鼻内镜下鼻腔鼻窦内翻性乳头状瘤切除术50例临床分析

目的回顾性分析鼻内镜下切除鼻腔鼻窦内翻性乳头状瘤的方法及疗效。方法对50例鼻腔鼻窦内翻性乳头状瘤患者,内镜下切除鼻腔鼻窦肿物及肿物基底部黏骨膜,对侵及上颌窦,尤其是内下角者,辅助柯陆氏入路彻底切除肿瘤。结果术后随访2～8年,50例患者中治愈42例（84%）,局部复发5例（10%）、恶变3例。结论鼻内镜手术治疗鼻腔鼻窦内翻性乳头状瘤疗效确切,对侵及上颌窦者辅已柯陆氏径路下内镜治疗。     

内翻性乳头状瘤切除术28例临床分析

目的探讨经鼻内镜手术治疗鼻腔鼻窦内翻性乳头状瘤的疗效。方法回顾性分析28例经鼻内镜手术治疗的鼻腔鼻窦内翻性乳头状瘤的病例资料及术后随访情况。结果随访3～7年,28例中4例复发,再次经鼻内镜手术后未再复发。结论经鼻内镜手术切除鼻腔鼻窦内翻性乳头状瘤疗效满意。准确的术前评估、骨膜下层切除肿瘤和术后定期随访是减少复发,提高疗效的主要因素。     

鼻内镜下手术治疗鼻腔鼻窦内翻性乳头状瘤的疗效观察

目的探讨鼻内镜手术治疗鼻腔鼻窦内翻性乳头状瘤的临床疗效。方法70例鼻腔鼻窦内翻性乳头状瘤患者在鼻内镜下行单纯切除或经柯-陆径路于骨膜下分离切除肿瘤,创面用电刀烧灼处理,术后使用抗生素1周预防感染。结果70例患者术后随访6个月以上,其中Ⅰ级、Ⅱ级患者治愈64例（90%）;Ⅲ级患者复发6例（10%）,经再次鼻内镜下手术彻底清除病灶后治愈。结论鼻内镜下治疗鼻腔鼻窦内翻性乳头状瘤创伤小,疗效好,有效预防术后复发;可作为治疗鼻腔鼻窦内翻性乳头状瘤的首选手术方式。     

鼻内镜下治疗鼻腔及鼻窦内翻性乳头状瘤

目的 探讨鼻内镜下治疗鼻腔鼻窦内翻性乳头状瘤的疗效.方法 总结28例鼻腔及鼻窦内翻性乳头状瘤经鼻内镜手术切除的治疗效果.结果 28例随访7个月～5年,仅6例术后复发（21%）,其中2例累及筛窦与蝶窦,4例累及上颌窦.结论 鼻内镜下行鼻腔及鼻窦内翻性乳头状瘤切除术有良好疗效.     

鼻内镜下T3期鼻内翻性乳头状瘤切除术

目的探讨鼻内镜下治疗T3期鼻腔鼻窦内翻性乳头状瘤的疗效。方法总结12例T3期鼻腔鼻窦内翻性乳头状瘤经鼻内镜手术切除的治疗效果。结果 12例随访7～36个月,仅2例术后复发(16.6%),其中1例累及上颌窦、筛窦与蝶窦,1例累及上颌窦、额窦、筛窦及蝶窦。结论鼻内镜下行T3期鼻腔及鼻窦内翻性乳头状瘤切除术有良好疗效。     

面中部翻欣术联合鼻内镜术切除鼻腔鼻窦内翻性乳头状瘤

目的 探讨面中部翻掀术联合鼻内镜术切除鼻腔鼻窦内翻性乳头状瘤的疗效。方法 采用面中部翻欣术联合鼻内镜术切除鼻腔鼻窦内翻性乳头状瘤１１例,上网检索了近５年鼻腔鼻窦内翻性乳头状瘤手术治疗的相关文献,对不同手术方式的复发率进行了统计分析。结果 随访１２－６６个月,无１例复发。结论 采用这种联合手术方式为鼻腔鼻窦内翻性乳头状瘤的彻底切除提供了一种较好的方法。具有避免面部切口、肿瘤切除彻底、复发率低的优点。术后定期鼻内镜随访可确保复发肿瘤的早期发现及妥善处理。     

38例鼻腔鼻窦内翻性乳头状瘤鼻内镜下切除术回顾性分析

目的分析鼻内镜手术在鼻腔鼻窦内翻性乳头状瘤外科治疗中的应用。方法38例鼻腔鼻窦内翻性乳头状瘤患者,于鼻内镜下(或结合下鼻道开窗及犬齿窝穿刺术)行肿瘤切除术,观察手术效果。结果38例患者中,术后仅有4例出现局部复发,再次鼻内镜下局部清理后治愈。本术式可用于大多数比较局限的鼻腔鼻窦内翻性乳头状瘤的切除,具有损伤小,不遗留面部瘢痕的优点。结论对经严格选择的鼻腔鼻窦内翻性乳头状瘤病例,鼻内镜下可较准确地判断肿瘤的原发部位及其范围,能够最大程度的完整切除肿瘤。     

鼻内镜下鼻内翻性乳头状瘤切除术(附46例报告)

目的:总结鼻内翻性乳头状瘤的临床特点,探讨鼻内镜手术切除鼻内翻性乳头状瘤的疗效。方法:对1995~2005年收治的46例鼻内翻性乳头状瘤患者施行鼻内镜手术。结果:46例患者均在鼻内镜下完整切除肿瘤(其中8例联合上颌窦根治术),随访12~72个月,5例术后24个月内复发,其余41例在随访期内未见复发。结论:鼻内镜手术治疗鼻内翻性乳头状瘤是一种安全有效的方法,对肿瘤广泛侵及上颌窦内的Ⅲ级病变联合上颌窦根治术效果较好。     

鼻内镜下联合低温等离子刀切除鼻腔鼻窦内翻性乳头状瘤37例

目的 回顾性分析鼻腔鼻窦内翻性乳头状瘤的临床特点,探讨鼻内镜下联合低温等离子刀切除鼻腔鼻窦内翻性乳头状瘤的可行性。 方法 在鼻内镜下使用低温等离子刀切除37例鼻腔鼻窦内翻性乳头状瘤,根据Krouse分级标准:T1期8例,T2期18例,T3期11例。术后鼻内镜下随访4~10年。 结果 37例均在鼻内镜下成功使用低温等离子刀切除肿瘤,3例术后复发,再次手术未复发。 结论 鼻内镜下联合低温等离子刀切除T1-T3期鼻腔鼻窦内翻性乳头状瘤安全、微创,术后复发率低。     

鼻内镜下切除鼻腔及鼻窦内翻性乳头状瘤

目的 探讨鼻内镜下切除鼻腔及鼻窦内翻性乳头状瘤的治疗效果.方法 根据Krouse的分期,回顾性分析30例行鼻内镜手术并运用内镜随访24个月Ⅰ～Ⅲ级鼻腔及鼻窦内翻性乳头状瘤患者的临床资料.结果 30例均在鼻内镜下彻底切除肿瘤,无并发症发生.1例在手术后10个月复发恶变;2例分别在术后6和7个月复查时出现复发,咬除并以微波烧灼病变及基底黏膜,其后的随访中未出现复发;其余病例术腔光滑,在随访期间均未见复发.本组复发率为10%,恶变率为3.3%.结论 鼻内镜下切除鼻腔及鼻窦内翻性乳头状瘤,有良好的治疗效果,术后复发率较低.     

Outcomes of the extended endoscopic approach for management of inverted papilloma

BACKGROUND: Inverted papilloma (IP) is a benign tumour involving the paranasal sinuses. Given its tendency to recurrence and potential for malignancy, complete removal of the papilloma remains the treatment of choice. Since 1994, we have routinely employed an extended endoscopic approach for the resection of inverted papillomas. We present our methods and outcomes. METHOD: The study was conducted in an academic tertiary care hospital-based practice. It is a retrospective review of patients treated by a single surgeon. IP was diagnosed by biopsy before surgery. With computed tomography and magnetic resonance imaging, we attempt to identify the sites of origin and extent of IP. Cases with previous medial maxillectomy or invasive disease are treated via the open approach. Otherwise, the extended endoscopic approach is used. The tumour is debulked, and its attachment points are identified. Endoscopic medial maxillectomy is then performed. If maxillary sinus involvement in its anterior, inferior, superior, or lateral portion is suspected, a Caldwell-Luc approach is performed to allow for mucosal excision and complete removal of the anterior lateral nasal wall. When the lamina papyracea or ceiling of the ethmoid or sphenoid sinus is involved, the bony wall is resected. The frontal recess can be approached via a Lynch incision or an endoscopic transorbital approach. RESULTS: Twenty-two patients were referred for IP. Nineteen patients were treated via the extended endoscopic approach. The average follow-up period was 23 (3-66) months. Only 3 of 19 patients (16%) presented with a recurrence or failure of initial surgery that required revision surgery. CONCLUSION: The extended endoscopic approach offers a safe, effective, and aesthetically acceptable treatment of most cases of IP.     

鼻内镜下上颌窦良性病变的手术入路

上颌窦的良性病变主要包括炎性病变或良性肿瘤性病变, 在鼻内镜技术出现之前, 治疗方式主要为Caldwell-Luc术式, 即经典上颌窦根治术。随着鼻内镜技术的发展应用, 一些上颌窦良性病变手术可经下鼻道或中鼻道完成, 临床上已经基本上代替了Caldwell-Luc术式, 一些开放性的手术也在鼻内镜辅助下有所改进。鼻内镜技术优势在于有良好的手术视野及对患者所造成的创伤小, 可以最大程度的保留下鼻甲、鼻泪管等生理结构组织。在鼻内镜技术日益成熟的今天, 许多术式在不断的发展创新, 该文通过文献复习, 对鼻内镜下上颌窦病变的手术入路进行综述。     

Minimally invasive treatment of the nasal inverted papilloma

BACKGROUND: The purpose of this work is to evaluate our results in the treatment of the nasal inverted papillomas with an endoscopic approach using a retrospective case series. METHODS: Between 1993 and 2000 we treated 27 patients with nasal inverted papillomas. All patients underwent endoscopic nasal surgery under general anesthesia. None of the inverted papillomas extended outside of the paranasal sinuses. All tissue samples underwent polymerase chain reaction and hybridization in situ to detect genetic sequences of the human papilloma virus and Epstein Barr virus. RESULTS: The study population consisted of 16 men and 11 women with a median age of 52 years (range, 22-77 years). Ten patients (37%) had undergone a previous nasal surgery. The median follow-up was 5 years (range, 2-8 years). None of the patients presented with bilateral nasal involvement or a synchronous carcinoma. Seven patients underwent an additional surgical approach (two endoscopic approaches via a Caldwel-Luc approach, four sublabial approaches via a Caldwel-Luc approach, and one external ethmoidectomy). There were no surgical complications. Two patients (7%) had recurrent papilloma 4 and 6 years after surgery and again underwent endoscopic resection. The amplification both by polymerase chain reaction and hybridization in situ for human papilloma virus and Epstein Barr virus were negative in the specimens from all patients. CONCLUSIONS: According to the literature and our own experience, we believe that the initial surgical management of primary and recurrent inverted papillomas limited to the nasal cavity and paranasal sinuses should be endoscopic sinus surgery.     

经鼻内镜治疗鼻腔鼻窦内翻性乳头状瘤18例

探讨内镜下切除鼻腔鼻窦内翻性乳头状瘤的效果。方法：对18例鼻腔鼻窦内翻性乳头状瘤患者行鼻内镜手术。结果：随访1～4.5年,仅1例复发。结论：鼻内镜治疗鼻腔鼻窦内翻性乳头状瘤有多视角、清晰度高、损伤小、不毁容等优点。     

Endoscopic sinus surgery for unilateral chronic sinusitis]

Functional endoscopic sinus surgery has become an increasingly popular treatment for chronic sinusitis. This approach is aimed at re-establishment of ventilation and mucociliary clearance of the sinuses. However, some otolaryngologists believe that the Caldwell-Luc procedure should be routinely used for unilateral chronic sinusitis, because it is often associated with the maxillary sinus carcinomas. To evaluate the state of endoscopic sinus surgery for the diagnosis and treatment of unilateral chronic sinusitis, we analyzed the cases of 39 patients with unilateral chronic sinusitis who underwent endoscopic sinus procedures. These patients were unresponsive to appropriate antibiotic management for more than 6 months. Generally, endoscopic ethmoidectomy and antrostomy were performed with preservation of the middle turbinate. After the ostium was enlarged, the maxillary sinus was cleaned and carefully inspected for the presence of associated neoplasms using 30 and 70 degree endoscopes. Preoperative computed tomography (CT), postoperatve pathologic diagnosis, fiberscopic findings of the maxillary sinus, and symptomatic improvement were evaluated. Three patients had CT evidence of bone destruction of the lateral nasal wall. Pathological diagnosis demonstrated that three patients had maxillary sinus mycoses caused by Aspergillus species, one patient had inverted papilloma, and the other 35 patients had chronic sinusits. No associated malignancy was found. Eighty-one percent of the patients had almost normal endoscopic findings of the maxillary sinus by postoperative fiberscopic examination 4 to 8 months following surgery. With an average follow-up of 26 months, 88% of the patients were judged as having significantly improved in their presenting complaints of mucopurulent rhinorrhea, nasal obstruction, and facial pain. The results of this series suggest that endoscopic sinus surgery is an effective procedure for the diagnosis and treatment of unilateral chronic sinusitis.     

双进路鼻腔鼻窦内翻性乳头状瘤切除术

目的 探讨鼻腔鼻窦内翻性乳头状瘤的手术疗法。方法 对25例单侧鼻腔内翻性乳头状瘤患者进行鼻内窥镜和柯－陆氏双进路手术，除去病变。结果 术后随访时间1．5年，复发3例，复发率12．0％。结论 该方法融合了鼻内窥镜及柯－陆氏手术的长处，可彻底清除鼻腔、筛窦及上颌窦的肿瘤，降低了该病的复发率。     

鼻内窥镜手术切除鼻腔鼻窦内翻性乳头状瘤

［摘要］目的：探讨内窥镜下切除鼻腔鼻窦内翻性乳头状瘤的效果。方法：对15例鼻腔鼻窦内翻性乳头状瘤患者施行鼻内窥镜手术。结果：随访2～4年，仅1例复发，余者均未见复发。结论：鼻内窥镜有多视角、清晰度高、损伤小、不毁容等优点，是治疗鼻腔鼻窦内翻性乳头状瘤的一种很好的方法。     

Endonasal endoscopic surgical treatment of paranasal sinus inverted papilloma--first experiences.

PURPOSE: Surgical excision is generally regarded as the treatment of choice for inverted papilloma. However, the approach and extent of surgery has been subject of much debate. The purpose of this study is to evaluate the results of endoscopic sinus surgery in the treatment of paranasal sinus inverted papilloma. PATIENTS AND METHODS: Thirteen cases of inverted papilloma of the paranasal sinuses treated via endoscopic sinus surgery were evaluated. The follow-up averaged from 9 months to 48 months with a mean of 27 months. RESULTS: A close follow-up of all patients was maintained. Seventy-seven per cent (10/13) of the patients had no recurrence after the initial endoscopic procedure. Three patients had recurrences of their tumor within 11 months after surgery, which means a rate of 23% (3/13). In 2 patients, the recurrences were treated endoscopically. In one patient, recurrence and malignant transformation (squamous cell carcinoma) developed after 36 months, which means that the associated carcinoma rate was 7% (1/13). This patient underwent radical maxillectomy and postoperative radiotherapy. None of the patients died of inverted papilloma. CONCLUSION: Endoscopic sinus surgery is a viable treatment alternative for paranasal sinus inverted papilloma in selected cases. This approach should be performed by experienced surgeons and a close follow-up is mandatory. When the disease is more extensive, it should be approached by radical surgery, e.g. en-bloc excision by medial maxillectomy via lateral rhinotomy or mid-facial degloving.     

Surgical revision of the post-Caldwell-Luc maxillary sinus

BACKGROUND: Endoscopic sinus surgeons are commonly faced with the management of patients with persistent maxillary sinusitis despite previous Caldwell-Luc surgery. Given the potential for altered mucociliary clearance in the post-Caldwell-Luc maxillary sinus, the optimal approach for surgical revision has not been well characterized. The objective of this study was to review our experience in endoscopic versus repeat Caldwell-Luc approaches in patients who have failed Caldwell-Luc surgery for chronic maxillary sinusitis. METHODS: Retrospective chart review was performed on patients who had a history of a Caldwell-Luc procedure and who then underwent a surgical revision for persistent maxillary sinusitis at the Oregon Health and Science University and Medical College of Wisconsin between 1983 and 2002. RESULTS: Sixty-eight patients were identified, with a total of 156 revision procedures performed on 103 maxillary sinuses. Fifty-three percent of the sinuses underwent endoscopic maxillary antrostomy as the first surgical revision, while 47% underwent a revision Caldwell-Luc procedure. Sixty-seven percent of the sinuses in the revision endoscopic group had clinical resolution with a single surgical revision, and 60% of the sinuses in the revision Caldwell-Luc group had clinical improvement with one surgical revision (p = 0.46). The endoscopic group averaged 1.3+/-0.5 revision procedures per sinus to achieve clinical resolution, and the revision Caldwell-Luc group averaged 1.7+/-1.0 revision procedures per sinus (p = 0.3). Mean follow-up was 25 months. CONCLUSION: Endoscopic revision of the maxillary sinus yields comparable outcomes to repeat Caldwell-Luc procedure in patients with a history of previous failed Caldwell-Luc surgery. Endoscopic revision surgery is a viable alternative for surgical rehabilitation of the post-Caldwell-Luc maxillary sinus.