由于毛细现象液面上升高度计算的思考

毛细现象在日常生活和科技生产中都有着重要的作用。大部分同学在计算毛细管中液面上升高度时,往往因为不能抓住模型的本质而产生错误。本文针对两种不同的模型通过对比计算方法,指出了错误产生的原因从而加以规避。     

A test for the assessment of the duration of the action of neostigmine and of the relative potencies of various anticholinesterases using the pupil of the mouse

The miotic effect of anticholinesterases was used to monitor the duration of their activity and to compare the relative potency of different members of this group. Female albino mice were used and the diameter of their pupils measured with the help of a monocular microscope at a magnification of × 60. After a suitable control period, readings were taken at 30 min intervals. This test was found to be superior to previous tests described for the same purpose.     

对药事监督管理中行政公益诉讼制度建立的探讨

通过对一起药事监管管理中行政公益诉讼案件的分析，剖析了公益诉讼的概念扣特征以及建立公益诉讼制度的必要性，对构建公益诉讼制度进行深入思考，阐明现代司法的发展趋势及本案应立案审理的观点。     

白花前胡提取成分对心血管作用的研究进展

目的介绍国内外中药白花前胡提取成分对心血管作用的研究进展 ,为研究和开发中草药提供参考。方法以国内外大量有代表性的文献为基础 ,进行分析、整理和归纳。结果白花前胡提取成分保护心血管作用可能通过以下机制 :a .阻滞钙内流 ;b .抑制血小板聚集作用 ;c .促钾通道开放 ;d .调节心肌细胞动作电位 ;e .抗氧自由基和脂质过氧化作用实现。结论白花前胡及其有效成分在研究和开发防治心血管疾病新药方面具有广阔前景     

Lack of influence of the carbamoyl group on the stereochemistry of the acid-catalyzed opening of the aziridine ring of the mitomycins and of congeners

The acid-catalyzed opening of the aziridine ring of mitomycins A and C is known to occur predominantly with cis stereochemistry. We have observed that the presence or absence of a carbamoyl group at C-10 of mitomycin C and in certain of its analogues does not have a significant influence on the stereochemistry of the opening of this ring. The trans product obtained from mitomycin C was shown to be stable when treated with acid under the conditions of its formation. Mitomycin B was also shown to yield predominantly the cis product when it was subjected to acid-catalyzed opening of its aziridine ring. The 1H NMR spectra of acetate derivatives prepared from mitomycin B show two sets of signals that are due to two populations of rotamers. The analysis of these spectra has substantiated several previous spectral assignments. This paper also presents some thoughts on acid-catalyzed bifunctional DNA alkylation by mitomycins and 10-decarbamoyloxy-9-dehydromitomycins.     

质疑处方“划价”易位的合理性

目的:合理推进医院服务改革,促进《处方管理办法》的深入落实。方法:比较财务"划价"与调剂"划价"对患者的优势与劣势。结果与结论:财务人员"划价"注重的是经济收入;调剂人员"划价"注重的是处方的合理性,后者对于防范医疗风险、保障患者用药安全起着无可替代的作用。建议将药品价格内容与财务收费联网,让财务划价人员与药剂人员联合办公。     

治疗痤疮药物使用情况分析

目的了解目前医院治疗痤疮的药物使用情况。方法选取本院门诊300张临床诊断为痤疮的处方进行分析。结果本院治疗痤疮药物的使用频率前六位依次是螺内酯、维生素B6、氯唑乳膏、克林霉素、羚羊角滴丸、异维A酸;抗生素的使用存在一些不合理情况。结论痤疮治疗中抗菌药物的使用应规范合理,以减少耐药的产生和药物不良反应的发生率。     

GABA-ergic mechanisms of the action of ketamine on the structures of the hippocampo-reticulo-neocortical system of the brain

In freely mobile rabbits with electrodes preliminarily implanted in the brain structures ketamine (5 mg/kg intravenously or 20 mg/kg intramuscularly) exhibited properties of GABA receptor agonist decreasing the direct excitability of the mesencephalic reticular formation and periaqueductal gray matter and reducing their activating effect on the frontal cortex (FC) and dorsal region of the hippocamp (DH). GABA-mimetics (muscimol, baclofen, aminooxyacetic acid) as well as GABA system antagonists (bicuculline, thiosemicarbazide) attenuated ketamine action at the level of DH and especially FC.     

半导体激光治疗老年人压疮疗效观察

目的探讨半导体激光局部照射治疗老年人压疮疗效.方法:收集2012年1月-2015年6月48例压疮患者,分为半导体组和常规组各24例.常规组采用常规治疗,半导体组采用半导体激光加常规治疗,10 d为1个疗程,不超过3个疗程.疗程结束后比较两组疗效.结果:半导体组压疮愈显率为83.33％,创面愈合时间为(12.75±5.51)d,常规组分别为54.17％和(19.63±8.65)d,组间差异有统计学意义(P＜0.05),两组均未见不良反应.结论:半导体激光加常规治疗压疮效果肯定,无明显不良反应,且操作简便.     

Effect of reserpine on the acetylcholine content of the heart, the ileum and the hypothalamus of the dog

The effect of intravenous administration of reserpine in 10 dogs was studied on the acetylcholine content of the sino-atrial node, the right auricle and the right ventricle of the heart, the ileum and the hypothalamus of dog. The general sedation, the bradycardia, and the purgative effects of reserpine were also noted. Tissues were removed for estimation of acetylcholine when bradycardia was maximal. Reserpine increased the acetylcholine content of all the tissues studied. The increase in the peripheral tissues was greater than in the hypothalamus. The bradycardia and the purgative effects of reserpine may be related to the increase of the acetylcholine content of the sino-atrial node and the ileum.     

The nature of the adrenergic receptors of the trachea of the guinea-pig

The adrenergic receptors of the guinea-pig isolated trachea have been characterised as β-receptors by established criteria. No evidence was obtained that any α-receptors are present. (-)-Isoprenaline was 17 times more potent than (-)-adrenaline which was 10 times more potent than (-)-noradrenaline. High concentrations of piperoxan, thymoxamine and dihydrogenated ergot alkaloids did not antagonise the catecholamines, while phentolamine and phenoxybenzamine potentiated them, isoprenaline almost as much as noradrenaline. Propranolol, pronethalol and the 3, 4-dichloro-analogues of (+)-noradrenaline, adrenaline and isoprenaline each specifically antagonised the catecholamines, isoprenaline moreso than noradrenaline. The characteristics of this blockade by pronethalol and propranolol fulfilled established criteria for competitive antagonism; propranolol (pA₂ against noradrenaline 6·56 + 0·21) was 18·6 (11·4 to 30·5) times more potent than pronethalol, (pA₂ against noradrenaline 5·29 + 0·07).