布地奈德联合沙丁胺醇治疗小儿支气管哮喘疗效分析

Objective To investigate the effect of Budesonide combined with Salbutamol in treatment of chil-dren with bronchial asthma.Methods 100 cases of children with asthma were randomly divided into conventional therapy group(Group A)50 cases and combined treatment group(Group B)50 cases;Conventional therapy was given to group B and Group A Was givend the conventional therapy puls Budesonide combined with salbutamol treatment,2 times a day.The course of treatment was 10d;The effect of clinical symptom score、clinical recovery and adverse reac-tions in two groups were observed.Results The total efficiency of 47 cases(94.O%) in group A were significantly higher than the B group 36 cases(72.0%)(P<0.05);The index of breathing diffculties、coushing、wheezing、wheezing sustain and sleep satisfaction after treatment were significantly decreased compared with before treatment in two groups(all P<0.01);The time of recovery of breath shortness、cough、asthma、wheezing and therapy hys in group A were less than group B(all P<0.05).Condusion Atomizing inhalation treatment of Bedesonide combined with Sallbutamol was effective to treat children with bronchial asthma.     

布地奈德联合沙丁胺醇治疗小儿支气管哮喘疗效分析

Objective To investigate the effect of Budesonide combined with Salbutamol in treatment of chil-dren with bronchial asthma.Methods 100 cases of children with asthma were randomly divided into conventional therapy group(Group A)50 cases and combined treatment group(Group B)50 cases;Conventional therapy was given to group B and Group A Was givend the conventional therapy puls Budesonide combined with salbutamol treatment,2 times a day.The course of treatment was 10d;The effect of clinical symptom score、clinical recovery and adverse reac-tions in two groups were observed.Results The total efficiency of 47 cases(94.O%) in group A were significantly higher than the B group 36 cases(72.0%)(P<0.05);The index of breathing diffculties、coushing、wheezing、wheezing sustain and sleep satisfaction after treatment were significantly decreased compared with before treatment in two groups(all P<0.01);The time of recovery of breath shortness、cough、asthma、wheezing and therapy hys in group A were less than group B(all P<0.05).Condusion Atomizing inhalation treatment of Bedesonide combined with Sallbutamol was effective to treat children with bronchial asthma.     

依达拉奉和银杏叶提取物注射液联合高压氧治疗急性一氧化碳中毒后迟发性脑病疗效观察

目的 探讨依达拉奉、银杏叶提取物注射液联合高压氧治疗一氧化碳中毒后迟发性脑病(DEACMP)的临床疗效.方法 将2007年1月至2010年6月我院64例DEACMP患者完全随机分为治疗组及对照组,各32例.对照组给予高压氧等常规治疗,治疗30 d.治疗组在高压氧等常规治疗基础上加用依达拉奉30 mg/次,2次/d静脉滴注,连用14 d;银杏叶提取物注射液70 mg,加入0.9%氯化钠注射液250 ml静脉滴注,1次/d,连用30 d.治疗前后均用长谷川智能量表(HDS)检测智能评分,并统计2组治疗总有效率.结果 治疗组有效28例,总有效率为87.5%;对照组有效20例,总有效率为62.5%,2组疗效比较差异有统计学意义(x2=5.33,P＜0.05),治疗组治疗后HDS评分明显高于对照组[治疗后15 d:(13.6±2.3)分比(9.4±2.1)分,P＜0.05;治疗后30 d:(19.3±2.1)分比(12.8±2.7)分,P＜0.01].结论 依达拉奉、银杏叶提取物注射液联合高压氧治疗DEACMP疗效好,值得临床推广.

Abstract：

Objective To research the clinical curative effect of edaravone and extract of gingo biloba leaves injection combined hyperbaric oxygen for treatment of delayed encephalopathy after carbon monoxide poisoning (DEACMP). Methods Sixty-four patients with DEACMP were randomly divided into treatment group of 32 cases and control group of 32 cases. The basic treatments of two groups were identical. Based on the basic treatments, treatment group was treated with edaravone 30 mg/d, intravenously drip for 14 days, plug extract of gingo biloba leaves injection 70 mg/d, intravenously drip for 30 days. The changes of HDS were measured and the total effective rate were counted in two groups before and after treatment. Results The total effective rate in treatment group was 87.5% , and while control group was 62. 5%. The total effective rate had a significant difference in two groups (P＜0.05). The improvement of HDS in the treatment group was more significant than that in control group (P＜ 0. 05). Conclusion Edaravone and extract of gingo biloba leaves injection combined hyperbaric oxygen has favorable cognitive effect on DEACMP.     

参芎注射液联合七叶皂苷钠治疗急性胰腺炎的临床观察

目的 了解参芎注射液及七叶皂苷钠对急性胰腺炎(AP)患者血浆内皮素浓度的影响及其改善微循环的作用.方法 将87例AP患者完全随机分为对照组20例、单用组33例、联合组34例.3组均采用常规治疗,单用组加用参芎注射液治疗,联合组加用参芎注射液和七叶皂苷钠治疗,观察各组腹痛、腹部压痛、血尿淀粉酶及内皮素等变化情况.结果 单用组和联合组腹部压痛消失、肠道功能恢复、血尿淀粉酶和影像学恢复时间及平均治疗时间均短于对照组(P＜0.05);联合组肠道功能恢复、血尿淀粉酶和影像学恢复时间及平均治疗时间均短于单用组(P＜0.05).单用组和联合组患者治疗后血浆内皮素浓度[(64.79±7.58)ng/L、(47.80±7.14)ng/L]明显低于治疗前[(104.77±6.57)ng/L、(103.41±7.53)ng/L](P＜0.05).结论 在常规治疗的基础上联合应用参芎注射液、七叶皂苷钠治疗AP具有良好的临床疗效,值得临床推广.

Abstract：

Objective To study clinical effects of Shenxiong injection and aescinate in the treatment of acute pancreatitis,and to understand the effect of Shenxiong injection and aescinate on the concentration of plasma endothelin(ET) in patients with acute pancreatitis(AP). Methods Eighty-seven cases of AP patients were randomly divided into group A(20 cases) and the control group B(33) and group C(34). A group had conventional therapy,B group had the conventional treatment plus Shenxiong injection and C group had conventional treatment plus Shenxiong injection and aescinate. The plasma concentrations of ET were mensurated with radiation immunoassay(RIA). Results The pain disappearance time had no significant difference(P ＞0.05) among the three groups.The time of abdominal tenderness disappearance,intestinal function recovery,hematuria amylase recovery,imaging recovery and average hospitalization were shorter in B group and in C group than those in control group(A group)(P ＜0.05). The plasma ET concentrations after treatment were significantly lower than that before treatment in group B and C(P＜0.05). Conclusions The therapy based on the conventional treatment combined with Shenxiong injection and aescinate has good curative effect in patients with acute pancreatitis.     

纤溶酶联合血塞通注射液治疗急性脑梗死临床研究

Objective To explore the total curative effects of Xuesaitong injection combined whth fibrinogenase on acute cerebral infarction(ACI). Methods One hundred and twelve patients with ACI were randomly and equally divided into two groups, 56 cases in the treatment group were treated with Xuesaitong injection combined Fibrinogenase, while 56 cases in the control group were treated with compound danshen injection, once a day for 15days. Results Coagulation indicators of the treatment group was obviously better than that of the control group(P ＜0.05 or P ＜ 0.01 ). The total effective rate (91.1% ) of the treatment group was obviously higher than that of the control group( 69.6% )( P＜ 0.05 ). The Neurological deficit scores of therapy group were significantly improved (P ＜ 0.05). There was no obvious adverse reaction. Conclusion Xuesaitong injection combined fibrinogenase are remarkablyeffective and safe in treating ACI.     

纤溶酶联合血塞通注射液治疗急性脑梗死临床研究

Objective To explore the total curative effects of Xuesaitong injection combined whth fibrinogenase on acute cerebral infarction(ACI). Methods One hundred and twelve patients with ACI were randomly and equally divided into two groups, 56 cases in the treatment group were treated with Xuesaitong injection combined Fibrinogenase, while 56 cases in the control group were treated with compound danshen injection, once a day for 15days. Results Coagulation indicators of the treatment group was obviously better than that of the control group(P ＜0.05 or P ＜ 0.01 ). The total effective rate (91.1% ) of the treatment group was obviously higher than that of the control group( 69.6% )( P＜ 0.05 ). The Neurological deficit scores of therapy group were significantly improved (P ＜ 0.05). There was no obvious adverse reaction. Conclusion Xuesaitong injection combined fibrinogenase are remarkablyeffective and safe in treating ACI.     

中西医结合治疗腰椎间盘突出症的临床研究

Objective To investigate the curative effect of western combined with traditional Chinese medicine in treatment of acute lumbar disc herniation.Methods 200 patients with lumbar disc herniation were randomly divided into western combined with traditional Chinese therapy group(group A) and western medicine group(group B) ,each group 100 cases.B group was conducted with the general anti - inflammatory, dehydration, nerve pain and nutritional therapy,and A group was given the traditional Chinese medicine treatment on the base of B group.After 3 weeks treatment, the curative effect, VAS score and hospital stay were observed.Results A total effective rate 90.0% in group A was higher than B group 73.0% ( x2 = 3.987 ,P < 0.05); The scores of VAS after treatment 4 weeks[(1.1 ±1.23、0.9 ±0.6)/point]were lower than before treatment[(8.6 ± 1.43,8.8 ± 1.382)/point]in two groups(t =2.301,2.335,all P<0.05) ;The scores of VAS after treatment 3d and 1 week in group A[(5.5 ±0.92) point,(2.7±1.14) point] were lower than group B[(8.2 ±0.59) point,(5.3 ±0.91) point] (t =2.405,2.435,all P<0.05);The hospital days(20.1 ±3.5)d in group A was significantly lower than group B(27.6 ±4.3)d( t = 2.314,P <0.05).Conclusion Western combined with traditional Chinese medicine had better clinical efficacy in teatrent of patients with acute lumbar disc hemiation.     

氨溴特罗口服液佐治小儿肺炎支原体肺炎疗效分析

目的 观察氨溴特罗口服液协助治疗小儿肺炎支原体肺炎的临床疗效,探讨肺炎支原体肺炎发病机制.方法 将96例肺炎支原体肺炎住院患儿完全随机分为治疗组48例、对照组48例,2组患儿均采用阿奇霉素治疗,治疗组在此基础上联合氨溴特罗口服液,连续治疗7 d.观察2组临床总有效率和不良反应率并记录病情好转时间.结果 治疗组总有效率93.8%(45/48)明显好于对照组的85.4%(41/45)(x2=11.68,P＜0.05),住院期间治疗组患儿肺部哮鸣音消失时间、止咳时间、肺部啰音消失时间及住院时间均比对照组明显缩短[分别为(2.3±1.1)d比(4.2±1.6)d,(3.4±1.1)d比(6.0±2.3)d,(3.3±1.2)d比(4.9±2.1)d,(5.8±1.0)d比(7.8±2.4)d].2组不良反应率较小,差异无统计学意义(P＞0.05).结论 氨溴特罗口服液联合阿奇霉素治疗小儿支原体肺炎疗效确切,安全,有助于缩短疗程.

Abstract：

Objective To study the effect of ambroxol hydrochloride and clenbuterol hydrochloride oral solution in treating mycoplasma pneumonia pneumonia, and to explore the possible immunopathogenesis. Methods Ninety-six hospitalized children with mycoplasma pneumonia were randomly divided in two groups. The treatment group (n=48) received ambroxol hydrochloride and clenbuterol hydrochloride oral solution in addition to conventional therapy and the control group (n=48) received routine therapy. Results The curative effect of the treatment group was superior to that of the control group[93.8% vs 85.4%, P＜0.05]. The disappearance time of the lungs wheeze, cough time, pulmonary rales disappeared time and length of stay of children in the treatment group were significantly shorter than that in the control group [(2.3 ±1. 1)d vs(4.2 ± 1. 6)d, (3.4 ± 1. 1)d vs(6. 0 ±2. 3)d, (3.3±1.2)d vs(4.9 ±2.1)d, (5.8±1.0)d vs(7.8±2.4)d]. Conclusion Oral administration of ambroxol hydrochloride and clenbuterol hydrochloride oral solution combined azithromycin is effective, secure and convenient for treatment of patients with mycoplasma pneumonia.     

腹腔镜下手术治疗老年胆石症临床分析

Objective To explore the clinical effect of laparoscopy in treatment of elderly patients with cholelithiasis. Method The clinical data of 120 elderly patients with cholelithiasis were retrospectively analyzed,which were divided into observation group and control group. Result The operation time, hemorrhage amount of operations,length of stay and recurrence rate after operation of the observation group were lower than that of the control group, and the stone clearance rate in the observation group had significantly higher than that of the control group ,the difference was statistical significance( all P ＜ 0. 05). Conclusion The clinical curative effect of laparoscopy in treatment of elderly patients with cholelithiasis was good.     

免疫抑制治疗期间乙型肝炎病毒再激活的诊断及治疗

Objective To explore clinical curative effect of lamivudine in treatment of HBV reactivation.Methods The clinical data of HBV reactivation patients in immunosuppressive therapy were retrospectively analyzed. Results The clinical symptom and liver function recovery rate, HBV-DNA darkening rate, HBeAg darkening rate and HBe-Ag/anti HBe frequence of seroconversion of detection group were higher than that of control group,the difference was statistically significant( all P ＜ 0. 05 ). Conclusion The clinical curative effect of HBV reactivation in immunosuppressive therapy by Lamivudine was good.     

孟鲁司特治疗儿童变应性鼻炎合并支气管哮喘的临床研究

目的:研究孟鲁司特治疗儿童变应性鼻炎合并支气管哮喘的疗效。方法:120例变应性鼻炎合并支气管哮喘患儿随机分为治疗组与干预组,分别采用糖皮质激素及加用孟鲁司特治疗,总疗程3个月。观察2组临床症状及肺功能改善情况。结果:干预组在改善变应性鼻炎症状方面较治疗组有效,在哮喘症状和肺功能改善上较治疗组显著(P<0.05)。结论:孟鲁司特能有效缓解变应性鼻炎症状,在治疗哮喘方面与吸入性糖皮质激素药物联用优于单纯使用吸入激素。     

孟鲁司特联合吸入糖皮质激素治疗小儿中度持续哮喘的疗效及机制

目的 观察孟鲁司特联合吸入糖皮质激素治疗小儿中度持续哮喘的临床疗效及探讨孟鲁司特的抗炎机制。方法 采用随机分组的方法，将60例2～5岁的中度持续哮喘患儿分为两组：孟鲁司特4mg／d口服联合吸入布地奈德200ug／d为A组（n=30）、单纯吸入布地奈德200ug／d为B组（n=30）进行3个月的治疗，于治疗开始、治疗第4周和第3个月进行临床评估，同时检测血清半胱氨酰白三烯（CysLTs）和IL-5水平。结果 治疗前，中度持续哮喘患儿血清CysLTs、IL-5水平均明显高于正常组（P〈0．01）；治疗3个月后，A组的患儿哮喘的症状评分、每次发作持续的天数、发作次数和全身使用糖皮质激素的总量均明显低于B组（P〈0．01），同时A组患儿血清CysLTs、IL-5水平较B组显著下降（P〈0．05，P〈0．01），而B组患儿治疗前后血清CysLTs水平差异无统计学意义（P〉0．05）。结论 孟鲁司特联合吸入糖皮质激素可佩著提高中度持续哮喘患儿的疗效，同时减少全身使用糖皮质激素的总量。孟鲁司特能降低中度持续哮喘患儿血清CysLTs、IL-5水平，抑制炎症介质释放，抑制效应可能是孟鲁司特抗哮喘呼吸道炎症的重要机制。     

孟鲁司特钠对哮喘儿童肺功能的影响

目的 探讨孟鲁司特钠对学龄前哮喘患儿肺功能的影响.方法 对86例首次符合哮喘诊断标准的学龄前患儿给予孟鲁司特钠治疗4周(1次/d,4mg/次,睡前服).分别在治疗前、开始治疗后1周、治疗结束后进行随访,测定肺功能,并与健康对照组比较.结果 哮喘患儿治疗前肺功能明显低于对照组(P＜0.01).孟鲁司特钠治疗1周后,哮喘患儿肺功能与治疗前相比差异无显著性,治疗4周后,肺功能明显改善.结论 孟鲁司特钠用于学龄前儿童哮喘的治疗,对缓解症状和改善肺功能均能收到良好效果.     

布地奈德和孟鲁司特治疗儿童轻度持续性哮喘的随机对照研究

目的 对比布地奈德和孟鲁司特治疗儿童轻度持续性哮喘的临床疗效,优化儿童轻度持续性哮喘的最佳治疗方案.方法 选择2010-2012年符合入组标准的70例轻度持续性哮喘患儿,按随机数字表法分为Ⅰ组35例和Ⅱ组35例,Ⅰ组吸入布地奈德治疗,200μg/次,2次/d,早晚吸入.Ⅱ组口服孟鲁司特,＜5岁4mg每晚,5～12岁5mg每晚.两组均治疗12周.治疗前后进行患儿日间、夜间症状评分,进行诱导痰嗜酸性粒细胞计数（EOS）,检测肺功能指标第1秒用力呼吸容积（FEV1）,记录患者治疗期间复发情况.结果 Ⅰ组和Ⅱ组治疗后日间、夜间症状评分均较治疗前降低,差异有统计学意义（P＜0.05）,Ⅰ组治疗后日间、夜间症状评分低于Ⅱ组,差异有统计学意义（P＜0.05）;Ⅰ组治疗后FEV1较治疗前提高,差异有统计学意义（P＜0.05）,EOS较治疗前降低,差异有统计学意义（P＜0.05）,Ⅱ组治疗前后FEV1、EOS差异无统计学意义（P＞0.05）;Ⅰ组治疗期间复发次数少于Ⅱ组,差异有统计学意义（P＜0.05）.结论 布地奈德在改善轻度持续性哮喘肺功能及减轻气道炎症的效果明显优于孟鲁司特,能更有效缓解患者症状,可作为首选治疗方案.     

布地奈德联合特布他林雾化吸入在小儿哮喘急性发作期的疗效及其对肺功能的影响

目的探讨布地奈德联合特布他林雾化吸入在小儿哮喘急性发作期的疗效及其对肺功能的影响。方法回顾分析2012年3月～2013年3月在本院儿科就诊的哮喘发作患儿90例的资料．根据治疗方法不同分为观察组48例,对照组42例,两组患者均接受常规基础治疗,对照组患儿给予特布他林雾化吸入治疗,观察组患儿给予布地奈德联合特布他林雾化吸人治疗,两组均治疗5d后观察疗效。结果治疗后两组患儿症状均有所改善,且观察组总有效率、临床症状改善时间及肺功能指标均明显优于对照组（P〈0.05）。结论布地奈德联合特布他林雾化吸人治疗小儿哮喘急性发作,能明显改善患者临床症状及肺功能状态,不良反应少,值得推广。     

干扰素α1b联合孟鲁司特钠治疗小儿喘息性支气管炎84例疗效观察

目的:观察干扰素α1b联合孟鲁司特钠治疗小儿喘息性支气管炎的临床疗效.方法:84例小儿喘息性支气管炎患儿按照随机数表方法分为两组各42例,两组在常规治疗的基础上,治疗组加用干扰素α1b 5万U/(kg·d)雾化吸入,并每晚口服孟鲁司特钠4 mg,对照组给予利巴韦林10~15 mg/kg静脉滴注,对比观察两组疗效.结果:...     

雾化吸入布地奈德与口服孟鲁司特治疗咳嗽变异性哮喘比较研究

目的:比较雾化吸入布地奈德混悬液与口服孟鲁司特治疗儿童咳嗽变异性哮喘(CVA)的疗效。方法:118例CVA患儿分为:A组40例,使用空气压缩泵雾化吸入布地奈德混悬液;B组40例,口服孟鲁司特;C组38例,口服氯雷他定。每组患儿每日做观察日记,记录日间、夜间咳嗽情况、可能出现的气喘、药物使用情况。治疗4周内每周随访1次,症状控制后每月随访1～2次,其间电话随访,若出现气喘,嘱门诊随访。随访时分别观察记录3组治疗后1、2、3、4、8、12周日间、夜间咳嗽症状,并进行总评分;治疗6个月后,评估哮喘控制情况,继续随访18个月,观察3组患儿2年内的复发情况;观察3组2年内出现喘息发作、转变成典型哮喘(CA)人数,并记录治疗过程中不良反应等。结果:三组有效控制率分别为97.5%、95%、18.4%,与C组比较,A、B组疗效差异有统计学意义(χ2=16.004,P<0.01)。A组与B组比较,差异无统计学意义(χ2=1.946,P>0.05)。三组治疗后1、2、3、4、8、12周,日间、夜间咳嗽症状总评分比较,A、B组在治疗的第1、2、3、4周,总评分较治疗前均有不同程度下降,在第2、3周,咳嗽评分A组较B组下降更明显,差异有统计学意义(P<0.05);三组患儿经治疗后2年内CVA复发及出现喘息人数,A、B组少于C组,而A组复发比率为7.5%,出现喘息比率为10%,少于B组的25%、35%,差异有统计学意义(χ2=8.467,P<0.05)。结论:压缩泵雾化吸入布地奈德混悬液和口服孟鲁司特比较,前者可更好、更快缓解临床症状,减少CVA复发,有效预防转变为典型哮喘,长远疗效优于口服孟鲁司特。     

孟鲁司特联合吸入型糖皮质激素治疗儿童咳嗽变异性哮喘的疗效观察

目的评价白三烯受体拮抗剂孟鲁司特治疗儿童咳嗽变异性哮喘的疗效。方法152位被诊断为儿童咳嗽变异性哮喘的病例随机分为治疗组78例和对照组74例。治疗组用孟鲁司特和吸入糖皮质激素,而对照组仅使用吸入糖皮质激素。并观察呼吸峰流速（PEF）,以及临床疗效。结果治疗组呼吸峰流速（PEF）变异率明显高于对照组。结论孟鲁司特联合吸入激素治疗儿童咳嗽变异性哮喘可以明显提高治疗效果。