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1.
Ovarian cystic tumors with a mural nodule are a rare entity. We report a case of a mural nodule of anaplastic spindle cell carcinoma in an ovarian mucinous cystic tumor of borderline malignancy. The patient was a 45-years-old Japanese woman who presented with an ovarian cyst. She suffered from mature cystic teratoma of both ovaries 9 years before the present history. Image analysis and laboratory data showing a high serum CA19-9 level suggested ovarian malignancy. She underwent bilateral salpingo-oophorectomy with hysterectomy and omentectomy. There was a mural nodule in the ovarian mucinous cystic lesion. Microscopically, the nodule was composed of spindle-shaped cells with severe nuclear atypia. Immunohistochemical analysis allowed the cells to be categorized as anaplastic spindle cell carcinoma. Fifteen months after the operation the patient is alive without any clinical findings of tumor recurrence. To the best of our knowledge in the English literature, this is the first report of a mural nodule of an anaplastic spindle cell carcinoma within an ovarian mucinous cystic borderline tumor harboring previously confirmed cystic teratoma. 相似文献
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Primary retroperitoneal mucinous cystadenoma of borderline malignancy: a case report and review of the literature. 总被引:5,自引:0,他引:5
Masakazu Matsubara Tanri Shiozawa Ryota Tachibana Takaaki Hondo Kumi Osasda Kenji Kawaguchi Kaoru Kimura Ikuo Konishi 《International journal of gynecological pathology》2005,24(3):218-223
A case of primary retroperitoneal mucinous cystic tumor of borderline malignancy is reported. A 36-year-old, nulliparous woman complained of abdominal fullness. Physical examination revealed a cystic mass 12-cm x 8-cm in size. At laparotomy, a cystic tumor was observed in the right retroperitoneal space. Both ovaries appeared normal and the uterus was almost normal except for small myomatous nodules. Removal of the retroperitoneal tumor, an appendectomy, and a myomectomy were performed. The histologic diagnosis was a primary retroperitoneal mucinous cystic tumor of borderline malignancy, similar to findings for ovarian tumor. There was no evidence of disease 6 months after the surgery. 相似文献
4.
Ling-Hui Chu Hung-Cheng Lai Yu-Tso Liao 《Taiwanese journal of obstetrics & gynecology》2021,60(1):136-138
ObjectiveOsteosarcoma as a mural nodule in the ovary is extremely rare. We aimed to describe a case of a mural nodule with features of an osteosarcoma arising in an ovarian mucinous cystadenoma.Case reportThe 65-year-old woman presented with progressive abdominal swelling and poor intake. Image studies showed a huge (diameter, >30 cm) intra-abdominal multiloculated cystic lesion, suspected to be an ovarian tumor. She underwent unilateral salpingo-oophorectomy with no postoperative adjuvant therapy. She was disease-free at 16-month follow-up.ConclusionOsteosarcoma presenting as a primary ovarian neoplasm is rare, either as a pure osteosarcoma or arising from a teratoma. However, two osteosarcoma cases occurring arising from a mural nodule in an ovarian mucinous neoplasm have been reported. There is no consensus regarding the treatment strategy for osteosarcomatous mural nodules in mucinous tumors because of its rarity. More case studies are needed before its pathogenesis can be fully understood. 相似文献
5.
S. Rifki Jai R. Bouffetal F. Chehab D. Khaiz A. Bouzidi 《Archives of gynecology and obstetrics》2009,280(3):479-483
Primary retroperitoneal mucinous cystic tumors are extremely rare, and although their histopathogenesis is still uncertain,
several theories have been proposed. Traditionally, transabdominal laparotomy and enucleation of the cyst is the treatment
of choice. The anatomopathological examination of the mass is imperative in the fact to eliminate malignant lesions. We report
the case of a 43-year-old woman, with primary retroperitoneal mucinous cystic tumor, revealed by an abdomino-pelvic mass.
During laparotomy, a totality of the tumor was removed. The anatomopathologic study permitted the diagnosis. 相似文献
6.
Ovarian-type mucinous tumours occur very rarely in the retroperitoneum. We present a case of primary retroperitoneal mucinous
tumour of borderline malignancy in a 58-year-old woman, detected as an incidental finding. The patient presented with acute
renal failure, investigation for which revealed a complex pelvic mass initially thought to be in the right adnexa and consistent
with an ovarian neoplasm. Surgical findings revealed a 130-mm, right-sided non-communicating retroperitoneal pelvic mass,
posterior to the appendix, which was completely resected. Both ovaries were normal. Macroscopically, it was a multi-loculated
cystic structure with a smooth external surface containing clear and mucinous fluid. Microscopic examination showed a mucinous
tumour of borderline malignancy. The literature contains approximately nine other cases of primary mucinous retroperitoneal
tumour of borderline malignancy. These cases have occurred in women aged 36–60 years. Most patients were asymptomatic and
the mass was detected as an incidental finding. The patients have been followed up for up to 6 to 18 months and, to date,
none have recurred. There are limitations to pre-operative radiological imaging. A definitive diagnosis can only be made after
complete surgical excision and histological examination, having excluded retroperitoneal involvement by mucinous tumours from
sites such the ovaries, bowel, appendix and pancreas. 相似文献
7.
Three cases (two ovarian and one retroperitoneal) of mucinous tumors with solid nodules are reported. The predominant picture in the three cases was that of a mucinous cystic tumor, but small nodules of solid anaplastic carcinoma were found in all three cases. In addition, one case showed microscopic foci of microcyst rupture with histiocytic response reminiscent of sarcoma-like mural nodules, one case showed several sarcoma-like nodules, and one case showed apparent transition from anaplastic carcinoma to spindle cell sarcoma. Histologic and immunohistochemical characteristics of the lesions are given, as differentiation of these nodules is important. 相似文献
8.
Ovarian mucinous cystadenoma with leiomyomatous mural nodule 总被引:1,自引:0,他引:1
B Lifschitz-Mercer R Dgani N Jacob M Fogel B Czernobilsky 《International journal of gynecological pathology》1990,9(1):80-85
A case of an ovarian mucinous cystadenoma with a leiomyomatous mural nodule is described. The diagnosis was confirmed by immunohistochemical methods. This is the first report of a mural nodule of leiomyomatous nature, thus widening the histologic spectrum that may be encountered in these lesions. 相似文献
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Sarcoma-like mural nodules combined with a microfocus of anaplastic carcinoma in mucinous ovarian tumor 总被引:2,自引:0,他引:2
A case of mucinous ovarian tumor with sarcoma-like mural nodules, one of which coexisted with a microfocus of anaplastic carcinoma, was studied by light, electron microscopic, and histochemical examinations. The case suggested that the formation of sarcoma-like mural nodules may be the result of the proliferation of undifferentiated mesenchymal cells which exist beneath the mucinous epithelium by some stimulation like hemorrhage in the cyst wall. Histologically, the mononucleated cells composing the sarcoma-like mural nodules had epithelioid characteristics, particularly at the areas where the covering mucinous epithelium had already detached. The case also suggested that the findings of epithelioid characteristics in the sarcoma-like mural nodules themselves do not imply these nodules to be anaplastic carcinoma, but merely an epithelioid differentiation from undifferentiated mesenchymal cells, namely one of reactive products. However, the existence of a microfocus of anaplastic carcinoma combined with the sarcoma-like mural nodule necessitates a careful histologic analysis of mural nodules for the treatment of patients and the determination of the prognosis. 相似文献
10.
BACKGROUND: Gangliocytic paraganglioma is a rare neoplasm involving the small intestine, stomach, and spinal cord. Ovarian gangliocytic paraganglioma has not been reported in the medical literature. CASE: A 55-year-old caucasian woman underwent exploratory laparotomy, total abdominal hysterectomy, and bilateral salpingo-oophorectomy for evaluation of a persistent right adnexal mass. Microscopic examination of the right ovary revealed a mature cystic teratoma with a mural nodule consistent with gangliocytic paraganglioma. As there was no evidence of significant pleomorphism or neoplastic infiltration, surgical staging was not performed. CONCLUSION: Gangliocytic paraganglioma may arise from ovarian cystic teratoma. Although most cases of gangliocytic paragangliomas are benign, surgical staging and retroperitoneal lymphadenectomy may be required if histopathology is suggestive of invasive disease or if enlarged lymph nodes are noted. 相似文献
11.
Retroperitoneal mucinous cystadenoma 总被引:1,自引:0,他引:1
Kehagias DT Karvounis EE Fotopoulos A Gouliamos AD 《European journal of obstetrics, gynecology, and reproductive biology》1999,82(2):213-215
A case of retroperitoneal mucinous cystadenoma histologically confirmed in a 21-year-old woman is reported. Although ultrasound, CT and MR detected the tumor, a preoperative diagnosis could not be established by imaging methods. The cystic tumor was removed and microscopic examination revealed a mucinous cystadenoma. Mullerian mesothelial metaplasia of peritoneal invagination into the retroperitoneal space is the most likely explanation for the histogenesis of these tumors. 相似文献
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Takeuchi K Kitazawa S Deguchi M Maruo T 《European journal of gynaecological oncology》2005,26(5):511-513
A 83-year-old woman received bilateral salpingo-oophorectomy and hysterectomy due to a provisional diagnosis of ovarian cystic tumor. The tumor had a unilocular cystic cavity demonstrating serous cystadenoma and a solid mural nodule representing a biphasic pattern with mesenchymal and glandular components. The glandular elements were composed of benign serous cells, whereas the mesenchymal components consisted of an admixture of fibromatous stromal cells without atypia and sarcomatous overgrowth. The area of transition from a fibromatous component to sarcomatous overgrowth was identified. After a 2-year follow-up, there were no signs of tumor recurrence or systemic disease. To the authors' knowledge, this is the first reported case of adenofibrosarcoma originating from a mural nodule of ovarian serous cystadenoma. 相似文献
13.
Elliot B. Tapper Adam B. Shrewsberry Gabriella Oprea Bhagirath Majmudar 《Archives of gynecology and obstetrics》2010,281(1):167-169
Primary retroperitoneal mucinous cysts are rare. Most often malignant, lesions present on a spectrum, fitting the histopathological
categories of benign, borderline and malignant. The rarest form is the benign mucinous cystadenoma adenocarcinoma, of which
only 20 cases have been reported. We present here the curious case of a 37-year-old woman with two large, fast growing, cystic,
benign, primary retroperitoneal mucinous cystadenomas treated definitively by local resection. 相似文献
14.
Balat O Aydin A Sirikci A Kutlar I Aksoy F 《European journal of gynaecological oncology》2001,22(6):454-455
Primary mucinous cystic tumors of the retroperitoneum are rarely encountered and have been reported in approximately 25 cases in the literature. The histogenesis of primary mucinous cystadenomas is not clear. Most authors suggest that it develops through mucinous metaplasia in a pre-existing mesothelium-lined cyst. Surgery is the only treatment. In this report we present an additional case of primary retroperitoneal mucinous cystadenoma in a 44-year-old female. 相似文献
15.
W.-C. Chang B.-C. Sheu M.-C. Lin† S.-N. Chow & S.-C. Huang 《International journal of gynecological cancer》2005,15(3):549-553
Epithelial ovarian tumors of borderline malignancy are tumors with histologic features and biologic behavior between benign and frankly malignant epithelial ovarian neoplasms. To date, we cannot accurately predict the patients who are prone to an aggressive course of disease. Here, we present a 35-year-old patient with carcinosarcoma-like mural nodule in intestinal-type mucinous ovarian tumor of borderline malignancy. Foci of intraepithelial carcinoma (about 10%) without stromal invasion are also noted. Total hysterectomy, bilateral salpingo-oophorectomy, appendectomy, and omentectomy were performed, and the frozen pathology during operation showed mucinous tumor of borderline malignancy of left ovary on April 18, 2002. The patient was followed at our outpatient department for 19 months after operation and was free of the disease without any adjuvant chemotherapy. It is difficult to determine whether intestinal-type borderline mucinous tumors with intraepithelial carcinoma are associated with a worse prognosis compared with those with epithelial atypia alone due to disparate results in the published literature. In contrast, most patients with mural nodules of anaplastic carcinoma have had a malignant, often rapid, course. However, too few cases of carcinosarcoma-like mural nodule in mucinous tumor have been published to warrant a conclusion regarding their prognosis. 相似文献
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Dhouibi A Denoux Y Touil N Devouassoux Shisheboran M Carbonnel M Baglin AC 《Journal de gynecologie, obstetrique et biologie de la reproduction》2011,40(5):469-472
The occurrence of mural nodules in serous or mucinous ovarian tumours is not frequent. Mural nodule can be developed in benign, borderline or malignant tumours. They can be benign, malignant or mixed type. Thus the prognosis of the ovarian tumour can be dramatically modified by the presence if these nodules. Eighty-two cases of mural nodules were reported in the literature, among which we account four cases of mixed nodules type. We report an additional case of mixed type mural nodules of anaplastic carcinoma and sarcoma-like developed in an ovarian mucinous borderline tumour at a 60-year-old woman.We give details about the classification, the differential diagnosis and prognosis of theses nodules. 相似文献
17.
Tomoko Kihara Masato Komatsu Toshiko Sakuma Yoshiki Mikami Koushou Takasu Yuki Nakashima Shinsuke Mochizuki Motoyoshi Maruo 《Journal d'obstetrique et gynecologie du Canada》2019,41(1):72-75
Background
The presence of anaplastic and sarcomatoid components in ovarian mucinous carcinoma is extremely rare.Case
A 64-year-old woman underwent radical surgery for right ovarian cancer. Pathological examination showed mucinous adenocarcinoma with a focal mural nodule of anaplastic and sarcomatoid carcinoma (FIGO stage IIB). She underwent adjuvant chemotherapy but developed severe respiratory failure and died after 9 months. Autopsy showed that the bilateral pulmonary parenchyma was filled with a multinodular hemorrhagic mass, and the cardiac wall had a massive invasive lesion. Histopathological examination of the lung and myocardium revealed diffuse invasion of the anaplastic carcinoma component with infiltrating osteoclastic giant cells.Conclusion
This case is very rare, and the clinical management of anaplastic carcinoma arising in mucinous neoplasms remains challenging. 相似文献18.
Ching-Hui Chen Li-Hsuan Chiu Jui-Yu Lin Wei-Min Liu 《Taiwanese journal of obstetrics & gynecology》2013,52(1):117-119
ObjectiveThe diagnosis and treatment of adnexal mass during pregnancy is a major challenge for obstetricians. A rare case is reported of retroperitoneal cystic lesion during pregnancy.Case ReportA 31-year-old woman was diagnosed with an adnexal cystic lesion at 8 weeks of gestation and underwent laparoscopic surgery at 14 weeks of gestation. During laparoscopic surgery, the bilateral ovaries and tubes were normal, but the lesion was located on the right-side retroperitoneal area. Aspiration and enucleation were performed successfully by laparoscopy. The pathology report revealed mucinous cystadenoma. The patient had a smooth pregnancy course and delivered a healthy baby at 39 weeks of gestation.ConclusionLaparoscopic surgery is a safe procedure in the management of pregnant women with suspicious adnexal cystic lesions. 相似文献
19.
BACKGROUND: Primary retroperitoneal mucinous borderline tumors are rare. These tumors can be present in women with otherwise normal pelvic anatomy. CASE: A 22-year-old woman with abdominal pain was found to have a large midline mass superior to the uterus with ascites. In surgery, a large mass was arising from the sigmoid mesentery. The pelvis was normal on inspection. Final pathology of the mass revealed borderline tumor (tumor of low malignant potential) and focus of ovarian tissue. CONCLUSION: This is a case report of primary retroperitoneal mucinous borderline tumor. The gynecologic oncologist should be aware of primary retroperitoneal tumors and the differential diagnosis. 相似文献
20.
Erdem S Iskender C Avsar AF Altundag OB Ustunyurt E 《The journal of obstetrics and gynaecology research》2006,32(6):628-630
We report a case of a 48-year-old woman with a complaint of chronic pelvic pain with a pelvic mass not related with uterus or adnexes. Preoperative ultrasonography or contrast enhanced computed tomography did not give accurate information on the origin of tumor. At laparotomy a cystic, retroperitoneal mass was totally resected without rupture. Final histopathological examination revealed that cystic spaces with abundant lymphocytes suggesting lymphangioma. No recurrence was detected in the follow up 6 months after total resection. As a result cystic lymphangioma should be considered as a rare cause of pelvic mass in women. 相似文献