等离子射频消融治疗慢性肥厚性鼻炎

目的：探讨等离子低温射频消融对慢性肥厚性鼻炎的临床疗效.方法：对100例经临床诊断为慢性肥厚性鼻炎的病例进行下鼻甲等离子消融治疗.结果：术后随访3～6个月,所有患者均取得满意效果.治疗后3个月及6个月VAS积分与术前相比差异均有显著性（P＜0.001）.结论：等离子低温射频消融对慢性肥厚性鼻炎患者具有较好的近期疗效,且方便、安全、微创、恢复快、无不良反应,值得推广应用.     

低温等离子射频消融治疗慢性肥厚性鼻炎的护理探讨

目的 探讨低温等离子射频消融治疗慢性肥厚性鼻炎的围手术期护理,减少并发症发生.方法 回顾性分析56例慢性肥厚性鼻炎患者行低温等离子射频消融治疗临床护理资料.结果 术前加强心理护理,完善术前各项检查,术后观察鼻腔渗血情况,指导正确的鼻腔滴药,56例患者均获成功,未出现并发症.结论 配合精心的护理,可减少术后并发症.     

等离子射频消融治疗慢性肥厚性鼻炎56例体会

目的 探讨等离子低温射频消融对慢性肥厚性鼻炎的临床疗效.方法 自2008年3月应用下鼻甲等离子消融治疗治疗慢性肥厚性鼻炎患者56例,回顾性分析总结分析临床疗效.结果 术后随访6月,治愈45(80.5%),有效9例(16%),有效率96.5%.无并发症发生.结论 等离子低温射频消融是治疗慢性肥厚性鼻炙的一种安全、简便、有效的方法,无不良反应.     

等离子射频消融治疗慢性肥厚性鼻炎56例体会

目的探讨等离子低温射频消融对慢性肥厚性鼻炎的临床疗效。方法自2008年3月应用下鼻甲等离子消融治疗治疗慢性肥厚性鼻炎患者56例,回顾性分析总结分析临床疗效。结果术后随访6月,治愈45例（80.5%）,有效9例（16%）,有效率96.5%。无并发症发生。结论等离子低温射频消融是治疗慢性肥厚性鼻炎的一种安全、简便、有效的方法,无不良反应。     

低温等离子射频对慢性肥厚性咽炎的疗效评价

目的对比分析低温等离子射频和常规药物对慢性肥厚性咽炎治疗的方法及效果。方法随机抽取本院收治的120例慢性肥厚性咽炎患者,采用随机抽样法平均分成2组,实验组行低温等离子射频治疗,对照组行常规药物治疗。治疗后随访3～12个月,比较两组患者的临床疗效和复发率。结果随访期间两组比较,实验组患者的总有效率为93.5%,明显高于对照组的79.3%;实验组的复发率为9.68%,明显低于对照组的13.8%,差异有统计学意义（P〈0.05）。结论应用低温等离子射频治疗慢性肥厚性咽炎,可显著改善患者临床疗效,减少复发率。     

102例慢性肥厚性鼻炎微波治疗临床观察

目的 探讨微波对慢性肥厚性鼻炎的临床疗效.方法 回顾性分析102例慢性肥厚性鼻炎患者使用微波治疗的临床资料.结果 所有患者治疗后随访6月～1.5a,临床治愈50例(49%)、显效38例(37%)、有效14例(14%),未见无效者,总有效率100%.结论 微波治疗慢性肥厚性鼻炎效果显著,有定位准确、创伤小、不易出血、伤口愈合快等优点,值得临床进一步运用.     

等离子低温射频消融术联合鼻内镜治疗慢性鼻-鼻窦炎疗效分析

目的探讨等离子低温射频消融术联合鼻内镜治疗慢性鼻-鼻窦炎疗效。方法对我院自2010年1月至2012年1月收治的慢性鼻-鼻窦炎98例患者采用前瞻性研究,按照随机分配原则分为观察组和对照组,观察组(49例)采用等离子低温射频消融术联合鼻内镜进行治疗,对照组(49例)仅采用鼻内镜进行治疗,对2组的疗效进行比较。结果观察组术后1个月和1年的总有效率分别为为91.84%、89.80%,对照组术后1个月和1年的总有效率分别为77.55%和73.47%,2组比较差异有统计学意义(P0.05)。结论等离子低温射频消融术联合鼻内镜治疗慢性鼻-鼻窦炎近远期疗效显著,值得临床推广应用。     

慢性肥厚性鼻炎微波热凝术的疗效观察

慢性肥厚性鼻炎患者经保守治疗无效的,我科采用微波热凝术治疗了180例,取得了一定疗效,现报告如下: 1 资料和方法 1.1 一般资料 180例患者中,男122例,女58例.年龄22至65岁.病史2至38年,平均11年.经口服抗生素10天,步长香菊胶囊28天,鼻塞症状仍不缓解的患者,建议微波热凝术.     

低温等离子射频消融术联合金莲花软胶囊治疗肥厚性咽炎的临床疗效探讨

目的探讨低温等离子射频消融术联合金莲花软胶囊治疗慢性肥厚性咽炎的临床效果。方法选取慢性肥厚性咽炎患者共80例,随机分为观察组和对照组各40例。其中观察组采用低温等离子射频消融术联合金莲花软胶囊进行治疗,对照组采用金莲花软胶囊进行治疗,比较两组患者的临床疗效。结果治疗后,观察组的与对照组的总有效率分别为98.2%、72.7%,观察组的总有效率明显高于对照组,差异均具有统计学意义。结论低温等离子射频消融术联合金莲花软胶囊治疗慢性肥厚性咽炎效果显著,具有临床应用及推广价值。     

支撑喉镜电视内镜下低温等离子射频消融术治疗会厌囊肿的疗效评价

目的:研究支撑喉镜电视内镜下低温等离子射频消融术治疗会厌囊肿患者的效果.方法:选取2019年1月至2020年10月我院会厌囊肿患者96例,随机分成消融组与切除组(n=48).切除组患者采用传统手术切除囊肿,消融组患者采用支撑喉镜电视内镜下低温等离子射频消融术消除囊肿,观察患者围手术期指标,术前、术后1 d采用放射免疫法测定血管紧张素Ⅱ(AngiotensinⅡ,AngⅡ)、去甲肾上腺素(Norepinephrine,NE)及皮质醇(Cortisol,Cor)水平,同时观察并发症和复发情况.结果:消融组手术时间、术中失血量、住院时间、术后咽痛时间、会厌囊肿评分、NE、Cor、AngⅡ、复发率均明显低于切除组(P<0.05);而两组患者并发症发生率无明显差异(P>0.05).结论:支撑喉镜电视内镜下低温等离子射频消融术治疗会厌囊肿患者,可优化围术期指标,改善症状,降低复发率,减少血清NE、Cor、AngⅡ水平.     

肝癌的射频消融治疗进展

目的：探讨射频消融在肝癌治疗中的治疗进展。方法：查阅相关中外文献,对射频消融治疗肝癌的效果进行综述。结果：射频消融治疗肝癌疗效确切、微创小,发展迅速。射频消融联合其他治疗进一步扩大了治疗范围,提高了治疗效果。结论：射频消融是治疗手术不能切除的肝癌的理想方法。     

Development of a Simultaneous Cryo-Anchoring and Radiofrequency Ablation Catheter for Percutaneous Treatment of Mitral Valve Prolapse

Mitral valve prolapse (MVP) is one subtype of mitral valve (MV) disease and is often characterized by enlarged leaflets that are thickened and have disrupted collagen architecture. The increased surface area of myxomatous leaflets with MVP leads to mitral regurgitation, and there is need for percutaneous treatment options that avoid open-chest surgery. Radiofrequency (RF) ablation is one potential therapy in which resistive heating can be used to reduce leaflet size via collagen contracture. One challenge of using RF ablation to percutaneously treat MVP is maintaining contact between the RF ablation catheter tip and a functioning MV leaflet. To meet this challenge, we have developed a RF ablation catheter with a cryogenic anchor for attachment to leaflets in order to apply RF ablation. We demonstrate the effectiveness of the dual-energy catheter in vitro by examining changes in leaflet biaxial compliance, thermal distribution with infrared (IR) imaging, and cryogenic anchor strength. We report that 1250?J of RF energy with cryo-anchoring reduced the determinant of the deformation gradient tensor at systolic loading by 23%. IR imaging revealed distinct regions of cryo-anchoring and tissue ablation, demonstrating that the two modalities do not counteract one another. Finally, cryogenic anchor strength to the leaflet was reduced but still robust during the application of RF energy. These results indicate that a catheter having combined RF ablation and cryo-anchoring provides a novel percutaneous treatment strategy for MVP and may also be useful for other percutaneous procedures where anchored ablation would provide more precise spatial control.     

小剂量米非司酮联合射频消融术治疗子宫肌瘤95例疗效观察

目的探讨小剂量米非司酮对子宫肌瘤的疗效。方法 190例患者随机分为试验组95例和对照组,分别使用米非司酮和射频消融术及单纯使用射频消融术进行治疗,术后随访,观察其疗效。结果所有患者均手术成功,术后均未出现阴道大出血、感染等并发症,均无复发。二组月经量减少、痛经、下腹酸痛坠胀、贫血纠正情况及子宫大小比较,差异有统计学意义。结论与单纯手术相比,米非司酮联合射频消融术治疗子宫肌瘤效果更好。     

肿瘤射频消融技术及临床应用研究进展

目的 该研究旨在探讨射频消融在大尺寸肿瘤中存在的技术难题及解决方法,以提高射频消融技术在临床治疗中的应用效果。方法?该研究基于射频消融的原理,分析“降滚”现象对大尺寸肿瘤完全消融的限制,并探讨大血管散热引起的消融不完全问题,从而引出在射频消融中应用数学建模仿真来判断消融损伤程度的方法。结果和结论 该研究基于相关研究现状,强调数学建模仿真在射频消融中的作用,即术前模拟以预测消融效果,指导临床优化治疗方案以提高治疗效果。创新之处 该研究总结了优化消融器械设计、模拟仿真等措施以改进治疗效果,并展望了射频消融技术的发展方向,如引入肿瘤联合治疗和智能化技术,以提高射频消融的精准性和完全性。     

鼻中隔矫正联合筛前神经射频消融治疗变应性鼻炎伴鼻中隔偏曲的疗效分析

探讨鼻中隔矫正联合筛前神经射频消融治疗变应性鼻炎伴鼻中隔偏曲的疗效。方法 选取81例就诊于我科的变应性鼻炎伴鼻中隔偏曲患者,随机分为对照组40例和治疗组41例。对照组采用鼻中隔矫正术治疗,治疗组采用鼻中隔矫正联合射频消融治疗。观察两组治疗后3个月、6个月和1年的临床疗效以及并发症情况。结果 两组患者术后3个月治疗总有效率比较,差异无统计学意义（P＞0.05）;治疗组患者术后6个月和术后1年的治疗总有效率分别为85.00%和82.50%,均高于对照组的63.41%和58.54%,差异具有统计学意义（P＜0.05）。手术病例均未见鼻中隔穿孔、鼻腔粘连、下鼻甲萎缩等严重并发症。结论 相对于单纯鼻中隔矫正术,鼻中隔矫正联合筛前神经射频消融治疗变应性鼻炎伴鼻中隔偏曲的远期疗效明显,安全性较高。     

Radiofrequency Ablation for Hepatic Metastasis from Gastric Adenocarcinoma

The prognosis for gastric cancer with liver metastasis continues to be poor. We present our preliminary findings from 4 cases of liver metastasis from gastric adenocarcinomas treated using radiofrequency ablation (RFA). Between 1995 and 2004, the clinical history and course of 4 patients who underwent radiofrequency ablation for liver metastases from gastric cancer were reviewed. Two patients with smaller metachronous metastasis are currently alive without recurrence at 16 and 14 months and the other patients with larger synchronous metastatic lesions died after 4 and 12 months after RFA. Although this study was limited to a few cases and had a short follow-up duration, our findings suggest that RFA may provide an alternative treatment modality for liver metastasis resulting from gastric adenocarcinoma. Additional study is needed with a larger group of patients and longer follow up to evaluate the efficacy of RFA.     

A Nanoengineered Embolic Agent for Precise Radiofrequency Ablation

The purpose of the work is to investigate whether the electromagnetic properties of multi-walled carbon nanotubes (MWCNT) in the presence of radiofrequency (RF) energy is (1) safe, and (2) improves the precision of the therapeutic efficiency of the RF-ablation (RFA) procedure. An in vitro phantom was created for evaluating temperature near RF treated nanotubes. For the in vivo study, three baboons and six pigs were submitted for RFA procedure in superior/inferior kidney poles embolized with a non-adherent, lipophilic embolic agent (marsembol) with or without MWCNT. Tissue damage in the surrounding kill zone was assayed through caspase-3 activation. The in vitro results showed marked heat increase only in the region of the nanotubes. In vivo, necrosis/ischemic damage resulted from RFA therapy alone, RFA plus marsembol only. In marsembol + MWCNT condition, dramatic disruption of cell membranes and sub-cellular organelles was found whereas the nuclear membranes and basal cell membranes remained largely intact. The marsembol vaporized under RFA and tissue fluid filled the space. This caused the MWCNT to cluster within the new aqueous environment. RFA plus marsembol + MWCNT created a well-defined demarcation between healthy and apoptotic cells as evidenced by a marked reduction of caspase-3 expression. By contrast, there was a much less defined ablation zone in the absence of MWCNT. In conclusion, the combination of RFA plus marsembol + MWCNT embolization delineated the kill zone in vitro and in vivo. We demonstrate that MWCNTs remain in the ablation region thus minimizing their migration to the systemic circulation.