正常与冠心病人体表穴位红外辐射光谱特征研究

实验采用自制高灵敏度人体红外辐射光谱检测装置，记录到31例正常人及31名冠心病人内关穴穴区的红外光谱。实验发现，冠心病人原始的红外辐射光谱之间的差异较正常人的光谱更大。此外，对正常人和冠心病人内关穴数据进行了成组t检验。发现在一些波段内差别有显著意义。且经过归一化处理后数据的差异性更加明显．表明在应用红外光谱检验疾病时。应用归一化后的数据更有利于分析病人的病理情况。     

人体体表穴位点红外辐射光谱特征及其与ATP能量代谢的关系

使用高灵敏度红外光谱测量装置,记录到人体体表穴位和ATP水解反应过程中释放的红外光谱,在扣除同温度的黑体辐射本底后发现在3μm附近存在一明显辐射峰.研究发现的人体穴位辐射光谱与ATP水解过程发射的红外光谱存在同样峰值,这表明人体体表的红外辐射中含有ATP能量代谢的生物医学信息,对它的研究将为应用红外光谱无损检测到人体ATP能量代谢奠定基础.     

三种高效红外理疗辐射板的研制和临床应用

目的：提高红外理疗疗效。方法：以红外辐射与人体红外吸收光谱相匹配为指导，研制出三种红外理疗辐射板。结果：通过热辐射率谱和疗效观察，显示其具有高辐射率、高疗效等优点。结论：是值得推广的红外理疗辐射板。     

血氧饱和度的红外光谱光电法测量

红外光谱光电法研究人体组织血氧状态具有安全可靠、连续实时及无损伤的特点，有广泛的研究和应用前景。本文介绍了红外光谱无损伤测量人体组织血氧饱和度的基本测量原理及红外光谱血氧计发展概况，讨论了现行脉搏血氧计、肌血氧计、脑血氧计的基本测量原理、临床应用情况，并对各自存在的局限性进行了分析     

三种远红外理疗仪器工作光谱测试与机理探讨

选取市售三种远红外理疗仪器,采用两种不同波段的光栅光谱仪在1～15μm谱段上对其进行了工作光谱的测试,结果表明它们的辐射光谱基本相同,都是2.7～6μm、峰值波长为3.8μm左右的以远红外辐射为主的光谱,此外,有的仪器辐射波段只是远红外波段上的一段,并未达到产品所提出的宽频辐射或模拟人体频谱.最后探讨了远红外理疗仪器的治病机理.本文对红外理疗仪器的研究和开发有重要意义.     

血氧饱和度的红外光谱光电法测量

红外光谱光电法研究人体组织血氧状态具有安全可靠，连续实时及无损伤的特点，有广泛的研究和应用前景。     

远红外辐射材料在医学上的应用(综述)

当前用于加热目的的远红外辐射材料(辐射体或涂料),主要是SIC金属氧化物、硫化物、硼化物和硒化物等构成,由于这些材料存在极强的极性振动,在远红外光谱区表现为极强的振动吸收峰(带),因此决定了远红外辐射材料的高辐射性。人体是一个天然的辐射源,人体对红外吸收受人体内生物大分子氢键振动和三磷酸腺苷分子(ATP)中高能磷酸键释放的影响,ATP是细胞代谢、活动、分裂所必需的能量,其能量均处于2．5～4．0μm及5．6～15μm的远红外光谱范围,这就关系到病灶部位的物质代谢和组织更新及完成这些动力学过程的能量供给问题。     

艾灸干预免疫抑制兔细胞毒性T淋巴细胞抗原-4的作用效应分析

目的：比较不同艾灸干预下免疫抑制兔细胞毒性T淋巴细胞相关抗原4(CTLA-4)及程序性死亡受体1(PD-1表达变化的异同。方法：20只大耳白兔随机分为空白组、模型组、艾条灸（MSM）组与隔药饼灸（HPM）组,每组5只,连续7 d腹腔注射环磷酰胺（CTX）诱导免疫抑制模型。造模成功后分别进行MSM与HPM干预,均为隔日灸,共治疗10次。治疗结束后麻醉白兔,取血清、肝脏与脾脏,ELISA检测血清中PD-1、PD-L1含量,免疫组化法检测肝组织PD-1含量,RT-qPCR检测肝、脾组织CTLA-4 mRNA含量。结果：HPM和MSM均可降低免疫抑制下PD-1及PD-L1水平,并可有效抑制脾脏CTLA-4和肝脏PD-1、CTLA-4水平升高,与免疫抑制模型组相比差异均存在统计学意义（P<0.05）,且Pearson相关性检验表明肝组织中CTLA-4与PD-1呈显著正相关（r=0.780 7,P<0.001）。结论：HPM可通过调控多个免疫抑制位点改善机体免疫功能。     

人体体温下UHMWPE人工髋臼材料压缩性能的试验研究

模拟人体体温下对超高分子量聚乙烯（UHMWPE）人工髋臼材料进行了压缩力学性能的试验研究,并与室温下的试验结果进行了对比.当由室温22℃升高到体温37℃和40℃时,其屈服应力呈明显的下降趋势,分别下降了23.1%和31.9%,由体温37℃升高到40℃时,二者仅差3℃,其屈服应力亦下降了11.5%.同时还对不同加载速度下UHMWPE试件压缩变形过程进行了红外辐射温度的监测与分析.不同加载速度下试件压缩变形过程中的红外辐射温度均有明显升高,加载时间越长,试件平均红外辐射温度越高.试验结果分析表明,不能忽视植入人体后UHMWPE人工髋臼局部受压时温度的升高,特别不能忽视植入人体后在人体体温作用下其力学性能的改变和下降,人体体温的作用是UHMWPE人工髋臼出现过早失效的原因之一.本试验研究为UHMWPE材料在人体环境中的应用研究提供了参考.     

不同性别的兔髌腱,跟腱及屈趾肌腱生物力学特性测试

本文以３．５％的应变值对雌、雄性成年日本大耳白兔髌腱、跟腱肌腱进行２５次循环加载和应力松驰以及断裂试验，对不同性别三种肌腱的归一化滞后环面积、循环蠕变、归一化应力松驰、应力松驰衰减因子、弹性特征、结构及材料力学参数进行了测定和比较；发现三种肌腱性别之间的粘弹性及断裂特性无明显差异，因此作者认为在选用兔肌腱作生物力学实验时可不考虑性别；而肌腱之间的粘弹性和结构力学、材料力学特性相差甚远，作用认为这是     

艾灸生成物干预大鼠尿液代谢组学研究

背景：艾灸过程中产生的艾烟等艾灸生成物是灸法研究的热点之一。运用代谢组学理论与技术,可更为全面、系统地研究艾烟等艾灸生成物对机体的影响。 目的：从尿液代谢组学角度观察不同浓度艾灸生成物对大鼠的影响。 方法：40只SD大鼠随机等分为正常对照组、低、中、高剂量艾灸生成物组、高剂量艾灸生成物恢复组,低、中、高剂量艾灸生成物组和高剂量艾灸生成物恢复组大鼠在艾灸生成物与纯净气的浓度比分别为0.4∶2.0,0.8∶2.0,1.6∶2.0,1.6∶2.0中暴露4 h/d,每周5 d,持续60 d;高剂量艾灸生成物恢复组经60 d高剂量艾灸生成物刺激后,在空气中自然暴露21 d作为恢复期。正常对照组大鼠常规饲养60 d。 结果与结论：气相色谱-飞行时间质谱联用仪分析各组大鼠尿液,共鉴定出108个代谢物,标准品库核实64个。各组大鼠尿液典型代谢物的变化与艾灸生成物浓度呈现一定的正相关关系,其中高剂量艾灸生成物组和正常对照组大鼠尿液代谢物差异最明显,葡萄糖醛酸、维生素C等22个差异代谢物主要参与维生素C代谢等15条糖、氨基酸相关代谢途径,提示艾灸生成物干预大鼠机体能量代谢增加,机体解毒、抗氧化作增强。 中国组织工程研究杂志出版内容重点：组织构建;骨细胞;软骨细胞;细胞培养;成纤维细胞;血管内皮细胞;骨质疏松;组织工程全文链接：     

非接触式灸疗温度场的估计

目的研究非接触性艾灸的温度场分布,为调控灸疗过程和提高灸疗效果提供依据。方法根据生物传热的相关理论,建立描述人体组织内部在非接触性艾灸时的温度场理论模型,并据此推导当艾灸强度确定时,影响该温度场分布的体内异常热源深度与施灸处皮肤温度的对应关系。结果在不同艾灸强度下,根据对应关系计算出的结果与有限元的分析结果进行比较,结果显示对体内异常热源深度的估测结果与有限元仿真分析结果十分接近。而组织内部温度场理论模型的正确性也得到了物理实验的验证。结论本文提出的根据人体皮肤表面温度和艾灸强度估计体内异常热源的深度信息,继而估计出组织内温度场的方法具有一定的适用性,将有助于临床灸疗的方案设计。     

耳穴热敏灸治疗常见病的临床观察

目的 探讨耳穴的热敏现象及耳穴热敏灸治疗常见病的疗效。方法 采用普通艾条点燃后选择耳穴行灸法,治疗手部冻疮、颈腰痛、面瘫患者共计31例。结果 31例患者经过1~8次治疗后均临床治愈,总有效率100.00%。结论 出现热敏及经络感传现象对症状的好转和治愈呈正相关性;局部灸耳穴存在热敏感传现象。     

家兔不同发热反应的体温功率谱分析

本研究对不同热型的发热体温信号作功率谱分析,发现各具时域特征的多种发热在频域中表现为相当一致的统一性,即它们的功率谱均为低频段的单一谱峰,其幅值大小与发热反应强弱成正比。功率谱密度值与时域指标体温反应指数(TRI)有极好的相关性。     

Study on the Interaction Between Tangerine Peel and Beer by Absorption Spectrum

This paper presents a new method to study the interaction between tangerine peel and beer by absorption spectrum.The author explores the change laws and the differences of the absorbance on some wave band from the absorption spectrums of tangerine peel and the mixture of tangerine peel and beer. The results show that there is an obvious difference around 323 nm though the absorbance values of the two samples are almost similar in the most bands. The absorbance value of the mixture is obviously greater than that of tangerine peel at 276 nm in the spectrums, and there is a shift of the peak position in the absorption spectrum of the mixture, which shows the differences of the absorbance values and the peak positions of the two samples. Through comparing the characteristics of the two samples＇ absorption spectrums, a new method for researching new pharmacological action of tangerine peel is presented in this paper. The result indicates that the technology of spectrum analysis will play an important role in the research and development of Chinese herbal pharmacology and new pharmacology.     

Anti-fungal activity of cold and hot water extracts of spices against fungal pathogens of Roselle (Hibiscus sabdariffa) in vitro

Crude extracts of seven spices, viz. cardamom, chilli, coriander, onion, garlic, ginger, and galangale were made using cold water and hot water extraction and they were tested for their anti-fungal effects against the three Roselle pathogens i.e. Phoma exigua, Fusarium nygamai and Rhizoctonia solani using the ‘poisoned food technique’. All seven spices studied showed significant anti-fungal activity at three concentrations (10, 20 and 30% of the crude extract) in-vitro. The cold water extract of garlic exhibited good anti-fungal activity against all three tested fungi. In the case of the hot water extracts, garlic and ginger showed the best anti-fungal activity. Of the two extraction methods, cold water extraction was generally more effective than hot water extraction in controlling the pathogens. Against P. exigua, the 10% cold water extracts of galangale, ginger, coriander and cardamom achieved total (100%) inhibition of pathogen mycelial growth. Total inhibition of F. nygamai mycelial growth was similarly achieved with the 10% cold water extracts garlic. Against R. solani, the 10% cold water extract of galangale was effective in imposing 100% inhibition. Accordingly, the 10% galangale extract effectively controlled both P. exigua and R. solani in vitro. None of the hot water extracts of the spices succeeded in achieving 100% inhibition of the pathogen mycelial growth.     

Studies on the antimutagenic activities of garlic extract

Experiments with Salmonella tester strains indicated that aqueous garlic extract possesses antimutagenic properties toward ionizing radiation, peroxides, adriamycin, and N-methyl-N'-nitro-nitrosoguanidine. The assumption that radical scavenging garlic constituents, i.e., molecules with sulfur moieties, might be responsible for the inhibitory effect of aqueous extract toward mutagenesis induced by radiation and radiomimetic compounds was confirmed by the results of subsequent experiments; 1) garlic extract attenuated the lethal effects of gamma-rays on repair-deficient E. coli strains; 2) the garlic constituent allicin (thio-2-propene-1-sulfinic acid S-allyl ester) is partly responsible for the reduced radiation-induced mutagenesis in Salmonella typhimurium TA 102. No such inhibitory effects were detected with alliin (S-allyl-L-cysteine sulfoxide) or cysteine; 3) aqueous garlic extract inhibited hydrogen-peroxide-induced lipid peroxidation. Results obtained in preliminary experiments with Chinese hamster ovary cells suggest that the antimutagenic properties of garlic extract are not restricted to procaryotic cells.     

肺音信号的谱分析

应用细化FFT法获得40位正常人与肺疾病患者的肺泡呼吸音、罗音、哮喘音的功率谱,统计了谱峰频率的分布,指出正常人的肺泡呼吸音和异常呼吸音(罗音、哮喘音)在谱峰分布上存在的显著区别。     

Anti-inflammatory and Anti-oxidant Properties of <Emphasis Type="Italic">Curcuma longa</Emphasis> (Turmeric) <Emphasis Type="Italic">Versus Zingiber officinale</Emphasis> (Ginger) Rhizomes in Rat Adjuvant-Induced Arthritis

Turmeric (rich in curcuminoids) and ginger (rich in gingerols and shogaols) rhizomes have been widely used as dietary spices and to treat different diseases in Ayurveda/Chinese medicine since antiquity. Here, we compared the anti-inflammatory/anti-oxidant activity of these two plants in rat adjuvant-induced arthritis (AIA). Both plants (at dose 200 mg/kg body weight) significantly suppressed (but with different degrees) the incidence and severity of arthritis by increasing/decreasing the production of anti-inflammatory/pro-inflammatory cytokines, respectively, and activating the anti-oxidant defence system. The anti-arthritic activity of turmeric exceeded that of ginger and indomethacin (a non-steroidal anti-inflammatory drug), especially when the treatment started from the day of arthritis induction. The percentage of disease recovery was 4.6–8.3% and 10.2% more in turmeric compared with ginger and indomethacin (P < 0.05), respectively. The present study proves the anti-inflammatory/anti-oxidant activity of turmeric over ginger and indomethacin, which may have beneficial effects against rheumatoid arthritis onset/progression as shown in AIA rat model.