幽门螺杆菌感染与慢性荨麻疹的相关性研究进展

慢性荨麻疹是一种常见的过敏性皮肤病,病因复杂,治疗棘手。机体内存在的慢性感染如幽门螺杆菌感染可能参与了慢性荨麻疹的发生与发展,针对幽门螺杆菌的治疗能够缓解部分患者的症状,关于两者之间相关性的研究较多,但结果尚存争议。本文对近年来有关幽门螺杆菌感染与慢性荨麻疹的相关性研究进展作一综述。     

儿童慢性荨麻疹与幽门螺杆菌关系的探讨

目的探讨儿童慢性荨麻疹与幽门螺杆菌的关系，幽门螺杆菌抗体检测在治疗慢性荨麻疹中的意义。方法对随机抽取的门诊慢性荨麻疹的患儿检测幽门螺杆菌抗体。结果试验组的阳性率高于健康对照组，P〈0．01；Hp（＋）的患者给予三联疗法配合抗组胺药物治疗，效果较显著。结论慢性荨麻疹患者应考虑幽门螺杆菌感染的可能，并给予抗幽门螺杆菌的正规治疗，这对慢性荨麻疹的治疗有一定参考。     

慢性荨麻疹患者血清白细胞介素-18和白细胞介素-10的检测

目的检测慢性荨麻疹患者Th1型细胞因子IL-18和Th2型细胞因子IL-10血清水平,进一步探讨慢性荨麻疹免疫学发病机制。方法采用ELISA法检测30例皮肤变应原试验阳性的荨麻疹患者及20例正常人外周血血清IL-18和IL-10水平。结果慢性荨麻疹患者IL-18水平低于正常人(P<0.05),IL-10水平高于正常人(P<0.05)。结论慢性荨麻疹的发病与机体免疫有关,Th1/Th2失衡在慢性荨麻疹的发病中具有重要作用。     

幽门螺杆菌感染与慢性荨麻疹相关关系的研究进展

慢性荨麻疹是皮肤科的一种常见病、多发病，其病因复杂、诱发因素较多，治疗也较为棘手。有学者认为机体内存在慢性感染病灶是荨麻疹反复发作、久治不愈的原因。近年来幽门螺杆菌感染与慢性荨麻疹的发病关系引起皮肤界的重视，但结果尚有争议。本文主要就两者之间的研究进展作一简要综述。     

梅州城区幽门螺杆菌感染与慢性荨麻疹的关系探讨

目的探究梅州城区幽门螺杆菌感染与慢性荨麻疹的关系。方法选取我院在2016年1月—2017年1月期间收治的常住或工作在梅州城区的慢性荨麻疹患者共90例,设为试验组,同期选取在我院进行健康检查者90例,设为正常组。将试验组中幽门螺杆菌阳性的患者随机分为对照组和观察组,对照组患者给予氯雷他定分散片治疗,观察组患者在上述治疗的基础上同时给予克拉霉素缓释胶囊、兰索拉唑肠溶胶囊和阿莫西林分散片,分析幽门螺杆菌的感染与慢性荨麻疹的关系。结果试验组患者幽门螺杆菌感染阳性率显著高于正常组,差异有统计学意义(P0.05);观察组患者治疗效果显著优于对照组,差异有统计学意义(P0.05)。通过临床随访3个月还发现,对照组复发率为28.95%,高于观察组的13.33%。结论梅州城区幽门螺杆菌感染与慢性荨麻疹存在一定的相关性,且抗幽门螺杆菌药物对于治疗慢性荨麻疹有一定的作用,临床上值得进一步推广应用。     

慢性荨麻疹部分发病机制的研究进展

慢性荨麻疹是临床常见的一种反复发作的过敏性疾病,其发病机制除了肥大细胞脱颗粒释放组胺以外,还有IgE及其受体的自身抗体FcεRI引发的自身免疫反应、Th1/Th2细胞亚群失衡,以及炎症递质白三烯释放所导致的后续炎症反应等参与.这些异常免疫反应将给那些难以单纯用抗组胺药物治疗的慢性荨麻疹带来更多的治疗靶位.     

Thl-Th2失衡与慢性荨麻疹

Th1-Th2亚群失衡在慢性荨麻疹发生及发展中的作用正日益引起人们的重视。研究表明,慢性荨麻疹是由于相应变应原的刺激引起Th2为主的免疫应答,从而产生临床症状。该文阐述了Th1-Th2的分化途径、与慢性荨麻疹的关系及相应治疗方法。     

幽门螺杆菌感染与寻常性银屑病的相关性

目前普遍认为幽门螺杆菌感染与慢性荨麻疹、酒渣鼻等皮肤病有关,但幽门螺杆菌感染与银屑病发病关系的研究不多。为研究寻常性银屑病发病与幽门螺杆菌感染是否存在相关性,我们对103例寻常性银屑病患者进行幽门螺杆菌抗体检测,现报道如下。     

幽门螺杆菌感染与皮肤系统疾病的关系

近年来研究发现幽门螺杆菌感染在许多胃肠道外疾病的发病中起一定作用 ,其中皮肤系统许多疾病与幽门螺杆菌感染有关 ,现综述近年来幽门螺杆菌感染与慢性特发性荨麻疹、血管神经性水肿、酒渣鼻及其他皮肤疾病关系的报道     

荨麻疹

20052395 慢性特发性荨麻疹患血清中P物质和神经生长因子检测，20052396 Th1、Th2失衡与慢性荨麻疹（综述），20052397 荨麻疹过敏原筛选及特异性治疗,20052398 酶免疫分析法体外检测过敏原在荨麻疹病因筛查中的价值,20052399 急性荨麻疹伴心电图异常与变应原检测相关性研究。     

New fillers for the new man

ABSTRACT:  Two new collagen-based lidocaine-containing dermal fillers, ArteSense™/ArteFill™ (Artes Medical, San Diego, CA) and Evolence® (Colbar LifeScience Ltd., Herzliya, Israel), have proved to be of particular interest to men, many of whom seek a long-lasting or permanent correction. ArteFill™ has been available in the United States since 2006, and it is expected that Evolence® will reach the American market in 2008. The properties of the two products will be described, and experience based on the administration of many hundreds of syringes of both products by a Canadian dermatologist will be detailed here, with tips and precautions to optimize patient outcomes.     

Outcomes and adverse effects of ablative vs nonablative lasers for skin resurfacing: A systematic review of 1093 patients

It is generally believed that ablative laser therapies result in prolonged healing and greater adverse events when compared with nonablative lasers for skin resurfacing. To evaluate the efficacy of ablative laser use for skin resurfacing and adverse events as a consequence of treatment in comparison to other modalities, a PRISMA‐compliant systematic review (Systematic Review Registration Number: 204016) of twelve electronic databases was conducted for the terms “ablative laser” and “skin resurfacing” from March 2002 until July 2020. Studies included meta‐analyses, randomized control trials, cohort studies, and case reports to facilitate evaluation of the data. All articles were evaluated for bias. The search strategy produced 34 studies. Of 1093 patients included in the studies of interest, adverse events were reported in a total of 106 patients (9.7%). Higher rates of adverse events were described in nonablative therapies (12.2% ± 2.19%, 31 events) when compared with ablative therapy (8.28% ± 2.46%, 81 events). 147 patients (13.4%) reported no side effects, 68 (6.22%) reported expected, transient self‐resolving events, and five (0.046%) presented with hypertrophic scarring. Excluding transient events, ablative lasers had fewer complications overall when compared with nonablative lasers (2.56% ± 2.19% vs 7.48% ± 3.29%). This systematic review suggests ablative laser use for skin resurfacing is a safe and effective modality to treat a range of pathologies from photodamage and acne scars to hidradenitis suppurativa and posttraumatic scarring from basal cell carcinoma excision. Further studies are needed, but these results suggest that ablative lasers are a superior, safe, and effective modality to treat damaged skin.     

Multiple New-Onset Subcutaneous Nodules of the Upper Extremity Digits: Giant Cell Tumor of Tendon Sheath and Lipoma

A black woman with the concurrent onset of two subcutaneous nodules located on the digits of her upper extremities is described. Initially, a single systemic disorder was considered; yet, the lesions differed in morphology and consistency. Microscopic examination of the nodules showed a giant cell tumor of tendon sheath and a lipoma. Although Occam's “razor” suggests that multiple lesions in the same person are more likely to represent variable manifestations of a single disorder than several different diseases in that individual, the simultaneously appearing lesions in this patient represented two different conditions.     

Genetic alterations in RAS‐regulated pathway in acral lentiginous melanoma

Studies integrating clinicopathological and genetic features have revealed distinct patterns of genomic aberrations in Melanoma. Distributions of BRAF or NRAS mutations and gains of several oncogenes differ among melanoma subgroups, while 9p21 deletions are found in all melanoma subtypes. In the study, status of genes involved in cell cycle progression and apoptosis was evaluated in a panel of 17 frozen primary acral melanomas. NRAS mutations were found in 17% of the tumors. In contrast, BRAF mutations were not found. Gains of AURKA gene (20q13.3) were detected in 37.5% of samples, gains of CCND1 gene (11q13) or TERT gene (5p15.33) in 31.2% and gains of NRAS gene (1p13.2) in 25%. Alterations in 9p21 were identified in 69% of tumors. Gains of 11q13 and 20q13 were mutually exclusive, and 1p13.2 gain was associated with 5p15.33. Our findings showed that alterations in RAS‐related pathways are present in 87.5% of acral lentiginous melanomas.     

Medición del impacto psicológico en pacientes con psoriasis en tratamiento sistémico

Background and objectives

The negative impact of psoriasis on patient quality of life can be as important as the physical consequences of the disease. We could assume that clearance of the disease would also lead to an improvement in its psychosocial impact. The present study assesses the psychological state of patients with psoriasis receiving systemic treatment in a psoriasis unit, especially those with mild or no disease involvement.