人发中铜与铜／锌比值与妇科肿瘤关系初步探讨

采用原子吸收分光法测定了68例妇科恶性肿瘤、37例妇科良性疾病和30例正常妇女头发中的微量元素铜、铁、锌及铜/锌比值,发现恶性肿瘤患者的铜、铜/锌比值明显高于对照组和其它妇科疾病患者。有87%的恶性肿瘤患者的铜/锌比值超过正常范围。因而,铜/锌比值在妇科肿瘤的诊断中有一定的意义。     

滋养细胞肿瘤患者血清微量元素的变化

采用原子吸收光谱法检测１６例滋养细胞肿瘤患者治疗前后血清微量元素铜、锌、锰和铬的含量，结果表明，滋养细胞肿瘤患者血清铜水平和铜／锌比值均显著高于正常未孕对照组（Ｐ〈０．０１）。经手术和ＡＣＭ三联序贯化疗后，随着病情的完全缓解，血清铜水平和铜／锌比值则明显下降（Ｐ〈０．０１），我们认为血清铜水平和铜／锌比值与滋养细胞肿瘤的病情和疗效有关。     

血清中微量元素铜,锌,镉,锰与恶性脑瘤关系的研究

本文使用原子吸收分光光度计测定30例恶性脑瘤、50例良性脑瘤患者手术前后血清中微量元素铜、锌、镉、锰含量,并以70例一般神经性疾病患者和98例健康人作对照组。统计结果揭示:1.恶性脑瘤组手术前血清中铜、锌、镉、锰含量显著高于术后(P<0.01),良性脑瘤组除术前血清锰低于术后,余者均显著高于术后(P<0.01),两组脑瘤手术前后铜/锌比差异均无显著性(P>0.05),2.不同病理状态血清铜和铜/锌比改变也有差别,即恶性脑瘤>良性脑瘤>一般脑疾病>健康人,而术后两组脑瘤血清铜水平下降接近正常人,可提示术前血清铜水平在鉴别脑瘤性质及区分一般脑疾病具有潜在的诊断价值;术后血清铜水平对估计恶性和良性脑瘤预后方面有重要意义。     

血清唾液酸在恶性肿瘤中的临床应用价值

目的探讨血清唾液酸（SA）在恶性肿瘤中的临床应用价值。方法采用酶法对50名健康人、90例良性疾病及160例恶性肿瘤患者血清SA的水平进行检测,分析血清SA水平在肿瘤不同病理类型及相关治疗前后的表达变化。结果恶性肿瘤各组血清SA水平均显著高于良性疾病组及健康对照组（P〈0．01）,恶性肿瘤各组阳性率亦显著高于良性疾病组（P〈0．01）;各组织学类型恶性肿瘤组血清SA水平显著高于良性疾病组及健康对照组（P〈0．01）,但各组织学类型恶性肿瘤组之间血清SA水平差异无统计学意义（P〉0．05）;恶性肿瘤患者经相关治疗后,病情好转组血清SA水平明显下降,与治疗前相比差异有统计学意义（P〈0．01）;病情恶化组血清SA水平有上升趋势,但与治疗前相比差异无统计学意义（P〉0．05）。结论血清SA对恶性肿瘤的诊断、治疗、疗效判断、病情监测及预后判断具有一定临床应用价值。     

血清唾液酸对消化道恶性肿瘤诊断与治疗临床价值探讨

目的：研究血清唾液酸（sialicacid,SA）在消化道恶性肿瘤诊断及治疗监测中的临床价值。方法：2010-10-01-2012-10-30烟台市烟台山医院收治的恶性肿瘤患者318例作为恶性肿瘤组,同时选取同期同院查体中心的健康体检者100名作为健康对照组,以及同期同院确诊的消化系统良性疾病患者167例作为良性疾病组。采用BECKMANCOUL-TERUniCelDxC800全自动分析仪对各组患者的血清SA含量进行检测,并对各组患者的血清SA进行统计学分析。结果：恶性肿瘤Ⅰ～Ⅳ期患者血清SA分别为（623±89）、（719±122）、（782±176）和（913±235）mg／L。恶性肿瘤患者的血清SA水平明显高于良性疾病组和健康对照组,P〈0．01。45例接受手术治疗的肿瘤患者,血清SA浓度由术前的（685±98）mg／L降为术后的（605±90）mg／L。连续接受化疗的96例患者,病情好转或病情稳定的有72例,4次化疗后血清SA浓度明显降低为（624±95）mg／L。结论：血清唾液酸对消化道恶性肿瘤的诊断和治疗监测等有重要临床价值。     

血清SA,Cu／Zn比值联合检测诊断肺癌患者的临床意义

对１７８例原发性肺癌患者血清唾液酸（ＳＡ）含量、铜／锌（Ｃｕ／Ｚｎ）比值进行了测定分析，并与８０例正常人作对照。结果表明：原发性肺癌患者血清ＳＡ含量（１２２．２０±３６．３０）、Ｃｕ／Ｚｎ比值显著高于对照组，（Ｐ＜０．０１）。单项检测：两项指标对肺癌的诊断敏感性分别为７６．４％和６１．２％，特异性为９７．５％和７６．３％；联合检测：以两项之一阳性为诊断依据时，特异性可达９８．７％。表明ＳＡ和Ｃｕ／Ｚｎ比值联合检测较单项检测对肺癌的诊断更有临床应用价值。     

肺癌患者血清铜锌离子水平与体力状况评分及预后的关系

目的探讨铜、锌元素在肺癌患者中的临床意义,及与预后的关系。方法分别对123例肺癌患者和22例健康人血清铜、锌离子浓度进行测定,同时对肺癌患者的体力状况进行评分,追踪其预后情况。结果不同分期肺癌患者血清铜离子浓度及铜/锌值高于健康对照组（P〈0.05）,血清锌离子浓度低于对照组（P〈0.05）,但各亚组之间差异无统计学意义;不同ZPS评分的肺癌患者其血清铜离子浓度、锌离子浓度、铜/锌有差异（P〈0.05）。随着ZPS评分增加,血清铜离子浓度、铜/锌值升高,锌离子浓度降低;分期和铜/锌影响是肺癌患者生存期的危险因素。结论铜锌比值可影响肺癌患者的生存期,铜锌比值高的肺癌患者其预后要差于铜锌比值低的患者,且血清铜离子浓度、锌离子浓度、铜/锌与患者的ZPS评分密切相关,因此测定其值及其变化可作为肺癌患者判断临床疗效与预后的试验依据之一。     

铜/锌比值偏高是恶性淋巴瘤危险因素

山西省肿瘤医院研究人员采用原子吸收分光光度计对３７０例恶性淋巴瘤患者 ,１００例健康成人进行血清微量元素含量的测定及分析 ,实验显示 :恶性淋巴瘤患者组血清铜、铜／锌比值、锰含量高于对照组 ,而锌、铁、钙含量均低于对照组 ,且差异明显。通过进一步实验分析了每种元素与恶性淋巴瘤发病的关系 ,结果表明 :血清中铁元素含量低 ,是恶性淋巴瘤发病的保护因素 ,而血清中铜／锌比值偏高 ,对恶性淋巴瘤的发生是一种危险因素。这项研究为恶性淋巴瘤患者的病因调查、临床诊断、形态鉴别及其疗效观察提供了重要的依据 ,对恶性淋巴瘤的预防及发…     

检测妇科肿瘤患者血清铜,锌及铜／锌比值的临床意义

近年来,国内外对肿瘤患者血清微量元素进行了深入的研究。学者们曾报道,肉瘤、消化道癌、宫颈癌等恶性肿瘤患者血清铜(SCu)升高,血清锌(SZn)降低。对妇科肿瘤患者的血清铜锌报道甚少。本文采用生化法对妇科良、恶性肿瘤患者及正常女性血清SCu和SZn水平进行测定,以探讨铜/锌比值与恶性肿瘤及分期的关系。资料与方法一、观察对象我科住院的肿瘤患者95例,其中妇科恶性肿瘤26例(见表1),良性肿瘤69例,包括子宫肌瘤,卵巢瘤等。良、恶性肿瘤的确诊依据为组织学检查,恶性肿瘤的分期按临床检查和术中所见而定,正常女性36     

恶性肿瘤患者血清铜,铜／锌比值的临床流行病学

国内外大量报道表明,恶性肿瘤患者血清锌降低,而钢/锌比值升高;在手术或治愈后血清钢锌恢复到原有水平,可作为肿瘤诊断、鉴别诊断、评价疗效、监视复发和估计预后的重要参数.因此提出这二种元素的升降是肿瘤存在的结果,而不是肿瘤的病因.1 消化道肿瘤周永淑等检测92例消化道恶性肿瘤患者血清铜、锌水平.并与50例浅表性胃炎和50名健康人进行了比较,结果:(1)胃炎组血清铜含量较健康人为高(P<0.05);胃炎组血清     

血清锌,铜与铜／锌比值对肺癌诊断,疗效和预后判断的临床价值

本文对60例肺癌和100例健康对照组用原子吸收法测定了血清锌(SZn)、铜(SCu)含量.肺癌组SZn明显低于对照组.SCu与血清铜/锌(SCu/Zn)比值明显高于健康组(P均<0.001).肺癌组按TNM分期,其SCu与SCu/Zn比值各期均较对照组明显增高,且随病期进展而增高,即Ⅳ期>Ⅲ期>Ⅱ期>Ⅰ期.SCu以1.191ppm,SCu/Zn 以1.38为分界,其特异性分别为 87%和88%;敏感性分别为 88.33%和 81.66%.较同期所测血清癌胚抗原(CEA)36.58%和肿瘤DNA聚合酶[DNA—P(CA)]18.18%为高.提示 SCu、SCu/Zn的测定是肺癌辅助诊断、疗效观察及预后判断的辅助指标.     

Use of the copper/zinc ratio in the diagnosis of lung cancer

Serum zinc (Zn), copper (Cu), and the Cu/Zn ratio were evaluated in 84 patients with pulmonary lesions before surgery and in 100 healthy normal controls. There were 20 patients with benign and 64 with malignant lung tumors. Only the mean (+/- SD) Cu/Zn ratio was significantly higher in malignant tumors (2.24 +/- 0.78) than in benign tissue (1.63 +/- 0.33) (P less than 0.001). In the normal group, the Cu/Zn ratio was significantly lower (1.43 +/- 0.29). Patients with advanced disease (Stage III) had higher Cu/Zn ratio than patients in Stages I and II (2.65 +/- 0.86 versus 1.9 +/- 0.27) (P less than 0.001). At a cutoff value of 1.72, Cu/Zn ratio had a sensitivity of 89%, specificity of 84%, positive predictive value of 78%, and negative predictive value of 92% between controls and lung cancer patients. Between lung cancer patients and patients with benign pulmonary lesions the aforementioned values were 89%, 70%, 90%, and 70% respectively. A correlation between increasing Cu/Zn ratio and tumor extension and postoperative survival was observed. These findings suggest that Cu/Zn ratio may be used as a diagnostic test in lung cancer patients.     

微量元素与消化道癌Logistic回归分析及临床意义

 本文测定了130例食管癌，100例胃癌，60例结直肠癌，22例肝癌，56例消化道良性疾患。结果表明：消化道癌患者血清中铜，铁含量，铜/锌比显著高于健康人（P＜0.05～P<0.001），锌，钙含量明显低于健康人（P<0.05～P相似文献   

Serum Copper/Zinc Superoxide Dismutase (Cu/Zn SOD) and Gastric Cancer Risk: a Case-Control Study

We conducted a case-control study to evaluate the association between serum levels of copper/zinc superoxide dismutase (Cu/Zn SOD) and the risk of gastric cancer. Cases were 214 patients who had been diagnosed with gastric cancer and controls were 120 persons who underwent medical checkups. Serum levels of Cu/Zn SOD were determined by enzyme-linked immunosorbent assay (ELISA). Compared with the lowest quartile, the OR (odds ratio) was 4.54 (95% CI (confidence interval), 1.62–12.66) for the third quartile and 15.75 (95% CI, 5.84–42.46) for the highest quartile. With both early and advanced cancers, as well as with the intestinal and diffuse types, a significant increase in risk was observed with increasing levels of serum Cu/Zn SOD. Our case-control study showed that serum levels of Cu/Zn SOD were significantly elevated in gastric cancer patients compared with apparently healthy controls, and higher Cu/Zn SOD levels may be associated with an increased risk of gastric cancer.     

Copper, zinc, and Cu/Zn ratio in carcinoma of the gallbladder

INTRODUCTION: The exact role of copper and zinc in the etiology of carcinoma of the gallbladder is unclear. Some studies suggest the Cu/Zn ratio is a good indicator of the extent and prognosis in carcinoma of the gastrointestinal tract. The aim of the present study is to estimate the micronutrient profile and Cu/Zn ratio in the serum, tissues, and bile of patients with benign and malignant gallbladder diseases. METHODS: The present study was carried out in 60 patients comprising 30 each of carcinoma of the gallbladder and cholelithiasis, and 30 age and sex matched controls. Copper and zinc levels were estimated in blood, bile, and tissue using a Perkin Elmer Model 2380 Atomic absorption Spectrophotometer. RESULTS: The mean serum zinc levels were significantly lower in patients with carcinoma of the gallbladder than in patients with cholelithiasis and in healthy controls (P < 0.001). The mean serum copper levels were significantly higher in patients with carcinoma of the gallbladder as compared to patients with cholelithiasis and healthy controls (P < 0.001). Biliary and tissue zinc levels were significantly lower in patients with carcinoma of the gallbladder than in patients with cholelithiasis. Biliary and tissue copper levels were higher in patients with carcinoma of the gallbladder than in patients with cholelithiasis. The serum Cu/Zn ratio showed a gradual and significant increase from 1.11 in healthy controls to 1.35 in patients with cholelithiasis and 2.12 in patients with carcinoma of the gallbladder. The biliary and tissue Cu/Zn ratios were also significantly increased in patients with carcinoma of the gallbladder than in patients with cholelithiasis (P < 0.001). CONCLUSIONS: Our data support an association between lower zinc levels and consequently an increased Cu/Zn ratio and carcinoma of the gallbladder. Whether zinc supplementation has a protective effect in preventing carcinoma of the gallbladder needs to be studied further.     

卵巢肿瘤患者血清微量元素与CA125关系的研究

联合测定１９例卵巢良性肿瘤、１７例卵巢恶性肿瘤及２１例健康妇女血清ＣＡ１２５及微量元素。结果发现肿瘤患者血清Ｃｒ、Ｆｅ水平较对照组明显降低，Ｃｕ、Ｚｎ和ＣＡ１２５水平明显升高；良、恶性肿瘤间无差异。恶性肿瘤患者Ｃｒ和ＣＡ１２５异常率高于良性肿瘤，两者的Ｃｕ、Ｚｎ和Ｃｕ／Ｚｎ比值异常率相近。表明联合测定ＣＡ１２５及Ｃｒ有助于卵巢恶性肿瘤的早期诊断。     

微量元素铜锌硒,抗氧化酶类,维生素E与恶性肿瘤的关系

本文作者对６７例恶性肿瘤患者同时作了血清铜（ＳＣｕ）、锌（ＳＺｎ）、硒（ＳＳｅ）含量和血红细胞超氧化物歧化酶（ＲＢＣ－ＳＯＤ）、谷胱甘肽过氧化物酶（ＧＳＨ－Ｐｘ）活性及维生素Ｅ、丙二醛（ＭＤＡ）含量测定。     

腹水SA和Cu/Zn与妇科肿瘤的关系及临床意义

目的为了寻找一种灵敏、可靠的诊断方法,鉴别妇科疾病患者的腹水良恶性。方法对80例妇科疾病患者腹水的唾液酸水平(SA)、铜/锌比值(CZR)及部分微量元素采用751分光光度计和3030型原子吸收分光光度计进行测定。结果结果表明卵巢癌患者腹水中SA水平和CZR明显高于宫颈癌和妇科良性疾病,差异显著,分别P<0.01,并呈高度的线性关系。同时卵巢癌和宫颈癌患者腹水中锌和钙明显低于良性疾病组,差异显著,分别P<0.01。结果还表明如以SA31mg/dl和CZR1.10为界值对卵巢癌的诊断阳性率为71%和55%。结论腹水中SA和CZR的测定对鉴别妇科良恶性肿瘤有重要的临床价值,同时对探讨卵巢癌的发病因素提供重要线索。     

Diagnostic value of serum copper/zinc ratio in gynecologic tumors

Serum copper/zinc levels were determined in 39 patients with gynecologic tumors and 20 normal individuals. Of these 39 patients, twenty-two had primary malignant tumors and seventeen had benign growths. All the patients were divided into two groups: treated and untreated. The serum Cu/Zn ratio in the untreated benign tumors was significantly higher than of the normal controls (P less than 0.05). The ratio was much higher in the untreated Stage II-IV malignant tumors than that of the benign group (P less than 0.01). The measurement of serum Cu/Zn ratio is also helpful in observing the clinical course of the disease.