共查询到20条相似文献，搜索用时 687 毫秒
1.
Objective
To observe the clinical efficacy of acupuncture–moxibustion therapy of "banking up original qi and consolidating the foundation" for prevention and treatment of seasonal allergic rhinitis.Methods
Sixty included patients were divided into two groups according to the random number table method with 30 patients in each group. In acupuncture group, warming-needle moxibustion was carried out at Zúsānl? (足三里ST 36), and cone moxibustion on Fùz? (附子Radix Aconiti Lateralis Praeparata) cake was conducted at Guānyuán (关元CV 4), Qìh?i (气海CV 6) and Dàzhuī (大椎GV 14). The treatment was conducted in May or June (2 months before the onset of rhinitis in this area). The treatment was carried out for once every other day and three times per week. Treatment for 24 times was considered as 1 course of treatment. No intervention treatment was conducted in control group. The score of rhinitis symptom, the visual analogue scale (VAS) score changes of total nasal symptom score (TNSS) and total non-nasal symptom score (TNNSS) of patients in 2015 and in 2016 were observed, and the clinical efficacy of the two groups was compared.Results
(1) The score of rhinitis symptom, the VAS score changes of TNSS and TNNSS in acupuncture group in 2016 declined when compared with the results in 2015, which were 4.57?±?0.82?vs 9.40?±?1.89, 13.37?±?4.01?vs 30.80?±?4.77 and 15.93?±?6.30?vs 46.13?±?9.79 (P?<?0.001), the results in acupuncture group after treatment were lower than that in control group at same time, which were 4.57?±?0.82?vs 7.53?±?2.06, 13.37?±?4.01?vs 27.17?±?6.84,15.93?±?6.30?vs 35.53?±?11.69(all P?<?0.001). According to comparison, there was no obvious difference in the results in control group at the two time points, which were 8.60?±?2.39?vs 7.53?±?2.06, 29.63?±?6.30?vs 27.17?±?6.84 and 40.90?±?12.31?vs 35.53?±?11.69 (all P?>?0.05). (2) The total effective rate was 96.7% (29/30) in acupuncture group and 10% (3/30) in control group, and the difference was statistically significant (P?<?0.001).Conclusion
Acupuncture–moxibustion therapy of "banking up original qi and consolidating the foundation" was effective on prevention and treatment of seasonal allergic rhinitis. 相似文献2.
Xiumi YOU Juan YANG Jinbang XU Ying LIU Jian HUANG Qiuping LIN Junxin ZHANG Jingjing DUN Shan HUANG 《世界针灸杂志》2018,28(1):25-28
Objective
To explore the effect of warming-needle moxibustion on the endometrial thickness and pregnancy outcome.Methods
Forty infertility women, selected from those who visited the TCM department of Maternity and Child Care Centers in Fujian Province from October 2015 to October 2016, were enrolled in this study. These women had mature follicle and successful ovulation according to B ultrasound monitoring, but their endometrial thickness was thinner than 7?mm. The women were divided into warming-needle moxibustion group (group A, 20 cases) and medication group (group B, 20 cases). In group A, acupuncture, warming-needle moxibustion and electroacupuncture were conducted at different clinical stage. In group B, progynova was given to the patients from the 7th day of menstruation to the 14th day after ovulation (2 tablets, bid oral administration in the morning and evening). The treatment lasted for 3 menstrual cycles, and the endometrial thickness changes and pregnancy rate of the patients in the two groups were compared after treatment.Results
The endometrial thickness of patients in the two groups increased after treatment when compared with the thickness before treatment. The average endometrial thickness in group A increased from (5.23?±?1.57) mm before treatment to (8.31?±?2.80) mm after treatment, while the average endometrial thickness in group B increased from (5.27?±?0.99) mm before treatment to (8.32?±?1.97) mm after treatment, and the differences were statistically significant (both P?<?0.05). The increase of endometrial thickness of the patients in group A after treatment was slightly larger than that in group B, and the difference was not statistically significant (P?>?0.05). After treatment for 3 menstrual cycles, the pregnancy rate of infertility women in group A was 25%(5/20) and 15%(3/20) in group B.Conclusion
Warming-needle moxibustion can increase the endometrial thickness to a certain extent, thus improving the endometrial receptivity, enhancing the embryo implantation rate, and improving the pregnancy outcome. 相似文献3.
Juan WANG Yan LI Xuan ZHANG Mei-na WANG Long CAO Na NU Yuan LI Gui-lan LI 《世界针灸杂志》2018,28(4):287-290
Objective
To observe the clinical effects on simple obesity treated with the combined therapy of penetration needling, flash-fire cupping method and auricular acupuncture.Methods
In 90 patients of simple obesity, the Bo's abdominal acupuncture therapy was adopted. Taking Shénquè (神阙 CV 8), the points 2 cun directly below CV 8 and 2 cun directly above CV 8 as the landmarks, 3 cun bilateral to each of the above three points, and penetrated through to the conception vessel. Then the electroacupuncture apparatus was connected, with the disperse-dense wave for 30?min. After acupuncture, the glass cup of the middle size was used to stimulate the selected points with the flash-fire cupping method. The cupping stimulation stopped when the skin turned to be slightly red. One treatment was given each day and every other day after 5 days. The 10 treatments made one course. In the auricular acupuncture therapy, Jīdi?n (饥点), Shénmén (神门TF4), Nèifēnmì (内分泌CO18) and Sānjiāo (三焦 CO17) were selected. The auricular acupuncture therapy was given once every two days and 10 treatments made one course. After 3 courses of treatment, the waist circumference, hip circumference, body weight and body mass index (BMI) were observed.Results
Compared to before treatment, after 3 courses of treatment, the waist circumference of patients was (92.3?±?2.4?vs 80.4?±?2.3) cm, hip circumference (110.6?±?2.3?vs 99.2?±?2.5) cm, body weight (74.2?±?3.1?vs 68.2?±?2.4) kg and BMI (29.8?±?3.1?vs 25.2?±?2.1), they were all reduced obviously, indicating the significant differences (all P?<?0.05). Seventy-nine patients lost three to five kilograms, accounting for 87.8%.Conclusion
The combined therapy of penetration needling at abdomen, flash-fire cupping method and auricular acupuncture achieves the significant therapeutic effects on simple obesity. 相似文献4.
Ze-qin REN Xu YUAN Rong ZHAO Jin-long XU Ze-guan YANG Jian AI Zhi-xiong ZUO Ding-jun CAI 《世界针灸杂志》2018,28(3):161-166
Objective
To test the neural electrophysiological basis of acupuncture treatment on attention deficit of insomnia patients.Methods
Thirty insomnia attention deficit patients were enrolled as the patient group in this study, and 30 normal people were collected as the normal group as the compare. In patient group, acupuncture was adopted and the acupoints were Bǎihuì (百会 GV20), Shéntíng (神庭 GV24), Sìshéncōng (四神聪 EX-HN1), Shénmén(神门 HT7) and Sānyīnjiāo(三阴交 SP6), even reinforcing and reducing method, once a day, 10 times as a course and totally 2 courses. There was no intervention for the normal group. Pittsburg Sleep Quality Index (PSQI) for assessing the sleep quality, Schulte grid scale and the event-related potential (ERP) for assessing the attention deficit were evaluated before the treatment, 10 days after the treatment and after the treatment. The normal group were taken evaluation at the same time point.Results
1. PSQI. The PSQI score in the patient group before the treatment was (16.20?±?2.02) and was (4.20?±?1.64) after the treatment. The difference was statistically significant (P?<?0.05). The normal group was (4.00?±?1.52) at the same point after the treatment, and the differences was not statistically significant (P > 0.05). 2. Schulte grid scale. The Schulte grid scale rating score was decrease from (32.87?±?6.71) s before the treatment to (12.82?±?3.40) s after the treatment, and the difference was statistically significant (P?<?0.05). The normal group was (12.29?±?3.47) s at the same point after the treatment, and the differences was not statistically significant (P > 0.05). 3. ERP. (1) P300: in the patient group, the latency of P3a decreased from (316.60?±?18.42) ms before the treatment to (300.10?±?12.03) ms after the treatment; the latency of P3b decreased from(328.32?±?16.32) ms before the treatment to (304.63?±?13.248) ms after the treatment; the amplitude of P3a increased from (5.501.16) μV before the treatment to (15.20?±?2.12) μV after the treatment; the amplitude of P3b increased from(5.76?±?1.87) μV before the treatment to (16.76?±?2.37) μV after the treatment, and the differences were statistically significant (all P?<?0.05). (2) CNV: in the patient group, the latency of point A decreased from (404?±?129) ms before the treatment to (369?±?105) ms after the treatment; the latency of point C decreased from (2584?±?563) ms before the treatment to (2308?±?369) ms after the treatment; the amplitude of A-B increased from (10.3?±?17.4) μV before the treatment to (13.7?±?24.8) μV after the treatment, and the differences were statistically significant (all P?<?0.05).Conclusion
Acupuncture can improve the sleep quality and the attention deficit condition of insomnia attention deficit patients by regulating the nerve electrophysiology of the brain. 相似文献5.
目的：研究桑白皮（Morus alba）的化学成分及其α-葡萄糖苷酶抑制和DPPH自由基清除活性方法：采用硅胶、凝胶柱色谱和制备HPLC等方法进行分离纯化,通过高分辨质谱和核磁鉴定化合物结构结果：从桑白皮提取物中分离得到了13个化合物,其中化合物1,3和8表现出显著的α-葡萄糖苷酶抑制活性,IC50值分别为147.1 ± 1.1,314.1 ± 0.8和207.6 ± 0.1 µM,均低于阳性对照阿卡波糖（418.6 ± 0.1 µM）。化合物10和11均表现出良好的DPPH自由基清除活性,EC50值分别为2.9 ± 0.1和5.0 ± 0.1 µM,均低于阳性对照维生素C的EC50值（54.8 ± 0.1 µM)结论：化合物1、3和8的α-葡萄糖苷酶抑制活性为首次测定。 相似文献
6.
Pei WANG Cai-rong ZHANG De-chun CHEN Ke-qing ZHUANG Zhi-lan HUANG Can DONG Han-qing HONG Zhi-zhong RUAN 《世界针灸杂志》2018,28(4):246-250
Objective
To compare the clinical efficacy differences of acupotomy therapy guided by the meridian sinew theory and acupotomy therapy guided by the anatomy theory of western medicine in the treatment of knee osteoarthritis.Methods
Sixty-three patients were randomly divided into the acupotomy group of the meridian sinew theory (Group A, n?=?32) and the acupotomy group of the anatomy theory (Group B, n?=?31). For Group A, with positive reaction points such as the tenderness points of three yang meridians and three yin meridians of the foot, and funicular nodules as the points of needle insertion, the needle-knife, after disinfection and anesthesia, gives priority to longitudinal dissection after insertion, and then carries out subcutaneous sweeping maniplation. For Group B, with 8 points for needle insertion, including the origins and terminations of the medial and lateral collateral ligaments, the origins and terminations of the patellar ligament, the terminations of the quadriceps femoris tendon, and pes anserinus bursa point, the treatment was performed in strict accordance with the four-step procedures of acupotomy (positioning, orientating, pressurizing to separate, and puncturing) after disinfection and anesthesia. The treatment was conducted once a week and three times in total. Statistical analysis was conducted with the Western Ontario and McMaster Universities (WOMAC) Osteoarthritis Index and Visual Analogue Scale (VAS) for overall pain before treatment and at week 2 and 4 during treatment, and the adverse reactions of patients were observed and recorded to evaluate the curative effect.Results
During the treatment period, the overall response rates (ORRs, that is markedly effective?+?effective) were compared between the two groups. The ORR of Group A was 90.63% and that of Group B was 87.09%. There was no statistical significant difference between the two groups (P?>?0.05). After treatment, the WOMAC function score of Group A was significantly lower than that before treatment (17.28?±?10.22?vs 32.75?±?14.88, P?<?0.001), and that of Group B was lower than that before treatment (24.87?±?16.48?vs 30.90?±?16.64, P?<?0.05), there was a statistical significant difference between the two groups (P?<?0.05). As for the comparison of VAS pain scores, in Group A, there was statistical significant difference (4.48?±?1.60?vs 5.05?±?1.60, P?<?0.05) between at Week 2 and before treatment, and statistically significant difference (1.88?±?1.03?vs 5.05?±?1.60, P<0.001) between at Week 4 and before treatment. In Group B, there was no significant difference (P>0.05) between at Week 2 and before treatment, and there was statistically significant difference (3.31?±?1.56?vs 4.77?±?1.68, P<0.001) between at Week 4 and before treatment. The VAS pain score of Group A was significantly lower than that of Group B (P?<?0.001), and 2 cases of mild adverse reactions occurred in Group A and 3 in Group B.Conclusion
Both acupotomy therapies guided by the meridian sinew theory and by the anatomy theory of Western medicine have good curative effect on knee osteoarthritis, but acupotomy guided by the meridian sinew theory has more superiorities in operability, safety and effectiveness, which is easy to be generalized in grass-roots and community hospitals. 相似文献7.
Xiao-xue SUN Li-yun YANG Yu-lei LIANG Xin-hua LI Fei GAO Xiao-yi DU Xiao-hong ZHOU Yang CHEN Xue-na LI Li-hong SUN 《世界针灸杂志》2018,28(2):103-108
Objective
To observe the differences in analgesic effect of moxibustion at different intervention times on dysmenorrhea rats and explore its effect mechanism.Methods
Forty-five female Wistar rats were randomly divided into blank control group (group A), model group (group B), pre-moxibustion group (group C), instant moxibustion group (group D) and pre-instant moxibustion group (group E), with 9 rats in each group. Cold-damp coagulation and stagnation type dysmenorrhea models were established. In group C, mild moxibustion on “Shénquè (神阙 CV 8) ” and “Guānyuán (关元 CV 4)” was carried out from the time after modeling on the 8th day for 3 consecutive days. In group D, mild moxibustion was given as the same methods with group C after injection with oxytocin on the 11th day. In group E, mild moxibustion was given as the same methods from the time after modeling on the 8th day to that after injection with oxytocin on the 11th day for 4 consecutive days. The writhing behavior and the changes in levels of ET-1 and NO in uterine tissues of rats with dysmenorrhea in each group were observed.Results
Comparison of the latent period: compared with (4.38?±?1.06) min in group B, the latent period of rats in group C (9.67?±?1.32) min, group D (11.78?±?1.30) min and group E (15.00?±?1.22) min obviously prolonged (all p < 0.01). Compared with group C, the latent period of group E obviously prolonged (p < 0.01). Compared with group D, the latent period of group E obviously prolonged (p < 0.01).Comparison of the writhing times: compared with (4.38?±?1.06) in group B, the writhing times of rats in group C (9.67?±?1.32), group D (11.78?±?1.30) and group E (15.00?±?1.22) reduced (all p < 0.01). Compared with group C, the writhing times of rats in group D and group E reduced (both p < 0.01). Compared with group D, the writhing times in group E reduced (p < 0.05). Comparison of the total writhing score: compared with (4.38?±?1.06) in group B, the total writhing score of rats in group C (9.67?±?1.32), group D (11.78?±?1.30) and group E (15.00?±?1.22) decreased (all p < 0.01). Compared with group C, the total writhing score of rats in group D and group E decreased (both p < 0.01). Compared with group D, the total writhing score of rats in group E decreased (p < 0.05). Comparison of ET-1 level: compared with (4.80?±?0.47) in group A, the ET-1 level in uterine tissues of rats in group B (7.57?±?0.69) significantly increased (P < 0.01). Compared with group B, the ET-1 level in uterine tissues of rats in group C (6.20?±?0.50), group D (5.67?±?0.29) and group E (5.16?±?0.33) obviously decreased (all p < 0.01). Compared with group C, the ET-1 level in uterine tissues of rats in group D and group E obviously decreased (p < 0.05, p < 0.01). Compared with group D, the ET-1 level in uterine tissues of rats in group Eobviously decreased (p < 0.05). Comparison of NO level: compared with (6.63?±?1.83) in group A, the NO level in uterine tissues of rats in group B (1.62?±?0.58) significantly decreased (p < 0.01). Compared with group B, the NO level in uterine tissues of rats in group C (3.60?±?0.59), group D (4.77?±?0.67) and group E (5.99?±?0.63) obviously increased (all p < 0.01). Compared with group C, the NO level in uterine tissues of rats in group Dand group E obviously increased (p < 0.05, p < 0.01). Compared with group D, the NO level in uterine tissues of rats in group E obviously increased (p < 0.01).Conclusion
The analgesic effect of mild moxibustion at different intervention times on cold-damp coagulation and stagnation type dysmenorrhea rats was different, which was the most significant in pre-instant moxibustion group. One of the mechanisms of action may be related with the adjustment of abnormal levels of ET-1 and NO. 相似文献8.
Objective
To observe the clinical therapeutic effects on acne treated with the combined therapy of acupuncture, cupping and circling moxibustion.Methods
At the ratio of 4:3, a total of 70 patients were randomized into an acupuncture-cupping group (40 cases) and a western medication group (30 cases). In the acupuncture-cupping group, acupuncture was used in combination with cupping and circling moxibustion. The therapy was given once every other day for totally 30 days. In the western medication group, the routine medication of minocyline capsules was prescribed, 2 times per day and 30 days were in total.Results
After the treatment, the total effective rates were 95.00% and 76.67% in the acupuncture-cupping group and the western medicine group respectively, indicating the significant difference in statistic (P?<?0.05). In the acupuncture-cupping group, the therapeutic effect was the best for the cases differentiated as heat accumulation in the lung and stomach and the total effective rate was 100%. It was 71.43% for the type of damp-heat of the intestine and stomach and was 70.00% for phlegm-damp stagnation.Conclusion
Acupuncture combined with cupping and circling moxibustion achieves the superior clinical therapeutic effects as compared with minocyline. This therapy deserves to be promoted in clinical practice. 相似文献9.
Objective
To explore the therapeutic effects of scalp acupuncture on sleep disorder induced by pre-examination anxiety in the undergraduates.Methods
A total of 60 undergraduates with sleep disorder induced by the final examination anxiety were randomized into three groups, named a control group (20 cases), a traditional acupuncture group (20 cases) and a scalp acupuncture group (20 cases). In the control group, no any treatment was given. In the traditional acupuncture group, acupuncture was given at Sìshéncōng (四神聪EX-HN1), bilateral Shénmén (神门HT 7) and bilateral Sānyīnjiāo (三阴交SP 6). The needles were manipulated with the even-needling technique and retained for 30?min. In the scalp acupuncture group, acupuncture was applied to upper-middle line of occiput (枕上正中线MS 12), middle line of vertex (顶中线MS 5) and middle line of forehead (额中线MS 1). The needles were manipulated with the even-needling technique and retained for 30?min. The treatment was given once a day and 5 treatments made one course. There were 2 days at interval among the courses. The therapeutic effects were analyzed statistically after 4 courses of treatment. Before and after treatment, the Hamilton anxiety scale (HAMA) and the Pittsburgh sleep quality index (PSQI) were adopted to evaluate the conditions of pre-examination anxiety and sleep in the patients.Results
In comparison of PSQI score, compared with those before treatment, the score in the scalp acupuncture group (12.95?±?1.76?vs 15.95?±?1.82) and in the traditional acupuncture group (13.75?±?1.62?vs 15.75?±?1.86) after 1-week of treatment were reduced (both P?<?0.05). Compared with control group, the score in the scalp acupuncture group (12.95?±?1.76 vs15.78?±?2.02) and in the traditional acupuncture group (13.75?±?1.62?vs 15.78?±?2.02) were better (both P?<?0.05). The difference was not significant between the scalp acupuncture group and the traditional acupuncture group (P?>?0.05). In 2 and 4 weeks of treatment, as well as 1 week after treatment termination, compared with the control group at the same time point, the scores in the scalp acupuncture group (in 2-week treatment: 8.95?±?1.88?vs 15.94?±?1.89, in 4-week treatment: 5.95?±?1.05?vs 16.5?±?1.95, 1 week after treatment termination: 4.7?±?0.77?vs 9.78?±?2.10) and the traditional acupuncture group (in 2-week treatment: 11.15?±?1.31?vs 15.94?±?1.89, in 4-week treatment: 8.05?±?0.89?vs 16.5?±?1.95, 1 week after treatment termination: 6.25?±?0.85?vs 9.78?±?2.10) were all lower (all P?<?0.05) separately. The scores in the scalp acupuncture group were superior to the traditional acupuncture group (all P?<?0.05). In comparison of HAMD score, compared with those before treatment, the score in the scalp acupuncture group (22.4?±?5.31?vs 25.2?±?6.18) and in the traditional acupuncture group (22.4?±?5.31?vs 25?±?5.97) after 1-week of treatment were reduced (both P?<?0.05). Compared with control group, the score in the scalp acupuncture group (22.4?±?5.31?vs 23.28?±?5.53) and in the traditional acupuncture group (22.4?±?5.31?vs 23.28?±?5.53) were better (both P?<?0.05). The difference was not significant between the scalp acupuncture group and the traditional acupuncture group (P?>?0.05). In 2 and 4 weeks of treatment, as well as 1 week after treatment termination, compared with the control group at the same time point, the scores in the scalp acupuncture group (in 2-week treatment: 18.5?±?4.56?vs 24.22?±?5.22, in 4-week treatment: 5.8?±?3.52?vs 21.22?±?6.7,1 week after treatment termination: 4.55?±?2.72?vs 11.78?±?9.36) and the traditional acupuncture group (in 2-week treatment: 17.5?±?4.59?vs 24.22?±?5.22, in 4-week treatment: 6.95?±?3.33?vs 21.22?±?6.7, 1 week after treatment termination: 5.8?±?2.76?vs 11.78?±?9.36) were all lower (all P?<?0.05) separately. The scores in the scalp acupuncture group were superior to the traditional acupuncture group (all P?<?0.05). In 4-week treatment and 1 week after treatment termination, compared with control group, the total effective rates in the traditional acupuncture group (in 4-week treatment: 95% vs 11%, 1 week after treatment termination: 100% vs 83.33%, both P?<?0.05) and the scalp acupuncture group (in 4-week treatment: 95% vs 11%, 1 week after treatment termination: 100% vs 83.33%, both P?<?0.05) were better and the difference was not significant between the traditional acupuncture group and the scalp acupuncture group (both P?>?0.05).Conclusion
Both scalp acupuncture and traditional acupuncture therapies are effective on sleep disorder induced by pre-examination anxiety in the undergraduates. The scalp acupuncture therapy achieves the better effects on the instant relief of symptoms. 相似文献10.
Fei-yi ZHAO Zhe-yuan ZHANG Ying-xia ZHAO Hai-xia YAN Yu-fang HONG Xiao-jie XIA Hong XU 《世界针灸杂志》2018,28(4):231-236
Objective
To investigate if electroacupuncture (EA) preconditioning can mitigate cognitive impairments and reduce the incidence of postoperative cognitive dysfunction (POCD) following knee replacement and its safety among elderly.Methods
Totally 60 participants met the inclusion criteria were enrolled in a randomized controlled trial a ratio of 1:1, with 30 cases allocated to the treatment group and 30 cases allocated to the control group, respectively. The participants in the treatment group were provided with real-EA therapy whereas participants in control group were provided with placebo-EA therapy (Streitberger Placebo-needle). In both groups, Tou sanshen (头三神) acupoints, including Sìshéncōng (四神聪EX-HN1), Shéntíng (神庭 GV24), and bilateral Běnshén (本神GB13) were adopted as the main acupoints, while Bǎihuì (百会GV20), bilateral Hégǔ (合谷LI4), and bilateral Tàichōng (太冲LR3) were adopted as matching acupoints. Interventions were offered 5 days prior to the surgery, once daily, and continued for total 5 days. The global scores of Mini-Mental State Examination (MMSE), and levels of serum inflammatory cytokines including interleukin 1β (IL-1β) and tumor necrosis factor-α (TNF-α), and S100-β protein were observed at 24 h prior to the surgery, and postoperative 24 and 72 h respectively for assessing the incidence of POCD and the severity of cognitive impairments among patients. Meanwhile, adverse effects were monitored and recorded.Results
(1) Compared with baseline, MMSE global scores in both treatment and control groups markedly decreased at postoperative 24 h. MMSE global scores in treatment group decreased from 29.43?±?0.97 to 27.10?±?1.95 while that in control group decreased from 29.27?±?1.01 to 26.83?±?2.25 (all ?P?<?0.05), and this trend continued until postoperative 72 h (at postoperative 72 h, MMSE global scores in treatment group was 26.53?±?2.26 versus 24.79?±?3.03 in control group). Moreover, decline in control group was more significant than that in treatment group at postoperative 72 h (P?<?0.05). (2) Compared with baseline, levels of serum IL-1β, TNF-α and S100-β in both groups increased markedly at postoperative 24 and 72 h. IL-1β in treatment group increased from 43.13?±?5.51 to 73.13?±?2.32 at postoperative 24 h and reached 83.17?±?5.95 at postoperative 72 h, while IL-1β in control group increased from 44.87?±?5.83 to 91.10?±?3.55 at postoperative 24 h and reached 111.93?±?9.18 at postoperative 72 h; TNF-α in treatment group increased from 51.27?±?6.48 to 88.80?±?3.55 at postoperative 24 h and reached 94.37?±?5.22 at postoperative 72 h, while TNF-α in control group increased from 52.07?±?7.48 to 116.37?±?3.14 at postoperative 24 h and reached 121.40?±?3.68 at postoperative 72 h (both ?P?<?0.05), furthermore, increases of IL-1β and TNF-α levels in control group were more significant (P?<?0.05). Statistical difference in level of S100-β was not observed (P?>?0.05). (3) There was no statistical difference in POCD incidence at postoperative 24 h and postoperative 72 h between two groups (P?>?0.05), though the incidence of POCD in patients receiving real-EA therapy was indeed much lower than that in patients receiving placebo-EA therapy, particularly at postoperative 72 h (POCD incidence rate at postoperative 24 h in treatment group was 26.67%, 30.00% in control group; POCD incidence rate at postoperative 72 h in treatment group was 30.00%, 46.67% in control group). (4) No serious adverse events were reported in this trial. No one dropped out from this trial.Conclusion
EA preconditioning can mitigate cognitive impairments at post-knee replacement surgery 24 and 72 h in elderly through inhibiting expression of inflammation. However, there is insufficient evidence to support that EA pretreatment can reduce the incidence of POCD. 相似文献11.
目的 侵袭性肺念珠菌感染发病率高、治疗棘手、预后差、死亡率高,研究桂皮醛对白念珠菌细胞壁(1, 3)-β-D-glucans的影响,为研发新型靶向抗真菌药物提供依据。方法 对免疫抑制BALB/c小鼠经鼻腔灌注1x107 cfu/ml 50ul白念珠菌菌悬液,口服桂皮醛240mg.kg-1. d-1,连续14d后,取肺组织标本进行 (1, 3)-β-D-glucans测定及透射电镜观察,以氟康唑为对照。结果 肺组织 (1, 3)-β-D-glucans（1160.62±89.65 pg/ml）,氟康唑对照组（4285.87±215.62 pg/ml）,两组之间对比较P＜0.01有统计学差异。肺组织电镜显示, 白念珠菌细胞壁外2-3层（1,3）-β-D葡聚糖层,胞壁溶解脱落,导致胞壁严重缺损,但细胞膜清晰、完整。结论 桂皮醛对肺白念珠菌细胞壁（1, 3）- β-D-glucans具有显著影响,但细胞膜不受影响。说明,桂皮醛有独特的抗白念珠菌细胞壁(1, 3)-β-D -glucans效应。 相似文献
12.
Qiong LIU Wei ZHU Mailan LIU Xia LIU Jianan CAO Shuning HU Xiaorong CHANG Xianghong JING 《世界针灸杂志》2018,28(4):257-262
Objective
To observe the influence of acupuncture stimulus and thermal stimulus on the expression of mast cells (MCs) and 5-hydroxytryptamine (5-HT) in local acupoint area of Guānyuan (关元 CV 4) and serum 5-HT in rats.Methods
Thirty-nine male C57BL/6 rats were randomly divided into blank control group, acupuncture stimulus group and thermal stimulus group, with 13 rats in each group. The rats were stimulated by manual acupuncture at CV 4 for 5?min in acupuncture stimulus group, while those in thermal stimulus group were stimulated by adopting a thermal moxibustion apparatus on CV 4 for 30?min. The expression of MC and 5-HT in the skin in the acupoint area of CV 4 before and after acupuncture stimulus and thermal stimulus was observed and analyzed via adopting toluidine blue staining method and immunofluorescence histochemical method (5 rats were selected from each group), and the 5-HT content in serum before and after stimulus was determined through enzyme-linked immunosorbent assay (ELISA) (8 rats were selected from each group). The influence of acupuncture stimulus and thermal stimulus on the contents of MC and 5-HT in the skin and serum 5-HT in rats was analyzed and compared.Results
① After acupuncture stimulus or thermal stimulus on CV 4 of C57BL/6 rats, the number of MC in the acupoint area significantly increased when compared with that in blank group (the acupuncture stimulus group 12.40?±?2.07 vs. the blank group 3.00?±?5.96; thermal stimulus group 26.20?±?10.85 vs. the blank group 12.40?±?2.07, both P?<?0.05), and MC aggregation and degranulation were observed (the acupuncture stimulus group 17.80?±?4.55 vs. the blank group 8.00?±?3.16; the thermal stimulus group 24.00?±?9.05 vs. the blank group 8.00?±?3.16, P?<?0.05, P?<?0.01). ② After acupuncture stimulus or thermal stimulus, 5-HT was released by MCs in the acupoint area, which aggregated around the blood vessels, and the number of 5-HT in the acupoint area significantly increased when compared with that in blank group (the blank group 3.00?±?1.28 vs. the acupuncture stimulus group 10.02?±?3.21; the blank group 3.00?±?1.28 vs. the thermal stimulus group 14.00?±?3.94, both P?<?0.01). ③ Compared with blank group, both acupuncture stimulus and thermal stimulus could reduce the 5-HT content in serum (the blank group 0.72?±?0.2372 vs. acupuncture stimulus group 0.43?±?0.21; the blank group 0.72?±?0.24 vs. thermal stimulus group 0.32?±?0.18, both P?<?0.01), and the effect in thermal stimulus group was slightly superior to that in acupuncture stimulus group (P?<?0.05).Conclusion
Both acupuncture stimulus and thermal stimulus can cause the aggregation and degranulation of MCs and high expression of 5-HT in the acupoint area. The effect of thermal stimulus was superior to that of acupuncture stimulus in degranulation. 相似文献13.
目的 制备共同时递送紫杉醇-油酸前药(PTX-OA)和鸦胆子油(BJO)的分子配型纳米乳制剂(CMNEs)。方法 对基于分子配型组装技术的紫杉醇-油酸/鸦胆子油纳米乳制剂体外对HepG2细胞的抑制、细胞周期、细胞凋亡和体内抑制裸鼠肿瘤生长的评价。结果 紫杉醇-油酸/鸦胆子油纳米乳（PTX-OA/BJO CMNEs）粒径为108.7 2.3 nm,包封率> 95%。PTX-OA/BJO CMNEs对HepG-2细胞的毒性作用有浓度和时间依赖性,细胞周期试验表明PTX-OA/BJO CMNEs增加了G2/M期阻滞。注射PTX-OA/BJO CMNEs后的裸鼠模型中,对比注射生理盐水组,裸鼠肿瘤体积明显减少 (P<0.05),表明PTX-OA/BJO CMNEs在体内有很好抗肿瘤效果。进一步研究发现,PTX-OA/BJO CMNEs的抗肿瘤作用增强与诱导肿瘤细胞凋亡的能力有关,尤其是PTX-OA/BJO CMNEs可明显抑制肿瘤细胞的增殖和TOPO II的活性。结论 不同机制的两种药物联合给药能同时阻断不同的抗癌途径,从而提高治疗反应,降低毒性。 相似文献
14.
Jiang-yun WU Yi-ni SUN Qing-chen ZHOU Lei WANG Zhi-hong WEN Xue-si HOU Shu-han QU Yi-fan JIA Ji-ping ZHAO 《世界针灸杂志》2018,28(3):204-208
Objective
To explore the tenderness response at the acupoints on the medial crus in the patients of pelvic inflammatory disease.Methods
A total of 30 patients of pelvic inflammation and 30 healthy people were included. WAGNER FDX body mechanics algometer was used to determine the score of the visual analogue scale (VAS) and tenderness threshold value at Yīnlíngquán (阴陵泉 SP 9), Sānyīnjiāo (三阴交SP 6) and Lígōu (蠡沟 LR 5). The changes in the tenderness on the body surface at the relevant acupoints were compared and analyzed in the patients of pelvic inflammation.Results
The occurrence rate of tenderness at LR 5 at the pelvic inflammation group was higher significantly than the health group (86% Vs 42%, P<0.01). In SP 9, SP 6 and LR 5,the VAS scores at the acupoints in the pelvic inflammation group were higher significantly than the health group (test 1:55.00?±?15.12 vs 27.25?±?10.31, 47.07?±?18.38 vs 29.75?±?14.30, 47.16?±?19.4 vs 20.16?±?10.76; test 2:53.40?±?17.23 vs 33.42?±?13.07, 45.95?±?15.74 vs 29.15?±?11.97, 42.50?±?21.67 vs 21.05?±?11.97; test 3: 48.50?±?14.97 vs 40.08?±?13.20, 38.24?±?15.29 vs 29.29?±?12.37, 37.93?±?19.17 vs 23.09?±?12.26) , P?<?0.01, P?<?0.05 .In SP 9, SP 6 and LR 5,the tenderness threshold values at the acupoints in the pelvic inflammation group were higher significantly than the health group (test 1:0.86?±?0.95 vs 0.53?±?0.39, 0.86?±?0.95 vs 0.53?±?0.39, 0.85?±?0.77 vs 0.47?±?0.47; test 2:0.88?±?0.81 vs 0.44?±?0.32, 0.98?±?0.83 vs 0. 44?±?0. 32, 0.85?±?0.77 vs 0.47?±?0.47; test 3:0.98?±?0.80 vs 0.36?±?0.26, 1.11?±?0.92 vs 0. 36?±?0. 26, 0.85?±?0.77 vs 0.47?±?0.47), P?<?0.01, P?<?0.05 (P?<?0.05).Conclusion
The VAS scores and tenderness threshold values at SP 9, SP 6 and LR 5 in the patients of pelvic inflammation are higher significantly than those in the healthy people. The occurrence rate of tenderness at LR 5 is higher significantly as compared with the healthy people. 相似文献15.
目的 采用响应面法优化石榴皮多糖的酶法提取工艺,并对石榴皮多糖体外抗氧化活性进行研究,为药物制剂和功能性食品寻找新的生物成分。方法 采用RSM Box-Behnken设计法,考察酶解时间、液料比、加酶量对石榴皮多糖提取率的影响。用酶标仪测定DPPH自由基清除作用、羟自由基清除作用、超氧阴离子自由基清除活性和还原力测定。结果 最佳提取条件为：酶解温度为55℃,pH为5,酶解时间为88 min,液料比为22:1mL/g,加酶量为0.93%。在最佳提取条件下,石榴皮多糖得率为（22.31±0.07）%,与Box-Behnken设计模型的预测值22.35%很好地吻合。石榴皮多糖对DPPH（1,1-二苯基-2-吡啶基肼）自由基清除、羟自由基清除、超氧阴离子自由基清除和还原能力有明显的抗氧化作用。结论 建议采用优化的酶解辅助方法提取石榴皮多糖,该法制得的石榴皮多糖可作为一种良好的抗氧化剂。 相似文献
16.
Objective
To observe the clinical therapeutic effects on entrapment syndrome of superficial radial nerve treated with the short thrust needling at Shànglián (上廉LI 9).Methods
A total of 52 patients of entrapment syndrome of superficial radial nerve were treated with the short thrust needling at LI 9. Firstly, the needle was inserted gradually and deeply until the needle tip touched the radial periosterum. Secondly, the needle body was tilted to form an angle about 30° with the skin surface. Thirdly, the needle handle was lifted and trusted shortly and swiftly to induce the gentle rubbing of the needle tip on the periosterum. The stimulation intensity of this needling technique was determined by the obvious soreness and distention in the local area or the needling sensation radiated to the radial sides of the thumb, the index figure and the middle figure of the affected limb. Afterward, the needle was retained for 20?min. The treatment was given once a day, five treatments made one course and a total of 2 courses of treatment were required.Results
Of 52 cases, 50 cases were cured, accounting for 96.2% and 2 cases remarkably effective, accounting for 3.8%. The mean conduction velocity of the superficial radial nerve was (49.38?±?2.97) m/s after treatment, faster than (29.31?±?5.94) m/s before treatment, indicating the significant difference (P?<?0.05).Conclusion
The short thrust needling at LI 9 achieves the satisfactory clinical therapeutic effects on entrapment syndrome of superficial radial nerve. This therapeutic method is feasible to be promoted in clinical practice because of its less point selection and short treatment course. 相似文献17.
Objective
To observe the clinical therapeutic effects of acupuncture on chemotherapy-induced hand-foot syndrome (HFS).Methods
A total of 60 patients treated with chemotherapy of capecitabine and suffering from the chemotherapy-induced HFS were divided into an acupuncture group and a Vitamin B6 group according to the random number table, 30 cases in each one. In the acupuncture group, after chemotherapy, acupuncture was given at B?ihuì (百会 GV 20), Hég? (合谷 LI 4), Wàiguān (外关 TE 5), Zúsānl? (足三里 ST 36) and Ashi points. The needles were retained for 30?min in each treatment, once a day, totally for 2 weeks. In the Vitamin B6 group, after chemotherapy, Vitamin B6 was taken orally, 300?mg a day, totally for 2 weeks. Separately, on the day of enrollment and after 2 weeks of treatment, the scores of Karnofsky performance scale (KPS) and the quality of life (QLQ-C30) were evaluated in the acupuncture group and the Vitamin B6 group. After 2 weeks of treatment, the therapeutic effects were evaluated.Results
The effective rate of chemotherapy-induced HFS was 70.0% in the acupuncture group and was 36.7% in the Vitamin B6 group. The result in the acupuncture group was higher than the Vitamin B6 group, indicating the significant difference (P?<?0.05). After treatment, the KPS scores (84.23?±?10.49) in the acupuncture group were higher obviously than the Vitamin B6 group (77.84?±?10.33), indicating the significant difference (P?<?0.05). Regarding QLQ-C30 evaluation, after 2-week treatment, the scores in the items of physical function, role function, emotional function, cognitive function and social function were all reduced remarkably as compared with those before treatment in the two groups, indicating the significant differences (all P?<?0.05). After treatment, the scores of physical function (7.13?±?1.56?vs 16.72?±?4.29), emotional function (4.89?±?0.87?vs 11.76?±?1.29) and cognitive function (6.32?±?1.23?vs 18.17?±?4.1) in the acupuncture group were all lower obviously than those in the Vitamin B6 group, indicating the significant differences (all P?<?0.05); and the scores of role function and social function were not different significantly as compared with the VB6 group (all P?>?0.05).Conclusion
Acupuncture is effective for HFS induced by the chemotherapy with capecitabine and its effects are better than the oral administration of Vitamin B 6 in terms of physical function, emotional function and cognitive function. 相似文献18.
Acupuncture on back-shu points of five zang for chronic fatigue syndrome: A randomized control trial
Objective
To observe the clinical efficacy of acupuncture on back-shu points of five zang in treating chronic fatigue syndrome (CFS).Methods
Sixty patients were randomized into treatment group and control group. In treatment group, the back-shu points of five zang organs were adopted for acupuncture. Shènshū (肾俞 BL23) was perpendicularly needled 15–30?mm in depth. The rest of the selected points were inserted obliquely 15–30?mm in the direction of the spine with even method of lifting-thrusting and twisting-twirling, 10?s for each acupoint. In control group, the acupoints were approximately 1.5–2?cm away outward from the back-shu points of five zang organs (about on the middle of the two sidelines of the bladder meridian of foot-taiyang) and the points from the bladder meridian of foot-taiyang were excluded. Acupoints were needled 6–9?mm in depth, and deqi was not required, without any manipulation. The treatments were carried out twice a week for twenty minutes each time, a total of eight treatments were given. The clinical efficacy of acupuncture treatment for CFS was evaluated through the Fatigue Scale-14 (FS-14) and the Symptom Check-List 90 (SCL-90) after treatment.Results
The total effective rate was 86.67% in the treatment group and 53.33% in the control group (P?<?0.01). In treatment group, FS-14 total scores, somatic fatigue scores, and mental fatigue scores were significantly reduced than before treatment (all P?<?0.01). In control group, FS-14 total scores and somatic fatigue scores were significantly reduced (both P?<?0.01). The improvement of FS-14 total scores, somatic fatigue scores, and mental fatigue scores in the treatment group were better than those in the control group (P?<?0.01, P?<?0.05). After treatment, SCL-90 total scores and somatization, compulsion, interpersonal sensitivity, depression, anxiety, hostility, psychoticism, and other factors scores were significantly reduced in the treatment group compared with before treatment (P?<?0.01). In control group, the SCL-90 total scores and the scores of somatization, compulsion, hostility, and other factors after treatment were lower than those before treatment (P?<?0.01). The total scores of SCL-90 and somatization, compulsion, interpersonal sensitivity, depression, anxiety, psychoticism, and other factors in the treatment group were significantly lower than those in the control group (P?<?0.01, P?<?0.05).Conclusions
Acupuncture on back-shu points of five zang can significantly improve the somatic fatigue and mental fatigue of the patients, and at the same time improve their psychological status. Significant therapeutic effect was found on CFS. Compared with the control group, the acupuncture treatment can significantly improve the patient's somatic fatigue, mental fatigue and psychological status. 相似文献19.
Objective
To observe the effect of acupuncture at Jǐngjiājǐ (颈夹脊) on the repair and regeneration of cochlear hair cells of guinea pigs with sensorineural deafness.Methods
Sixty healthy guinea pigs were selected, 20 guinea pigs were randomly assigned to the normal control group (group A), and other guinea pigs were randomly divided into model control group (group B) and acupuncture treatment group (group C) after injection with gentamicin sulfate in order to induce deafness. No intervention was given to the guinea pigs in group A and group B, and acupuncture at Jǐngjiājǐ was given to the guinea pigs in group C for 30 days. ABR threshold, DPOAE amplitudes and hair cells counting of guinea pigs in each group were recorded after intervention for 30 days.Results
After intervention for 30 days, ABR threshold in group C was significantly lower than that in group B (38.46?±?7.36?vs 82.94?±?6.47, P<0.01), and the DPOAE amplitudes in group C were obviously higher than that in group B (28.06?±?5.64?vs 25.23?±?5.38, P<0.01). The number of cochlear hair cells in group C increased significantly, over 50% of the hair cells survived, accounting for 66.67% of the observation cases. The number of cochlear hair cells in the 3rd and 4th gyri was close to the normal level, and plenty of proliferous sustentacular cells can be seen. Compared with group B, the number of cochlear outer hair cells in each gyrus in group C significantly increased (36.76?±?1.97?vs 28.59?±?2.24, P<0.01), indicating that acupuncture at Jǐngjiājǐ can promote the repair and regeneration of cochlear hair cells.Conclusion
Acupuncture at Jǐngjiājǐ can promote the repair and regeneration of cochlear hair cells, thus improving the hearing of guinea pigs with deafness. 相似文献20.
Chen Chen Zhi-ying Weng You-lan Wang Chang-bo Zheng Yang Li JianYang Ze-lan Dai Wei-min Yang 《中草药(英文版)》2019,11(1):103-107
Objective: To investigate the antagonistic cell injury effect and molecular mechanism of scutellarin(SCU)in hypoxia reoxygenation(HR) treated human cardiac microvascular endothelial cells(HCMECs).Methods: The method of 12 h hypoxia following by 12 h reoxygenation was used to culture HCMECs in vitro to built cell injury model. The groups were divided into control group, model(HR) group, and HR + SCU(0.1 μmol/L, 1 μmol/L, and 10 μmol/L) group. The cell viability was determined by MTT, and oxidative stress was detected by malondialdehyde(MDA) levels by biochemical assay kit. Protein expression of JAK2/p-JAK2 and STAT3/p-STAT3 were evaluated by Western blot.Results: The results of MTT and MDA showed that HR decreased the cell viability(P 0.05) and increased MDA level significantly(P 0.05), SCU played a contrary role in these processes. Western blot analysis indicates that, the expression of JAK2 and p-JAK2, STAT3, and p-STAT3 were increased in model group when compared with control group(P 0.05); Compared with model group, their expression were reduced by SCU(P 0.05).Conclusion: SCU took a protective effect on HR-treated HCMECs, and the molecular mechanism may be associated with the inhibition of JAK2/STAT3 signal transduction pathway. 相似文献