青年人胃癌32例分析

胃癌是常见的消化道肿瘤，青年人发病较少。我院１９８０－１９９６年共收治３０岁以下胃癌３２例，均经及病理证实，病理显示以未分化癌和低分化腺癌为主，前者１０例，后者１３例，随访的２３例中，无１例生存５年，说明青年人胃癌发病隐匿、病程短、恶性程度高、预后差。     

青年人胃癌31例分析

青年人胃癌３１例分析王长胜，王山城胃癌多发于中老年人，发病高峰在５０～７０岁，但青年人也不少见。本院自１９８５年～１９９５年间，共收治３５岁以下的胃癌患者３１例，均经病理证实。本文就青年人胃癌的临床病理特征分析如下。临床资料一、一般资料本组３１例，男...     

青年人胃癌32例分析

胃癌是常见的消化道肿瘤，青年人发病较少。我院１９８０～１９９６年共收治３０岁以下胃癌３２例，均经手术及病理证实，病理显示以未分化癌和低分化腺癌为主，前者１０例（１０／２５），后者１３例（１３／２５），随访的２３例中，无１例生存５年，说明青年人胃癌发病隐匿、病程短、恶性程度高、预后差     

青年人胃癌：附93例临床分析

胃癌是中年及老年人易患的疾病,发病高峰为50～70岁,但青年人并不罕见。本院自1981年至1991年10年间经病理证实,共收治93例。本文就青年人胃癌的临床病理特点结合病例及文献复习分析如下:临床资料1.年龄、性别:本组男性38例,女性55     

青年人胃癌临床病理特点

目的 分析青年人胃癌的临床、病理特点。提高对青年人胃癌的诊治水平。方法 对54例青年人胃癌进行回顾性分析。结果 青年人胃癌以低分化腺癌和粘液腺癌为主，确诊的主要方法是胃镜和上消化道造影检查，并经病理证实。结论 青年人胃癌恶性度高，进展快，预后差。     

青年人胃癌28例临床分析

近年来，青年人胃癌有上升趋势。我院自1996年8月—2000年10月经胃镜(或手术后)病理确诊青年人(年龄≤35岁)胃癌28例。为提高对青年人胃癌的早期确诊率，我们对28例青年人胃癌的临床、胃镜、病理特征及误诊原因分析如下。……     

青年人胃癌22例临床分析

胃癌多见于中老年,但在青年人中并非少见。我院1973年至1987年收治的胃癌中,年龄在30岁以下的22例(均经手术、病理证实),占同期确诊胃癌的3.8％。现将其临床及X线表现作一分析。     

42例青年人胃癌分析

目的 探讨青年人胃癌发病的特点。方法 1987-1997年收治了30岁以下胃癌42例,对其病理检查。幽门螺杆菌检查结果及预后进行了分析。结果 青年人胃癌以未分化癌（12例）和低分化腺癌（21例）为多。32例胃癌病理组织切片染色查幽门螺杆菌（Hp)18例阳性（56.3%),随访35例中,无一例生存5年。结论 青年人胃癌发病隐匿,病程短,恶性程度高,预后差。     

青年人胃癌

目的 探讨青年人胃癌的临床、病理特点。方法 １９６８年１月￣１９９３年１月２５年间经手术治疗、病理诊断的青年人胃癌３１２例,占同期收治胃癌的５．１％。将所有病例以年龄组划分为４组：≤３５岁组,３６￣５０岁组,５１￣６５岁组,≥６６岁组。对≤３５岁青年人胃癌与各组进行对照观察。结果 青年人胃癌发病率女性高于男性,组织病理学类型以低分化腺癌（４９．２％）、粘液细胞癌（２６．６％）为多,８３．３％的病例     

42例青年人胃癌分析

目的探讨青年人胃癌发病的特点。方法1987～1997年收治了30岁以下胃癌42例，对其病理检查、幽门螺杆菌检查结果及预后进行了分析。结果青年人胃癌以未分化癌(12例)和低分化腺癌(21例)为多。32例胃癌病理组织切片染色查幽门螺杆菌(Hp)18例阳性(56.3%)。随访35例中，无一例生存5年。结论青年人胃癌发病隐匿，病程短，恶性程度高，预后差。     

Clinicopathological characteristics and prognostic analysis of gastric cancer in the young adult in China

The incidence of gastric cancer in young has increased steadily in the last decades. Little is known about the clinicopathologic features and prognostic factors of young adult gastric cancer patients. The clinicopathological characteristics of 294 young adult gastric cancer patients between 20 and 50 years old were reviewed retrospectively from hospital records in Sun Yat-Sen University Cancer Center between 1996 and 2006. They were compared with 706 elder patients 51 years of age or over. A steady increasing in the proportion of female in the gastric carcinoma patients as the age decreasing was found. The distinguishing histological features of young adult patients were higher percentage of poorly differentiated grade and distant metastasis. The distribution of tumor–nodes–metastasis (TNM) stage was similar between these two groups. The 5-year disease-specific survival rate in the young adult group was significantly higher than in the elderly group. More patients receiving adjuvant chemotherapy were found in the young adult group. Multivariable analysis demonstrated that TNM stage and presence of angiolymphatic invasion were the independent negative predictors of survival for young patients with gastric cancer. Gastric cancer in young patients differs from that in elderly patients including a lack of male predilection, more aggressive histologic features, and better survival rate.     

青年与老年胃癌的临床特征与预后分析*

目的　探讨青年与老年胃癌的临床病理特点及影响预后的因素。方法　回顾性分析６６９例胃癌患者的临床资料,并根据年龄分为≤３０岁组、３１～７０岁组和＞７０岁组。对３组患者的病理特征及淋巴结转移等方面进行比较,Ｋａｐｌａｎ-Ｍｅｉｅｒ法计算患者的生存率,Ｌｏｇ-ｒａｎｋ检验分析年龄与患者预后的关系。结果　不同年龄胃癌组之间在组织分化程度、组织类型、浸润深度以及淋巴结转移均存在差异,≤３０岁组具有分化程度差、恶性程度高、侵袭力强、进展快的特点,其总生存率及预后最差,其次为＞７０岁组,３１～７０岁组预后相对较好。结论　年龄与胃癌的临床病理特征关系密切,不同年龄人群具有不同的发病特点。     

Gastric cancer in the young,with special reference to 14 pregnancy-associated cases: Analysis based on 2,325 consecutive cases of gastric cancer

Clinicopathologic features of gastric cancer in young women were analyzed with special reference to pregnancy (P). Among 2,325 consecutive patients, there were 152 young patients under 40 years of age (57 males and 95 females), and 14 P-associated cases were identified. The male-to-female ratio was 1.7:1.0 on the whole, but 1.0:1.7 in the young group with more females predominating as the age of patients decreased. Among characteristics of gastric cancer in the young females, we noted a significantly higher frequency of both Borrmann type 4 cancer and poorly differentiated adenocarcinoma with the scirrhus type of growth and peritoneal metastasis. These characteristics were more pronounced in the P-associated cases. Although we were unable to determine the mechanism for these tendencies, our findings suggest that the development and growth of gastric cancer in young women may be influenced by their natural, biological and hormonal circumstances. The prognosis of the young women with or without associated pregnancy was good afer curative surgery. Both early detection of gastric cancer and subsequent potentially curative surgery are the best ways to obtain good survival for young women, as is the case for members of other age and sex groups. © 1995 Wiley-Liss, Inc.     

以转移性卵巢癌为首发表现的胃癌25例临床分析

目的探讨胃癌伴卵巢转移（krukenberg瘤）的临床特点、诊断及治疗经验,以减少误诊。方法回顾性分析经手术和病理证实的25例胃癌伴卵巢转移患者的临床资料。结果25例患者年龄27～56岁,平均37．5岁,绝经前21例,占84．0％。首发的主要临床症状为腹胀、腹痛及下腹部包块。病理类型以印戒细胞癌为主,共14例,占56．0％。侵及双侧卵巢者15例,占60．0％。术前误诊为卵巢原发肿瘤者9例,占36．0％。la生存率为51．9％,2a生存率为21．3％。结论胃癌伴卵巢转移常以转移性卵巢癌为首发表现,好发于绝经前中青年妇女,易误诊,预后差;发现卵巢肿瘤的患者,应常规行胃肠道检查以排除转移瘤的可能。     

青年人胃癌187例临床病理特征分析

[目的]探讨青年人胃癌的临床病理特点。[方法]回顾性分析1999年1月至2008年12月青年人（35岁以下）胃癌的临床病理资料,并与同期180例老年人（≥75岁）的临床病理资料对比分析。[结果]35岁以下青年人胃癌占全部胃癌的5.4%,男女比例0.56∶1。肿瘤最常见位置为胃下1/3;Bormann分型以溃疡型和浸润溃疡型为主。93.6%胃癌病理类型为低分化癌、黏液腺癌和印戒细胞癌;Ⅲ～Ⅳ期占64.2%。19.7%患者一级亲属有胃癌家族史。与75岁以上老年人胃癌相比,性别比例、肿瘤位置、肿瘤分化和胃癌家族史等方面有明显差异。[结论]青年人胃癌恶性程度高,应加强青年人胃癌的早期诊断和治疗研究,以期提高预后。     

Clinico-pathological study of autopsy cases of nonresected gastric cancer in the young and old

To elucidate the difference between the natural history of gastric cancer in young and old patients, this study was carried out. Fifty-four cases were studied, representing the autopsy findings of gastric cancer patients who did not undergo operation. The characteristics of the gastric cancer in the young patients were as follows: had infiltrative macroscopical types, had histologically diffuse types, had deeper and wider infiltration, showed a severer invasion into the vessels, and, showed marked lymphatic disseminated, and distant metastasis. The elderly, in comparison, showed various types of gastric cancers. The extension of the cancer in the old group was significantly, less than in the young, even in the same diffuse type. The period from the onset to death was almost same in both groups. The age of the host seems one of the important factors influencing the natural history of gastric cancer.     

Gastroscopy plus cytology for the diagnosis of gastric cancer or precancerous diseases--report of 127 cases

One hundred and twenty-seven patients with gastric tumor or precancerous diseases were examined by gastroscopy plus cytology, and the results were compared with that of histopathology after operation. Out of 127 cases, 70 were diagnosed as gastric cancer (15 cases as early cancer, 55 as advanced cancer). The positive rate for early cancer was 21.4%, it comprised 11.2% of all gastric cancers diagnosed by gastroscopy during the same period. The preoperative positive rate of early gastric cancer was 100% (13/13) as examined by the combination of touch, brush cytology and mucosal biopsy. The combined method may increase the positive rate and the accuracy, not only for advanced but also for early gastric cancers. It is suggested that the combination of these methods be routinely used in the diagnosis of suspicious cancer in the gastric mucosa.     

Preoperative endoscopic analysis of thymidine phosphorylase and dihydropyrimidine dehydrogenase in gastrointestinal cancer

Thymidine phosphorylase (TP) and dihydropyrimidine dehydrogenase (DPD) are considered to be key enzymes affecting the prognosis for patients with advanced gastrointestinal cancer. Preoperative examination of TP and DPD expression levels and assessment of these enzymes in inoperable cancer patients may contribute to successful treatment. We tried to prove the correlation of TP and DPD expression in preoperative specimens by endoscopy and in surgical specimens. The present study was designed to quantify TP and DPD levels by enzyme-linked immunosorbent assay (ELISA) in tumor tissue obtained from 30 gastrointestinal cancer patients by preoperative endoscopy and surgery, including 15 gastric and 15 colorectal cancers. Successful cases as those in which cancer cells were demonstrated histologically in preoperative specimens by endoscopy were 12 (success rate: 80%) in gastric cancer patients, and 15 (success rate: 100%) in colorectal cancer patients. In successful cases, there were almost significant correlations in all cases, gastric cancer, and colorectal cancer among the expression of TP, DPD, and TP/DPD ratio in each preoperative specimen by endoscopy and surgical specimen, respectively. On the other hand, in the gastric cancer group, 3 unsuccessful cases resulted in a significant departure from ideal equation compared with 12 successful cases. In actual clinical care, physicians should pay attention to and evaluate carefully the data from endoscopical biopsy specimens in which cancer cells may not be demonstrated histologically. Thus, endoscopic analysis of TP and DPD expression in preoperative or inoperable cancer patients may contribute to successful treatment.     

胃癌患者血清可溶性E-选择素检测的临床意义

目的:探讨血清可溶性E-选择素（sE-selectin ）检测在胃癌诊治中的临床意义。方法:采用ELISA 法检测200 例胃癌患者、45例胃良性疾病患者和40例健康体检者血清中的可溶性E-选择素水平,比较其中140 例胃癌患者手术前后血清可溶性E-选择素水平的变化,并对胃癌患者血清可溶性E-选择素、CEA 、CA199 和CA724 的阳性率进行比较。结果:胃癌组血清可溶性E-选择素表达水平为69.12± 18.19ng/mL,与正常对照组（15.85± 5.27ng/mL）及良性疾病组（19.47±7.88ng/mL）比较,差异性具有统计学意义（P<0.01）。 血清可溶性E-选择素阳性表达与肿瘤部位及组织学分型无明显相关（P>0.05）,但与病理分期及肝转移呈正相关（P<0.05,P<0.01）。胃癌患者手术后血清可溶性E-选择素水平明显下降。胃癌患者血清可溶性E-选择素阳性率远远高于其他消化道肿瘤标物（CEA 、CA199、CA724）,P<0.01。结论:可溶性E-选择素有可能成为胃癌早期辅助诊断、预测复发转移及评估预后有价值的肿瘤标记物。