玫瑰糠疹的微生物病因学研究进展

玫瑰糠疹是一种常见的皮肤炎症性疾病。病因和发病机制尚未明确，在过去的数年里，主要围绕人类疱疹病毒、巨细胞病毒、EB病毒、细小病毒B19、军团杆菌等感染与玫瑰糠疹的关系展开了广泛的研究。目前尚未发现玫瑰糠疹的发病与以上病原体有明显的相关性。     

玫瑰糠疹的微生物病因学研究进展

玫瑰糠疹是一种常见的皮肤炎症性疾病。病因和发病机制尚未明确,在过去的数年里,主要围绕人类疱疹病毒、巨细胞病毒、EB病毒、细小病毒B19、军团杆菌等感染与玫瑰糠疹的关系展开了广泛的研究。目前尚未发现玫瑰糠疹的发病与以上病原体有明显的相关性。     

玫瑰糠疹与病毒感染

玫瑰糠疹（pityriasis rosea，PR）是一种急性的、病程呈自限性的炎症性皮肤病，病因及发病机制尚不清楚。其临床特点和实验室研究表明玫瑰糠疹的发病可能与病毒感染有关，国内外众多学者通过不同方法研究了多种病毒与玫瑰糠疹发病的关系，其结果不尽一致，尚未确定是哪种病毒导致玫瑰糠疹的发病。     

玫瑰糠疹与病毒感染

玫瑰糠疹(pityriasis rosea,PR)是一种急性的、病程呈自限性的炎症性皮肤病,病因及发病机制尚不清楚。其临床特点和实验室研究表明玫瑰糠疹的发病可能与病毒感染有关,国内外众多学者通过不同方法研究了多种病毒与玫瑰糠疹发病的关系,其结果不尽一致,尚未确定是哪种病毒导致玫瑰糠疹的发病。     

玫瑰糠疹

玫瑰糠疹是一种常见的红斑、丘疹、鳞屑性皮肤病，文中对其病因、临床表现、鉴别诊断和治疗等作了较全面的复习，特别是介绍了该病病因方面的研究进展和各种不典型玫瑰糠疹的类型，以加深对该病的认识。     

玫瑰糠疹269例临床分析

玫瑰糠疹是一种较为常见的炎症性皮肤病，病因不清。为进一步了解玫瑰糠疹在东北地区的发病特点，我们对2001年5月1日-2002年5月1日在本科门诊顺序就诊的玫瑰糠疹患者进行观察与分析，现将结果报告如下。     

复方青黛胶囊与雷公藤多甙联合治疗玫瑰糠疹42例疗效观察

玫瑰糠疹为常见的炎症性皮肤病，病因和发病机制尚未明了。我们自2004-2005年用复方青黛胶囊与雷公藤多甙联合治疗玫瑰糠疹42例取得较好疗效，现报道如下。     

泛发性丘疹型玫瑰糠疹2例

泛发性丘疹型玫瑰糠疹国内少见文献报道，并且尚未见玫瑰糠疹合并病毒性脑膜炎的病例，现将我科最近治疗复发性泛发性丘疹型玫瑰糠疹及泛发性丘疹型玫瑰糠疹合并病毒性脑膜炎各1例报道如下。     

玫瑰糠疹的研究进展

一些病毒包括HHV-6、HHV-7、HHV-8、甲型H1N1流感病毒以及很多种药物与部分玫瑰糠疹发病有关,T淋巴细胞介导的细胞免疫在玫瑰糠疹的发生、发展中起重要的作用,HLA-DQB1*04可能参与玫瑰糠疹发病的遗传易感性.部分玫瑰糠疹临床表现不典型,皮疹形态、大小、分布、部位、数量及病程等与典型玫瑰糠疹不同.妊娠期的玫瑰糠疹患者早产、流产的发生率较高.药物诱导所致的玫瑰糠疹病情相对较重.目前尚无特异性疗法,阿昔洛韦、UVB、UVA1在部分玫瑰糠疹的治疗中显示较好的临床疗效.     

窄波UVB治疗48例玫瑰糠疹的临床观察

玫瑰糠疹是一种常见的病因不明的自限性疾病，病程4～8周，有些病人甚至持续数月至1年以上。我们从2002年开始用窄波UVB治疗玫瑰糠疹48例。对照组40例，给常规药物治疗，报道如下。     

Fluorescence fibre-optic confocal microscopy of skin in vivo: microscope and fluorophores

BACKGROUND/AIMS: Fibre-optic confocal imaging in vivo is a new approach in the assessment of human skin. The objective is to describe a novel instrument and its operation and use in combination with fluorophores. METHODS: The Stratum is a fibre-optic fluorescence confocal microscope especially developed for the study of skin and mucous membranes. The system is flexible and any body site can be studied with a hand-held scanner. The light source is a 488 nm argon ion laser. Horizontal (en face) images of the epidermis and outer dermis are produced with cellular resolution. Magnification is approximately 1000 x . Fluorescein sodium is routinely used as fluorophore (intradermal injection or application to the skin surface). This fluorophore is safe for human use in vivo, but other substances (rhodamine B, Acridine Orange, green fluorescent protein, curcumin) have also been studied. RESULTS: The instrument produces sharp images of epidermal cell layers from the epidermal surface to the sub-papillary dermis, with sub-cellular resolution. The scanner is flexible in use. The technique of intradermal fluorophore injection requires some skill. CONCLUSIONS: We consider this fibre-optic instrument a potentially important tool in skin research for non-invasive optical biopsy of primarily the epidermis. Present use is focussed on research applications, where the fluorophore distribution in the skin may illustrate morphological changes in the epidermis.     

120例健康育龄妇女阴道sIgA浓度检测及其与阴道念珠菌感染的关系

用放射免疫法检测了１２０例健康育龄妇女、４１例念珠菌性阴道炎患者和２９例阴道念珠菌带菌者阴道ｓＩｇＡ的浓度。念珠菌性阴道炎组根据白带直接镜检下念珠菌的形态分为两组：以孢子、芽管为主者为念珠菌性阴道炎１组，以菌丝为主者为念珠菌性阴道炎　组。结果表明，健康育龄妇女阴道ｓＩｇＡ浓度范围为２０６．０　１００．１　ｇ／ｍｌ，念珠菌带菌者阴道ｓＩｇＡ与健康对照组无差异。念珠菌性阴道炎　组阴道ｓＩｇＡ低于健康对照组，念珠菌性阴道炎　组则相反。     

Unsupervised segmentation for digital dermoscopic images

Background: Skin cancer is among the most common types of cancer. Melanoma is the most fatal of all skin cancer types. The only effective treatment is early excision. Recognising melanoma is challenging both for general physicians and for expert dermatologists. A computer‐aided diagnostic system improving diagnostic accuracy would be of great importance. Segmenting the lesion from the skin is the first step in this process. Methods: The present segmentation algorithm uses a multiscale approach for density analysis. Only the skin mode is found by density analysis and then the location of the lesion mode is estimated. The density estimates are attained by Gaussian kernel smoothing with several bandwidths. A new algorithm for hair recognition based on morphological operations on binary images is incorporated into the segmentation algorithm. Results: The algorithm provides correct segmentation for both unimodal and multimodal densities. The segmentation is totally unsupervised, with a digital image as the only input. The algorithm has been tested on an independent set of images collected in dermatological practice, and the segmentation is verified by three dermatologists. Conclusion: The present segmentation algorithm is fast and intuitive. It gives correct segmentation for most types of skin lesions, but fails when the lesion is brighter than the surrounding skin.     

浅谈皮肤性病学教学之沟通

沟通是一门技巧和艺术,是一个人综合素质的体现,更是教育工作者必须具备的能力之一。皮肤性病学教学具有病种繁多、形态学特征各异、教学课时少等特点。有无良好的沟通技巧,直接影响教学效果。如何做好教学中的沟通,确保在有限的时间内完成教学任务尤为重要。也是每个皮肤性病学教育工作者值得探讨的课题。该文力求阐明在皮肤性病学的教学过程中,如何进行有效沟通,探讨教学沟通技巧,以期共勉。     

系统性红斑狼疮男性患者临床特征研究进展

系统性红斑狼疮（SLE）是常见的自身免疫性疾病,女性SLE患病率明显高于男性,其临床特征存在性别差异。SLE男性患者临床表现谱与女性患者相似,但两者在受累器官、疾病严重程度、并发症及预后等方面存在差异,尤其SLE男性患者疾病严重程度和病死率明显高于女性患者。SLE男性患者治疗原则与女性相似,但在药物选择、累计剂量方面存在差异。本文对系统性红斑狼疮男性患者临床特征进行综述,以提高对男性SLE的早期识别与诊断能力。     

Seguridad en procedimientos dermatológicos: complicaciones oftalmológicas

Ophthalmological complications are uncommon in dermatologic surgery. Nonetheless, all surgeons should know the basics of recognizing, preventing, and treating the 4 complications addressed in this article from the series ‘Safety in Dermatologic Procedures’. The first complication that surgeons should be familiar with is eye damage due to chemical irritants. This is a common complication in operating rooms given the presence of irritant substances and the performance of procedures in the eyebrow and eyelid region. The second complication is laser-induced eye damage. In this case, eye protection with safety glasses or eye caps is crucial. The third complication is accidental eyeball perforation, which can occur during certain surgical procedures. The fourth and final complication is retinal artery vasospasm or embolism due to drugs or filler materials. This complication is rare but important to recognize, as early treatment can prevent permanent blindness.     

[Translated article] Safety in Dermatologic Procedures: Ophthalmologic Complications

Ophthalmological complications are uncommon in dermatologic surgery. Nonetheless, all surgeons should know the basics of recognizing, preventing, and treating the 4 complications addressed in this article from the series ‘Safety in Dermatologic Procedures’. The first complication that surgeons should be familiar with is eye damage due to chemical irritants. This is a common complication in operating rooms given the presence of irritant substances and the performance of procedures in the eyebrow and eyelid region. The second complication is laser-induced eye damage. In this case, eye protection with safety glasses or eye caps is crucial. The third complication is accidental eyeball perforation, which can occur during certain surgical procedures. The fourth and final complication is retinal artery vasospasm or embolism due to drugs or filler materials. This complication is rare but important to recognize, as early treatment can prevent permanent blindness.     

表皮生长因子在皮肤科临床应用的安全性研究进展

表皮生长因子及其受体通路在上皮细胞增殖分化中发挥重要作用,表皮生长因子在皮肤科临床应用中主要作为外用制剂使用,红斑、瘙痒等不良反应发生率低且能耐受。本文就表皮生长因子在皮肤科临床应用的安全性进行综述。     

HLA antigens and scleroderma

Summary The European dermato-histologist is only rarely confronted with the diagnosis of granulomatous and systemic mycosis. The proper identification in sections and smears of blastomycetes of systemic importance is rather problematic, as Russell bodies may simulate fungi in certain stains. An own observation is reported with particular emphasis on differential diagnosis.The kind support from the Alfred-Marchionini-Foundation and Dr. K. Hermann is gratefully acknowledged     

鲜红斑痣的发病机制研究进展

鲜红斑痣（port-wine stains, PWS）是一种主要发生于皮肤及黏膜的血管疾病，在新生儿中的发病率约为0.3%~0.5%。PWS的发病机制目前尚不清楚，可能与体细胞基因突变、血管神经比例异常、遗传等因素相关，本文将对PWS的发病机制进行综述。