Endometriosis and the role of the integrins in the pathogenesis of the endometriosis

The endometriosis is gynecological disease what is characterized with the presence of endometrial lesions are composed of endometrial epithelial and stromal cells outside of the uterus. There are many theories for the development of the disease endometriosis. The most widely accepted theory is the theory what is postulated the endometriosis is a result of retrograde menstruation. The essential stage in the process of development of endometrial lesions is the process of adhesion of endometrial cells on the peritoneal surface and on the organs, are situated in the peritoneal cavity. The adhesion molecules (integrins) have the most essential role in this first stage. The integrins are cell surface receptors with glycoprotein structure. They have part in process of adhesion of the endometrial cells to the proteins from EC matrix outside the uterus. The integrins have part like signal molecules in the processes of proliferation and invasion of endometrial implants. They are very essential molecules what influence the viability of endometrial implants as well as the angiogenesis in the new forming endometrial implants. Improvement of the studies, related to the roles of the integrins in the pathogenesis of endometriosis would be give new possibilities to search more effective methods for therapy of the endometriosis.     

子宫内膜异位症病灶分泌的细胞因子与腹腔液微环境关系的研究

目的探讨子宫内膜异位症(内异症)病灶分泌的细胞因子与腹腔液之间的关系及其对生殖的影响.方法对因内异症进行手术治疗或不孕症行腹腔镜检查的妇女43例,其中内异症24例(内异症组)及正常盆腔19例(对照组),采用单核细胞趋化实验分析、斑点杂交分析、酶链免疫吸附测定及胞浆游离钙浓度([Ca2+]i)测定等方法,测定两组患者的腹腔液、腹腔巨噬细胞及异位内膜细胞的特性,并比较两组腹腔液及异位内膜细胞对精子活动力及鼠胚胎卵裂率的影响.结果内异症组及对照组患者腹腔液趋化单核细胞移动的距离分别为(87.2±9.4) μm、(51.9±3.7) μm,两组比较,差异有极显著性(P<0.01);腹腔巨噬细胞数分别为(1.47±0.87)×106/ml、(0.67±0.73)×106/ml(P<0.01);异位内膜细胞可表达低水平的单核细胞趋化蛋白(MCP)-1[吸光度(A)值为18.34±3.95],经白细胞介素(IL)-1β及肿瘤坏死因子(TNF)-α刺激后,其分泌MCP-1mRNA A值分别为56.84±3.21、41.58±2.48,刺激前后比较,差异有极显著性(P<0.01);内异症组腹腔液及异位内膜细胞明显抑制精子的活动力和鼠胚的发育.结论异位症病灶与腹腔液微环境相互影响,腹腔巨噬细胞和异位症病灶合成及分泌某些细胞因子的能力增强,同时可干扰生殖过程的某些环节.     

导乐分娩对母婴的影响

目的:导乐陪伴分娩是一种新型的分娩方式,这种分娩方式正受到越来越多的关注和应用。她主要用来观察导乐陪伴分娩这种分娩方式对产妇产程、产后出血和新生儿的影响,以提供导乐陪伴分娩作为新型分娩方式的依据,并介绍我院在实施导乐陪伴分娩中的一些经验和措施。方法:选择无产可合并症和并发症的足月出产产妇,将产妇分为实验组和对照组,实验组即导乐陪伴组188,对照组190,观察两组产妇产程及产后出血情况并进行比较。结果:两组产妇在年龄、孕周、新生儿性别与体重方面均无显著差异(P>0.05),而总产程及产后出血,新生儿Ap-gar评分结果比较,两组均有显著性差异(P<0.05)。结论:本研究显示导乐陪伴分娩可缩短产程,减少产后出血减少新生儿窒息的发生。这些结果为导乐陪伴分娩作为新型分娩方式提供了依据。     

Adolescent sexuality and the internet: the good, the bad, and the URL

The Internet has become a widely used resource for sexual health information, especially among adolescents. The appeal lies in the ease and anonymity with which online seekers can obtain advice and reassurance, particularly regarding sensitive topics. This article reviews the positive and negative influences of the Internet on this age group. Specific aspects of how this medium affects adolescents as well as how it can be used to assist them are discussed.     

会阴正中切口左侧切口缝合术临床效果分析

探讨会阴正中切口缝合术与会阴左侧切口缝合术的临床应用效果,根据产妇会阴体的条件,有无产科合并症胎儿的大小等情况,选择最佳的会阴切口方式,以减轻产妇的疼痛,减少切口出血量,分析比较两种切口方式术后并发症和后遗症的发生率。     

The value of the cytocins and the solubility of theirs receptors in the serum of the patients with the cervical cancer

The study encompassed 146 women with recognized invasive cervical cancer in 4 clinical stages. Patients underwent therapy in Oncologic Gynaecology Department of Wroc?aw Medical University in 2001 and 2002 years. The correlation between pretreatment serum level of proangiogenic and inflammation factors--VEGF, sTNF-R1, IL-6 and clinical stage or early effects of therapy were observed. The strong and statistically significant relationship between pretreatment serum level of IL-6 and sTNF-R1 and clinical stage with early effect of treatment were found. The statistically significant correlation between serum level of all investigated parameters and clinical stage of cervix cancer was noticed. VEGF wasn't an independent prognostic factor in the study, but the prognostic value of IL-6 was demonstrated.