癫痫患者智能状况与事件相关电位P300的研究

目的探讨癫痫患者智能状况、事件相关电位P300(ERP P300)的特点及ERP P300对癫痫患者智能状况的评定价值.方法对40例癫痫患者进行智商及ERP P300测定.结果40例癫痫患者中总智商FIQ≤89者14例,占35%;P300异常者16例,占40%.癫痫智能障碍组的VIQ、PIQ、FIQ、P300 PL分别与智能正常组及正常对照组比较,均具有显著性差异(P<0.01).且癫痫患者P300PL与VIQ、PIQ、FIQ呈负相关.结论癫痫患者易发生智能损害,且智能损害无选择性.智力量表和ERPP300二种检测方法对评判癫痫患者智能障碍具有良好的一致性,而ERP P300能更早期、更客观、快捷、准确地评价癫痫患者智能状况.     

癫痫患者智能障碍相对选择性的探讨

目的：探讨癫痫患者的智能障碍。方法：对６６例癫痫患者进行韦氏成人智力测验（ＷＡＩＳ－ＲＣ）和事件相关电位（ＥＲＰＰ３００）的测定。结果：发现癫痫智能障碍组以算术、相似、填图、木块图、知识得分降低较明显。结论：Ｐ３００潜伏期与填图、数字符号、知识等分测验关系密切。癫痫患者的智能障碍存在一定程度的选择性。     

正常成人的事件相关电位P300

本研究采用短音刺激，以及两套触发和刺激系统，两个完全独立的分析时间窗口，对24例正常成人进行P300检测。分析了基本波型，提出了靶与非靶刺激时，Pz点，Cz点及Fz点P300的有关指标平均值，并对脑左右半球，性别与年龄等进行了比较，认为正常成人P300是稳定可靠的，是一种反映神经心理学认知过程的皮层认知诱发脑波。     

事件相关电位P300在抑郁症的应用意义

本文阐述了事件相关电位P300对抑郁症的评定作用，从而说明事件相关电位P300在抑郁症临床及科研中具有重要意义。     

焦虑症的事件相关电位P300研究

目的观察焦虑症患者事件相关电位P300的变化特点.方法对22例焦虑症患者和22例健康成年人,应用Nicolet Bravo脑诱发电位做事件相关电位P300检测.结果与正常组相比,焦虑症组靶N2潜伏期延长(P<0.05),靶P2波幅低(P<0.01),靶P3潜伏期长且波幅低(P<0.01),非靶P2波幅低(P<0.01).P300各指标在男女性别之间的差异无统计学意义(P>0.05).结论焦虑症患者P300有多项指标变化,值得进一步随访.     

雌激素对精神分裂症女性患者事件相关电位P300的影响

目的 探讨雌激素对女性精神分裂症事件相关电位P300的影响。方法 将67例女性精神分裂症患者随机分为研究组（32例）和对照组（35例）。研究组在利培酮（3．5—4．5mg／d）治疗的同时口服雌激素（妊马雌酮，0．625mg／d），疗程3个月。治疗前后对两组分别进行P300检查及阳性和阴性症状量表（PANSS）评定。结果 （1）P300：治疗前两组各项指标的差异无统计学意义（P〉0．05）。与治疗前比较，治疗后，在Cz点，研究组靶刺激P2，P3，P4波潜伏期缩短，P3，P4波波幅升高；非靶刺激P2波波幅升高（均P〈0．05—0．01）。在Pz点，研究组靶刺激中潜伏期的5项指标（N1，P2，N2，P3，P4）均缩短，波幅的3项指标（P2，P3，P4）均升高；非靶刺激P2波潜伏期缩短，其波幅升高（均P〈0．05—0．01）。而对照组各项指标治疗前后变化均无统计学意义（P〉0．05）。与对照组比较，治疗后，在Cz点，研究组靶刺激P2，N2，P3，P4波潜伏期短，P3，P4波波幅高；非靶刺激P2波潜伏期短，其波幅高（均P〈0．05—0．01）。在Pz点，研究组靶刺激中潜伏期的5项指标均短，3项指标的波幅均高；非靶刺激P：波潜伏期短，其波幅高（均P〈0．05—0．01）。（2）PANSS：治疗前，两组各因子评分的差异无统计学意义（P〉0．05）。治疗后，研究组的阴性症状、反应缺乏和抑郁因子分低于治疗前（均P〈0．01），亦低于对照组。对照组各因子治疗前后的变化无统计学意义（P〉0．05）。结论 雌激素治疗可使女性精神分裂症患者P姗主要波幅升高，部分潜伏期缩短，精神症状部分改善。     

抑郁症患者事件相关电位P300亚成分的研究

近年对事件相关电位Ｐ30 0 的研究证实 ,Ｐ30 0 可分出Ｐ3ａ、Ｐ3ｂ、Ｐ3ｅ和ＳＷ等亚成分[1 ] 。为验证此结论 ,我们做了以下工作。对象和方法　对象为上海市精神卫生中心患者 ,共 43例 (由于伪迹最后Ｆｚ脑区只有 35例 ,Ｃｚ脑区为 36例 )。均符合中国精神疾病分类方案与诊断标准第 2版修订本中情感性精神障碍抑郁发作标准 ;汉密尔顿抑郁量表 (ＨＡＭＤ)为(2 2 1± 3 8)分。 43例中男 2 2例 ,女 2 1例 ;平均年龄 (43±1 2 )岁。以上海市精神卫生中心职工为正常对照组 (ＮＣ组 ) ,共 39名。其中男 2 0名 ,女 1 9名 ;平均年龄 (39± 1 1 )…     

老年期抑郁症患者事件相关电位P300特征

目的：探讨有无自杀行为的老年期抑郁症患者认知功能的事件相关电位P300特征。方法：对60例老年期抑郁症患者（有自杀行为者20例,无自杀行为者40例）及60例性别、年龄匹配的正常老年人为对照,进行听觉诱发的事件相关电位P300检测。同时应用汉密尔顿抑郁量表（HAND）及老年认知功能量表（SECF）分别评价抑郁症组抑郁情绪及认知功能。结果：抑郁症组与对照组相比,P2、N2、P3潜伏期明显延长,P2、P3波幅明显降低;有自杀行为组N2、P3波幅比无自杀行为组明显降低。抑郁症组HAMD总分与P300各指标无相关,SECF总分与N2、P2、P3潜伏期显著负相关。结论：P300对老年期抑郁症患者早期认知功能损害评定具有一定价值,有、无自杀行为的老年期抑郁症患者认知功能损害不同。     

Event-related potentials (P300) in myotonic dystrophy

The P300 component of the auditory event-related potential in 8 patients with myotonic dystrophy was studied and compared with that of 13 healthy controls. Abnormalities of P300 (prolongation of the latency and/or decrease of the amplitude) were observed in 6. These observations imply that the function of cognitive and information processing are impaired in myotonic dystrophy.     

ORIGINAL ARTICLE: Inter-peak Latency of Auditory Event-related Potentials (P300) in Cases of Aged Schizophrenia and Alzheimer-type Dementia

Background : Both patients with schizophrenia and those with dementia show cognitive difficulties, and in many cases of schizophrenia the cognitive disturbance is progressive, as it is in dementia. Event-related potentials have revealed cognitive impairments in patients with schizophrenia and dementia, but most studies of event-related potentials in cases of psychiatric illness or dementia have focused on the single peak latency of the event-related potential components. In the present study, we investigated the cognitive function in elderly patients with schizophrenia and Alzheimer-type dementia (AID) using auditory event-related potentials (P300).
Methods : P300 was recorded using the tone discrimination task and peak latencies for N1, P2, N2 and P3 at the Pz electrode site were measured. In addition to analyzing peak latencies of P300, we also analyzed inter-peak latencies (IPL; N1-P2, P2-N2, and N2-P3). Twenty-two elderly residual-type schizophrenics and 36 patients with AID were compared with 39 age-matched healthy volunteers.
Results : The mean latencies of P3 and mean IPL of P2-N2 in elderly schizophrenic patients were longer than those of the controls. In ATD the mean latencies of N2 and P3 and the mean IPL of P2-N2 were longer than those of the controls. When the mean latencies of ATD patients were compared with those in patients with schizophrenia, P2, N2, and P3 latencies and N1-P2 and P2-N2 IPL were longer.
Conclusion : These findings suggest that a similar impairment of the cognitive process is found in elderly patients with schizophrenia and those with ATD and that the degree of the impairment of patients with ATD is more severe than that of elderly patients with schizophrenia.     

Event-related potential (P300) in epilepsy

The P300 component of auditory event-related potential was studied in 39 patients with temporal lobe epilepsy (TLE), 26 with idiopathic generalized epilepsy (IGE) and 28 controls. The age-corrected P300 latencies were significantly longer in TLE patients compared with those in IGE patients and controls. Neither the duration of epilepsy nor clinical manifestation was related to the P300 component in the same epileptic syndrome. The age-corrected P300 latencies recorded from Cz were significantly prolonged in TLE patients with bilateral temporal EEG foci compared with those with unilateral focus. The effects of anti-epileptic drugs on the P300 component were not significant. Our findings imply that prolonged P300 latency in TLE patients, especially in those with bilateral EEG foci is due to damage of the hippocampus, which is potentially an epileptogenic focus.     

酒精所致精神障碍患者事件诱发电位P300的研究

目的：探讨酒精所致精神障碍患者事件诱发电位P300的特点。方法：对30例酒精所致精神障碍患者（研究组）和31名正常人（正常对照组）进行事件诱发电位P300的检测,并与正常对照组进行配对t检验和相关分析。结果：与正常对照组比较,酒精所致精神障碍患者P300潜伏期N2、P3显著延长（t=2．318,沁2．335;P〈0．05）;P300波幅N1、N2、P3显著降低（t=-2．414;t=-2．613,t=-4．453;P〈0．05或P〈0．001）。相关分析显示,酒精所致精神障碍患者饮酒年限以及饮酒量与P300潜伏期、波幅之间无明显相关（r=-0．128～-0．274,r=-0．075～0．328;P均〉0．05）。结论：酒精所致精神障碍患者存在认知功能损害,P300可作为酒精所致精神障碍患者检测项目之一。     

帕金森病患者额叶认知功能和事件相关电位相关性研究

目的:探讨事件相关电位(P300)和额叶认知测试对帕金森病患者认知障碍评价的意义。方法:对31例非痴呆非抑郁帕金森病患者和25例年龄、性别、受教育程度相匹配的正常对照进行P300检测,同时采用词语流畅性、连线测验、Stroop字色干扰测验对病例组和对照组分别进行测试。结果:病例组与对照组比较:额叶认知功能评分较差,P300潜伏期延长(P<0.05),波幅下降;P300潜伏期与额叶认知功能障碍程度呈正相关。结论:非痴呆非抑郁帕金森病患者存在认知功能障碍。这种障碍可能是额叶功能受损后的表现。     

注意缺陷多动障碍儿童事件相关电位P300特征分析

目的:探讨注意缺陷多动障碍(ADHD)儿童事件相关电位(event related potential,ERP)P300的特点。方法:对100例ADHD患儿(研究组)[注意缺陷为主型(ADHD-I)34例、多动/冲动为主型(ADHD-HI)24例、混合型(ADHD-C)42例)]和100名正常儿童(对照组)前额区(Fz)、中央区(Cz)两个脑区的ERP P300潜伏期及波幅进行检测,比较分析研究组与对照组、ADHD各亚型及不同SNAP-Ⅳ评分分组(1.6~2.0为中度组、2.0为重度组)的P300潜伏期及波幅的差异。结果:1与对照组比较,研究组靶刺激在前额区(Fz)及中央区(Cz)P300潜伏期显著延长,波幅降低,差异具有统计学意义(P均0.01);2ADHD各亚型组间P300潜伏期与波幅差异无统计学意义(P0.05);3不同SNAP-IV评分组间,P300潜伏期与波幅差异无统计学意义(P0.05)。结论:ADHD患儿P300的潜伏期显著延长,波幅降低,提示ADHD患儿对信息加工处理的速度减慢,注意力、记忆力缺陷及认知加工能力不足。     

Auditory Event-Related Potentials (P300) and Regional Cerebral Blood Flow in Elderly Depressed Patients

Background: In order to evaluate the degree of impairment of cerebral function and the organic factors involved in elderly depressed patients, auditory event‐related potentials (ERP; P300) and N‐isopropyl‐p [¹²³I] iodoamphetamine (¹²³I‐IMP) single photon emission computed tomography (SPECT) were examined. Methods: Three groups of patients, the depression (D) group, consisting of 23 cases where the magnetic resonance imaging (MRI) showed no abnormalities, the depression with silent cerebral infarction (D/SCI) group, consisting of 28 cases with silent cerebral infarction, and the post‐stroke depression (D/PS) group, consisting of 19 cases at over six months after onset of cerebral infarction where no abnormalities in intellectual function were seen, but neurological symptoms such as hemiplegia were present, and 27 healthy individuals were investigated. All of the patients fulfilled the ICD‐10 diagnostic criteria for depressive episode, and disease onset occurred when the patients were over 55 years. The ERP (P300) was recorded using a tone discrimination task. Regional cerebral blood flow (rCBF) was measured by ¹²³I‐IMP SPECT, and the relative rCBF of each region of interest was evaluated by comparison with the mean cerebellar rCBF. In addition, the mean cerebral blood flow (MCBF) in the cerebral cortex was assessed. Results: The D group included many cases in which the P300 peak latency was relatively short and the MCBF was stable, relative to the other two groups. In the D/PS group, there were many cases where the P300 peak latency was prolonged and the MCBF was reduced. In the D/SCI group, many differences in the results from both indicators existed among individual cases, and no fixed trend was identified. Conclusion: From the perspective of determining therapeutic tactics for elderly depressed patients and forecasting prognosis, it is important to review in detail, on an individual basis, components such as higher brain functions including cognitive functions, cerebral circulatory dynamics, and psychological/environmental factors. We believe that it is useful to evaluate a combination of factors when making such a review, including diagnostic imaging such as MRI, ERP (P300), and rCBF.     

Sensitivity of P300 auditory event-related potentials for assessing cognitive impairment in elderly type 2 diabetic patients

BACKGROUND：In previous studies, cognitive function in elderly type 2 diabetic patients was evaluated by psychometric tests. These studies have confirmed that P300 event-related potential is an objective way of assessing cognitive function. OBJECTIVE： To analyze the objectivity of P300 for assessment of cognitive function in elderly type 2 diabetic patients. DESIGN, TIME AND SETTING： This case-control experiment was performed at the Department of Endocrinology of the Fourth Affiliated Hospital, Guangxi Medical University from January 2004 to December 2006. PARTICIPANTS： Seventy-two patients （38 males and 34 females） with type 2 diabetes mellitus were enrolled in this study. The patients were divided according to those with diabetes alone （diabetes alone group） （n=38） and those with diabetes and cerebral ischemia （diabetes and cerebral ischemia group） （n=34）. A further 31 healthy individuals （16 males and 15 females）, who received health examinations over the same period, were included as normal controls （normal control group）. METHODS： All subjects were assessed by Mini-Mental State Examination （MMSE）. Abnormalities in cognitive functions were identified by analyzing the auditory P300 event-related potentials. MAIN OUTCOME MEASURES： Auditory event-related potentials and MMSE scores. Multiple linear regression analysis was conducted using the ＂enter method＂ with the 72 elderly patients with type 2 diabetes mellitus. P3 latency, P3 amplitude and N2 latency served as dependent variables. Age, sex, education, course of the disease, glycosylated hemoglobin, and ischemic brain damage were used as independent variables. RESULTS： No significant difference in scores of MMSE was detected between the diabetes alone and normal control groups （P 〉 0.05）. MMSE score was significantly lower in the diabetes and cerebral ischemia group （P 〈 0.01） than in the normal control group. N2 and P3 latencies of auditory event-related potential were significantly longer, and P3 a     

草酸艾司西酞普兰对抑郁症患者事件相关电位P300的影响

目的:探讨草酸艾司西酞普兰对抑郁症患者的事件相关电位P300影响。方法:随机将年龄在18～65岁之间符合中国精神障碍分类与诊断标准第3版抑郁症诊断标准患者30例作为研究组,选择30例性别年龄健康者作为对照组。研究组予草酸艾司西酞普兰治疗。两组分别予听觉P300检测,比较P300潜伏期及波幅的差异。结果:研究组Fz、Pz点潜伏期分别为(319±23)ms、(315±20)ms均比对照组分别为(300±22)ms、(299±21)ms延长,研究组Fz、Cz、Pz点分别为(2.5±1.8)μV、(2.6±2.4)μV、(2.5±3.3)μV波幅均比对照组分别为(3.8±2.0)μV、(3.7±1.9)μV、(4.1±3.0)μV降低(P<0.05或P<0.01)。治疗8周后,研究组Fz、Pz点潜伏期分别为(301±19)ms、(305±19)ms]明显缩短,Fz、Cz、Pz点分别为(3.5±1.8)μV、(3.7±2.1)μV、(3.6±3.5)μV波幅明显升高(P<0.05)。结论:抑郁症患者存在P300异常,草酸艾司西酞普兰具有改善这种异常现象的作用。     

老年期焦虑抑郁患者事件相关电位P300特征

目的：探讨老年期焦虑抑郁共病患者认知功能的事件相关电位P300特征。方法：对60例老年抑郁症患者（以伴有焦虑者为共病组25例,单纯抑郁症者为抑郁症组35例）及60名性别、年龄匹配的正常老年人（对照组）进行听觉诱发的事件相关电位P300检测。同时应用汉密尔顿抑郁量表（HAMD）、汉密尔顿焦虑量表（HAMA）及老年认知功能量表（SECF）分别评价患者组抑郁、焦虑情绪及认知功能。结果：患者组P2、N2、P3潜伏期及反应时间比对照组明显延长,P2、P3波幅明显降低;共病组N2、P3波幅比抑郁症组明显降低,P3潜伏期明显延长。患者组HAMD、HAMA总分与P300各指标无相关,而SECF总分与N2、P2、P3潜伏期呈显著负相关。结论：P300对老年期抑郁症早期认知功能损害评定具有一定的价值,共病组患者认知功能损害程度大于抑郁症组。