腹膜后软组织肉瘤预后因素及预测工具的研究进展

腹膜后软组织肉瘤(retroperitoneal sarcoma,RPS)是一类少见的恶性肿瘤,但其病理类型复杂多样。随着对RPS认识的逐渐深入,临床发现组织学类型、TNM分期、手术范围、辅助治疗方式等均可不同程度地影响RPS患者预后。虽然目前有列线图能够预测部分RPS术后患者的总体生存(OS)及无病生存期(DFS),但价值有限且无法指导RPS患者术后治疗。因此,本文就RPS预后相关因素及预测工具作一述评。     

软组织肉瘤的现状与研究进展

软组织肉瘤是来源于间叶组织和与其交织生长外胚叶神经组织的恶性肿瘤,可发生于任何年龄,其特点是分布广泛,病理类型多,可分为50多种亚型。软组织肉瘤的治疗在过去以单纯手术治疗为主,术后的复     

儿童软组织肉瘤15例误诊分析

目的分析儿童软组织肉瘤的临床特征及误诊原因,总结防范误诊措施。方法回顾性分析2012年6月—2018年10月收治的误诊为其他疾病的儿童软组织肉瘤15例的临床资料。结果 15例均因患儿家长发现患儿体表肿块就诊,均为单发病灶,发病部位为躯干9例,四肢3例,头颈2例,阴唇1例,肿块直径为0.4～5(1.82±0.24)cm。误诊时间15～20 d,误诊为表皮样囊肿7例,皮脂腺囊肿、纤维瘤各3例,脂肪瘤2例,均行单纯性肿块切除。经术后病理检查确诊为软组织肉瘤,确诊为纤维肉瘤9例,横纹肌肉瘤、脂肪肉瘤各3例,确诊后行再次扩大切除术+化疗6例,行再次扩大切除术5例,行单纯化疗4例。15例3年生存率为60.00%(9/15),5年生存率为33.33%(5/15)。结论临床医师应加强对儿童软组织肉瘤的认识,综合分析相关资料,避免误诊误治。     

PICC在软组织肉瘤化疗中的应用及护理

软组织肉瘤是原发于纤维组织、神经纤维、滑膜、脂肪、血管、平滑肌及横纹肌等的恶性肿瘤,其治疗主要以手术切除、放射治疗、动脉内化疗、全身化疗及综合治疗为主.在软组织肉瘤的化疗中,本科主要采用ADI(ADM、DTIC、IFO)方案静脉滴注持续96 h化疗.但由于ADM、DTIC均属发疱性药物,外周静脉持续滴注对静脉损伤大,静脉炎发生率较高,一旦漏出血管外则可能引起局部组织损伤,有时甚至中断治疗.1999年12月～2003年1月我科对1 6例软组织肉瘤患者采用PICC置管术进行该方案化疗,解除了药物对周围血管的损伤 ,减少了局部不良反应,保证了化疗过程的顺利进行,解决了治疗和护理中的一大难题.现报告如下.     

PICC在软组织肉瘤化疗中的应用及护理

软组织肉瘤是原发于纤维组织、神经纤维、滑膜、脂肪、血管、平滑肌及横纹肌等的恶性肿瘤，其治疗主要以手术切除、放射治疗、动脉内化疗、全身化疗及综合治疗为主。在软组织肉瘤的化疗中，本科主要采用ADI(ADM、DTIC、IFO)方案静脉滴注持续96h化疗。但由于ADM、DTIC均属发疱性药物，外周静脉持续滴注对静脉损伤大，静脉炎发生率较高，一     

软组织肉瘤相关融合基因的研究现状与进展CSCD

软组织肉瘤(STS)是一种起源于间叶细胞的罕见异构肿瘤。由于软组织肿瘤与某些肿瘤在细胞形态学上相似,常导致误诊。分子检测技术的发展和分子靶向治疗为STS提供了个性化诊断和治疗。本文综述当前软组织肉瘤的主要分子检测RT-PCR和FISH技术的研究现状与进展,旨为今后软组织肉瘤的检测提供基本依据。     

软组织透明细胞肉瘤6例报道

软组织透明细胞肉瘤(clear cell sarcoma of softtissues,CCS)是一种患病率较低的软组织肿瘤,占软组织肉瘤的1%。WHO(2002)软组织肿瘤分类将其归类于分化不确定的肿瘤,因其肿瘤细胞具有黑色素细胞分化特点,将其归入恶性黑色瘤中的一种亚型。CCS的部分病例HE染色可见黑色素颗粒,也有文献称其为软组织恶性黑色素瘤(malignant melanoma of soft parts,MMSP)[1]。由于CCS临床表现多无特异性,易导致误诊、误治,为提高对其的认识,本文收集6例CCS临床病理资料,并结合有关     

大剂量异环磷酰胺治疗软组织肉瘤的护理

为探讨大剂量异环磷酰胺治疗软组织肉瘤的护理要点,笔者通过对15例软组织肉瘤37次使用大剂量异环磷酰胺治疗的观察,提出调节输注速度、饮食调护、对症护理,是防治不良反应的关键.     

大剂量异环磷酰胺治疗软组织肉瘤的护理

为探讨大剂量异环磷酰胺治疗软组织肉瘤的护理要点,笔者通过对15例软组织肉瘤37次使用大剂量异环磷酰胺治疗的观察,提出调节输注速度、饮食调护、对症护理,是防治不良反应的关键.     

软组织肉瘤的细胞遗传学研究进展

软组织肉瘤的细胞遗传学研究进展李家良，李甘地，杨光华（华西医科大学附一院病理学教研室成都６１００４１）近年来，软组织肉瘤的细胞遗传学研究已取得很大进展，在软组织肉瘤中，染色体的特征性易位发生率在６８～９３％，且和肿瘤的组织学特异性一致。因此，在软组织...     

手术结合大分割适形放射治疗腹膜后软组织恶性肿瘤

目的评价大分割适形放射治疗对腹膜后软组织肿瘤术后患者的治疗作用。方法对1998年10月-2003年4月收治的16例腹膜后软组织急性肿瘤术后患者行大分割适形放射治疗,设计临床靶区等效生物剂量为55-62Gy,观察放疗后2、5年局部控制率、生存率和无病生存情况。结果2、5年局部控制率较未行放疗患者明显提高并和其他放射治疗方式达到较高治疗剂量者近似;远期生存无改善,无病生存率较未行放疗患者有提高。结论大分割适形放射治疗方式对腹膜后软组织急性肿瘤术后患者有较好的局部控制作用,无瘤生存率有提高,远期生存无改善,无严重的远期放疗后遗症。     

腹壁滑膜肉瘤的病理及临床特征

目的 探讨腹壁滑膜肉瘤的临床病理特征,提高对该病的认识和诊治水平.方法 通过介绍本例及国内外已报道病例的临床与病理特征,分析该肿瘤的形态学特点、免疫组化特征及诊治要点.结果 X线检查常发现瘤内钙化灶;病理形态上有不同程度的双相分化特征;免疫组织化学对波形蛋白(Vimentin)、角蛋白(Keratin)和上皮腺抗原(EMA)呈不同程度阳性反应.结论 腹壁滑膜肉瘤是具有双相分化的软组织肉瘤,但因其发病部位特殊,容易误诊.     

腺泡状软组织肉瘤的影像学表现

目的探讨腺泡状软组织肉瘤的影像表现。方法回顾性分析3例腺泡状软组织肉瘤患者X线平片及MRI影像资料。结果3例x线平片均表现为软组织肿块影;MRI在T1WI呈等信号2例,稍高信号1例,在T2WI呈高信号,肿瘤内外可见血管流空信号。结论腺泡状软组织肉瘤MRI影像表现具有特征性,表现为T1WI呈等或稍高信号,T2WI呈高信号,肿瘤内外常可见血管流空现象,增强扫描呈不均匀明显强化。     

1434例软组织恶性肿瘤统计分析

目的为研究软组织恶性肿瘤的发病率及组成比。方法采用WHO分类，对我科及广州军区疑难病例读片的31年间的软组织恶性肿瘤资料进行统计和分析。结果1434例软组织恶性肿瘤中男女比例约1．4：1，最常见部位分别为四肢（45．5％）、躯干（21．5％）、头颈部（16％）；；最常见的组织类型分别是恶性纤维组织细胞瘤（19、6％）、横纹肌肉瘤（18．4％）、滑膜肉瘤（12．7％）；；结论为软组织肿瘤的诊断及研究提供有价值的参考。     

Endoscopic sonography and sonographically guided fine‐needle aspiration biopsy in the diagnosis of unusual pancreatic metastases from synovial sarcoma

Pancreatic metastases are commonly solitary solid lesions frequently derived from primary renal cell carcinoma, lung cancer, or melanoma. Very few case reports have described cystic‐appearing metastases in the pancreas and even fewer have reported a combination of cystic and solid metastatic lesions. Synovial sarcoma is a rare and aggressive soft tissue neoplasm, frequently metastasizing to the lungs and bones. We present a case of primary synovial sarcoma with multiple solid and cystic‐appearing pancreatic metastases diagnosed by endoscopic ultrasound and sonographically guided fine‐needle aspiration. © 2013 Wiley Periodicals, Inc. J Clin Ultrasound 42 :180–182, 2014     

小肠粒细胞肉瘤2例报道并文献复习

目的探讨小肠粒细胞肉瘤的临床病理特征、诊断及鉴别诊断。方法对2例小肠粒细胞肉瘤进行光镜及免疫组化检测。结果小肠粒细胞肉瘤的特点是肿瘤浸润呈膨胀性生长，原组织构架可保留，组织常无广泛破坏；临床上表现为肠梗阻症状：有恶心、呕吐、腹痛和腹胀。结论小肠粒细胞肉瘤常与急性髓细胞白血病(AML)同时或在其后发生；罕见的情况下，在急性髓细胞白血病开始出现之前形成。嗜酸性粒细胞的存在，常高度提示为小肠粒细胞肉瘤。免疫组化MPO、CD43、Lys和CD99有助于诊断。     

Low-grade fibromyxoid sarcoma of the liver: A case report

BACKGROUNDLow grade fibromyxoid sarcoma (LGFMS) is a rare and benign mesenchymal tumor with indolent course, most commonly found in young or middle-aged men. The majority of the LGFMSs are located in the trunk and deep soft tissue of the lower extremities. They appear as well circumscribed, although not encapsulated, which often leads to incomplete surgical resection. Despite their seemingly benign appearance, these tumors have aggressive behavior with high metastatic and recurrence rates. Accurate histopathologic examination of the specimen and its immunohistochemical analysis are mandatory for a precise diagnosis. CASE SUMMARYWe report a case of a 38 year-old-man who presented with jaundice and upper abdominal discomfort. Multi-detector computed tomography and magnetic resonance imaging showed a large left liver tumor mass, extending to the hepatoduodenal ligament. Left hepatectomy was performed with resection and reconstruction of hepatic artery and preservation of middle hepatic vein. Histopathologic examination confirmed the tumor being a low-grade fibromyxoid sarcoma. Three and a half years after surgery, the patient died after being diagnosed with spine metastasis.CONCLUSIONDue to poor response to all modalities of adjuvant treatment, we consider that the focus of treatment should be on surgery as the only option for curing the disease.     

Soft tissue sarcoma: An overview

Malignancy of soft tissue, referred to as sarcomas, are some of the rarest tumors in medicine. These tumors account for approximately 1% of all diagnosed malignancies. Diagnosis of soft tissue sarcoma (STS) is a complex process that includes history and physical examination of patient, diagnostic imaging studies, and biopsy when indicated. All clinicians should be able to identify the unique characteristics of malignant soft tissue tumors and assist patients with obtaining care from a specialist in the treatment of STS. Evidence-based medicine has shown that the critical difference in treating STSs is a multidisciplinary approach.     

Imaging findings of primary pulmonary synovial sarcoma with secondary distant metastases: A case report

BACKGROUNDSynovial sarcoma (SS) accounting for 6%-10% of primary soft tissue malignancies mainly occurs in deep soft tissue adjacent to joints of the limbs. Primary pulmonary SS (PPSS) is rare and has a poor prognosis. Cases of secondary distant metastases of PPSS occur rarely and there is a lack of corresponding imaging reports. We summarized the imaging findings of PPSS with multiple metastases confirmed by surgery and pathology, and shared valuable information on PPSS.CASE SUMMARYA 43-year-old female patient had a solid space occupying lesion in the right upper lobe of the lung. The results of a hemogram, erythrocyte sedimentation rate (ESR) and tumor markers were all within the normal range, tuberculin skin test (5 TU PPD) was negative (-). Chest computed tomography examination showed similar round soft tissue density in the posterior segment of the right upper lobe. Thoracoscopic-assisted wedge resection of the right upper lobe of the lung, right upper lobe resection and lymph node dissection were performed. Nine months after surgery, ultrasound examination showed multiple metastases on the chest wall and kidney.CONCLUSIONPPSS is a rare malignant lung tumor with strong invasiveness, early distant metastasis and poor prognosis. There are very few imaging reports. PPSS is often manifested as irregular tumor and calcification, and the metastases have extremely low echo on ultrasonography. Contrast-enhanced ultrasound indicates that the arterial phase of tumor metastases shows rapid centripetal high enhancement, manifested as “fast forward and fast regression”.     

上皮样炎性肌纤维母细胞肉瘤1例临床病理观察

目的 分析上皮样炎性肌纤维母细胞肉瘤(EIMS)的临床及病理特征,旨在提高对本病的认识及鉴别.方法 对1例EIMS进行免疫组化染色,荧光原位杂交检测ALK基因重排,观察其病理特点并复习文献.结果 患者女,56岁,腹痛2月余.肿物位于肠系膜,直径约15 cm,切面黏液样外观.镜下见肿瘤富于黏液背景,瘤细胞呈弥漫或团块状分...