共查询到20条相似文献，搜索用时 46 毫秒
1.
Manel Vila-Vidal Alessandro Principe Miguel Ley Gustavo Deco Adrià Tauste Campo Rodrigo Rocamora 《Clinical neurophysiology》2017,128(6):977-985
Objective
We introduce a method that quantifies the consistent involvement of intracranially monitored regions in recurrent focal seizures.Methods
We evaluated the consistency of two ictal spectral activation patterns (mean power change and power change onset time) in intracranial recordings across focal seizures from seven patients with clinically marked seizure onset zone (SOZ). We examined SOZ discrimination using both patterns in different frequency bands and periods of interest.Results
Activation patterns were proved to be consistent across more than of recurrent ictal epochs. In all patients, whole-seizure mean activations were significantly higher for SOZ than non-SOZ regions () while activation onset times were significantly lower for SOZ than for non-SOZ regions () in six patients. Alpha-beta bands (8–20 Hz) achieved the highest patient-average effect size on the whole-seizure period while gamma band (20–70 Hz) achieved the highest discrimination values between SOZ and non-SOZ sites near seizure onset (0–5 s).Conclusions
Consistent spectral activation patterns in focal epilepsies discriminate the SOZ with high effect sizes upon appropriate selection of frequency bands and activation periods.Significance
The present method may be used to improve epileptogenic identification as well as pinpoint additional regions that are functionally altered during ictal events. 相似文献2.
Cristian Donos Ioana Mîndruţă Mihai Dragoş Malîia Alin Raşină Jean Ciurea Andrei Barborica 《Clinical neurophysiology》2017,128(6):1043-1052
Objective
To perform a side-by-side comparison of two epileptogenicity biomarkers, high frequency oscillations (HFOs) and delayed responses (DRs), as a result of single-pulse electrical stimulation.Methods
We have recorded stimulation-evoked HFOs and DRs in 16 epileptic patients undergoing presurgical evaluation using the stereoelectroencephalographic method. To evaluate converging and complementary information provided by the biomarkers, we analyzed them individually and for logical “and”/“or” combinations between them. 3D maps of the biomarkers’ distributions by recording location (inbound maps) and by stimulation location (outbound maps) were created to analyze their relationship with the epileptogenic structures.Results
HFOs occur less frequently than DRs, by 18.7%, when counting by recording contacts, and more frequently, by 7.4%, when counting by stimulation contacts. 40.6% of the contacts exhibiting HFOs also exhibit DRs, and 44.1% of the contacts exhibiting DRs also exhibit HFOs. When combining biomarkers, there was a tradeoff between increased seizure onset zone (SOZ) sensitivity, from 21.3% to 73%, and decreased specificity, from 87.2% to 34.3%.Conclusions
There is a moderate similarity in the information provided by the DRs and HFOs.Significance
The biomarkers complement each other, but there is a tradeoff between different metrics for SOZ localization. 相似文献3.
Katsuya Kobayashi Riki Matsumoto Masao Matsuhashi Kiyohide Usami Akihiro Shimotake Takeharu Kunieda Takayuki Kikuchi Kazumichi Yoshida Nobuhiro Mikuni Susumu Miyamoto Hidenao Fukuyama Ryosuke Takahashi Akio Ikeda 《Clinical neurophysiology》2017,128(9):1673-1681
Objective
We aimed to clarify that high frequency activity (HFA) of cortico-cortical evoked potentials (CCEPs), elicited by single pulse electrical stimulation (SPES), reflects cortical excitability.Methods
We recruited 16 patients with refractory partial epilepsy who had chronic subdural electrode implantation for presurgical evaluation. A repetitive SPES was given to (1) the seizure onset zone (SOZ) and (2) the control cortices (non-seizure onset zone: nSOZ). CCEPs were recorded from the neighboring cortices within SOZ and nSOZ. We applied short-time Fourier transform to obtain the induced responses for the timing of early (<50 ms after SPES) and late CCEP components and analyzed the logarithmic power change for ripple (<200 Hz) and fast ripple (>200 Hz) bands.Results
Twenty-one clear CCEPs were recorded for both the SOZ and nSOZ. The HFA power of early CCEPs in SOZ significantly increased compared to that in nSOZ in both frequency bands, particularly in mesial temporal lobe epilepsy (MTLE).Conclusion
Similar to the features of spontaneous pathological HFOs, the power of stimulus-induced HFAs in SOZ were greater than that outside SOZ, particularly in MTLE.Significance
HFA overriding CCEPs can be a surrogate marker of cortical excitability in epileptic focus. 相似文献4.
Satsuki Watanabe François Dubeau Natalja Zazubovits Jean Gotman 《Clinical neurophysiology》2017,128(6):986-991
Objective
It has been reported that interictal epileptic discharges (IEDs) recorded in temporal regions on scalp EEG are unlikely to originate from mesial temporal structures. However, EEG-fMRI sometimes show mesial temporal activation. We hypothesized that BOLD activation in the temporal neocortex is weaker than in the mesial structures, reflecting the fact that propagated activity has less metabolic demand than the original discharge.Methods
Twelve patients with epilepsy who have BOLD response in mesial temporal structures were selected from our EEG-fMRI database. We searched the temporal lobe ipsilateral to IEDs and checked whether there is positive BOLD response in the neocortex.Results
All IED types showed a BOLD response in the temporal neocortex ipsilateral to the mesial temporal BOLD response. T-values were higher in mesial temporal structures than in neocortex in 13/16 cases.Conclusions
Hemodynamic changes were observed in the mesial temporal lobe at the time of IEDs recorded from the temporal region on the scalp. The finding of smaller BOLD changes in the ipsilateral neocortex is in agreement with our hypothesis.Significance
Our study indicates that scalp-recorded temporal lobe spikes are likely to result from mesial temporal spikes propagating neuronally to the neocortex. 相似文献5.
Tommaso Fedele Claudio Schönenberger Gabriel Curio Carlo Serra Niklaus Krayenbühl Johannes Sarnthein 《Clinical neurophysiology》2017,128(10):1851-1857
Objective
The detectability of high frequency oscillations (HFO, >200 Hz) in the intraoperative ECoG is restricted by their low signal-to-noise ratio (SNR). Using the somatosensory evoked HFO, we quantify how HFO detectability can benefit from a custom-made low-noise amplifier (LNA).Methods
In 9 patients undergoing tumor surgery in the central region, subdural strip electrodes were placed for intraoperative neurophysiological monitoring. We recorded the somatosensory evoked potential (SEP) simultaneously by custom-made LNA and by a commercial device (CD). We varied the stimulation rate between 1.3 and 12.7 Hz to tune the SNR of the N20 component and the evoked HFO and quantified HFO detectability at the single trial level. In three patients we compared Propofol® and Sevoflurane® anesthesia.Results
In the average, amplitude decreased in both in N20 and evoked HFO amplitude with increasing stimulation rate (p < 0.05). We detected a higher percentage of single trial evoked HFO with the LNA (p < 0.001) for recordings with low impedance (<5 kΩ). Average amplitudes were indistinguishable between anesthesia compounds.Conclusion
Low-noise amplification improves the detection of the evoked HFO in recordings with subdural electrodes with low impedance.Significance
Low-noise EEG might critically improve the detectability of interictal spontaneous HFO in subdural and possibly in scalp recordings. 相似文献6.
Shuang Wang Norman K. So Bo Jin Irene Z. Wang Juan C. Bulacio Rei Enatsu Shenyi Dai Zhong Chen Jorge Gonzalez-Martinez Imad M. Najm 《Clinical neurophysiology》2017,128(6):945-951
Objective
This study aimed to identify the subtype of interictal ripples that help delineate the epileptogenic zone in neocortical epilepsy.Methods
Totally 25 patients with focal neocortical epilepsy who had invasive electroencephalography (EEG) evaluation and subsequent surgery were included. They were followed up for at least 2 years. Interictal ripples (80–250 Hz) and fast ripples (250–500 Hz) during slow-wave sleep were identified. Neocortical ripples were defined as type I ripples when they were superimposed on epileptiform discharges, and as type II ripples when they occurred independently. Resection ratio was calculated to present the extent to which the cortical area showing an interictal event or the seizure onset zone (SOZ) was completely removed.Results
Fast ripples and types I and II ripples were found in 8, 19, and 21 patients, respectively. Only the higher resection ratio of interictal fast or type I ripples was correlated to the Engel 1a surgical outcome.Conclusions
Type I ripples could assist in localizing the epileptogenic zone in neocortical epilepsy.Significance
Type I and fast ripples both may be pathological high-frequency oscillations. 相似文献7.
Different seizure-onset patterns in mesiotemporal lobe epilepsy have a distinct interictal signature
Birgit Frauscher Nicolás von Ellenrieder François Dubeau Jean Gotman 《Clinical neurophysiology》2017,128(7):1282-1289
Objective
Experimental research demonstrated that distinct underlying mechanisms go along with different seizure-onset patterns on EEG. These different mechanisms may reflect different tissue abnormalities which, we hypothesize, could also be reflected in morphological differences in the interictal epileptic and background EEG activity.Methods
We searched our database of intracranial EEG recordings for mesiotemporal lobe epilepsy patients with either predominant low-voltage fast activity (LVF) or periodic spiking (PS). Interictal epileptiform discharges (IEDs) were characterized by the spike/polyspike amplitude, the amplitude of the post-spike slow wave, and the associated low-frequency and high-frequency power increases. The EEG background was assessed with the root mean square amplitude, the distribution of the instantaneous amplitude relative to the root mean square value, and the power spectral density.Results
We identified 18 patients with predominant LVF or PS. IEDs in PS were 1.7-times sharper as determined by the high-frequency power increase than IEDs in LVF. In contrast, IEDs in LVF had a 1.2-times higher post-spike slow wave amplitude, and a 1.5-times larger low-frequency power content than IEDs in PS. There was no difference in rates of IEDs/HFOs, spike amplitude, HFO co-occurrence, and EEG background.Conclusions
We demonstrated an association between the morphology of IEDs and the type of the seizure-onset pattern in mesiotemporal lobe epilepsy.Significance
Our findings therefore suggest that IED morphology is a marker of the underlying mechanisms of seizure generation. 相似文献8.
Alice D. Lam Douglas Maus Sahar F. Zafar Andrew J. Cole Sydney S. Cash 《Clinical neurophysiology》2017,128(9):1647-1655
Objective
In mesial temporal lobe (mTL) epilepsy, seizure onset can precede the appearance of a scalp EEG ictal pattern by many seconds. The ability to identify this early, occult mTL seizure activity could improve lateralization and localization of mTL seizures on scalp EEG.Methods
Using scalp EEG spectral features and machine learning approaches on a dataset of combined scalp EEG and foramen ovale electrode recordings in patients with mTL epilepsy, we developed an algorithm, SCOPE-mTL, to detect and lateralize early, occult mTL seizure activity, prior to the appearance of a scalp EEG ictal pattern.Results
Using SCOPE-mTL, 73% of seizures with occult mTL onset were identified as such, and no seizures that lacked an occult mTL onset were identified as having one. Predicted mTL seizure onset times were highly correlated with actual mTL seizure onset times (r = 0.69). 50% of seizures with early mTL onset were lateralizable prior to scalp ictal onset, with 94% accuracy.Conclusions
SCOPE-mTL can identify and lateralize mTL seizures prior to scalp EEG ictal onset, with high sensitivity, specificity, and accuracy.Significance
Quantitative analysis of scalp EEG can provide important information about mTL seizures, even in the absence of a visible scalp EEG ictal correlate. 相似文献9.
Mihai Dragos Mălîia Cristian Donos Andrei Barborica Ioana Mindruta Irina Popa Mirela Ene Sándor Beniczky 《Clinical neurophysiology》2017,128(6):1053-1060
Objective
To investigate functional coupling between brain networks using spectral changes induced by single-pulse electric stimulation (SPES).Method
We analyzed 20 patients with focal epilepsy, implanted with depth electrodes. SPES was applied to each pair of adjacent contacts, and responses were recorded from all other contacts. The mean response amplitude value was quantified in three time-periods after stimulation (10–60, 60–255, 255–500 ms) for three frequency-ranges (Gamma, Ripples, Fast-Ripples), and compared to baseline. A total of 30,755 responses were analyzed, taking into consideration three dichotomous pairs: stimulating in primary sensory areas (S1-V1) vs. outside them, to test the interaction in physiologic networks; stimulating in seizure onset zone (SOZ) vs. non-SOZ, to test pathologic interactions; recording in default mode network (DMN) vs. non-DMN.Results
Overall, we observed an early excitation (10–60 ms) and a delayed inhibition (60–500 ms). More specifically, in the delayed period, stimulation in S1-V1 produced a higher gamma-inhibition in the DMN, while stimulation in the SOZ induced a higher inhibition in the epilepsy-related higher frequencies (Ripples and Fast-Ripples).Conclusion
Physiologic and pathologic interactions can be assessed using spectral changes induced by SPES.Significance
This is a promising method for connectivity studies in patients with drug-resistant focal epilepsy. 相似文献10.
Hong Li Caihong Ji Lujia Zhu Peiyu Huang Biao Jiang Xiaojun Xu Jianzhong Sun Zhong Chen Meiping Ding Minming Zhang Shuang Wang 《Clinical neurophysiology》2017,128(5):830-838
Objective
To investigate the pattern of functional demarcation of hippocampal network and its relationship with memory performance in mesial temporal lobe epilepsy (mTLE) with unilateral hippocampal sclerosis.Methods
Resting state fMRI data were acquired from fifteen left mTLE patients, fourteen right mTLE patients and twenty healthy subjects. We explore the hippocampal-cortical alterations and corresponding inter-hemispheric functional connectivity (FC) across anterior and posterior hippocampal networks. The association between FC and memory performance was assessed.Results
Left mTLE showed increased intra-hemispheric FC in anterior hippocampal networks, including left anterior hippocampal-entorhinal cortex and right anterior hippocampal-orbitofrontal cortex, and decreased inter-hemispheric FC between anterior hippocampus, entorhinal cortex and posterior cingulate cortex. Right mTLE was associated with extensive reduction in inter-hemispheric FC along the areas of anterior and posterior hippocampal networks. Intra-hemispheric FC between left anterior hippocampus and entorhinal cortex was positively correlated with verbal memory in left mTLE. Inter-hemispheric FC between posterior parahippocampal gyrus was negatively correlated with verbal memory in right mTLE.Conclusions
Our findings suggested that left and right mTLE exhibit different neural reorganization patterns of anterior and posterior hippocampal networks associated with verbal memory.Significance
The findings may facilitate the characterization of mTLE associated with memory deficit. 相似文献11.
Yasushi Iimura Kevin Jones Kyoko Hattori Yushi Okazawa Atsuko Noda Kana Hoashi Yutaka Nonoda Eishi Asano Tomoyuki Akiyama Cristina Go Ayako Ochi O. Carter Snead Elizabeth J. Donner James T. Rutka James M. Drake Hiroshi Otsubo 《Clinical neurophysiology》2017,128(7):1197-1205
Objective
Subtotal hemispherectomy involves the resection of multiple lobes in children with drug-resistant epilepsy, skipping the motor area (MA). We determined epileptogenicity using the occurrence rate (OR) of high-frequency oscillations (HFOs) and the modulation index (MI), demonstrating strength of coupling between HFO and slow wave. We hypothesized that epileptogenicity increased over the multiple lobes but skipped the MA.Methods
We analyzed 23 children (14 subtotal hemispherectomy; 9 multilobar resections). Scalp video-EEG and magnetoencephalography were performed before surgery. We analyzed the OR(HFO) and MI(5 phases=0.5–8 Hz) on electrodes of total area, resection areas, and MA. We compared the data between good [International League Against Epilepsy (ILAE) class I–II] and poor (III–VI) seizure outcome groups.Results
ILAE class Ia outcome was achieved in 18 children. Among the MI(5 phases) in the resection areas, MI(3–4 Hz) was the highest. The OR(HFO) and MI(3–4 Hz) in both total area and resection areas were significantly higher in the good seizure outcome group than in the poor outcome group. The OR(HFO) and MI(3–4 Hz) in resection areas were significantly higher than in the MA.Conclusions
Our patients with multilobar drug-resistant epilepsy showed evidence of multifocal epileptogenicity that specifically skipped the MA.Significance
This is the first study demonstrating that the electrophysiological phenotype of multifocal epilepsy specifically skips the MA using OR(HFO) and MI(3–4 Hz). 相似文献12.
Mamede de Carvalho Artiom Poliakov Cristiano Tavares Michael Swash 《Clinical neurophysiology》2017,128(11):2200-2204
Objective
We studied motor unit recruitment to test a new method to identify motor unit firing rate (FR) variability.Methods
We studied 68 ALS patients, with and without upper neuron signs (UMN) in lower limbs, 24 patients with primary lateral sclerosis (PLS), 13 patients with spinal cord lesion and 39 normal subjects. All recordings were made from tibialis anterior muscles of normal strength. Subjects performed a very slight contraction in order to activate 2 motor units in each recording. 5–7 motor unit pairs were recorded in each subject. Mean consecutive differences (MCD) were calculated for each pair of potentials. The mean MCD for each muscle was estimated as the mean from the total number of pairs recorded. A p value < 0.01 was accepted as significant.Results
MCD of FR frequency was less in the subjects with spinal cord lesion and PLS. In addition, the FR frequency of the 1st motor unit in a pair of units was markedly reduced in PLS, and in subjects with spinal cord lesions.Conclusion
These results support a lower threshold and reduced FR fluctuation in spinal motor neurons of spastic patients.Significance
This method can be developed for detection of UMN lesions. 相似文献13.
I.C. Zibrandtsen P. Kidmose C.B. Christensen T.W. Kjaer 《Clinical neurophysiology》2017,128(12):2454-2461
Objective
Ear-EEG is recording of electroencephalography from a small device in the ear. This is the first study to compare ictal and interictal abnormalities recorded with ear-EEG and simultaneous scalp-EEG in an epilepsy monitoring unit.Methods
We recorded and compared simultaneous ear-EEG and scalp-EEG from 15 patients with suspected temporal lobe epilepsy. EEGs were compared visually by independent neurophysiologists. Correlation and time-frequency analysis was used to quantify the similarity between ear and scalp electrodes. Spike-averages were used to assess similarity of interictal spikes.Results
There were no differences in sensitivity or specificity for seizure detection. Mean correlation coefficient between ear-EEG and nearest scalp electrode was above 0.6 with a statistically significant decreasing trend with increasing distance away from the ear. Ictal morphology and frequency dynamics can be observed from visual inspection and time-frequency analysis. Spike averages derived from ear-EEG electrodes yield a recognizable spike appearance.Conclusions
Our results suggest that ear-EEG can reliably detect electroencephalographic patterns associated with focal temporal lobe seizures. Interictal spike morphology from sufficiently large temporal spike sources can be sampled using ear-EEG.Significance
Ear-EEG is likely to become an important tool in clinical epilepsy monitoring and diagnosis. 相似文献14.
Ruihua Zhang Ye Ren Chunyan Liu Na Xu Xiaoli Li Fengyu Cong Tapani Ristaniemi YuPing Wang 《Clinical neurophysiology》2017,128(9):1707-1718
Objective
Neural activity of the epileptic human brain contains low- and high-frequency oscillations in different frequency bands, some of which have been used as reliable biomarkers of the epileptogenic brain areas. However, the relationship between the low- and high-frequency oscillations in different cortical areas during the period from pre-seizure to post-seizure has not been completely clarified.Methods
We recorded electrocorticogram data from the temporal lobe and hippocampus of seven patients with temporal lobe epilepsy. The modulation index based on the Kullback-Leibler distance and the phase-amplitude coupling co-modulogram were adopted to quantify the coupling strength between the phase of low-frequency oscillations (0.2–10 Hz) and the amplitude of high-frequency oscillations (11–400 Hz) in different seizure epochs. The time-varying phase-amplitude modulogram was used to analyze the phase-amplitude coupling pattern during the entire period from pre-seizure to post-seizure in both the left and right temporal lobe and hippocampus. Channels with strong modulation index were compared with the seizure onset channels identified by the neurosurgeons and the resection channels in the clinical surgery.Results
The phase-amplitude coupling strength (modulation index) increased significantly in the mid-seizure epoch and decrease significantly in seizure termination and post-seizure epochs (p < 0.001). The strong phase-amplitude-modulating low- and high-frequency oscillations in the mid-seizure epoch were mainly δ, θ, and α oscillations and γ and ripple oscillations, respectively. The phase-amplitude modulation and strength varied among channels and was asymmetrical in the left and right temporal cortex and hippocampus. The “fall-max” phase-amplitude modulation pattern, i.e., high-frequency amplitudes were largest in the low-frequency phase range [?π, 0], which corresponded to the falling edges of low-frequency oscillations, appeared in the middle period of the seizures at epileptic focus channels. Channels with strong modulation index appeared on the corresponding left or right temporal cortex of surgical resection and overlapped with the clinical resection zones in all patients.Conclusions
The “fall-max” pattern between the phase of low-frequency oscillation and amplitude of high-frequency oscillation that appeared in the middle period of the seizures is a reliable biomarker in epileptogenic cortical areas. The modulation index can be used as a good tool for lateralization and localization for the epileptic focus in patients with epilepsy.Significance
Phase-amplitude coupling can provide meaningful reference for accurate resection of epileptogenic focus and provide insight into the underlying neural dynamics of the epileptic seizure in patients with temporal lobe epilepsy. 相似文献15.
Zhongwei Guo Xiaozheng Liu Jiapeng Li Fuquan Wei Hongtao Hou Xingli Chen Xinwei Li Wei Chen 《Clinical neurophysiology》2017,128(7):1344-1349
Objective
To explore brain activity in AD with depression (D-AD) based on fractional amplitude of low-frequency fluctuation (fALFF).Methods
Twenty-two D-AD and 21 AD without depression patients (nD-AD) were examined by magnetic resonance imaging during resting state. Neuropsychiatric Inventory and Hamilton Depression Rating Scale were employed to assess the severity of depression. We analysed the characteristics of fALFF in D-AD differing from nD-AD. We also examined the correlation between fALFF and the depression severity.Results
D-AD patients had higher fALFF in right fusiform gyrus, left caudate nucleus, and right middle temporal gyrus (MTG), meanwhile lower fALFF in supplementary motor area (SMA) than nD-AD patients.Conclusions
Abnormal fALFF changes in fusiform gyrus, caudate nucleus, MTG and SMA may be important neuropathophysiologic characteristics of depression in AD.Significance
We have clarified the potential neuropathological changes of depression in AD based on fALFF method, which is crucial for effective intervention. 相似文献16.
A. Valentín N. Hernando-Quintana J. Moles-Herbera D. Jimenez-Jimenez S. Mourente I. Malik R.P. Selway G. Alarcón 《Clinical neurophysiology》2017,128(3):418-423
Objective
To study retrospectively the impact of electrode modality (subdural or depth electrodes) during presurgical assessment on surgical outcome after temporal lobectomy.Methods
The study included 17 patients assessed with depth electrodes and 57 with bitemporal subdural strips.Results
MRI showed a larger proportion of bilateral pathology in patients undergoing depth recordings (29.41% versus 3.5%, p = 0.00069). Among the operated patients, those undergoing depth electrode recordings showed better outcome at one year after surgery (11/12 versus 22/33; p = 0.046). This difference disappears at longest follow up (10/12 versus 22/33; p = 0.138). Moreover, the probability of undergoing surgery and having good outcome after assessment with intracranial recordings is higher for the depth electrode group at one-year follow up (11/17 versus 22/57; p = 0.029) but statistical differences decrease to a trend for the longest follow up (10/17 versus 22/57; p = 0.069). No other statistical differences were noted between subdural and depth electrodes. Depth electrodes showed lower complication rates than subdural electrodes.Conclusion
Both depth and subdural electrodes are effective for presurgical assessment of temporal lobe epilepsy.Significance
Assessment with depth electrodes is associated with slightly increased likelihood of surgery and marginally better surgical outcome at one year follow up which disappears for longer follow up periods. Initial assessment with depth electrodes would have avoided a second implantation in 15% of patients. 相似文献17.
Lauren A. Shreve Anca Velisar Mahsa Malekmohammadi Mandy Miller Koop Megan Trager Emma J. Quinn Bruce C. Hill Zack Blumenfeld Camilla Kilbane Alessandra Mantovani Jaimie M. Henderson Helen Brontë-Stewart 《Clinical neurophysiology》2017,128(1):128-137
Objective
Determine the incidence of resting state oscillations in alpha/beta, high frequency (HFO) bands, and their phase amplitude coupling (PAC) in a large cohort in Parkinson’s disease (PD).Methods
Intra-operative local field potentials (LFPs) from subthalamic nucleus (STN) were recorded from 100 PD subjects, data from 74 subjects were included in the analysis.Results
Alpha/beta oscillations were evident in >99%, HFO in 87% and PAC in 98% of cases. Alpha/beta oscillations (P < 0.01) and PAC were stronger in the more affected (MA) hemisphere (P = 0.03). Alpha/beta oscillations were primarily found in 13–20 Hz (low beta). Beta and HFO frequencies with the greatest coupling, were positively correlated (P = 0.001). Tremor attenuated alpha (P = 0.002) and beta band oscillations (P < 0.001).Conclusions
STN alpha/beta band oscillations and PAC were evident in ?98% cases and were greater in MA hemisphere. Resting tremor attenuated underlying alpha/beta band oscillations.Significance
Beta band LFP power may be used to drive adaptive deep brain stimulation (aDBS), augmented by a kinematic classifier in tremor dominant PD. 相似文献18.
Koichi Hagiwara Julien Jung Romain Bouet Chifaou Abdallah Marc Guénot Luis Garcia-Larrea François Mauguière Sylvain Rheims Jean Isnard 《Clinical neurophysiology》2017,128(5):780-791
Objective
For a decade it has been known that the insular lobe epilepsy can mimic frontal lobe epilepsy. We aimed to clarify the pattern of functional coupling occurring during the frontal presentation.Methods
We analyzed five insular lobe epilepsy patients. Frontal semiology was predominant for three of them, whereas insular semiology was predominant for the two others. We applied the non-linear regression analysis to stereoelectroencephalography-recorded seizures. A directed functional coupling index was calculated during clonic discharge periods that were accompanied either with frontal or insular semiology.Results
We found significant functional coupling between the insula and mesial frontal/cingulate regions, with the former being a leader region for seizures propagation. Extra-insular regions showed significantly less or even no coupling with the mesial hemispheric regions. The three patients with frontal semiology showed strong couplings with the mesial frontal as well as cingulate regions, including the medial orbitofrontal cortex, pre-SMA/SMA, and the anterior to posterior cingulate. The two patients with the insular semiology only showed couplings between the insula and cingulate regions.Conclusions
The frontal semiology was expressed by strong functional couplings between the insula and mesial frontal regions.Significance
The insular origin of seizure should be considered in cryptogenic mesial frontal epilepsies. 相似文献19.
Sumiya Shibata Masao Matsuhashi Takeharu Kunieda Yukihiro Yamao Rika Inano Takayuki Kikuchi Hisaji Imamura Shigetoshi Takaya Riki Matsumoto Akio Ikeda Ryosuke Takahashi Tatsuya Mima Hidenao Fukuyama Nobuhiro Mikuni Susumu Miyamoto 《Clinical neurophysiology》2017,128(5):734-743
Objective
We describe temporal spread imaging (TSI) that can identify the spatiotemporal pattern of epileptic activity using Magnetoencephalography (MEG).Methods
A three-dimensional grid of voxels covering the brain is created. The array-gain minimum-variance spatial filter is applied to an interictal spike to estimate the magnitude of the source and the time (Ta) when the magnitude exceeds a predefined threshold at each voxel. This calculation is performed through all spikes. Each voxel has the mean Ta (<Ta>) and spike number (Nsp), which is the number of spikes whose source exceeds the threshold. Then, a random resampling method is used to determine the cutoff value of Nsp for the statistically reproducible pattern of the activity. Finally, all the voxels where the source exceeds the threshold reproducibly shown on the MRI with a color scale representing <Ta>.Results
Four patients with intractable mesial temporal lobe epilepsy (MTLE) were analyzed. In three patients, the common pattern of the overlap between the propagation and the hypometabolism shown by fluorodeoxyglucose-positron emission tomography (FDG-PET) was identified.Conclusions
TSI can visualize statistically reproducible patterns of the temporal and spatial spread of epileptic activity.Significance
TSI can assess the statistical significance of the spatiotemporal pattern based on its reproducibility. 相似文献20.
Daniela Mannarelli Caterina Pauletti Patrizia Mancini Alessandra Fioretti Antonio Greco Marco De Vincentiis Francesco Fattapposta 《Clinical neurophysiology》2017,128(3):411-417