福建省广州管圆线虫病流行病学调查

目的调查福建省广州管圆线虫的分布情况,分析福建广州管圆线虫病流行病学特征。方法调查全省各地的鼠类和各种软体动物广州管圆线虫的感染情况,并调查全省广州管圆线虫病人的发病情况和过程。结果福建省的沿海和山区均有广州管圆线虫的分布,终宿主主要为褐家鼠;中间宿主为福寿螺、褐云玛瑙螺和蛞蝓。人因食用或接触螺类而受感染患嗜酸性粒细胞增多性脑膜炎和脑膜脑炎,已有2起集体爆发和多例散发病例。该病用阿苯哒唑和甲苯咪唑治疗,效果良好。结论福建为广州管圆线虫病的流行区,动物感染严重,人易受感染而造成爆发流行,应引起重视,加强预防。     

云南省广州管圆线虫病流行现状概述

整理分析1980年以来云南省有关广州管圆线虫病的文献资料,从广州管圆线虫的自然疫源地、中间宿主、终宿主以及人群发病等几个方面对云南省广州管圆线虫病的流行现状进行综述,为今后广州管圆线虫病的防治提供线索和依据。     

大理州洱源县西湖地区广州管圆线虫自然疫源地调查

目的了解大理州广州管圆线虫疫源地的分布、宿主种类及感染情况,为预防控制广州管圆线虫病提供科学依据。方法以市售福寿螺主要来源地洱源县西湖为调查点,对广州管圆线虫中间宿主、转续宿主和保虫宿主感染情况进行调查。结果在调查点内发现广州管圆线虫中间宿主螺类3种(福寿螺、中国圆田螺、铜锈环棱螺),剖检未查见广州管线虫感染。捕获的保虫宿主(鼠)和转续宿主(鱼、虾、蟾蜍)经检查均无广州管圆线虫感染。结论大理州目前尚无广州管圆线虫自然疫源地存在,但具备了广州管圆线虫病流行的基本条件,是潜在的疫源地,一旦有广州管圆线虫传入则可引起传播,故应加强健康教育和疫情监测。     

江西省首次发现广州管圆线虫病自然疫源地

广州管圆线虫是一种以鼠类为终宿主,福寿螺等软体动物为中间宿主的自然疫源性寄生虫病。近年的调查资料显示,我国广州管圆线虫病呈现上升的趋势,而江西省的地理环境和气候适宜于福寿螺等中间宿主的生长、繁殖。为了解江西省广州管圆线虫病的流行情况,我们于2006年10月对江西省兴国县和九江县广州管圆线虫终宿主和中问宿主的感染情况进行了调查,报告如下。     

江苏省广州管圆线虫病疫源地调查

广州管圆线虫病为新近在我国流行的食源性寄生虫病，由于其病原体的宿主特异性较低，该病在我国分布广，扩散快，易引起局部地区暴发。目前，各地开展的广州管圆线虫病流行病学词查方法不统一，资料也不完整。为了解江苏省广州管圆线虫病疫源地分布现状，并为预防控制广州管圆线虫病提供科学依据，按照《全国广州管圆线虫病疫源地词查方案》要求，于2006年9～11月开展了广州管圆线虫病疫源地词查。     

1968—2017年我国广州管圆线虫感染及流行因素分析

目的了解我国广州管圆线虫感染情况,分析其流行因素及流行特点。方法从中国知网、维普数据库和万方数据库中获取相关文献全文,遵循纳入和排出标准筛选文献,按流行情况、地区分布、年龄、性别、职业、病史行为、住院时间、误诊情况、检查方法、治疗手段、死亡情况和动物宿主感染情况等因素进行统计学分析。结果1968—2017年全国患有广州管圆线虫病共521例,分别来自于台湾、云南、四川等13个省、市、自治区;误诊病例29例;中间宿主中褐云玛瑙螺的感染率最高(25.88%),终宿主中青毛鼠的感染率最高(25.00%),中间宿主和终宿主感染情况呈显著性相关(r=0.969,P<0.001)。结论广州管圆线虫可引起嗜酸性粒细胞增多性脑膜炎,病例多发生于沿海地区,与食入未熟的中间宿主密切相关;我国许多地区是广州管圆线虫病的自然疫源地,且近年两次出现暴发性流行;加强卫生宣传教育、改变不良的饮食习惯和生活习惯对防控广州管圆线虫病十分必要。     

广州管圆线虫及广州管圆线虫病研究概况——对PubMed中相关文献的分析

广州管圆线虫是一种寄生于鼠肺动脉系统的蠕虫,人类是其非正常宿主,因生食含有广州管圆线虫III期幼虫的螺肉而感染。幼虫侵入人体后,进入中枢神经系统可引起嗜酸性粒细胞增高性脑膜炎、嗜酸性粒细胞增高性脑炎或眼部广州管圆线虫病。本综述通过对PubMed中有关广州管圆线虫及广州管圆线虫病的文献进行检索,着重分析了近10年来有关广州管圆线虫及广州管圆线虫病的研究概况,对广州管圆线虫病原学、致病机制、诊断技术、治疗药物及方案、流行病学和预防等方面进行了阐述。     

广州管圆线虫病在我国的流行分析

该文按时序综合描述广州管圆线虫病在我国的流行情况以及针对广州管圆线虫的流行病学调查，从中发现我国在应对广州管圆线虫病中存在的问题，为我国广州管圆线虫病的防治提供参考依据。     

大理洱海周边福寿螺感染广州管圆线虫调查

广州管圆线虫成虫寄生于鼠类肺部血管,幼虫侵染人体引起嗜酸性粒细胞增多性脑膜脑炎和脑膜炎。人主要是食用含有广州管圆线虫第Ⅲ期幼虫的中间宿主或转续宿主而受到感染。福寿螺是广州管圆线虫重要的中间宿主,也是引起广州管圆线虫病暴发流行的重要生物因素之一。     

南安市广州管圆线虫病的流行病学调查及临床分析

广州管圆线虫是人体嗜酸性粒细胞增多性脑膜炎或脑膜脑炎的重要病原体,南安市于2000年首次发现广州管圆线虫病病人[1],至今已有疑似病人7例,确诊4例.为了解南安市广州管圆线虫的主要中间宿主感染情况及当地人群感染情况,作者等于2000～2002年进行广州管圆线虫病的流行病学调查.     

Human angiostrongyliasis

Human angiostrongyliasis caused by Angiostrongylus cantonensis, a rat lungworm, has been reported globally. Human infections are acquired by ingestion of raw or undercooked snails or slugs, paratenic hosts such as prawns, or contaminated vegetables that contain the infective larvae of the worm. So far, at least 2827 cases of the disease have been documented worldwide. During the past few years, several outbreaks of human angiostrongyliasis have been reported in mainland China, Taiwan, and the USA. Additionally, sporadic cases in travellers who have returned from endemic areas have been reported. We review the clinical features, diagnosis, and treatment of human angiostrongyliasis, and describe the geographical distribution and prevalence of A cantonensis. Educating the public about the dangers of eating raw or undercooked intermediate and paratenic hosts in endemic areas is essential for the prevention and control of this foodborne zoonotic disease.     

An outbreak of angiostrongyliasis in Guanging, People's Republic of China: migrants vulnerable to an emerging disease

Angiostrongyliasis has been frequently reported from the People's Republic of China during the last decade. An outbreak of angiostrongyliasis among migrant laborers in Guangning, Guangdong Province is described here. A questionnaire was developed to collect epidemiological and clinical information about 17 migrant laborers from the Bai ethnic group in Dali, Yunnan Province. Serum samples were collected and tested by enzyme-linked immunosorbent assay. Rats and mollusks from the same area where patients had collected Pomacea canaliculata were examined for presence of Angiostrongylus cantonensis. All 17 Bai migrant laborers consumed P. canaliculata and six had meningitis 3-19 days after consumption of P. canaliculata. Headache, myalgia and fatigue were the most common symptoms. Blood samples from 5 patients were positive for antibodies to A. cantonensis. The places where the migrant laborers collected P. canaliculata were identified as endemic areas for A. cantonensis. This outbreak highlights the vulnerability of migrants to angiostrongyliasis.     

广州管圆线虫病免疫诊断研究进展

广州管圆线虫病是一种由广州管圆线虫感染引起的人兽共患寄生虫病,该病主要表现为中枢神经系统病变,病情严重者可造成死亡.该病临床表现相当复杂,诊断困难,因此早期、快速、准确的诊断方法是该病预防与治疗的首要条件.该文概述了广州管圆线虫病免疫诊断技术的新进展,并对早期、快速、准确诊断广州管圆线虫病的临床检测方法进行了分析.     

广州管圆线虫病免疫诊断研究进展

广州管圆线虫病是一种由广州管圆线虫感染引起的人兽共患寄生虫病,该病主要表现为中枢神经系统病变,病情严重者可造成死亡.该病临床表现相当复杂,诊断困难,因此早期、快速、准确的诊断方法是该病预防与治疗的首要条件.该文概述了广州管圆线虫病免疫诊断技术的新进展,并对早期、快速、准确诊断广州管圆线虫病的临床检测方法进行了分析.

Abstract：

Angiostrongyliasis cantonensis is a parasitic zoonosis caused by Angiostrongylus cantonensis infection and the main pathologic changes involve the central nervous system,that may lead to death in severe cases. The clinical manifestations of angiostrongyliasis cantonensis are quite complex and the clinical diagnosis is difficult,so early,rapid,accurate diagnosis is essential for prevention and treatment of the disease. This article summarized the new development of immunodiagnosis technology of angiostrongyliasis cantonensis and evaluated the clinical detecting assays for early,rapid and accurate diagnosis of angiostrongyliasis cantonensis.     

Epidemic status of Angiostrongylus cantonensis in Hainan island, China

ObjectiveTo understand the current epidemiological status of Angiostrongylus cantonensis in Hainan island and provide the scientific evidences for prevention and control of the disease.MethodsThe investigation on nature infection condition of intermediate hosts and final hosts of Angiostrongylus cantonensis were carried out in five counties, Hainan Province, and enzyme linked immunosorbent assay (ELISA) was employed to detect antibodies of Angiostrongylus cantonensis in human hosts.ResultsA total of 1612 molluscs were examined, 21.3% of which harbored L3 of Angiostrongylus cantonensis. Among them, the infection rates of Pomacea canaliculata, Achatina fulica, Cepaea and Phlegm bilineatus were 12.36%(64/518), 22.66%(121/534), 20.93%(9/43), and 28.24%(146/517), respectively. Of the 118 rats trapped, 13 Rattus norvegicus were found to be infected with Angiostrongylus cantonensis. A total of 459 serum samples were collected and tested. 92 serum samples were Angiostrongylus cantonensis antibody-positive.ConclusionsThe survey revealed a wide distribution of Angiostrongylus cantonensis in Hainan island. Pomacea canaliculata and Achatina fulica are main intermediate hosts of Angiostrongylus cantonensis. Rattus novegicus is a nature definitive host, indicating that a considerable number of people are at risk of angiostrongyliasis. Health education, rigorous food inspection and surveillance are all needed to prevent angiostrongyliasis outbreaks in future.     

广州管圆线虫中间宿主螺类调查研究进展

本文回顾了广州管圆线虫中间宿主螺类及其感染情况的相关调查研究,全球共记述49科199种,其中淡水螺类11科87种,陆生螺类共38科112种。我国报道10科33种,其中淡水螺类2科11种,陆生螺类8科22种。尽管近年来我国广州管圆线虫病病例报告数在逐渐下降,但随着福寿螺的不断扩散,自然疫源地不断发现,广州管圆线虫病传播风险持续存在,加强相关中间宿主螺类调查对流行病学研究仍具有重要意义。     

中国不同品系福寿螺对广州管圆线虫易感性的分析

福寿螺作为广州管圆线虫的中间宿主在广州管圆线虫病的流行中扮演了重要的角色。根据福寿螺外壳及软组织特点将其分为三类：黑色福寿螺、黄色福寿螺、灰色福寿螺。将三类福寿螺用低剂量和高剂量的广州管圆线虫感染以观察其易感性,结果发现高剂量感染组中,黄色福寿螺感染率低于灰色福寿螺,这可能是黄色福寿螺在中国多个省份占优势的一个原因。通过对三类福寿螺对广州管圆线虫易感性的分析,期望为广州管圆线虫病的防治提供证据。     

Eosinophilic meningitis caused by Angiostrongylus cantonensis after ingestion of raw frogs

Angiostrongylus cantonensis is the most common cause of eosinophilic meningitis in humans after ingestion of raw or inadequately cooked intermediate hosts or food contaminated with infective third-stage larvae. Frogs are known to be a paratenic host of A. cantonensis, but have never been reported as the infectious source of human angiostrongyliasis in Taiwan. We report the first case of eosinophilic meningitis caused by A. cantonensis after ingestion of raw frogs (Rana plancyi).