(42.4±11.6)mmol/L、(7.1±2.3)ng/L,对照组分别为(2.1±0.5)mg/L、(7.6±1.5)mol/L、(7.1±2.3)ng/L].随梗死灶体增大及病情加重,Hcy、hs-CRP及TNF-α水平逐渐升高.结论 Hcy、hs-CRP及TNF-α参与了ACI的发病机制;血清Hcy、hs-CRP及TNF-α水平与脑梗死体积及临床神经功能缺损程度密切相关,检测Hcy、hs-CRP及TNF-α有助于ACI患者病情及预后的判断.

Abstract：

Objective To investigate the clinical significance of the serum levels of homocysteine (Hcy),high sensitive C-reaction protein (hs-CRP) and tumor necrosis factor (TNF)-αt in patients with acute cerebral infarction(ACI). Methods One hundred patients with ACI were enrolled. They were divided into different groups according to the size of infarction and clinical neurologic impairment degree score. Hcy and TNF-αt concentrations were detected by enzyme-linked immunosorbent assay (ELISA),The serum hs-CRP level was detected by immunoturbidimctry. Results The serum Hcy,hs-CRP and TNF-α levels in ACI Patients with ACI were significantly higher than those in the healthy subjects (P＜0.05). The serum levels of Hcy,hs-CRP and TNF-α increased with the volume of infarction and the differences between the groups were significant (all P＜0.05). The serum levels of Hcy,hs-CRP and TNF-αincreased with the clinical neurologic impairment degree score and the differences between the groups were significant (P＜0.05). Conclusions The serum levels of Hcy,hs-CRP and TNF-αare significantly elevated in the patients with ACI. The serum level of Hcy,hs-CRP and TNF-αare increased closely with the volume of infarction and the clinical neurologic impairment degree score,which suggests that Hcy,hs-CRP and TNF-α may play an important role in the Pathogenesis of ACI,and probalbly be a prognostic factor of ACI.     

血浆同型半胱氨酸和超敏C-反应蛋白水平与复发性脑梗死相关性的研究

目的:探讨血浆同型半胱氨酸水平(Hcy)和超敏C反应蛋白(Hs-CRP)水平与复发性脑梗死的关系。方法:选择120例急性脑梗死患者,其中复发性脑梗死58例(复发组),初发性脑梗死62例(初发组);采用免疫荧光法测定两组患者血浆同型半胱氨酸的水平。血清超敏C反应蛋白含量测定采用免疫透射比浊法。分析两者与复发性脑梗死的相关性。结果:复发组血浆同型半胱氨酸水平(25.6±5.7)μmol/L显著高于初发组(15.9±4.8)μmol/L;复发性脑梗死组超敏C反应蛋白(10.2±2.3)mg/L与初发组的(6.3±1.8)mg/L比较差异有统计学意义。两组间患者年龄、性别、吸烟、饮酒、身体质量指数、血脂水平及高血压病、糖尿病、心脏病的患病率比较差异无统计学意义(P>0.05)。结论:血浆Hcy和Hs-CRP水平与复发性脑梗死显著相关,检测和及时干预二者水平对防治脑梗死复发有重要意义。     

脑心通治疗对糖尿病并腔隙性脑梗死患者血清同型半胱氨酸水平的影响

目的了解脑。tD通治疗对糖尿病合并腔隙性脑梗死患者血清同型半胱氨酸（Hcy）水平的影响。方法收集2009年6月至2011年12月来我院门诊就诊的糖尿病合并腔隙性脑梗死患者51例,选取同期来我院行健康体检的42例健康人作为对照（对照组）。观察组给予脑心通治疗（1．6g／次,3次／d）2个月,治疗前后测定空腹血糖和血清Hcy水平。结果糖尿病合并腔隙性脑梗死患者治疗前血清Hcy水平为（25±8）μmol／L,高Hey血症的发生率为70．6％（36／51）,明显高于对照组[分别为（6±3）μmol／L和26．2％（11／42）]。经脑心通治疗2个月后,血清Hey水平明显下降[（16±7）μmo]／L,P〈0．01]。脑梗死治疗总有效率为88．2％（45／51）。结论糖尿病合并腔隙性脑梗死患者血清Hcy水平明显升高,脑心通在降低血清Hey水平同时对脑梗死恢复有益。