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内皮祖细胞(endothelial progenitor cell, EPC)是存在于骨髓和循环外周血的祖细胞亚群，具有在体内外分化为成熟内皮细胞的能力，参与血管发生和血管稳态。恶性肿瘤细胞产生多种细胞因子,使骨髓中的EPC动员至外周血,并募集到肿瘤组织的血管床,参与肿瘤血管生成、肿瘤生长和转移。外周血EPC水平与肿瘤的体积、抗新生血管治疗的反应性和预后等密切相关，因此EPC可作为肿瘤血管新生的生物标记物。EPC还可作为靶向肿瘤的细胞载体负载自杀基因、毒素或药物，为抗肿瘤治疗提供了新的途径。 相似文献
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Second hand smoke stimulates tumor angiogenesis and growth 总被引：7，自引：0，他引：7
Zhu BQ Heeschen C Sievers RE Karliner JS Parmley WW Glantz SA Cooke JP 《Cancer cell》2003,4(3):191-196
Exposure to second hand smoke (SHS) is believed to cause lung cancer. Pathological angiogenesis is a requisite for tumor growth. Lewis lung cancer cells were injected subcutaneously into mice, which were then exposed to sidestream smoke (SHS) or clean room air and administered vehicle, cerivastatin, or mecamylamine. SHS significantly increased tumor size, weight, capillary density, VEGF and MCP-1 levels, and circulating endothelial progenitor cells (EPC). Cerivastatin (an inhibitor of HMG-coA reductase) or mecamylamine (an inhibitor of nicotinic acetylcholine receptors) suppressed the effect of SHS to increase tumor size and capillary density. Cerivastatin reduced MCP-1 levels, whereas mecamylamine reduced VEGF levels and EPC. These studies reveal that SHS promotes tumor angiogenesis and growth. These effects of SHS are associated with increases in plasma VEGF and MCP-1 levels, and EPC, mediated in part by isoprenylation and nicotinic acetylcholine receptors. 相似文献