A comparison of treatment of atrial fibrillation with low-energy intracardiac cardioversion and conventional external cardioversion

AIM: Low-energy (1 to 15 J), catheter-based intracardiac cardioversionwas compared with transthoracic external cardioversion (360J) in a prospective, cross-over clinical trial. METHODS AND RESULTS: In 187 consecutive patients with chronic atrial fibrillation,over a period of a mean of 10·0±7·3 (SD)months, 217 cardioversion attempts were made. Intracardiac shockswere randomly applied between two 6-F catheters located in eitherthe right atrium and coronary sinus or between the right atriumand left pulmonary artery. When a cardioversion attempt withone method failed, the other method was implemented. After cardioversion,all patients were treated orally with sotalol with a mean dailydose of 174±54 mg. Internal cardioversion was more effective than external cardioversion(65/70=93% vs 92/177 =79%, P<0·01). The mean energyfor successful cardioversion was 5·8±3·2J for the internal and 313±71 J for the external cardioversiongroup. At a mean follow-up of 12·5±6·4months, 48% (38%) of the patients treated with internal (external)cardioversion were in sinus rhythm (P<0·05). In 22 of 25 patients in whom external cardioversion failed,sinus rhythm was restored with internal cardioversion at a meanenergy of 6·5±3·0 J. Overweight patientshad twice the risk of unsuccessful external cardioversion. CONCLUSION: Internal cardioversion is effective in restoring sinus rhythm.It might be indicated in patients in whom external cardioversionhad failed or in whom external cardioversion is assumed to bedifficult or even contraindicated.     

Low-Energy Internal Cardioversion for Atrial Fibrillation Resistant to External Cardioversion

Internal Cardioversion. introduction : This report describes the electrical conversion of atrial fibrillation in two morbidly obese patients refractory to external cardioversion at 360 J.
Methods and Results : The two patients were lightly sedated and underwent placement of decapolar catheters in the coronary sinus and right atrial appendage. All ten electrodes of each decapolar catheter were electrically coupled, and defibrillation was attempted at successively increasing levels using a biphasic decaying exponential waveform generated by an external defibrillator. Both patients were returned to normal sinus rhythm using <10 J without complication.
Conclusion : Internal cardioversion is effective in restoration of sinus rhythm in some patients refractory to conventional forms of therapy     

Transvenous Cardioversion of Atrial Fibrillation using Low-Energy Shocks

Recent reports have suggested that transvenous cardioversion ofatrial fibrillation is feasible using low-energy shocks and a right atriumcoronary sinus electrode configuration. We evaluated in a prospective studythe efficacy and safety of low-energy internal cardioversion of atrialfibrillation in 104 consecutive patients. Sixty-two patients presented withchronic atrial fibrillation (group I), 16 had paroxysmal atrial fibrillation(group II), and 26 had an induced atrial fibrillation episode (group III).The mean duration of the presenting episode of atrial fibrillation was 9± 19 months for group I, 4 ± 2 days for group II, and 18± 7 minutes for group III. Atrial defibrillation was performed usingtwo intracardiac catheters: one was placed in the right atrium (cathode) andthe other in the coronary sinus or in the left branch of the pulmonaryartery (anode). The catheters were connected to a customized externaldefibrillator capable of delivering 3/3-ms biphasic waveform shocks with avoltage programmable between 10 and 400 volts. The shocks were synchronizedto the R wave. Sinus rhythm was restored in 44 of the 62 patients in group I(70%), in 12 of the 16 patients in group II (75%), and in 20of 26 patients in group III (77%). The mean voltage and energyrequired for cardioversion were respectively 300 ± 68 V and 3.5± 1.5 J, for group I, 245 ± 72 V and 2.0 ± 0.9 J forgroup II, and 270 ± 67 V and 2.6 ± 1.2 J for group III. Theleading-edge voltage required for sinus rhythm restoration was significantlyhigher (p < 0.05) in the chronic atrial fibrillation group than in theparoxysmal or induced groups. No proarrhythmic effects ocurred for thedelivered 686 R-wave synchronized shocks. This study of a large group ofpatients confirms and extends the results of previous reports. Such findingsmay have clinical implications for elective cardioversion of atrialfibrillation and the development of an implantable atrial defibrillator.     

Internal Cardioversion of Persistent Atrial Fibrillation Using Rectilinear Biphasic Waveform

Internal electrical cardioversion is currently used in patients with persistent atrial fibrillation resistant to external electrical cardioversion. In external cardioversion, biphasic waveforms have shown a greater efficacy than monomorphic waveforms. The present study aimed to test the safety and efficacy of rectilinear biphasic waveform in converting patients with persistent atrial fibrillation to sinus rhythm using internal electrical cardioversion, and to compare it with that of classical monophasic waveform. Twenty-seven consecutive patients with persistent AF received 31 internal cardioversions, using monophasic waveform in 11 (group I), and rectilinear biphasic waveform in 20 cases (group II). Baseline patients characteristics were similar in both groups. Multipolar catheters were positioned in the distal coronary sinus and in the high right atrium. Synchronised shocks were delivered using an escalating protocol of 2, 5, 10, 15, 20, 30, and 50 Joules. In group I, 1 patient was resistant to maximal energy (success rate 91%). The mean energy of the maximal shock was 18 ± 13 J. In group II, all patients were converted to sinus rhythm. The mean energy of the maximal shock was 9 ± 5 J (p < 0.01 vs. group I). No significant complications occurred. At 3 months follow-up, 45% of group I and 60% of group II patients remained in sinus rhythm (p = NS).We conclude that internal cardioversion using rectilinear biphasic waveform is feasible and safe, and requires less energy than classical monophasic waveforms.     

Low-Energy Transvenous Cardioversion of Atrial Fibrillation Using a Single Atrial Lead System

Atrial Cardioversion Using a Single Atrial Lead System. Introduction: Clinical studies have shown that electrical conversion of atrial fibrillation (AF) is feasible with transvenous catheter electrodes at low energies. We developed a single atrial lead system that allows atrial pacing, sensing, and defibrillation to improve and facilitate this new therapeutic option. Methods and Results: The lead consists of a tripolar sensing, pacing, and defibrillation system. Two defibrillation coil electrodes are positioned on a stylet-guided lead. A ring electrode located between the two coils serves as the cathode for atrial sensing and pacing. We used this lead to cardiovert patients with acute or chronic AE. The distal coil was positioned in the coronary sinus, and the proximal coil and the ring electrode in the right atrium. R wave synchronized biphasic shocks were delivered between the two coils. Atrial signal detection and pacing were performed using the proximal coil and the ring electrode. Eight patients with acute AF (38 ± 9 min) and eight patients with chronic AF (6.6 ± 5 months) were included. The fluoroscopy time for lead placement was 3.5 ± 4.3 minutes. The atrial defibrillation threshold was 2.0 ± 1.4 J for patients with acute AE and 9.2 ± 5.9 J for patients with chronic AF (P < 0.01). The signal amplitude detected was 1.7 ± 1.1 mV during AF and 4.0 ± 2.9 mV after restoration of sinus rhythm (P < 0.001). Atrial pacing was feasible at a threshold of 4.4 ± 3.3 V (0.5-msec pulse width). Conclusions: Atrial signal detection, atrial pacing, and low-energy atrial defibrillation using this single atrial lead system is feasible in various clinical settings. Tbis system might lead to a simpler, less invasive approach for internal atrial cardioversion.     

风湿性二尖瓣狭窄伴心房颤动球囊二尖瓣成形术后复律治疗的临床评价

报道９０例风湿性二尖瓣狭窄伴心房颤动（简称二狭房颤）患者球囊二尖瓣成形术（ＰＢＭＶ）和复律治疗的结果，并与同期行ＰＢＭＶ的１６０例风湿性二尖瓣狭窄无房颤（窦性心律，简称二狭窦律）患者进行比较。结果表明临床上无血管栓塞并发症且经超声心动图检查无心房血栓的二狭房颤患者接受ＰＢＭＶ治疗与二狭窦律者一样具有良好的安全性和临床效果。８９例二狭房颤患者ＰＢＭＶ后经复律治疗转为窦性心律（其中１５例仅服用奎尼丁即可复律）。随访２３．５±１１．７月，２４例（２７％）复发。认为房颤持续时间长和左房明显扩大可能是房颤复发的影响因素；ＰＢ－ＭＶ的效果可能是房颤复律后远期疗效的影响因素     

Internal cardioversion with low-energy shocks in atrial fibrillation resistant to external electric cardioversion

BACKGROUND AND OBJECTIVE: Although external electrical cardioversion is effective in most patients with atrial fibrillation, there are cases refractory to external cardioversion. This study is aimed at showing our initial experience with an internal cardioversion system in patients with previous unsuccessful external cardioversion. PATIENTS AND METHODS: Between February, 1997 and September, 1998 nine consecutive patients with spontaneous chronic or persistent atrial fibrillation that failed external cardioversion, were included. Internal cardioversion was performed under sedation with two electrodes that had a 5.5 cm coil placed in the lateral right atrium and coronary sinus. Both electrodes were connected to an external defibrillator capable of delivering R-wave synchronized low-energy biphasic shocks following a minimum RR interval of 500 ms. Energy between 2 J and 10 J was applied until the restoration of sinus rhythm or a maximum of 2 shocks of 10 J. RESULTS: Sinus rhythm was achieved in the nine patients, but in two of them atrial fibrillation recurred after a few beats. Both had underlying structural heart disease. The other 7 patients, 5 of them without structural heart disease, were in sinus rhythm at discharge. No mechanic complications or ventricular arrhythmias were observed. Six patients are in sinus rhythm after 4 +/- 3 months of follow-up. CONCLUSIONS: Low-energy intracardiac cardioversion is useful in some patients with atrial fibrillation that had failed external cardioversion and can be performed without general anesthesia.     

Internal low-energy cardioversion: a therapeutic option for restoring sinus rhythm in chronic atrial fibrillation after failure of external cardioversion.

AIMS: Conventional external cardioversion remains the technique of choice for restoration of sinus rhythm in patients with chronic atrial fibrillation (AF). Recent reports have suggested that internal low-energy cardioversion is efficient and safe in terminating AF in patients with failed external cardioversion. METHODS AND RESULTS: In 20 of 118 consecutive patients with spontaneous chronic AF (>7/days), who underwent low-energy cardioversion, one or more attempts at restoring sinus rhythm with external cardioversion had failed. Low-energy internal cardioversion was performed under light sedation. Shocks were delivered (using an external custom defibrillator) between two nonapolar catheters positioned in the right atrium (cathode) and in the coronary sinus (anode). Heart disease was present in 12 and absent in eight patients ('lone' atrial fibrillation). Atrial fibrillation was established for a period ranging from 12 days to 53 months. Low-energy internal cardioversion restored sinus rhythm in 15 of the 20 patients (75%) with a mean energy of 4.5+/-1.2 J, a mean conversion voltage of 355+/-53 V and a mean impedance of 63+/-8 ohms. No complications were observed. With a mean follow-up of 6+/-7 months, 11 patients (73%) were in stable sinus rhythm. CONCLUSIONS: This study provides evidence in support of low-energy internal cardioversion as a valuable therapeutic option in patients in whom conventional external cardioversion failed. This technique is safe and does not require general anaesthesia.     

Time to Cardioversion of Recurrent Atrial Arrhythmias After Catheter Ablation of Atrial Fibrillation and Long‐Term Clinical Outcome

Introduction: It is unclear whether early restoration of sinus rhythm in patients with persistent atrial arrhythmias after catheter ablation of atrial fibrillation (AF) facilitates reverse atrial remodeling and promotes long‐term maintenance of sinus rhythm. The purpose of this study was to determine the relationship between the time to restoration of sinus rhythm after a recurrence of an atrial arrhythmia and long‐term maintenance of sinus rhythm after radiofrequency catheter ablation of AF. Methods and Results: Radiofrequency catheter ablation was performed in 384 consecutive patients (age 60 ± 9 years) for paroxysmal (215 patients) or persistent AF (169 patients). Transthoracic cardioversion was performed in all 93 patients (24%) who presented with a persistent atrial arrhythmia: AF (n = 74) or atrial flutter (n = 19) at a mean of 51 ± 53 days from the recurrence of atrial arrhythmia and 88 ± 72 days from the ablation procedure. At a mean of 16 ± 10 months after the ablation procedure, 25 of 93 patients (27%) who underwent cardioversion were in sinus rhythm without antiarrhythmic therapy. Among the 46 patients who underwent cardioversion at ≤30 days after the recurrence, 23 (50%) were in sinus rhythm without antiarrhythmic therapy. On multivariate analysis of clinical variables, time to cardioversion within 30 days after the onset of atrial arrhythmia was the only independent predictor of maintenance of sinus rhythm in the absence of antiarrhythmic drug therapy after a single ablation procedure (OR 22.5; 95% CI 4.87–103.88, P < 0.001). Conclusion: Freedom from AF/flutter is achieved in approximately 50% of patients who undergo cardioversion within 30 days of a persistent atrial arrhythmia after catheter ablation of AF.     

Immediate Reinitiation of Atrial Fibrillation Following Internal Atrial Defibrillation

Immediate Reinitiation of AF. Introduction: Although the recurrence rate of atrial fibrillation has been reported to be similar to that after external and internal cardioversion, little is known about immediate reinitiation of atrial fibrillation (IRAF) following internal cardioversion. Methods and Results: Thirty-eight patients (24 men; mean age 63 ± 13 years) underwent internal atrial defibrillation. Catheter-based defibrillation electrodes were positioned in the anterolateral right atrium and the coronary sinus. All patients were cardioverted at a mean threshold of 4.6 ± 3.4 J. Five of 38 patients (13%) had 1 to 4 episodes of IRAF. No difference in clinical and echocardiographic characteristics were observed when patients with and without IRAF were compared. Atrial fibrillation was always reinitiated by an atrial premature beat. When the earliest atrial endocardial activation time on the defibrillation catheters was analyzed, these atrial premature heats did not seem to originate from the defibrillation catheters. Twenty-one patients had atrial premature heats without IRAF. When the coupling intervals of the first atrial premature heat in patients without and with IRAF after conversion were compared, a significant difference was found (661 ± 229 vs 418 ± 79 msec, P < 0.05). IRAF was successfully treated with repeated shock delivery after the administration of atropine in 1 patient and intravenous flecainide in 2. Only repeated shock delivery was sufficient to treat IRAF in another 2 patients. Late recurrences of atrial fibrillation occurred in 3 of 5 with IRAK and in 19 of 33 patients without IRAF (P = NS). Conclusion: IRAF after internal atrial defibrillation occurred in 13% of patients, was always initiated by an atrial premature heat having a short coupling interval not originating from the defibrillation catheters, and was prevented by repeated shock delivery with or without preceding administration of pharmacologic agents. IRAF did not predict early recurrences of the arrhythmia after discharge from the hospital, emphasizing the necessity to treat immediate reinitiation promptly to achieve a successful cardioversion.     

Successful intracardiac electrical conversion of atrial flutter in patients with complex congenital heart disease.

Sixteen patients presenting on 21 occasions with atrial flutter in association with complex congenital heart disease were treated by intracardiac stimulation techniques combined with activation mapping. Nineteen episodes of atrial flutter were successfully converted to sinus rhythm. In the remaining two episodes atrial fibrillation was induced with spontaneous conversion to sinus rhythm within 12 hours in one episode and immediate DC cardioversion to sinus rhythm in the other. Intracardiac stimulation techniques were highly successful in this group and allowed reliable conversion to sinus rhythm without general anaesthesia and high energy cardioversion. In patients with atrial flutter associated with congenital heart disease intracardiac stimulation techniques should be tried first.     

Low-energy internal cardioversion in patients with long-lasting atrial fibrillation refractory to external electrical cardioversion: results and long-term follow-up.

AIM: Low-energy internal cardioversion is a new electrical treatment for patients with persistent atrial fibrillation. This paper evaluates the efficacy and safety of low-energy internal cardioversion in patients with long-lasting atrial fibrillation refractory to external electrical cardioversion, and the clinical outcome of such patients. METHOD AND RESULTS: The study population consisted of 55 patients [32 male, mean age 65 +/- 10 years, 48 (87%) with underlying heart disease] with long-lasting (mean 18 +/- 34 months) atrial fibrillation in whom external cardioversion had failed to restore sinus rhythm. Two custom-made catheters were used: one positioned in the right atrium and one in the coronary sinus or the left pulmonary artery. A standard catheter was inserted into the right ventricular apex to provide R wave synchronization. Sinus rhythm was restored in 52 patients (95%) with a mean defibrillating energy of 6.9 +/- 2.6 J (320 +/- 60 V). No complications were observed. During follow-up (mean 18 +/- 9 months), 16 patients (31%) suffered early recurrence (< or = 1 week) of atrial fibrillation and 20 patients (38%) had late recurrence (> 1 week, mean 3.5 +/- 3.6 months) of atrial fibrillation. Six patients with a late recurrence again underwent cardioversion and five of these maintained sinus rhythm. Therefore, a total of 21/52 patients (40%) were in sinus rhythm at the end of follow-up. No clinical difference was found between patients with and without recurrences. CONCLUSIONS: Low-energy internal cardioversion is a useful means of restoring sinus rhythm in patients with long-lasting atrial fibrillation refractory to external electrical cardioversion. More than one-third of patients maintained sinus rhythm during long-term follow-up.     

Successful intracardiac electrical conversion of atrial flutter in patients with complex congenital heart disease

Sixteen patients presenting on 21 occasions with atrial flutter in association with complex congenital heart disease were treated by intracardiac stimulation techniques combined with activation mapping. Nineteen episodes of atrial flutter were successfully converted to sinus rhythm. In the remaining two episodes atrial fibrillation was induced with spontaneous conversion to sinus rhythm within 12 hours in one episode and immediate DC cardioversion to sinus rhythm in the other. Intracardiac stimulation techniques were highly successful in this group and allowed reliable conversion to sinus rhythm without general anaesthesia and high energy cardioversion. In patients with atrial flutter associated with congenital heart disease intracardiac stimulation techniques should be tried first.     

Ventricular fibrillation in intra-atrial cardioversion of atrial fibrillation

Recently intra-atrial defibrillation has become an interesting alternative to external defibrillation and drug therapy for the treatment of atrial fibrillation. Low-energy intra-atrial defibrillation can be used to restore sinus rhythm f.ex. after a failed external cardioversion or during an electrophysiologic study when the administration of antiarrhythmic drugs should be avoided. Additionally this new technique has led to the development of implantable atrial defibrillators for the treatment of selected patients suffering from chronic atrial fibrillation. Intra-atrial defibrillation seems to be a highly effective and safe method, but little experience exists concerning the outcome so far. Especially the potential risk of inducing ventricular pro-arrhythmia is subject of current controversy. We report the case of a 79-year-old patient suffering from WPW syndrome with a concealed bypass tract who was subject to an intra-atrial defibrillation during an electrophysiologic study. At the beginning of the study atrial fibrillation could be converted to sinus rhythm by a single low-energy atrial defibrillation (3 J.). After a short period of time a second intra-atrial defibrillation had to be performed in the same way because of recurrent atrial fibrillation. By this atrial shock ventricular fibrillation was induced, so that high energy external defibrillation became necessary. Analyzing the ECG a correct R-wave synchronization was found, but a rather short preceding RR interval (252 ms). In conclusion, low energy atrial defibrillation is gaining importance as a highly effective new technique to restore sinus rhythm in patients suffering from atrial fibrillation resistant to conventional therapies. Nevertheless potential risks have to be considered such as the induction of ventricular pro-arrhythmia. Therefore, a correct R-wave synchronization is obligatory and shock delivery should be withheld after short RR intervals. Future prospective randomized studies will have to show whether this new technique is really safe enough and superior to the conventional methods for restoring sinus rhythm in patients suffering from atrial fibrillation.     

Prospective Randomized Trial of External Versus Internal Transcatheter Cardioversion in Patients with Chronic Atrial Fibrillation

To evaluate the safety and long-term efficacy of internal transcatheter cardioversion, forty patients with chronic, lone atrial fibrillation were studied. The patients were randomised to internal transcatheter cardioversion or to conventional external cardioversion. In cases where the procedure was unsuccessful, cross-over to the alternate method was performed. Oral anticoagulation therapy was started three weeks prior to the procedure and was maintained for another three weeks following successful cardioversion.Sinus rhythm was restored in 16/18 patients (88%) in the internal cardioversion group, versus 9/22 patients (40%) in the external cardioversion group (p < 0.01). In addition, 8/13 (61%) patients who were crossed-over to internal cardioversion were successfully cardioverted to sinus rhythm. In contrast, both patients who were crossed-over to external cardioversion remained in atrial fibrillation.During a mean follow-up period of 23 months, 13 (39.3%) patients maintained sinus rhythm. Using the intention to treat principle, the recurrence rate was not statistically different between the two methods.It is concluded that internal cardioversion is more effective in acutely restoring sinus rhythm compared to external cardioversion. However, both methods have similar long-term recurrence rates.     

经皮穿刺二尖瓣球囊扩张成形术后心房颤动复律的体会

对二尖瓣球囊扩张成形术后心房颤动（Ａｆ）同步直流电复律２０例患者的复律过程进行观察和随访，探讨复律的影响因素及窦性心律的维持。结果表明：复律时出现心律失常组的年龄（４３．４±３．１岁）、Ａｆ持续时间（５０．７±１６．８月）、心瓣膜病程（１６０．７±３０．２月）、左房内径（４８．２±７．３ｍｍ）等均高于未出现心律失常组（依次为：３４．７±４．５岁、２１．６±１０．２月、１０１．５±２３．５月、４２．１±４．５ｍｍ），Ｐ＜０．０５。经逐步回归分析发现复律放电能量与病人年龄、Ａｆ持续时间、转复时心率、左房内径等因素有关。复律时除应注意上述影响因素外，还应适当调整放电能量以使复律易于成功。对窦性心律的维持认为以口服胺碘酮效果较好     

Effect of Electrode Length on Atrial Defibrillation Thresholds

Electrode Length for Atrial Defibrillation. Introduction: Catheter-based electrodes have been used previously to terminate episodes of atrial fibrillation in animals and man. Typically, these electrodes span 6 to 7 cm, and lowest energy requirements are achieved when these electrodes are positioned in the distal coronary sinus and in the right atrium. The purpose of this study was to evaluate the use of longer electrode lengths for atrial defibrillation. Methods and Results: In 15 patients, two decapolar catheters were inserted, one into the distal coronary sinus and one in the right atrium. To provide longer electrodes lengths, a third catheter was inserted and alternated positioned in the right atrium or coronary sinus. A 6-cm electrode span was obtained by using the distal 8 rings on the coronary sinus catheter or 8 consecutive electrodes on the right atrial catheter and increased from 6 to 11 cm by connecting consecutive, nonoverlapping rings of the third catheter with the 10 rings of the initial right atrial or coronary sinus catheter. Atrial defibrillation thresholds were determined twice, in a randomized order, in each patient for each of the three combinations of electrode lengths. All 15 patients could he successfully converted to sinus rhythm without complications; however, one patient could be converted reproducibly with only 2 of the 3 electrode combinations. Mean thresholds were 306 ± 102 V, 5.9 ± 4.0 J for the 6 cm/6 cm electrode length combination with an impedance of 72 ± 18 ω. For the electrode combination using the 11-cm electrode in the right atrium, the defibrillation threshold was 296 ± 107 V, 5.8 ± 3.9 J with an impedance of 61 ± 17 ω and was 294 ± 91 V, 5.6 ± 3.6 J with an impedance of 55 ± 11 ω for the 11-cm electrode in the coronary sinus. There were no significant differences in defibrillation voltage or energy (P > 0.05) associated with the longer electrode lengths; however, the longer electrode lengths did significantly lower shock impedance (P < 0.05). Conclusion: The use of longer electrodes, when using the right atrium to coronary sinus shock vector, does not lower the defibrillation requirements for restoration of sinus rhythm.     

Waveform optimization for internal cardioversion of atrial fibrillation

Introduction

A novel atrial defibrillator was developed at the Royal Victoria Hospital in collaboration with the Nanotechnology and Integrated Bio-Engineering Centre, University of Ulster. This device is powered by an external pulse of radiofrequency energy and designed to cardiovert using low-tilt monophasic waveform (LTMW) and low-tilt biphasic waveform (LTBW), 12 milliseconds pulse width. This study compared the safety and efficacy of LTMW with LTBW for transvenous cardioversion of atrial fibrillation (AF).

Methods

Patients were anticoagulated with warfarin to maintain International Normalized Ratio between 2 and 3 for 4 weeks prior cardioversion. Warfarin international normalized ratio level was maintained in between 2 and 3 for 4 weeks prior cardioversion. St Jude's defibrillating catheter was positioned in the distal coronary sinus and right atrium and connected to the defibrillator via a junction box. After a test shock using a dummy load, the patient was cardioverted in a step-up progression from 50 to 300 V. Shock success was defined as return of sinus rhythm for 30 seconds or more. If cardioversion was unsuccessful at peak voltage, the patient was crossed over to the other arm of the waveform type and cardioverted at peak voltage.

Results

Thirty patients were randomized equally to LTBW and LTMW (15 each). Seven out of 15 patients (46%) cardioverted to sinus rhythm with LTBW, and 1 (6%) of 15, with LTMW (P = .035). Including crossover patients, 14 patients (46%) converted to sinus rhythm. After crossover, 4 patients were cardioverted with LTBW and 2 with LTMW. Overall mean voltage, current, and energy used for cardioversion were 270.53 ± 35.96 V, 3.68 ± 0.80 A, and 9.12 ± 3.73 J, respectively, and intracardiac impedance was 70.82 ± 13.46 Ω. For patients who were successfully cardioverted, mean voltage, current, energy, and intracardiac impedance were 268.28 ± 42.41 V, 3.52 ± 0.63 A, 8.51 ± 3.16 J, and 73.92 ± 12.01 Ω. There were no major adverse complications during the study. Cardiac markers measured postcardioversion were unremarkable.

Conclusion

Low-tilt biphasic waveform was more efficacious for low-energy transvenous cardioversion of AF. A significant proportion of patients were successfully cardioverted to sinus rhythm with low energy. Radiofrequency-powered defibrillation can be safely used for transvenous cardioversion of AF.     

Clinical Feasibility of Low Energy Internal Atrial Cardioversion with a Three-Electrode Configuration in Patients with Unsuccessful Conventional Configurations

Low energy internal cardioversion is a safe and highly effective method for atrial fibrillation termination. We will describe 6 patients in whom the conventional 2-electrode systems with the defibrillation leads positioned in the right atrium and in the coronary sinus or left pulmonary artery failed to terminate the arrhythmia despite the use of maximal available energies. A 3-electrode configuration including right atrium, coronary sinus and left pulmonary artery was used in order to encompass as much atrial mass as possible between the cathode and the anode. The atrial fibrillation was successfully interrupted in 4 out of 6 patients. The creation of a 3-electrode configuration may be a further technical expedient in order to increase the success rate of internal cardioversion when usual manoeuvres like lead repositioning, reversion of polarity, or addition of antiarrhythmic drugs are ineffective.     

Higher energy synchronized external direct current cardioversion for refractory atrial fibrillation

OBJECTIVES

We sought to evaluate the safety and efficacy of higher energy synchronized cardioversion in patients with atrial fibrillation refractory to standard energy direct current (DC) cardioversion.

BACKGROUND

Standard external electrical cardioversion fails to restore sinus rhythm in 5% to 30% of patients with atrial fibrillation.

METHODS

Patients with atrial fibrillation who failed to achieve sinus rhythm after at least two attempts at standard external cardioversion with 360 J were included in the study. Two external defibrillators, each connected to its own pair of R-2 patches in the anteroposterior position, were used to deliver a synchronized total of 720 J.

RESULTS

Fifty-five patients underwent cardioversion with 720 J. Mean weight was 117 ± 23 kg (body mass index 48.3 ± 4.1 kg/m²). Structural heart disease was present in 76% of patients. Mean left ventricular ejection fraction was 45 ± 12%. Atrial fibrillation was present for over three months in 55% of the patients. Sinus rhythm was achieved in 46 (84%) of the 55 patients. No major complications were observed. No patient developed hemodynamic compromise and no documented cerebrovascular accident occurred within one month after cardioversion. Of the 46 successful cardioversions, 18 patients (39%) remained in sinus rhythm over a mean follow-up of 2.1 months.

CONCLUSIONS

External higher energy cardioversion is effective in restoring sinus rhythm in patients with atrial fibrillation refractory to standard energy DC cardioversion. This method is safe and does not result in clinical evidence of myocardial impairment. It may be a useful alternative to internal cardioversion because it could be done within the same setting of the failed standard cardioversion and obviates the need to withhold protective anticoagulation for internal cardioversion.