STUDIES ON THE GAP JUNCTIONAL INTERCELLULARCOMMUNICATION OF HUMAN NASOPHARYNGEALCARCINOMA CELLS AND THE EFFECT OF RII

ＳＴＵＤＩＥＳＯＮＴＨＥＧＡＰＪＵＮＣＴＩＯＮＡＬＩＮＴＥＲＣＥＬＬＵＬＡＲＣＯＭＭＵＮＩＣＡＴＩＯＮＯＦＨＵＭＡＮＮＡＳＯＰＨＡＲＹＮＧＥＡＬＣＡＲＣＩＮＯＭＡ　ＣＥＬＬＳＡＮＤＴＨＥＥＦＦＥＣＴＯＦＲＩＩＨａｎＬｉｑｕｎ韩立群；ＧａｏＪｉｎ高进；...     

THE IMPACT OF RADIOTHERAPY COURSE LENGTH ON THE TREATMENT RESULTS OF NASOPH9

ＴＨＥＩＭＰＡＣＴＯＦＲＡＤＩＯＴＨＥＲＡＰＹＣＯＵＲＳＥＬＥＮＧＴＨＯＮＴＨＥＴＲＥＡＴＭＥＮＴＲＥＳＵＬＴＳＯＦＮＡＳＯＰＨＡＲＹＮＧＥＡＬＣＡＲＣＩＮＯＭＡ（ＮＰＣ）ＣｈｅｎＸｉａｎｚｈａｏ陈显钊；ＴａｎｇＱｉｘｉｎ唐启信（Ｄｅｐａｒｔｍｅｎｔ...     

THE ROLE OF MRI IN THE ILLUSTRATION OF METASTATIC LYMPHATIC PATHWAYS AND CLINICAL N-STAGING OF NASOPHARYNGEAL CARCINOMA

ＴＨＥＲＯＬＥＯＦＭＲＩＩＮＴＨＥＩＬＬＵＳＴＲＡＴＩＯＮＯＦＭＥＴＡＳＴＡＴＩＣＬＹＭＰＨＡＴＩＣＰＡＴＨＷＡＹＳＡＮＤＣＬＩＮＩＣＡＬＮＳＴＡＧＩＮＧＯＦＮＡＳＯＰＨＡＲＹＮＧＥＡＬＣＡＲＣＩＮＯＭＡＷｅｉＸｉｏｎｇ韦雄ＬｉＪｉａｎｊｕｎ李建军...     

Clinical Observations EFFECT OF THE COMBINATION OF CHOLESTEROL AND BILE ACID ON THE METABOLISM OF CHOLESTEROL，PHOSPHOLIPS AND

ＣｌｉｎｉｃａｌＯｂｓｅｒｖａｔｉｏｎｓＥＦＦＥＣＴＯＦＴＨＥＣＯＭＢＩＮＡＴＩＯＮＯＦＣＨＯＬＥＳＴＥＲＯＬＡＮＤＢＩＬＥＡＣＩＤＯＮＴＨＥＭＥＴＡＢＯＬＩＳＭＯＦＣＨＯＬＥＳＴＥＲＯＬ，ＰＨＯＳＰＨＯＬＩＰＳＡＮＤＢＩＬＥＡＣＩＤＩＮＨＥＰＡＴＯ...     

THE EFFECT OF ACTIVE COMPONENTS OF LYCIUM BARBARUM AND GARLIC（LB－GO）ON THE SYNTHESIS OF DNA AND ULTRASTRUCTURE OF U_（14） CERV

ＴＨＥＥＦＦＥＣＴＯＦＡＣＴＩＶＥＣＯＭＰＯＮＥＮＴＳＯＦＬＹＣＩＵＭＢＡＲＢＡＲＵＭＡＮＤＧＡＲＬＩＣ（ＬＢ－ＧＯ）ＯＮＴＨＥＳＹＮＴＨＥＳＩＳＯＦＤＮＡＡＮＤＵＬＴＲＡＳＴＲＵＣＴＵＲＥＯＦＵ_（１４）ＣＥＲＶＩＸＣＡＮＣＥＲＣＥＬＬＳＩＮＭＩＣ?..     

ESTABLISHMENT OF HIGH RISK POPULATION AND PRECANCEROUS LESION OF NASOPHARYNGEAL CARCINOMA(NPC)

ＥＳＴＡＢＬＩＳＨＭＥＮＴＯＦＨＩＧＨＲＩＳＫＰＯＰＵＬＡＴＩＯＮＡＮＤＰＲＥＣＡＮＣＥＲＯＵＳＬＥＳＩＯＮＯＦＮＡＳＯＰＨＡＲＹＮＧＥＡＬＣＡＲＣＩＮＯＭＡ（ＮＰＣ）ＨｕａｎｇＴｅｎｇｂｏ１黄腾波ＷａｎｇＨｕｉｍｉｎ２汪慧民ＬｉＪｉｎｇｌｉａｎ３李...     

ADYNAMIC STUDY OF THE CYTOTOXICEFFECTS OF HYPERTHERMIA COMBINED WITH CIS－DIAMINE DICHLOROLPLATINUM（DDP） ON HUMAN GASTRIC CANC

ＡＤＹＮＡＭＩＣＳＴＵＤＹＯＦＴＨＥＣＹＴＯＴＯＸＩＣＥＦＦＥＣＴＳＯＦＨＹＰＥＲＴＨＥＲＭＩＡＣＯＭＢＩＮＥＤＷＩＴＨＣＩＳ－ＤＩＡＭＩＮＥＤＩＣＨＬＯＲＯＬＰＬＡＴＩＮＵＭ（ＤＤＰ）ＯＮＨＵＭＡＮＧＡＳＴＲＩＣＣＡＮＣＥＲＣＥＬＬＬＩＮＥＳＭＫＮ...     

THE EFFECT OF HYPO－OSMOLAR SOLUTIONS WITH HIBITANE ON SHED CANCER CELLS IN PERITONEAL CAVITY OF PATIENTS WITH GASTRIC CANCER

ＴＨＥ　ＥＦＦＥＣＴＯＦＨＹＰＯ－ＯＳＭＯＬＡＲ　ＳＯＬＵＴＩＯＮＳ　ＷＩＴＨ　ＨＩＢＩＴＡＮＥＯＮ　ＳＨＥＤ　ＣＡＮＣＥＲ　ＣＥＬＬＳ　ＩＮ　ＰＥＲＩＴＯＮＥＡＬ　ＣＡＶＩＴＹ　ＯＦ　ＰＡＴＩＥＮＴＳ　ＷＩＴＨ　ＧＡＳＴＲＩＣ　ＣＡＮＣＥＲＤａｉＤ...     

A MOLECULAR EPIDEMIOLOGIC MARKER OF HEPATOCELLULAR CARCINOMA FROM AFLATOXIN B1 CONTAMINATED AREA IN THE SOUTHWEST OF GUANGXI

ＡＭＯＬＥＣＵＬＡＲＥＰＩＤＥＭＩＯＬＯＧＩＣＭＡＲＫＥＲＯＦＨＥＰＡＴＯＣＥＬＬＵＬＡＲＣＡＲＣＩＮＯＭＡＦＲＯＭＡＦＬＡＴＯＸＩＮＢ１ＣＯＮＴＡＭＩＮＡＴＥＤＡＲＥＡＩＮＴＨＥＳＯＵＴＨＷＥＳＴＯＦＧＵＡＮＧＸＩＤｅｎｇＺｈｕｏｌｉｎ邓卓霖ＭａＹ...     

AN ENZYMOCYTOCHEMICAL STUDY OF ALKALINE PHOSPHATASE ISOENZYMES IN GASTRIC CANCER－LIGHT AND ELECTRON

ＡＮＥＮＺＹＭＯＣＹＴＯＣＨＥＭＩＣＡＬＳＴＵＤＹＯＦＡＬＫＡＬＩＮＥＰＨＯＳＰＨＡＴＡＳＥＩＳＯＥＮＺＹＭＥＳＩＮＧＡＳＴＲＩＣＣＡＮＣＥＲ－ＬＩＧＨＴ　ＡＮＤＥＬＥＣＴＲＯＮＭＩＣＲＯＳＣＯＰＩＣＯＢＳＥＲＶＡＴＩＯＮＳＳｕＹｉｎｇｈａｏ苏英豪；...     

SERO-EPIDEMIOLOGICAL STUDIES OF EPSTEIN-BARR VIRUS(EBV) INFECTION BY TESTING ANTIBODIES AGAINST EBV SPECIFIC DNASE(EDAb) AS A METHOD FOR EARLY DETECTION OF NASOPHARYNGEAL CARCINOMA(NPC)

ＳＥＲＯＥＰＩＤＥＭＩＯＬＯＧＩＣＡＬＳＴＵＤＩＥＳＯＦＥＰＳＴＥＩＮＢＡＲＲＶＩＲＵＳ（ＥＢＶ）ＩＮＦＥＣＴＩＯＮＢＹＴＥＳＴＩＮＧＡＮＴＩＢＯＤＩＥＳＡＧＡＩＮＳＴＥＢＶＳＰＥＣＩＦＩＣＤＮＡＳＥ（ＥＤＡｂ）ＡＳＡＭＥＴＨＯＤＦＯＲＥＡＲＬＹ...     

Serological mass survey for early detection of nasopharyngeal carcinoma in wuzhou city,china

A serological mass survey was carried out in Wuzhou City of the Guangxi Autonomous Region, China. Sera were collected from 12,932 persons between the ages of 40 and 59. The positive rate of VCA/IgA antibody-positive persons was 5.3%, but no EA/IgA antibody was found in sera from VCA/IgA-negative persons. Thirteen and nine nasopharyngeal carcinoma (NPC) patients were detected from the VCA/IgA and EA/IgA antibody-positive persons, respectively. With the present combination method the detection rate of NPC for 12,932 persons was 100.5/100,000 and for 680 VCA/IgA antibody-positive persons it was 1,900/100,000. Thus, the rate was twice and 37 times higher, respectively, than the annual incidence rate of NPC in persons of the same age group from 1975-1978 in Wuzhou City. Of 13 NPC patients, 9 were in stage 1(70%) and 4 in stage II (30%). Therefore, it is possible to reduce the mortality rate of NPC in Wuzhou City by radiotherapy of NPC patients in the early stage of the disease. The present results further suggest that EB virus is closely associated with NPC.     

Prognosis and histology in Stage I nasopharyngeal carcinoma (NPC)

During 1969-1975, 212 new patients with Stage I nasopharyngeal carcinoma (NPC) with a tumor apparently confined to the nasopharynx were treated at Queen Elizabeth Hospital, Kowloon, Hong Kong. The initial histologies of 137 patients were available for review and further studies. The primary tumors were histologically classified into two major types--squamous cell carcinoma (35 patients) and undifferentiated carcinoma (102 patients). The latter was further divided into 4 sub-types: lymphoepithelioma of the Schmincke type, lymphoepithelioma of the Regaud type, spindle cell carcinoma, and undifferentiated carcinoma of the nasopharyngeal type. Such histological typing of the initial tumor was not of value in predicting the clinical outcome, whether in terms of 5-year crude or disease-free survival rate, or the tendency of the tumor to develop recurrence at the primary site, or distant metastases after a standardized course of radiation therapy. There is no significant correlation between the extent of mononuclear infiltration nor fibrosis in the tumor stroma and the survival or tumor control rates.     

鼻咽癌内血管内皮生长因子的表达及其病理临床意义初探

目的探讨血管内皮生长因子（ＶＥＧＦ）在鼻咽癌中的表达及其与病理、临床各因素之间的关系。方法利用免疫组化ＳＰ方法检测１０例鼻咽正常粘膜、１６例鼻息肉及５６例鼻咽鳞癌石蜡标本中ＶＥＧＦ的表达,用Ⅷ因子相关抗原显示肿瘤内的微血管数。结果鼻咽正常粘膜中ＶＥＧＦ均为阴性;１６例鼻息肉中有２例粘膜层呈ＶＥＧＦ阳性表达;鼻咽癌中ＶＥＧＦ表达阳性率为７１．４％（４０／５６）。ＶＥＧＦ阳性组血管密度明显高于ＶＥＧＦ阴性组（Ｐ＜０．０５）;ＶＥＧＦ的表达也与放疗后局部复发、远地转移及预后差有关,但与肿瘤的组织学分级及临床分期无关。结论ＶＥＧＦ表达与肿瘤血管生成有关,也是预测鼻咽癌复发、远地转移以及预后差的有用指标。     

Demonstration of Epstein-Barr virus antibodies in serum of patients with nasopharyngeal carcinoma

A total of eighty six blood samples (17, 19 & 50 of nasopharyngeal carcinoma, oesophageal cancer and normal healthy control respectively) were collected from Naga Hospital, Kohima, Nagaland and B. Barooah Cancer Institute, Guwahati, Assam and were processed for the detection of EBV-IgG antibody using Elisa test. The results showed that EBV positivity is higher among NPC patients as compared to oesophageal carcinoma patients and/or healthy control. The data also indicated that EBV antibody titre is significantly higher among NPC cases as compared to control.     

CLINICOPATHOLOGIC ANALYSIS ON 121 CASES OF NASAL AND NASOPHARYNGEAL LYMPHOMA (NPL)

One handled twenty- one cases of nasal and naso-pharyngeal lymphoma were analyzed in this paper. These cases were divided macroscopically Into 4 main types Including giant mass type, nodular type, thickbulgy type and ulcerating type. Microscopic histologic varieties were classified to non-Hodgkin' s lymphoma (NHL) and Hodg-Kin' s disease (HD).Differential diagnosis between NPL and nasopharyngeal carcinoma (NPC) and the problem how to ascertain the primary and secondary tumors were discussed.     

鼻咽癌患者外周血单个核细胞中P-gp和LRP的表达及其临床意义

目的通过检测鼻咽癌患者外周血单个核细胞中P-糖蛋白(P-gp)和肺耐药相关蛋白(LRP)的表达,探讨两者在鼻咽癌多药耐药中的作用及意义.方法采用流式细胞术对54例鼻咽癌患者化疗前后外周血单个核细胞中P-gp、LRP进行检测,同期选择鼻咽部非恶性肿瘤患者10例,正常健康人10例为对照组.结果 P-gp在正常人、非恶性肿瘤及鼻咽癌初治组中的表达差异无显著性,但在复发组的表达明显高于其他组,差异有显著性.LRP在初治及复发组中的表达明显高于对照组,且化疗前后差异有显著性.P-gp和LRP的表达与年龄、性别、临床分期、病理类型、淋巴结转移无显著相关.P-gp、LRP的表达与化疗疗效密切相关.结论 P-gp、LRP的表达在鼻咽癌多药耐药的产生中具有重要意义,对临床制定化疗方案具有潜在的指导意义.     

EB病毒DNA在鼻咽病变中的表现

本文通过原位杂交技术检测鼻咽活检组织不同病理改变时EBV—DNA的表现,以探讨EB病毒在鼻咽癌发生过程中的可能作用。结果显示:(1)本实验所有鼻咽低分化癌癌组织均出现EBV—DNA片段,且绝大部分病例的阳性细胞数及细胞阳性强度均在中等以上;(2)无论是鼻咽癌或慢性鼻咽炎病例,所见到的中-重度异型改变上皮或淋巴组织,均有数量不等的细胞存在阳性强度不同的EBV-DNA片段,粘膜下小涎腺内亦常见到一定数量的EBV-DNA片段。结果提示:(1)EB病毒与鼻咽低分化癌关系密切。EBV作为致鼻咽癌病因多因素中的一员是有可能的;(2)患者血清中EB病毒相关抗体,尤其是IgA抗体阳性率和滴度的升高,可能与鼻咽局部EBV感染及/或EBV激活有关;(3)在异型改变上皮中有中等或以上阳性强度EBV-DNA片段的检出,将有可能作为推测鼻咽癌癌前病变的有效指标。