Calcifying aponeurotic fibroma of the knee: A case report with radiological findings

Calcifying aponeurotic fibroma is a rare type of benign tumor that occurs most commonly in the distal extremities of young children. Due to its infiltrative growth, it has a high tendency of recurrence. Although the clinicopathological features of over 100 cases of this rare disease have been reported, its clinical and radiological features have yet to be described in detail. We present a case of calcifying aponeurotic fibroma of the knee from birth with radiological images, that demonstrate the peculiar features of this uncommon benign tumor and discuss its clinicopathological features based on computed tomography and magnetic resonance images.     

Diagnosis and management of nail psoriasis

Nail disease is a common chronic problem for psoriatics, with only limited scope for major improvement. Both the disease and its treatment can be categorized according to its features and treatment modalities or the significance of the therapy for the clinician and patient. Certain treatments are matched with certain features and some treatments are of potential value in all patients with nail psoriasis.     

Case of primary localized cutaneous amyloidosis with protean clinical manifestations: lichen, poikiloderma-like, dyschromic and bullous variants

Primary localized cutaneous amyloidosis (PLCA) commonly presents as macular and lichen variants. We present a case of a 27-year-old Chinese woman with cutaneous features of the rarely reported poikiloderma-like, dyschromic and bullous forms of PLCA, and the commoner lichen variant. There were no syndromic associations or systemic involvement, and the various morphological subtypes occurred in isolation from one another. We review the clinical spectrum of PLCA, highlight its protean clinical manifestations in this patient, and discuss its postulated pathogenesis in relation to its histopathological features.     

Solitary Piloleiomyoma with an Unusual Clinical Appearance

We present a 66-year-old man with a solitary piloleiomyoma on the forehead. The lesion had unusual clinical features; it was a crusted and dome-shaped nodule, which exhibited rapid growth. Histology revealed the typical features of piloleiomyoma. The unusual clinical features may have been due to its unique location, in which the downward growth of the tumor was prevented by the underlying frontal bone.     

Heterogeneity of blastomycosis‐like pyoderma: A selection of cases from the last 35 years

Blastomycosis‐like pyoderma is a form of pyoderma with variable clinical findings and histopathological features. We present a case series of 39 patients collected over a 35‐year period to demonstrate its clinical features and histological findings. The most common clinical presentations found were solitary plaques, solitary nodules, sinuses, crypts, verrucous plaques and discharge, usually on sun‐exposed skin. The most common histopathological findings were chronic granulomatous inflammation, suppurative inflammation, sinus and abscess formation, pseudoepitheliomatous hyperplasia, transepidermal elimination and scarring. We discuss its treatment and the recent literature that has focused on its response to acitretin.     

Progressive systemic sclerosis (scleroderma). First case report in a Nigerian.

The first case of progressive systemic sclerosis in a Nigerian is described. In addition to the typical features of the disease, the case shows affection of the peripheral nerves, a very rare complication. The latter led to a mistaken diagnosis of leprosy. The reasons for the rarity of this disorder in the indigenous Africans and its differentiating features from leprosy are discussed.     

Lupus erythematosus gyratus repens. Report of a case associated with a lung carcinoma

A 70-year-old male presented with a diffuse gyrate erythema with clinical and histological features suggestive of chronic lupus erythematosus. The lupus band test, however, was negative in both involved and uninvolved skin. The skin condition was finally found to be associated with a carcinoma of the lung. The features of lupus erythematosus gyratus repens and its possible relationship to underlying neoplasia are discussed.     

Lymphomatoid contact dermatitis due to ethylenediamine dihydrochloride

A case of contact sensitivity to ethylenediamine dihydrochloride is reported. The clinical and histological features were in keeping with early mycosis fungoides. The eruption cleared with avoidance of the allergen. Continued contact with the allergen was traced to its retention in a trouser pocket lining. The term "lymphomatoid contact dermatitis" should be confined to cases where the lymphomatoid features are due to a positively reacting allergen.     

麻风腓总神经及其分支损害的回顾性研究

麻风好侵犯腓总神经及其分支 ,导致感觉障碍 ,肌肉瘫痪等畸残 ,为了解腓总神经及其分支的受累情况 ,1997年至1999年间 ,我们对 2 75例麻风治愈病人进行了腓总神经及其分支损害的专项调查 ,现将有关资料分析如下 :1　材料和方法1 1　一般资料　对随机抽取的 4个乡镇和住院部的所有麻风病人以及处于ＭＤＴ监测期病人进行调查 ,计 2 75例 ,其中男199例 ,女 76例 ;型别ＬＬ 5 4例 ,ＢＬ 2 8例 ,ＢＢ 18例 ,ＢＴ 32例 ,ＴＴ 143例 ;年龄 18～ 92岁 ,平均 6 0 34± 12 0 6岁 ;麻风病期 1～ 5 0年 ,平均 7 86± 0 5 3年 ;住院病人 6 3例 ,院外病…     

Idiopathic Confetti-like leukoderma with unusual presentation

Idiopathic Confetti-like leukoderma in a young Indian is illustrated, emphasizing its cardinal clinical features and histopathological findings, and its differential diagnosis is briefly outlined for instant glance.     

Spectrum of Clinical Responses to Therapies in Infantile Bullous Pemphigoid

Infantile bullous pemphigoid (BP) is a rare autoimmune dermatosis characterized by the presence of antibodies against basal membrane zone proteins. Histologic and immunologic features are similar to those of the adult disease, but its clinical features may vary in children. We report here four cases of infantile BP whose atypical presentation or progression shed new light on the disease.     

Unusual cutaneous features of syphilis in patients positive for human immunodeficiency virus

Dermatologists commonly find it difficult to diagnose syphilis, because of its protean clinical features. In cases of co‐infection with human immunodeficiency virus (HIV) syphilis may present particularly unusual clinical features, further confounding the diagnosis. We report two cases of syphilis/HIV co‐infection in Japanese patients showing uncommon skin features that made the diagnosis of syphilis difficult. These cases underline the need for dermatologists to be more aware of atypical cutaneous features of syphilis in patients positive for HIV.     

A Case of Amelanotic Subungual Melanoma

Amelanotic subungual melanoma is a rare dermatosis, and it is frequently misdiagnosed probably because of its nonspecific clinical features. We herein report on a case of amelanotic subungual melanoma extended to the adjacent skin in a 36-year-old Korean woman. This case is interesting in that clinically, it needed differentiation from Bowen''s disease, lichen planus, sarcoidosis, etc. and very early invading features of the melanoma were observed on the histopathologic section.     

Congenital multiple fibromatosis

We present a case of congenital multiple fibromatosis to illustrate its characteristic clinical and histopathologic features. The importance of recognizing this disorder is emphasized because of its special clinical behavior and prognosis.     

种痘样水疱病样皮肤NK细胞淋巴瘤1例

目的:报告1例"面、躯干、四肢反复起丘疱疹伴发热6月"的8岁患儿的组织病理及免疫组织化学特征,探讨本病与EB病毒感染的关系,以求做出明确诊断.方法:进行组织病理学、免疫组化及EB病毒原位杂交等检查.结果:组织病理学显示真皮层皮肤附件及小血管周围异型淋巴细胞浸润.免疫组化显示真皮淋巴细胞LCA( + ),CD3( + ),CD45RO( + ),CD56( + ),TIA-1( + ),Ki67 (30%+).皮肤组织及外周血中检测到EB病毒基因.结论:种痘样水疱病淋巴瘤组织病理学特征通常是有小到中等大小的淋巴细胞浸润,没有明显的异型性和多形性.进一步检查包括免疫组化和EB病毒编码的RNA原位杂交检查对于早期诊断至关重要.     

Infantile hemangiopericytoma--case report and literature review

Infantile hemangiopericytoma is a rare soft tissue neoplasm of pericytic origin and is almost always benign, despite its worrisome pathologic features. We describe a 2-month-old male infant with a soft tissue mass on his right thigh. Histologically, the lesion showed a characteristic hemangiopericytoma-like vascular pattern, multilobulation, and moderate mitotic activity. These morphologic features were prediagnosed as infantile hemangiopericytoma. However, immunohistochemical and ultrastructural studies revealed a heterogeneous cellular composition, primarily pericytes and endothelial cells, similar to that observed in infantile myofibromatosis.     

FACE—facial Afro-Caribbean childhood eruption

Five cases of a distinctive facial eruption in Afro-Caribbean children are described. Distinctive features include monomorphic papules that are confined to the face, especially around the mouth, eyelids and ears, its greater prevalence in black children, and its tendency to persist for several months before spontaneous resolution. The aetiology of this condition is unknown and its importance lies in reassuring patients of the benign and purely cutaneous nature of the eruption.     

Sarcoidosis

Sarcoidosis is a disease of unknown etiology with protean manifestations. Its history is revealed in its many eponymic syndromes. The histologic features are nonspecific, as are most of the clinical manifestations. The diagnosis is made by exclusion. The immunologic abnormalities are fascinating, with features of both hyperactivity and depression. Therapy is nonspecific and generally symptomatic.     

Diagnosis and treatment of actinic prurigo

Actinic prurigo (AP) is an idiopathic photodermatosis that affects mainly the mestizo population in Latin America. It has an early onset, a slight predominance in women, and affects the sun-exposed areas of the skin, causing erythematous papules and lichenified plaques secondary to intense and chronic pruritus. Lesions can be induced by both ultraviolet A (UVA) and ultraviolet B (UVB). An association with several human leukocyte antigen (HLA) alleles has been reported. AP is unique among all photodermatoses in its remarkable response to thalidomide. In the past the microscopic features of AP have been considered as nonspecific; however, the constant finding of dense lymphocytic inflammatory infiltrates and the immunogenetic features of AP support the existence of an immunologic mechanism in its pathogenesis.