脐周变应性接触性皮炎121例斑贴试验结果分析

目的探讨脐周变应性接触性皮炎的致敏原特点。方法采用斑贴试验分析121例脐周变应性接触性皮炎患者的致敏原。结果斑贴试验结果主要的致敏原是硫酸镍98.35%,白降汞18.18%,重铬酸钾17.36%,橡胶Ⅳ(促进剂:D.P.G.TMTD混合物)8.26%,新霉素7.44%和对苯二胺5.79%。结论硫酸镍是脐周变应性接触性皮炎最主要的致敏原。     

杭白菊致接触性皮炎临床分析：附108例报告

接触性皮炎在临床上是一种常见病，而杭白菊引起接触性皮炎尚未见报道。作者通过斑贴试验，发现杭白菊致接触性皮炎的致敏原主要是杭白菊的花和叶、而根、茎则无致敏作用。本文就完整的１０８例杭白菊引起接触性皮炎的病因、临床表现、治疗及其发病机理进行了阐述。     

芒果致老年接触性皮炎30例临床分析

正芒果皮炎(mango dermatitis)是因为食用或接触芒果所导致的速发型接触性皮肤反应~([1])。我科收治芒果致老年接触性皮炎30例。现报告如下。1资料与方法1.0临床资料本组中男11例,女19例;年龄(57~91)岁。患者食用芒果后(2~72)小时发病。23例为首次发病,7例为有两次以上发病经历。临床表现为轻度16例:仅在唇红及口     

染发剂致系统性接触性皮炎7例分析

系统性接触性皮炎(systemic contactdermatitis,SCD)是在已具有接触致敏的个体,当半抗原通过口服、透皮、静脉注射或吸入进入机体到达皮肤而发生的一种炎症性皮肤病1。几年来我们在临床上陆续收治了染发剂致系统性接触性皮炎7例,结合文献分析如下。临床资料7例患者均来自我院皮     

163例斑贴试验阳性结果分析

斑贴试验是寻找外源性致敏原常用的检查方法。为了解接触性皮炎、湿疹等的致敏原特点,对2002年5月-2006年5月在我科诊断为接触性皮炎、湿疹的患者进行了斑贴试验,其中阳性患者163例,现将结果分析如下：     

洁尔阴致接触性皮炎3例

洁尔阴致接触性皮炎３例王光辉（云南楚雄市人民医院皮肤性病科，６７５０００）洁尔阴是当前国内皮肤科广泛外用的止痒杀菌清洁剂。由于该药物问世时间不长、药物致敏报道还不多见、笔者以洁尔阴致接触性皮炎３例报道如下：例１：男、２７岁，冠状沟及尿道口尖锐湿疣使用...     

职业性皮肤病

941410 镍过敏的临床分析和预防/刘玲玲…//临床皮肤科杂志。-1994,23(2).-102～103 60例对硫酸镍斑试阳性者中25例为接触性皮炎,13例为手湿疹,9例为湿疹或脂溢性湿疹,13例为其它病种。36例有明确的镍接触史(60％)。致敏物为金属表壳及表带者13例,金属眼镜架12例,耳环9例,项链5例,戒指3例,余为金属腰带扣、钥匙及钥匙链等。患者皮损多数局限,好发部位常为与致敏物接触的头面部、颈部、四肢和手部。 941411 荒酸二甲酯致接触性变应性皮炎11例临床分     

230例使用化妆品的接触性皮炎患者接触过敏原分析

目的:分析使用化妆品的接触性皮炎患者的临床特点与接触变应原的分布。方法:应用标准变应原斑贴试剂盒检测230例使用化妆品的接触性皮炎患者的可疑致敏原,并比较是否伴有特应性素质者斑贴试验阳性率有无差异。结果:230例患者中女性占87.83%,21~50岁占76.09%,文员占38.26%,大部分(57.46%)由一般护肤品引起。230例使用化妆品的接触性皮炎患者中斑贴试验呈阳性反应的有173例,阳性率为75.22%,位列前6位的致敏原依次为芳香混合物(25.22%)、硫酸镍(23.04%)、Cl+Me-异噻唑(20.86%)、氯化钴(19.13%)、重铬酸钾(10.43%)、甲醛(8.70%)。伴有特应性素质者55例,斑贴试验阳性率(58.18%)明显低于无特应性素质者(80.57%),差异具有统计学意义(x~2=11.25,P<0.05)。结论:使用化妆品的接触性皮炎患者以中青年女性为主,文员最多见,一般护肤品为主要的可疑致敏化妆品;最常见的致敏原是芳香混合物和防腐剂;伴有特应性素质的患者可能对接触致敏原的反应降低。     

接触性皮炎与特应性皮炎相关性的研究进展

接触性皮炎是皮肤或黏膜单次或多次接触外源性物质后发生的炎症反应;斑贴试验作为诊断接触性皮炎的金标准,有助于明确皮肤可疑致敏原。特应性皮炎也是一种常见的慢性、复发性、炎症性皮肤病,最基本的特征是皮肤干燥、慢性湿疹样皮炎及剧烈瘙痒,常伴发过敏性鼻炎和哮喘。关于接触性皮炎与特应性皮炎之间的关系,一直存在争论,而在近几年逐渐被皮肤科专家重视,并成为研究的热点。本文对接触性皮炎与特应性皮炎之间发病机制、临床表现、患病率、常见致敏原等的最新研究进展进行综述。     

系统性接触性皮炎的临床研究进展

【摘要】 系统性接触性皮炎是接触过致敏物的个体再次通过系统吸收方式接触同一变应原或具有交叉反应性变应原后发生的变应性炎症性皮肤病,皮疹表现多样且易被忽略。本文从临床表现、致敏物质、发病机制、诊治等多方面总结系统性接触性皮炎的临床相关进展,以期提高临床诊治水平。     

T cell lymphomatoid contact dermatitis: a challenging case and review of the literature

Lymphomatoid contact dermatitis is a pseudolymphoma with clinical and histological features of allergic contact dermatitis and cutaneous T cell lymphoma. Incorrect diagnosis may lead to unnecessary testing, unnecessary treatment, or patient harm. The objective of this study is to present a case to demonstrate the diagnostic challenge and overlap between allergic contact dermatitis and cutaneous T cell lymphoma in a patient with lymphomatoid contact dermatitis caused by methylchoroisothiazolinone/methylisothiazolinone and paraben mix, and to review the existing literature in order to summarize the demographics, clinical features, allergens and treatments reported for lymphomatoid contact dermatitis. A search of major scientific databases was conducted for English‐language articles reporting cases of lymphomatoid contact dermatitis or additional synonymous search headings. Nineteen articles with a total of 23 patients were analysed. Lymphomatoid contact dermatitis was more common in men, with an average age of 58.5 years. Fourteen unique allergens were identified and confirmed by patch testing. However, no single test or study was diagnostic of lymphomatoid contact dermatitis. Allergen avoidance was the most useful management tool, but selected patients required topical or systemic immunosuppression. In conclusion, without specific diagnostic features, evaluation for lymphomatoid contact dermatitis should include a thorough history and examination, patch testing, and biopsy with immunohistochemistry and clonality studies.     

Dermatitis in hairdressers

Occupational contact dermatitis in hairdressers is a common clinical dermatologic problem. Apparently often secondary to irritant contact dermatitis caused by shampooing in Europe, in North America, allergic contact dermatitis related to the chemicals handled, especially oxidation dyes and permanent waving components, is not infrequently the problem. The preponderance of women in the clinical populations reported may well explain the relation noted between a positive patch-test response to nickel and the presence of contact dermatitis in hairdressers rather than nickel allergy predisposing to the disease. There is at present no convincing evidence for excluding persons with a medical or family history of atopy with the proviso that those with a history of hand eczema or atopic dermatitis would be wise to avoid the trade. Improved worker education about the cutaneous risks of the occupation and appropriate simple cutaneous industrial hygiene measures may offer some hope of modifying the risk of developing skin disease.     

PICC置管术后透明敷料贴敷致接触性皮炎资料分析

目的：明确972例恶性肿瘤患者置入PICC置管术后因透明敷料所致接触性皮炎的发生率和危险因素。方法：对恶性肿瘤置入PICC导管后因透明敷料所致接触性皮炎患者的性别、年龄、体重指数、cTNM分期、药物过敏史、肿瘤类型、嗜酸性粒细胞和嗜碱性粒细胞水平等可能影响接触性皮炎发生的危险因素进行单因素和多因素分析。结果：972例置入PICC导管肿瘤患者中,有80例接触性皮炎（男21例,女59例）,发生率为8.23％;单因素分析显示,嗜酸性粒细胞水平、睡眠状态、体重指数、药物过敏史与接触性皮炎发生有关（P＜0.05）;多因素分析显示,失眠、肥胖、药物过敏史是接触性皮炎的独立危险因素（P＜0.001）。结论：PICC置管术后因透明敷料所致的相关接触性皮炎的发生率较高。失眠、肥胖、药物过敏史是PICC置管术后透明敷料所致接触性皮炎的独立危险因素。     

Tomato contact dermatitis

The tomato plant (Solanum lycopersicum) is an important crop worldwide. Whereas immediate‐type reactions to tomato fruits are well known, contact dermatitis caused by tomatoes or tomato plants is rarely reported. The aims of this study were to present new data on contact sensitization to tomato plants and review the literature on contact dermatitis caused by both plants and fruits. An ether extract of tomato plants made as the original oleoresin plant extracts, was used in aimed patch testing, and between 2005 and 2011. 8 of 93 patients (9%) tested positive to the oleoresin extracts. This prevalence is in accordance with the older literature that reports tomato plants as occasional sensitizers. The same applies to tomato fruits, which, in addition, may cause protein contact dermatitis. The allergens of the plant are unknown, but both heat‐stable and heat‐labile constituents seem to be involved. The fruit contains fragrance compounds that are also present in Myroxylon pereirae (balsam of Peru), possibly accounting for cross‐reactivity. The proteins in pulp and peel may contribute to protein contact dermatitis. Until more is known about the allergens, the diagnosis of contact dermatitis caused by tomato plants and fruit may be established with the use of ether extracts and fresh fruits, respectively.     

Contact dermatitis caused by diphenhydramine hydrochloride

Three cases of contact dermatitis caused by an ethanolamine antihistamine, diphenhydramine hydrochloride (Benadryl), are described. Patients who develop contact dermatitis from it should avoid its oral or parenteral administration because they may develop a localized or generalized flare of dermatitis. Dimenhydrinate (Dramamine), clemastine fumarate (Tavist), carbinoxamine maleate (Clistin-D), and doxylamine succinate (Decapryn) are also ethanolamine antihistamines. Since they may cross-react with diphenhydramine hydrochloride, they should be avoided in sensitive patients.     

香菇皮炎三例并文献复习

香菇皮炎又名鞭挞样皮炎,主要临床表现为条索状、线状的鞭挞样红斑,大部分患者伴瘙痒,有香菇食用史。本文报道3例香菇皮炎,患者1发病前曾两次食用未煮熟的香菇。患者2发病前48小时因聚会曾食用大量凉拌金针菇,患者3发病前1天食用大量未熟透的烧烤香菇。     

三氯乙烯致药疹样皮炎6例临床分析

目的了解三氯乙烯引发的职业性皮肤病。方法对本院2003~2004年收治的6例职业性三氯乙烯致药疹样皮炎患者进行回顾分析。结果6例患者均为新工人,潜伏期平均25天,发病剧烈程度与所接触三氯乙烯浓度不成正比,无明显剂量-效应关系;3例皮损为重症多形红斑,另3例为剥脱性皮炎;其中4例伴严重肝损害。结论皮肤科医生应加强对三氯乙烯引发的药疹样皮炎的认识,避免误诊的发生。     

2,4-二氯-5-甲基嘧啶致刺激性接触性皮炎64例研究

目的 了解2,4-二氯-5-甲基嘧啶(DCP)致接触性皮炎的临床特征,探讨治疗方法及防护措施.方法 对2,4-二氯-5-甲基嘧啶致接触性皮炎的64例患者进行分析.参与企业防护措施的持续改进.结果 64例患者均在接触DCP后1～ 12 min,平均7 min发病.皮损发生于DCP接触部位,表现为边界清楚的水肿性红斑,10例出现水疱,皮损面积58～5 600 cm2.48例自觉灼痛,16例自觉瘙痒.4例头痛,3例恶心、呕吐,1例晕厥.10例在避免接触DCP 1 ～4 d后,于DCP非接触部位出现皮疹,自觉瘙痒.8例皮损组织病理均为表皮细胞内及细胞间水肿,海绵形成,5例表皮内水疱,7例真皮乳头水肿,有炎症细胞浸润.糖皮质激素治疗有效.正压式充气防护服能将作业工人与外界完全隔离,可避免DCP所致接触性皮炎的发生.结论 2,4-二氯-5-甲基嘧啶所致接触性皮炎为刺激性接触性皮炎,少数患者在接触DCP后会发生迟发型过敏反应.正压式充气防护服可起到有效防护.     

Contact and photocontact allergy to musk ambrette

Musk ambrette, a contact and photocontact allergen, is a synthetic fragrance present in aftershave lotions and many toiletries. Thirty-four patients with contact and photocontact allergy to musk ambrette were studied. All had a facial eczema. Four distinctive clinical pictures were seen. These were plaques of eczema, jawline (mandibular) dermatitis, acute contact dermatitis and chronic actinic dermatitis. Twenty-six patients were light sensitive by history and 10 were diagnosed by clinical criteria as having chronic actinic dermatitis. Patch and photopatch testing to musk ambrette showed that seven patients had pure photocontact dermatitis to musk ambrette. Eight patients had contact dermatitis to musk ambrette but this was exacerbated by irradiation. Cross reaction with moskene occurred. Scrupulous avoidance of musk ambrette has resulted in clinical resolution in most patients.