Obstruktive Bronchitis – was tun?

Im Herbst und Winter erkranken S?uglinge und Kleinkinder h?ufig an respiratorischen Infekten. Viele Kinder kommen aus diesem Grund zum Kinderarzt. Wir freuen uns, Univ.-Prof. Dr. Manfred G?tz einige wichtige Fragen zur diagnostischen Zuordnung, zur Behandlung und letztlich zur Prognose von giemenden S?uglingen und Kleinkindern stellen zu dürfen.     

Reisemedizin – was gibt es Neues?

Ohne Zusammenfassung     

Obstipation bei Kindern und Jugendlichen – was tun?

Pädiatrie & Pädologie -     

Prenatal phthalate exposure was associated with croup in Swedish infants

Aim

This study examined whether prenatal phthalate exposure was associated with lower or upper airway inflammation in infants.

Methods

From 2007 to 2010, we used liquid chromatography‐tandem mass spectrometry, adjusted for creatinine, to analyse 14 phthalate metabolites and one phthalate replacement in the urine of 1062 Swedish mothers at a median of 10 weeks of pregnancy. This was used to determine any associations between prenatal phthalate exposure and croup, wheezing or otitis in their offspring until 12 months of age, using logistic regression, adjusted for potential confounders.

Results

There were significant associations between phthalate metabolites of butyl‐benzyl phthalate (BBzP) and di‐ethyl‐hexyl phthalate (DEHP) concentrations in maternal prenatal urine and croup in 1062 infants during the first year of life, when adjusted for potential confounders. A dose‐response relationship was found between prenatal phthalates exposure and maternal reported croup in the children, with a significant association in boys. There was no clear indication with regard to associations between prenatal phthalate exposure and wheezing or otitis media in the children during the first year of life.

Conclusion

Our analysis suggests that exposure to BBzP and DEHP phthalates was associated with maternal reports of croup in infants up to 12 months of age.