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1.
Chia-Lung Tsai Yun-Shien Lee Angel Chao Chih-Feng Yen Hsin-Shih Wang Tzu-Hao Wang 《Taiwanese journal of obstetrics & gynecology》2018,57(2):270-275
Objective
We have recently reported that stress-induced phosphoprotein 1 (STIP1) is over-expressed in endometriosis/adenomyosis tissues. STIP1 may also be involved in immune regulation, thus we attempted to study the association between STIP1 single nucleotide polymorphisms (SNPs) and endometriosis/adenomyosis.Materials and methods
Five STIP1 SNPs (rs7941773, rs2845597, rs4980524, rs2282490, and rs2236647) were selected for genotyping with matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS) in 286 patients with endometriosis/adenomyosis and 288 healthy postmenopausal controls. In vitro studies included luciferase promoter reporter assays and western blot analysis for STIP1 and MMP9 proteins.Results
The frequency of the G allele at rs4980524 was significantly higher in patients with endometriosis/adenomyosis than in control women. The promoter reporter with rs4980524 GG genotype significantly increased luciferase activity than that with TT genotype in endometrial cancer RL95-2 cells, and the primary endometrial stromal cells carrying rs4980524 GG genotype expressed higher protein levels of STIP1 and MMP9 than those carrying the TT one.Conclusion
The G/G allele of STIP1 SNP rs4980524 is associated with the increased expression of STIP1 and MMP9 in endometriosis. Further validation in independent cohorts of endometriosis patients may prove its usefulness as a genetic risk maker for endometriosis/adenomyosis. 相似文献2.
Aline Receveur Sophie Brisset Jelena Martinovic Anne Bazin Laurence Lhomann Claire Colmant Dominique Pineau Valérie Gautier Lucie Tosca Gérard Tachdjian 《Taiwanese journal of obstetrics & gynecology》2017,56(5):677-680
Objective
Isochromosome of the long arm of chromosome 20 (i(20q)) is a rare structural abnormality in prenatal diagnosis. Thirty prenatal cases of mosaic i(20q) have been reported, among which only four are associated with fetal malformations. We describe a new prenatal case of i(20q) with fetal malformations.Materials and methods
We also observed a discrepancy between uncultured and cultured amniotic fluid cells by using conventional cytogenetic, fluorescence in situ hybridization and array-SNP analysis.Results
The short arm deletion of chromosome 20 arising from the isochromosome encompassed two candidate genes PAX1 and JAG1 involved in cranio-facial and vertebral development.Conclusion
The data would allow establishing a phenotype–genotype correlation. Thus, we proposed to define a recognizable syndrome combining cranio-facial dysmorphism, vertebral bodies' anomalies, feet and cerebral malformations. 相似文献3.
Nannan Thirumavalavan Christopher R.V. Hoover Martin S. Gross 《The journal of sexual medicine》2018,15(8):1195-1197
Introduction
Cavernoscopy (using a cystoscope in the corpora) is traditionally used to retrieve rear tip extenders (RTEs) that are embedded at the time of removal or replacement of inflatable penile prostheses.Aim
To describe indications and techniques of cavernoscopy.Methods
We describe our preferred method of cavernoscopy to retrieve retained rear tips and present a thorough review of the literature regarding cavernoscopy.Main Outcome Measure
Ability of cavernoscopy to retrieve embedded rear tips without causing complications.Results
Cavernoscopy is feasible anecdotally in case reports, but other less-invasive methods of retrieving RTEs seem to have similar efficacy.Conclusion
Cavernoscopy is a technically feasible procedure that can be attempted as part of a stepwise algorithm for removing retained RTEs.Thirumavalavan N, Hoover CRV, Gross MS. Surgeons Corner: Cavernoscopy for Rear Tip Extender Removal. J Sex Med 2018;15:1195–1197. 相似文献4.
Laurine Vienet-Legué Barbara Hersant Anne Bisdorf Armand Aymard Clémentine Owen Claire Théodore Bernard Jean Paniel Bassam Haddad Cyril Touboul 《Journal of pediatric and adolescent gynecology》2018,31(1):58-61
Background
Congenital arteriovenous malformations (AVMs) are infrequent but represent a serious medical challenge because of their unpredictable progression and high hemodynamic activity.Case
We report on the treatment of a voluminous vulvar AVM in a 16-year-old girl. After failure of medical therapy, we performed a radical surgical resection with preliminary embolization and flap reconstruction.Summary and Conclusion
A multidisciplinary approach is required for AVM management. Early intervention and complete surgical resection combined with preliminary embolization represents the ideal therapy. 相似文献5.
Yen-Ling Lai Yu-Li Chen Chi-An Chen Wen-Fang Cheng 《Taiwanese journal of obstetrics & gynecology》2018,57(2):300-303
Objective
To evaluate the clinical presentations, diagnosis, management, and outcomes of torsion of the pedunculated subserous uterine leiomyoma.Materials and methods
We retrospectively reviewed medical records of patients with subserous uterine leiomyomas undergoing surgeries at National Taiwan University Hospital from January 2001 to December 2015.Results
Five cases of torsion of pedunculated subserous uterine leiomyoma were identified. All presented with sudden onset abdominal pain. Two patients received emergent surgeries, the other three cases received scheduled surgeries. The postoperative courses of these five women were uneventful without sequelae.Conclusions
Torsion of pedunculated subserous uterine leiomyoma is rare. Accurately diagnosing it prior to surgery is a major challenge. It should be one of the differential diagnosis in patients with uterine leiomyoma presenting with acute abdomen. 相似文献6.
Sara Reed Kelly A. Curran Amy B. Middleman 《Journal of pediatric and adolescent gynecology》2018,31(2):138-139
Background
Patients’ underlying medical conditions might affect the presentation and progression of an eating disorder.Case
We describe a patient with an undiagnosed, rare, genetic skeletal dysplasia with effects on body mass index that likely led to body image distortion and delayed the diagnosis of an eating disorder.Summary and Conclusion
It is critical to fully assess disordered eating in the context of each patient's clinical status. 相似文献7.
Julie S. Downs Amie M. Ashcraft Pamela J. Murray Elise D. Berlan Wändi Bruine de Bruin Joan Eichner Baruch Fischhoff Janie M. Leary Robert B. McCall Elizabeth Miller Jennifer Salaway Janell Smith-Jones Gina S. Sucato 《Journal of pediatric and adolescent gynecology》2018,31(3):291-298.e2
Study Objective
To assess the effects of the Seventeen Days interactive video on young women's perceived self-efficacy for using condoms 6 months after being offered the intervention, relative to a control.Design
Multisite randomized controlled trial.Setting
Twenty participating health clinics and county health departments in Ohio, Pennsylvania, and West Virginia.Participants
Sexually active female adolescents ages 14 to 19 years.Interventions
Seventeen Days (treatment intervention; sex education) vs Driving Skills for Life (control intervention; driving education).Main Outcome Measures
Perceived self-efficacy for condom use.Results
Participants in the Seventeen Days group reported higher perceived condom acquisition self-efficacy after 6 months than those in the driving group. This finding held after controlling for baseline self-efficacy scores and other covariates.Conclusion
The Seventeen Days program shows promise to improve perceived self-efficacy to acquire condoms among sexually active female adolescents—an important precursor to behavior change. 相似文献8.
Patrick Campbell Michael Krychman Thomas Gray Holly Vickers John Money-Taylor Weiguang Li Stephen Radley 《The journal of sexual medicine》2018,15(11):1515-1517
Introduction
Vaginal laxity is increasingly recognized as an important condition, although little is known regarding its prevalence and associated symptoms.Aim
To report the prevalence of self-reported vaginal laxity in women attending a urogynecology clinic and investigate its association with pelvic floor symptoms and female sexual dysfunction.Method
Data were analyzed from 2,621 women who completed the electronic Personal Assessment Questionnaire-Pelvic Floor (ePAQ-PF).Main Outcome Measure
Response data from ePAQ-PF questionairre.Results
Vaginal laxity was self-reported by 38% of women and significantly associated with parity, symptoms of prolapse, stress urinary incontinence, overactive bladder, reduced vaginal sensation during intercourse, and worse general sex life (P < .0005).Clinical Implications
Clinicians should be aware that vaginal laxity is prevalent and has an associated influence and impact on sexual function.Strength & Limitations
The main strength of this study is the analysis of prospectively collected data from a large cohort of women using a validated questionnaire. The main limitation is lack of objective data to measure pelvic organ prolapse.Conclusion
Vaginal laxity is a highly prevalent condition that impacts significantly on a woman’s sexual health and quality of life.Campbell P, Krychman M, Gray T, et al. Self-reported vaginal laxity—Prevalence, impact, and associated symptoms in women attending a urogynecology clinic. J Sex Med 2018;15:1515–1517. 相似文献9.
Ha Ly Thi Thanh Huong Le Thi Thanh Long Hoang Luong Thinh Huy Tran Su-Ching Liu Hai Nam Truong Thanh Van Ta The - Hung Bui Van Khanh Tran 《Taiwanese journal of obstetrics & gynecology》2018,57(3):435-441
Objective
The thalassemias is a group of hereditary disorders with impaired production of functional hemoglobin. In this report we described a rare case of compound heterozygous mutation of South-East Asia type hereditary persistence of fetal hemoglobin (SEA-HPFH) and β -thalassemia that allowed prenatal diagnosis to be performed in a subsequent pregnancy in the family.Case report
The father showed a SEA-HPFH thalassemia trait phenotype, while his genotype revealed that he was heterozygous for the SEA-HPFH deletion; The mother genotype was heterozygote for IVS-II-654 mutation; the second child had co-inherited both parental mutations and was, thus, a compound heterozygote for β-thalassemia (IVS-II-654)/SEA-HPFH deletion. His phenotype was intermediate β-thalassemia. Prenatal genotyping of a fetal sample during the third pregnancy confirmed the fetus was only heterozygote for SEA-HPFH deletion and the parents elected to continue the pregnancy.Conclusion
We described the clinical and molecular characterization of the first detected case of compound β-Thalassemia/SEA-HPFH deletion in Northern Vietnam. The report also highlighted the accuracy and necessity of mutation screening for families with thalassemia to inform accurate genetic counseling and targeted prenatal diagnosis when desired. 相似文献10.
Palmira Santos Jennifer Gaudet Hefele Grant Ritter Jennifer Darden Cassandra Firneno Ann Hendrich 《Journal of obstetric, gynecologic, and neonatal nursing : JOGNN / NAACOG》2018,47(1):32-42
Objective
To re-examine the risk factors for shoulder dystocia given the increasing rates of obesity and diabetes in pregnant women.Design
Retrospective observational study.Setting
Five hospitals located in Wisconsin, Florida, Maryland, Michigan, and Alabama.Participants
We evaluated 19,236 births that occurred between April 1, 2011, and July 25, 2013.Methods
Data were collected from electronic medical records and used to evaluate the risk of shoulder dystocia. Data were analyzed using a generalized linear mixed model, which controlled for clustering due to site.Results
When insulin was prescribed, gestational diabetes was associated with an increased risk of shoulder dystocia (odds ratio = 2.10, 95% confidence interval [1.01, 4.37]); however, no similar association was found with regard to gestational diabetes treated with glycemic agents or through diet. Use of epidural anesthesia was associated with an increased risk for shoulder dystocia (odds ratio = 3.47, 95% confidence interval [2.72, 4.42]). Being Black or Hispanic, being covered by Medicaid or having no insurance, infant gestational age of 41 weeks or greater, and chronic diabetes were other significant risk factors.Conclusion
With the changing characteristics of pregnant women, labor and birth clinicians care for more pregnant women who have an increased risk for shoulder dystocia. Our findings may help prospectively identify women with the greatest risk. 相似文献11.
Roberto Paradisi Giulia Ferrini Carlotta Matteucci Chiara Facchini Letizia Zannoni Renato Seracchioli 《Taiwanese journal of obstetrics & gynecology》2017,56(3):371-373
Objective
At present, there is growing evidence of the existence of a genetic predisposition in both thrombophilic disorders and endometriosis. The aim of our study was to evaluate for the first time the prevalence of some thrombophilic disorders in patients with endometriosis.Materials and methods
We conducted a retrospective study on 138 patients with endometriosis and 278 healthy control women. All women were subjected to a blood examination testing for thrombophilic screening and the variables examinated were: hyperhomocysteinemia, factor V Leiden and factor II prothrombin G20210A mutations in heterozygosis and homozigosis.Results
A significant reduced prevalence (p < 0.05) of factor V Leiden mutation in endometriosis patients was found, whereas no significant differences (p = NS) for factor II and hyperhomocysteinemia were observed.Conclusion
Our preliminary data do not show any association between thrombophilic condition and endometriosis. Before assuming hormonal therapies, a thrombophilic plasmatic screening seems to be unnecessary in patients affected by endometriosis. 相似文献12.
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14.
Ahmed M. Maged Wesam Sayed Deeb Sahar Elbaradie Ahmed R. Elzayat Ahmed A. Metwally Mohamed Hamed Ahmed Shaker 《Taiwanese journal of obstetrics & gynecology》2018,57(3):346-350
Objective
To compare the effect of local infiltration and intravenous dexamethasone on postoperative pain and recovery after Cesarean Section (CS).Material and methods
A Prospective, randomized study conducted on 120 pregnant women attending the labor wards. All participants were scheduled for elective CS under spinal anaesthesia and were randomly divided into 3 equal groups. Group 1 received 16 mg Dexamethasone IV drip. Group II received 16 mg Dexamethasone subcutaneous injection around the caesarean section scar after skin closure and Group III received Placebo (500 cc saline infusion). All cases were followed up for 48 h for assessment of level of pain by using a 10-cm visual analog scale (VAS). Primary outcome parameters were VAS score and the need for additional analgesics. Other parameters were hemodynamic changes and occurrence of side effects or complications.Results
there was a highly statistically significant difference between placebo and local infiltration groups and between the placebo and IV groups regarding the needs for postoperative morphine. Comparing both interventional groups revealed statistically significant difference between local infiltration and IV groups regarding the needs for postoperative morphine.Conclusion
Local infiltration of dexamethasone is more effective than systemic administration to decrease postoperative pain with weaker antiemetic effect.NCT02784340. 相似文献15.
Marcos J. Cuerva Carlos S. Piñel Javier Caceres Jose A. Espinosa 《Taiwanese journal of obstetrics & gynecology》2017,56(3):366-367
Objective
To analyze the benefits of external cephalic version (ECV) with epidural analgesia at term and labor induction just after the procedure.Materials and methods
This is a retrospective observational study with patients who did not want trying a breech vaginal delivery and decided trying an ECV with epidural analgesia at term and wanted labor induction or cesarean section after the procedure. We present the results of 40 ECV with epidural analgesia at term and labor induction or cesarean section just after the ECV.Results
ECV succeeded in 26 out of 40 (65%) patients. Among the 26 successful ECV, 6 delivered by cesarean (23.1%). 20 patients delivered vaginally (76.9%; 50% of all patients).Conclusion
Considering that a high number of cesarean deliveries can be avoided, induction of labor after ECV with epidural analgesia at term can be considered after being discussed in selected patient. 相似文献16.
Jennifer E. McCabe-Beane Sara M. Stasik-O&#x;Brien Lisa S. Segre 《Journal of obstetric, gynecologic, and neonatal nursing : JOGNN / NAACOG》2018,47(1):105-113
Objectives
To examine the incremental identification of emotional distress in mothers of hospitalized newborns by screening for anxiety in addition to depression and to provide practical information about anxiety screening scales to facilitate instrument selection and screening implementation by nurses in the NICU.Design
In this secondary data analysis, screening data from the recruitment phase of a feasibility trial to evaluate a nurse-delivered counseling intervention for emotionally distressed mothers of newborns in the NICU were used to examine the effect of anxiety screening.Setting
A Level IV NICU at a large academic medical center in the Midwestern United States.Participants
Women 18 years of age and older (N = 190) with newborns in the NICU.Methods
Participants completed multiple measures of depression and anxiety symptoms.Results
Of participants who had negative screening results on a depression-only screening instrument, 4.7% to 14.7% endorsed clinically significant anxiety symptoms depending on the screening instrument used.Conclusion
Screening for anxiety in mothers of newborns in the NICU resulted in identification of distressed mothers who would otherwise have been missed during routine depression-only screening. Multiple options for anxiety screening exist that add incremental information to depression-only screening and require little additional burden on providers and mothers of newborns in the NICU. 相似文献17.
18.
Pi-Lin Sung Kuo-Chang Wen Huann-Cheng Horng Chia-Ming Chang Yi-Jen Chen Wen-Ling Lee Peng-Hui Wang 《Taiwanese journal of obstetrics & gynecology》2018,57(2):255-263
Objective
Our previous study has shown that high expression of α2,3-sialytransferase type I was associated with advanced stage serous type epithelial ovarian cancer (EOC). The aim of the current study further attempts to evaluate the altered α 2,3-sialylation on the behavior of clear cell type EOC (C-EOC).Materials and methods
Immunohistochemistry staining, bioinformatics analysis and tissue array were used to disclose the clinical significance of over α2,3-sialylation in C-EOC. An α2,3 sialylation inhibitor, soyasaponin I (SsaI) was used to investigate the behavior change of the C-EOC cell line.Results
We reconfirmed that α2,3-sialylation, instead of α2,6- sialylation, was associated with late-stage C-EOC. Soyasaponin I could inhibit α2,3-sialylation of C-EOC cell lines and increase E-cadherin expression with subsequently suppressing migration of C-EOC cells.Conclusions
The current study demonstrated the important role of α2,3-linked sialylation in C-EOC and targeting of α2,3-linked sialylation might offer as a potential therapeutic strategy in the future. 相似文献19.