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1.
Faten Fawzy Mohammed Mohamed Hamdy Ismail 《The Egyptian Journal of Radiology and Nuclear Medicine》2018,49(4):1103-1109
Background
Multiple sclerosis (MS) is a chronic disease with a wide range of pathologic changes that modify the apparent diffusion coefficient (ADC) value.Patients & methods
A prospective study included Forty two MS patients, underwent conventional and diffusion weighted MR imaging with ADC measurement in plaques and normally appearing white matter (NAWM), compared with normal white matter (NWM) of a control group (n?=?21). They were followed-up six months later.Results
Significantly higher ADC values were found in acute and secondary progressive cases than relapsing remitting (RR) cases and all values were higher than in normal white matter. A higher ADC values was found in NAWM than control cases and in the newly developed plaques relative to old plaques in all types. A cut off ADC value 1.02?±?0.20?×?10?3?mm2/sec was detected for MS diagnosis, a value 1.41?±?0.10?×?10?3?mm2/sec to separate between acute and chronic RR cases and 1.2?±?0.10?×?10?3?mm2/sec to differentiate chronic sub-types.Conclusion
ADC value has the validity in diagnosis and follow-up of MS patients with different clinical sub-types. 相似文献2.
Tamer F. Taha Ali Mona A. ElHariri Mohamed M. Riad 《The Egyptian Journal of Radiology and Nuclear Medicine》2018,49(1):239-244
Aim of study
Evaluate the potential value of the normal peripheral zone as a reference organ to normalize prostatic lesion apparent diffusion coefficient (ADC) to improve its evaluation of prostatic lesions.Patients and methods
This prospective study included 38 patients with clinical suspicion of cancer prostate (increased PSA levels (>4?ng/ml, hard prostate in digital rectal examination) and who are scheduled to undergo a TRUS-guided biopsy. Conventional and DW-MRI was done and ADC was calculated. The normalized ADC value was calculated by dividing the ADC of lesion by ADC of reference site (healthy peripheral zone). DWI-MRI results were compared to the results of biopsy. Comparison of ADCs and nADCs of benign and malignant lesions was done. Receiver operating characteristics (ROC) curve analysis was done.Results
The patients were classified by histopathology into non-malignant group (16 patients) and malignant group (22 patients). Significant negative correlation between ADC and normalized ADC (nADC) and malignancy was detected. There was no significant difference between the mean ADC of peripheral health prostatic zones (PZ) between benign and malignant cases (2.221?±?0.356 versus 1.99?±?0.538x10?3 mm2/sec, p?=?0.144).There was significant difference between the mean ADC and mean nADC in benign and malignant lesions (1.049?±?0.217 versus 0.659?±?0.221x10?3 mm2/sec, p?<?0.001) and (0.475?±?0.055 versus 0.328?±?0.044, p?<?0.001) respectively.There was significant higher diagnostic performance of nADC than ADC with ADC Cut-off value 0.75?×?10?3 mm2/sec and nADC cut-off value 0.39 could significantly differentiate between benign and malignant lesion with sensitivity, specificity, PPV,NPV of 86.36,75,82.61 and 80% respectively, p?<?0.0001 for ADC and 95.45, 93.75, 95.45 and 93.75%, p?<?0.0001 for nADC.Conclusion
diagnostic performance of nADC using normal peripheral zone is higher than ADC in discrimination between cancerous and non-cancerous lesions of the prostate. 相似文献3.
Eman Muhammad Abdelsalam Mohamed Ali EL Adalany Mohamed Elsayed Ahmed Fouda 《The Egyptian Journal of Radiology and Nuclear Medicine》2018,49(2):509-518
Aim of the study: to evaluate the role of diffusion weighted magnetic resonance imaging in urinary bladder cancer grading in comparison to histopathological grading.
Patients and methods
This prospective study included 50 patients; 30 males and 20 females with mean age 66.4?years. All patients were referred clinically for bladder cancer and hence all of them underwent MR imaging. T2 weighted images were acquired followed by diffusion study in the same plane, b value?=?800?s/mm2.Results
pathologic staging was between Tis and T1 (superficial) in 28% of tumors. More than T1 (Deep) in 72%. The mean ADC value was 1.203?×?10–3 with a standard deviation of ±0.385?×?10–3. The mean ADC value for stages Tis to T1 tumors was 1.505?×?10–3?±?0.270 SD; and stages T2 to T4 tumors was 1.085?±?0.385 SD; P?<?0.001. Cutoff ADC value was 1.275?×?10–3 as a useful indicator for differentiating stages Tis to T1 from T2 to T4; P?<?0.005.Conclusion
DW imaging is a noninvasive reliable modality for predicting histopathological aggressiveness of bladder cancer. 相似文献4.
Ismail E. Mohamed Ayman G. Ibrahim Hamdy M. Zidan Hesham S. El-Bahkiry Adel Y. El-sahragti 《The Egyptian Journal of Radiology and Nuclear Medicine》2018,49(2):477-484
Outline
To address the correspondence of measured and predicted doses for different malignant tumours utilizing various gamma criteria and QA for confirmation of VMAT with an EPID and 2D array detector.Methods
24 patients with different malignant tumors were treated by VMAT techniques on Varian IX linear accelerator with 6 MV photon beams. Eclipse treatment planning system (TPS) is used to plan Patient’s charts. Gamma Index (GI) variation was compared to the procedure of pre-treatment verification in VMAT plans.Results
The gamma criteria (DD/DTA) of dose difference and distance to agreement for (3%/3?mm), mean?±?SD are γ≤1%?=?99.42%?±?0.67%, γmax?=?2.11?±?0.56 and γavg?=?0.19?±?0.05 by EPID, and γ%≤1?=?99.36%?±?0.53%, γmax?=?1.65?±?0.45 and γavg?=?0.22?±?0.05 by using 2D array detector.Conclusions
Specific QA of VMAT patient (using EPID or 2D array) display great possibility to spare time and to verify individual IMRT fields. 3%/3?mm is the most appropriate of gamma criteria (DD/DTA) for VMAT plans quality assurance. Control charts are a beneficial method for verification assessment for patient specific quality control. 相似文献5.
Marwa Romeih Tarek Raafat Mohamed Khalaf Kareem Sallam 《The Egyptian Journal of Radiology and Nuclear Medicine》2018,49(2):400-407
Purpose
To assess the utility of diffusion-weighted (DW) images and magnetic resonance imaging (MRI) in the detection and characterization of musculoskeletal soft tissue tumours (STTs) and in the determination of whether these tumours are benign or malignant.Patients and methods
A prospective study was performed between March 2016 and March 2017 that included all patients referred to the radio-diagnosis department for evaluation of musculoskeletal STTs. Contrast-enhanced MRI and DW images were performed for all included patients, and diagnoses were confirmed by biopsy and histopathological examination.Results
The apparent diffusion coefficient (ADC) of benign STTs was significantly higher than that of malignant (mean?±?SD, ?1.43?±?0.56?×?10?3 mm2/s versus 0.74?±?0.18?×?10?3 mm2/s, respectively (P?<?0.001), ADC cut off value ≤1.10?×?10?3 mm2/s with a sensitivity of 83.3%, specificity of 72.7%, and PPV and NPP of 80%; the area under the receiver operating characteristic curve was?=?0.892 (SE?=?0.084, 95% CI (P?<?0.001) and the Youden's index was calculated 58.4.Conclusion
To date, MRI has been considered the method of choice for the characterization of musculoskeletal STTs; however, DW-MRI with ADC mapping is a rapidly, valuable, non-invasive, non-contrast tool for reliably differentiating between benign and malignant STTs. 相似文献6.
Faten Fawzy Mohamed Hosam N. Almassry Ayman M. Ismail 《The Egyptian Journal of Radiology and Nuclear Medicine》2018,49(3):711-718
Background
Early diagnosis and management of intra medullary spinal cord lesions is crucial for improving the outcome. This can be achieved by adding DW-MRI to spinal imaging protocol.Patients & methods
A prospective study included 42 patients proved to have intramedullary SOLs of non-traumatic causes based on cMRI, were subjected to DWI and ADC value measurement. Our findings were correlated to the clinical outcome in non-neoplastic lesions and o the histopathological results in neoplastic lesions.Results
20 cases of non-neoplastic lesions (group I) showed nonrestricted diffusion with variable increased ADC values (mean?=?1.46?±?0.35?×?103?mm2/s), except in cord acute ischemia which had restricted diffusion and reduced ADC value (mean?=?0.85?±?0.07?×?103?mm2/s). 22 cases of neoplastic lesions (group II) showed reduced ADC values (mean 1.05?±?0.21?×?103?mm2/s), the lowest was in metastatic lesions (mean 0.75?±?0.15?×?103?mm2/s) and medulloblastoma (mean 0.81?±?0.09?×?103?mm2/s) while a diagnostic overlap occurred between astrocytoma and ependymoma (mean 1.19?±?0.07, 1.1?±?0.07?×?103?mm2/s respectively). A cut off value 1.25?×?103?mm2/s was found to differentiate between the two groups.Conclusion
Optimum diagnosis for non-traumatic intra-medullary spinal cord lesions can be achieved by using DWI and ADC value measurement. 相似文献7.
Mohamed I. Amin Hanan A. Hassan Mohamed I.A. Mousa 《The Egyptian Journal of Radiology and Nuclear Medicine》2018,49(1):12-22
Purpose
Is to compare the role of 128 MDCT in quantitative evaluation of left ventricle function in patients with coronary artery disease compared to 2D echocardiography.Patients and methods
Fifty patients with suspected coronary artery disease underwent contrast enhanced MDCT using retrospective gating without dose modulation. Ten phases of cardiac cycle were processed to assess end-systolic and end-diastolic phase at LV short-axis view. 2DSE was performed in the same day. LVSV, LVDV, LFEF, LVSV were calculated using the Simpson's method in MDCT and modified Simpson's method in echocardiography.Results
LVSV, LVDV, LVSV, LFEF were 74.30?±?24.92, 185.46?±?56.25, 84.15?±?33.16, 48.88?±?13.32 respectively on MSCT and 71.43?±?21.93, 182.31?±?56.49, 81.74?±?32.88, 47.82?±?13.64 respectively on echocardiography with excellent correlation between the modalities (P?<?0.001) using linear regression analysis. A Bland-Altman analysis showed that MDCT had slightly higher LVSV, LVDV, and LVSV, LFEF values with mean value of differences of 2.9, 3, 2.4 and 1% respectively.Conclusion
MDCT is an accurate method for quantitative evaluation of global left ventricular function compared to 2D echocardiography. 相似文献8.
Purpose
Diffusion tensor imaging (DTI) in flexion (F) and extension (E) may serve as a sensitive diagnostic tool in early symptoms of myelopathy. The aim of this study was to compare values of water diffusion parameters on dynamic cervical DTI in early stage of myelopathy.Methods
Study enrolled 10 patients with an early stage of cervical myelopathy, in grade I/II of Nurick classification. All subjects were scanned with flexion-extension 3T MRI. Fractional anisotropy (FA), apparent diffusion coefficient (ADC), RD (radial diffusivity), AD (axial diffusivity) and TRACEW (trace diffusion) were measured at C2, compression level (CL) and C7. Parameters were compared between 3 levels and F and E positions.Results
Flexion DTI revealed significant difference only for TRACEW between C2 and C7 (105.8?±?18.9 vs. 83.7?±?14, respectively; p?=?0.0029). Extension DTI showed differences for ADC between CL and C7 (1378.9?±?381.8 vs. 1227.2?±?269.2; p?=?0.001), reduced FA from 664.6?±?56.3 at C2 down to 553.1?±?75.5 (p?=?0.001) at CL and 584.7?±?40.7 at C7 (p?=?0.002). Differences of RD in E were significant through all levels and reached 612.9?±?105.1, 955.3?±?319.4 and 802.1?±?194.1 at C2, CL and C7, respectively. TRACEW lowered from 92.3?±?14.4 at C2 to 66.9?±?21.1 at CL (p?=?0.0001) and 64.4?±?15.5 at C7 (p?=?0.0002). Comparison of DTI between F and E showed differences for all parameters except AD. RD was significantly higher in E at CL (p?=?0.003) and C7 (0.013), but TRACEW increased in F at CL by 27.4% (p?=?0.001) and at C7 by 23.1% (p?=?0.013). FA was reduced at CL in E (p?=?0.027) and similarly ADC in F (p?=?0.048).Conclusion
Dynamic DTI of the cervical spine is feasible and can detect subtle spinal cord damage of functional relevance in cervical myelopathy. A marked increase of RD and decrease of FA and TRACEW values in extension were found to be indicative for an early structural cord injury in myelopathy.9.
Logain Nabil Salem Dina Moghazy Mohammed Dina Hazem Ziada M.H. Elshafey 《The Egyptian Journal of Radiology and Nuclear Medicine》2018,49(3):597-607
Objective
To assess diagnostic role of multi-detector computed tomographic perfusion in evaluating the therapeutic response of trans-arterial chemo-embolization in hepatocellular carcinoma.Patients & methods
Post trans-arterial chemoembolization HCC patients underwent follow up by hepatic CT perfusion, CT attenuation value and perfusion parameters {arterial flow perfusion (AFP), portal venous perfusion (PVP) & hepatic perfusion index (HPI)} were measured in hypervascular area of treated lesion at perfusion color map suspected as residual disease and adjacent hepatic parenchyma to assess therapeutic efficacy. Parameters distribution were described by their quartile values and statistically analyzed.Results
This study included 31(86%) male and 5(14%) female HCC patients with mean age (54?years). The residual lesion was observed in 25 patients of the 36 patients with increased CT attenuation value(HU), AFP (ml/min/100?ml), HPI (%) and decreased PVP (ml/min/100?ml) in the residual disease compared to surrounding cirrhotic liver parenchyma with P value?<?0.05. The calculated parameters in the residual disease: CT attenuation value was 145.50?±?25.26, AFP was 124.68?±?19.69, PVP was 30.89?±?11.52 & HPI was 78.07?±?6.25. The calculated parameters in surrounding liver parenchyma: CT attenuation value was 99.53?±?25.09, AFP was 37.12?±?8.99, PVP was 56.38?±?15.60 & HPI was 32.78?±?8.55.Conclusion
CT perfusion evaluates treatment response in TACE treated HCC patients by providing a quantitative assessment of vascularization of residual tumour. 相似文献10.
Objectives
Radiotherapy for breast cancer has been associated with various side effects including cardiac sequelae. Our study aimed to define the spatial arc of spread of coronary vessels in a radian angle.Materials and methods
We analysed the records of 51 CT coronary angiographies done in our hospital from January 2016 to July 2016. Left anterior descending (LAD) and right coronary (RC) were contoured for each patient. In each axial section, the radial spread of each artery was noted. A 5?mm brush tool was used to join the start and stop angles for making the summated “coronary strips”.Results
Start and end angle of LAD with 95% confidence interval (CI) (in clockwise direction) were 23.9?±?4° and 79.0?±?6.6°, respectively. Mean LAD arc length?±?SD (standard deviation) noted was 55.1°?±?7.7° (95% CI). For RC the smallest start angle and the largest end angle in all patients was 297.6° and 322.6°, respectively. RC start angle, end angle and arc length for 95% confidence interval were 322.2?±?6.1°, 292.4?±?11.6° and 29.8?±?13.1°, respectively.Conclusions
Our study provides a measure of the radial spread of the coronary arteries, especially from the perspective of breast radiotherapy. We have proposed a new organ at risk (OAR) of coronary strip. This should provide an easy and cost-effective way to delineate the coronary vasculature in breast cancer patients undergoing radiotherapy.11.
Purpose
Although epilepsy in the elderly has attracted attention recently, there are few systematic studies of neuroimaging in such patients. In this study, we used structural MRI and diffusion tensor imaging (DTI) to investigate the morphological and microstructural features of the brain in late-onset temporal lobe epilepsy (TLE).Methods
We recruited patients with TLE and an age of onset >?50 years (late-TLE group) and age- and sex-matched healthy volunteers (control group). 3-Tesla MRI scans, including 3D T1-weighted images and 15-direction DTI, showed normal findings on visual assessment in both groups. We used Statistical Parametric Mapping 12 (SPM12) for gray and white matter structural normalization and comparison and used Tract-Based Spatial Statistics (TBSS) for fractional anisotropy and mean diffusivity comparisons of DTI. In both methods, p <?0.05 (family-wise error) was considered statistically significant.Results
In total, 30 patients with late-onset TLE (mean?±?SD age, 66.8?±?8.4; mean?±?SD age of onset, 63.0?±?7.6 years) and 40 healthy controls (mean?±?SD age, 66.6?±?8.5 years) were enrolled. The late-onset TLE group showed significant gray matter volume increases in the bilateral amygdala and anterior hippocampus and significantly reduced mean diffusivity in the left temporofrontal lobe, internal capsule, and brainstem. No significant changes were evident in white matter volume or fractional anisotropy.Conclusions
Our findings may reflect some characteristics or mechanisms of cryptogenic TLE in the elderly, such as inflammatory processes.12.
S.M. Shehata F.M. Zaiton M.H. Abo Warda 《The Egyptian Journal of Radiology and Nuclear Medicine》2018,49(2):329-337
Objective
The aim of this study was to clarify the association between epicardial fat volume and coronary atherosclerosis.Materials and methods
A total of 90 patients with clinically suspected coronary artery disease underwent MDCT coronary angiography. The images were interpreted for Calcium score, quantification of epicardial adipose tissue (EAT) volume, and coronary artery disease (CAD) which was classified according to the number of affected vessels, location, extension, component of the lesion and degree of obstruction. EAT was correlated to CAD and Calcium score using 125?cm3 as a cutoff value for acceptable EAT volume.Results
The patients were classified into 3 groups: patients with 1-normal CCTA, 2-non-significant CAD and 3-significant CAD. A high statistical significant difference was found among the 3 groups regarding mean coronary calcium score (P value?=?0.00) and mean EAT volume; Group 1 (125.14?±?56.88?cm3), in group 2 (217.38?±?56.88?cm3) and the largest EAT volume was seen in group 3 (327.94?±?90.17?cm3), (P value: 0.00).Conclusion
The estimation of EAT volume could be considered as a screening test for any patients suspicious for CAD. 相似文献13.
Ahmed Mohamed Shokry Talaat A. Hassan Ahmed A. Baz Ahmed Shaaban Owis Ahmed Mohamed Hamdallah Zedan 《The Egyptian Journal of Radiology and Nuclear Medicine》2018,49(4):1014-1021
Objective
Is to evaluate the potential application of diffusion-weighted echo planar imaging in the differentiation of benign and malignant thyroid nodules in patients referred for FNAC and to correlate the imaging patterns & values of these lesions with their pathological nature.Subjects and methods
30 patients were included in a retrospective study (10 Males & 20 Females)0.17 cases (56.7%) were new cases of thyroid nodules and 13 cases (43.3%) were recurrent cases post total thyroidectomy. The patients' ages ranged from 29 to73 years with a mean age?±?SD (53.8?±?13.1?years). All patients performed MRI examination and underwent an ultrasound-guided FNAC.Results
17 cases were positive for malignancy (56.7%) while 13 cases were negative (43.3%). The statistical analysis in this study revealed that the ADC values were significantly (P-value?<?0.001) lower in malignant lesions. The ADC cutoff value differentiating the benign and the malignant lesions was 1.15; this had 88.2% and 92.3% sensitivity and specificity respectively.Conclusions
Our study concluded that the DW-MRI has a useful role in the assessment of the thyroid nodules and post thyroidectomy recurrent nodules providing a good determining tool by the measurement of the ADC value, thus differentiating the benign and malignant nodules. 相似文献14.
Reham Ali Abd El-Aleem Eman Abo El-Hamd Hosam A. Yousef Moustafa E.M. Radwan Rabab Ahmed A. Mohammed 《The Egyptian Journal of Radiology and Nuclear Medicine》2018,49(1):272-280
Objective
To evaluate the role of diffusion-weighted magnetic resonance imaging (DW-MRI) with calculation of the apparent diffusion coefficient (ADC) value in characterizing benign and malignant breast lesions.Patients and methods
The imaging data of thirty-nine female patients (mean age 48 years) who underwent breast MRI using conventional pulse sequences. DW-MRI and dynamic contrast enhanced (DCE) study were all analyzed and correlated with the results of histopathological evaluation.Results
Forty-six breast lesions were detected in the thirty-nine patients of the study. According to the histopathological analysis, there were 27 malignant lesions (58.69%) and 19 benign lesions (41.31%). The malignant lesions showed a mean ADC value of 0.93?±?0.42?×?10?3?mm2/s. and the benign lesions showed a mean ADC value of 1.54?±?0.43?×?10?3?mm2/s. The receiver operating characteristic (ROC) curve could identify an ADC 1.26?×?10?3?mm2/s as a cut-off value to differentiate between benign and malignant lesions with sensitivity and specificity of 89% and 94.7% respectively.Conclusion
DW-MRI is useful for differentiating malignant and benign breast lesions, increasing the specificity of breast MRI. DW-MRI doesn't cause significant increase in the total examination time and is recommended to be incorporated in the standard breast MRI protocol. 相似文献15.
Amr F. Mourad Mona M. Sayed Hussein Fakhry 《The Egyptian Journal of Radiology and Nuclear Medicine》2018,49(4):908-913
Aim
To assess how beneficial is adding Magnetic Resonance Diffusion-Weighted Imaging (DWI) to conventional MRI in the identification, characterization, and prognostic assessment of pancreatic duct adenocarcinoma (PDAC).Materials and Methods
We included 34 consecutive patients with pancreatic malignancies who had conventional MRI and DWI performed and were followed up after treatment.Results
The apparent diffusion coefficient (ADC) values of malignant pancreatic mass lesions ranged from 0.9 to 1.5?×?10?3s/mm2 at b-1000, with a mean of 1.2?±?0.18093. For the surrounding parenchyma, the ADC values were from 1.8 to 2.9?×?10?3s/mm2 at b-1000, with a mean of 2.3?±?0.35506. These values showed a statistically significant difference (P?<?0.001). The ADC cut-off value for the differentiation of malignant pancreatic masses from surrounding normal tissue, in this group of patients was, 1.7?×?10?3 s/mm2 with a sensitivity of 97% and a specificity 93%.In PDAC, a statistically significant difference in survival was found according to ADC (p?=?0.026), as patients with high ADC had better survival.Conclusion
DWI added to conventional imaging is a superior modality that aids in differentiating PDAC from the unaffected parenchyma, but not from other malignancies, with a recommended b-value 1000?s/mm2. Higher ADC may also be associated with better survival for PDAC patients. 相似文献16.
Randa Osama Kaddah Mohsen Elsayed Khalil 《The Egyptian Journal of Radiology and Nuclear Medicine》2017,48(1):169-178
Objective
To detect the value of MR Arthrography over MRI in evaluation of labral and chondral lesions in all types of FAI, and to correlate the findings with arthroscopy as a gold standard.Patients and methods
50 patients including 33 males and 17 females, age ranges from 19 to 54 years old (mean age 39 ± 5.5), underwent MRI and MR Arthrography of the hip joint followed by arthroscopy correlation. Images were evaluated for labral abnormalities, cartilage and osseous abnormalities associated in FAI. α angle. Acetabular lateral edge angle and degree of focal retroversion were measured.Results
Cam type detected in 20, Mixed type in 28, pincer type in 2, MRI detected 28 labral injury, 51 cartilage affection in 33 cases, MR Arthrography detected 38 labral injury, fraying of the L/C zone in 23 cases, 53 cartilage affection in 33 cases, cam type ch.ch by large α angle, anterosuperior femoral cartilage lesion and osseous bump formation; mixed type include the previous cam findings with a deep acetabulum and posteroinferior cartilage lesions. Anterosuperior labral (AS) tears are more common than postersuperior (PS).Conclusion
Hip MR Arthrography is a faithful evaluation modality for diagnosing the acetabular labral tears, and cartilage abnormalities associated with different types of FAI. 相似文献17.
Amr Abdel-Kerim Mohamed Shehata Basma El Sabaa Shady Fadel Anwar Heikal Yasser Mazloum 《The Egyptian Journal of Radiology and Nuclear Medicine》2018,49(1):172-175
Objective
To determine the diagnostic value of mean apparent diffusion coefficient (ADC) measures to distinguish between benign (grade I) and atypical (grade II) cranial meningiomas.Patients and methods
Forty-seven patients (10 men and 37 women) with cranial meningiomas were included in the study and underwent MRI examination including diffusion-weighted imaging (DWI). Signal characteristics on conventional MR and diffusion-weighted images were evaluated. The intratumoral mean ADC values were obtained and correlated with the final histopathological findings of the excised tumors. The optimum cutoff value of mean ADC measurements to differentiate between grade I and II was determined using the generated receiver operating characteristic (ROC)Results
Thirty-six meningiomas were benign (WHO grade I), while 11 were atypical (grade II). No grade III meningiomas were encountered during the study period. At standard MRI sequences, only the enhancement pattern had produced a significant statistical correlation with the tumoural grade (p?=?0.001). Tumoural margins, peritumoural edema, and the DWI signal showed none statistical relationship (p?=?0.105, 0.11 and 0.219 respectively). Intratumoral mean ADC values were significantly lower in grade II meningiomas (p?<?0.001). The mean ADC value was 1.02?±?0.16?×?10?3?mm2/s for grade I meningiomas and 0.72?±?0.09?×?10?3?mm2/s?1 for grade II. According to the generated receiver operating curve (ROC), we determined a threshold of 0.79?×?10?3?mm2/s?1 to produce the best diagnostic performance to distinguish between grade I and II meningiomas (sensitivity 81.2%, specificity 91.7% and accuracy 89.3%). The positive and negative predictive values were 75% and 94.3%.Conclusion
The intratumoral mean ADC measurement provides a discriminative feature to discriminate between benign (grade I) and atypical (Grade II) cranial meningiomas. 相似文献18.
Takanaga Niimi Mamoru Nanasato Hisatoshi Maeda 《Nuclear Medicine and Molecular Imaging》2017,51(3):227-232
Purpose
This study quantified the contraction synchronicity (CS; with 100% representing full synchrony and ?100% dyssynchrony) and contraction work (CW, millijoules per centimeter squared; representing myocardial area) in patients with reduced left ventricular ejection fraction (LVEF) associated with coronary artery disease (CAD).Methods
CS, CW and LVEF in 104 subjects (54 CAD patients and 50 control subjects without CAD) were measured using rest electrocardiography-gated single-photon emission computed tomography (ECG SPECT). Contraction amplitude (CA), synchronous contraction index (SCI), and CW were evaluated using the program Quantification of Segmental Function by Solving the Poisson Equation (QSFP) developed in-house.Results
The mean CA, SCI and CW of 17 segments in the control subjects were 33.8?±?4.1% (±SD), 96.6?±?1.4%, and 6.9?±?1.0 mJ/cm2, respectively. In the patients with CAD, the respective values were 26.1?±?7.3%, 82.1?±?16.8%, and 5.4?±?1.6 mJ/cm2. In the CAD patients with LVEF <40% (n?=?14), the mean CA, SCI,and CW were 17.9?±?4.0%, 63.0?±?18.4%, and 3.5?±?1.1 mJ/cm2, respectively. These values were significantly lower than in the control subjects (p?<?0.005). Using receiver operating characteristic analysis, values for the area under the curve showing the performance of CA, CS, CW and LVEF in the diagnosis of CAD were 0.81, 0.86, 0.78, and 0.84, respectively.Conclusion
Asynchrony shown using the QSFP is useful for CAD detection.19.
Koji Yamashita Takashi Yoshiura Akio Hiwatashi Osamu Togao Koji Yoshimoto Satoshi O. Suzuki Koichiro Abe Kazufumi Kikuchi Yasuhiro Maruoka Masahiro Mizoguchi Toru Iwaki Hiroshi Honda 《Neuroradiology》2013,55(2):135-143
Introduction
Our purpose was to evaluate the diagnostic performance of arterial spin labeling (ASL) perfusion imaging, diffusion-weighted imaging (DWI), and 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) in differentiating primary central nervous system lymphomas (PCNSLs) from glioblastoma multiformes (GBMs).Methods
Fifty-six patients including 19 with PCNSL and 37 with GBM were retrospectively studied. From the ASL data, an absolute tumor blood flow (aTBF) and a relative tumor blood flow (rTBF) were obtained within the enhancing portion of each tumor. In addition, the minimum apparent diffusion coefficient (ADCmin) and the maximum standard uptake value (SUVmax) were obtained from DWI and FDG-PET data, respectively. Each of the four parameters was compared between PCNSLs and GBMs using Kruskal–Wallis test. The performance in discriminating between PCNSLs and GBMs was evaluated using the receiver-operating characteristics analysis. Area-under-the-curve (AUC) values were compared among the four parameters using a nonparametric method.Results
The aTBF, rTBF, and ADCmin were significantly higher in GBMs (mean aTBF ± SD?=?91.6?±?56.0 mL/100 g/min, mean rTBF ± SD?=?2.61?±?1.61, mean ADCmin ± SD?=?0.78?±?0.19?×?10?3 mm2/s) than in PCNSLs (mean aTBF ± SD?=?37.3?±?10.5 mL/100 g/min, mean rTBF ± SD?=?1.24?±?0.37, mean ADCmin ± SD?=?0.61?±?0.13?×?10?3 mm2/s) (p?<?0.005, respectively). In addition, SUVmax was significantly lower in GBMs (mean ± SD?=?13.1?±?6.34) than in PCNSLs (mean ± SD?=?22.5?±?7.83) (p?<?0.005). The AUC for aTBF (0.888) was higher than those for rTBF (0.810), ADCmin (0.768), and SUVmax (0.848), although their difference was not statistically significant.Conclusion
ASL perfusion imaging is useful for differentiating PCNSLs from GBMs as well as DWI and FDG-PET. 相似文献20.
Amina Ahmed Sultan MagdaAli HanyAl-backry Eman Mohamed Alhefney Amany Ezzat Mosa Heba Elmetwally Abdallah Farahat 《The Egyptian Journal of Radiology and Nuclear Medicine》2018,49(1):45-53