系统性红斑狼疮患者血清泌乳素水平的检测及其临床意义

目的：探讨系统性红斑狼疮(SLE)患者血清泌乳素(PRL)水平检测的临床意义。方法：应用免疫放射量度分析法测定了75例SEE患者与25例健康人血清PRL水平。结果：SLE患者血清PRL水平明显高于正常对照组，且活动期升高更明显；高泌乳素血症(HPRL)发生率为40％，伴HPRL的患者肾损害发生率明显高于血清PRL正常者；血清PRL水平与SLEDM评分、抗ds-DNA抗体滴度倒数呈正相关，与C3呈负相关。结论：SLE患者血清PRL水平升高与病情活动相关，其检测可作为监测狼疮病情活动性的指标之一；血清PRL水平升高与肾脏损害相关，提示PRL可能在SLE肾损害中起作用。     

前列腺癌患者血清IGF-Ⅰ、PRL及SE-cad测定的临床意义

目的:探讨前列腺癌患者血清IGF-Ⅰ、PRL及SE-cad水平的变化及临床意义.方法:血清IGF-Ⅰ采用放射免疫分析;fPSA及PRL采用化学发光法;血清SE-cad采用酶联免疫分析法.结果:前列腺增生组患者血清IGF-Ⅰ水平较对照组升高显著(P＜0.05);血清PRL含量也较对照组显著升高(P＜0.05);SE-cad浓度其测定数值也存在显著性差异(P＜0.05).而前列腺癌患者组血清IGF-Ⅰ水平较对照组升高更为显著(P＜0.01);血清PRL含量也较对照组升高极其显著(P＜0.01);SE-cad浓度其测定数值升高同样非常显著(P＜0.01).灵敏度分析表明,fPSA+IGF-Ⅰ和fPSA+SE-cad两组灵敏度显著高于fPSA单项测定组;fPSA+PRL组灵敏度略低,但P＞0.05.特异性分析则fPSA+SE-cad组fPSA单项测定组显著增高(P＜0.05),fPSA+PRL降低明显,fPSA+IGF-Ⅰ组与单项组差异并不显著(P＞0.05).结论:血清IGF-Ⅰ、PRL及SE-cad水平的变化与前列腺癌的发生关系密切,与fPSA的联合测定可提高诊断的灵敏度及特异性,有助于前列腺癌的辅助诊断.     

SLE中淋巴毒素β基因表达及相关性研究

目的:探讨LT-β在SLE发病及免疫调节紊乱中的作用.方法:用ELISA法检测血清LT-β水平,PBL RNA斑点杂交测定LT-β基因转录水平;PCR-RLFP法分析LT-β基因多态性.结果:SLE患者血清 LT-β水平比正常显著增高(P＜0.05);活动期比正常增高更显著(P＜0.01).SLE患者基因转录水平比正常对照显著增高(P＜0.05);活动期比正常亦显著增高(P＜0.05); 未发现LT-β基因的XhoⅠ酶切位点具有多态性.结论:提示LT-β是导致SLE发生的主要因子;LT-β参与SLE的免疫调节紊乱.     

乙肝后肝硬化患者血清CTGF、PDGF、TGF-β_1测定的意义

目的：探讨乙型肝炎后肝硬化患者血清CTGF、PDGF、TGF-β1水平的变化及临床意义。方法：将50例乙肝后肝硬化患者按不同的病情分为轻度、中度及重度三组;设体检健康人45名作为对照组。血清TGF-β1水平采用放射免疫分析;CTGF及PDGF则采用ELISA测定。并将测定结果进行统计分析。结果：结果显示,血清CTGF水平轻度组与对照组比较略有升高,但无统计学意义（P〉0.05）;中度组患者该指标水平则显著高于对照组（P〈0.05）;重度组水平更为显著（P〈0.01）。且发现其递增规律与肝硬化病情的严重程度呈明显的平行关系。PDGF测定值显示,轻度组水平显著高于对照组（P〈0.05）,中度和重度两组水平则较对照组升高更为显著（P均〈0.01）。其水平的递增关系也与病情的严重程度相一致。TGF-β1水平的变化趋势同PDGF。结论：本文患者三项血清指标水平的变化与乙肝后肝硬化的发病及病情进展有关;其测定有助于了解本病的发生机制和预后评估。     

慢性牙周炎患者龈沟液EA、COL-Ⅱ和KGF-1水平的变化及其意义

目的:探讨慢性牙周炎(chronic periodontitis,CP)患者龈沟液(gingival crevicular fluid,GCF)弹性蛋白酶(elastase,EA)、Ⅱ型胶原酶(collagenase-Ⅱ,COL-Ⅱ)和角质细胞生长因子-1(keratinocyte growth factor-1,KGF-1)水平的变化及其临床意义.方法:正常对照组为58名正常成人和儿童.将62例CP患者根据不同病情分为:轻度(30例),中度(18例),重度(14例)三组.GCF中EA、COL-Ⅱ和KGF-1测定分别采用底物催化法和酶联免疫分析法.结果:EA水平轻度组与正常对照组比较略高,但无统计学差异(P>0.05),中度和重度组则显著高于正常对照组(P<0.05,P<0.01),重度组又分别显著高于轻度和中度组(P<0.05,P<0.01).COL-Ⅱ水平的变化规律同EA.KGF-1水平则轻度组与正常对照组比较呈显著高水平(P<0.05),中度和重度组水平与正常对照组比较升高更为显著(P均<0.01),重度组则显著高于轻度和中度组(P<0.05,P<0.01).结论:CP患者GCF中三项指标水平变化与病情的进展关系密切.其测定对于CP的诊断和炎症程度的评估有一定的帮助.     

脑梗死患者炎性细胞因子变化与神经功能缺损的关系

目的:探讨脑梗死患者血清中炎性细胞因子水平与病情严重程度的关系.方法:收集2006-01/2008-12脑梗死患者82例为研究组, 80例同期门诊体检的健康人为对照组, 检测其外周血清中肿瘤坏死因子α(TNF-α)、白细胞介素1β(IL-1β)和可溶性细胞间黏附分子1(sICAM-1)水平.结果:急性期、恢复期脑梗死患者血清IL-1β、 TNF-α及sICAM-1水平均较对照组显著增高(P ＜0.01或P＜0.05), 脑梗死组急性期较恢复期明显增高(P＜0.01);中度损伤组和重度损伤组患者血清IL-1β、 TNF-α及sICAM-1水平均较轻度损伤组显著增高(P＜0.01或P＜0.05), 重度损伤组患者TNF-α及sICAM-1水平较中度损伤组明显增高(P＜0.01);多元线性回归分析结果显示, IL-1β、 TNF-α及sICAM-1表达水平与脑梗死患者的神经功能缺损程度评分呈线性正相关, 标准回归系数依次为0.618、 0.613和0.606.结论:IL-1β、 TNF-α及sICAM-1互相作用参与了急性脑梗死的炎症反应和再灌流损伤.对它们的监测可为早期临床治疗及康复干预提供试验指标, 以便控制脑卒中的进展及复发.     

系统性红斑狼疮患者血清IL-10的水平及临床意义

目的 观察系统性红斑狼疮(systemic lupus erythematosus,SLE)患者血清IL-10的表达与疾病活动的关系.方法 选取22例SLE患者及24名健康人作为对照,根据狼疮疾病活动指数(SLE disease activity index,SLEDAI)将SLE患者分为活动期组和非活动期组,检测血清抗dsDNA抗体,血清总补体溶血活性(CH50)及C反应蛋白(C reactive protein,CRP),酶联免疫吸附法(ELISA)检测血清IL-10表达.结果 与对照组[(18.11±6.97)ng/L]相比,IL-10在SLE活动期组[(78.54±5.62)ng/L,P＜0.01]及非活动期组[(30.36±10.98)ng/L,P＜0.05]均有所增高,活动期组增高更为明显(与非活动期组相比,P＜0.05).IL-10水平与SLEDAI呈正相关(SLE活动期,r=0.77,P＜0.01;SLE非活动期,r=0.84,P＜0.01),IL-10的水平与抗dsDNA抗体(r=0.71,P＜0.01)、CRP(r=0.63,P＜0.01)和CH50(r=-0.56,P＜0.05)均相关.结论 IL-10在SLE患者血清中表达升高,在疾病活动时更为明显,IL-10能反应疾病活动的程度,可以做为临床观察SLE疾病活动的指标之一.     

系统性红斑狼疮患者抗磷脂抗体与低水平补体C3、C4的关系

目的补体活化和低补体血症常见于系统性红斑狼疮(SLE)患者,15%~40%SLE患者抗磷脂抗体(antiphospholipid,a PL)呈阳性。本文探讨SLE患者血清抗磷脂抗体与低水平补体的关系。方法选取我院2013年2月至2015年2月住院及门诊部诊治的SLE患者126例(SLE组)和健康体检者162例(健康对照组),根据SLE疾病活动指数(systemic lupus erythematosusdisease activity index,SLEDAI)将SLE组又分为SLE轻度活动组、中度活动组和重度活动组(n分别为48、52、26)。所有样本行抗β2糖蛋白1(β2GP1)抗体、抗心磷脂抗体(a CL)、C-反应蛋白、抗ds DNA抗体、补体C3、C4检测。观察a PL抗体与补体C3、C4的相关性。结果与健康对照组相比,SLE组血清CRP水平,各种亚型a PL抗体滴度显著升高,差异均有统计学意义(P均0.05),SLE轻度和中度活动组患者血清C3、C4水平差异均无统计学意义(P均0.05),而SLE重度活动组患者血清补体C3、C4水平显著降低,差异均有统计学意义(P均0.05);SLE轻度、中度、重度活动组三者相比,各类亚型a PL抗体均呈显著升高趋势,差异均有统计学意义(P均0.05);SLE患者血清补体C3、C4水平与各类亚型a PL抗体滴度均呈显著负相关(r=-0.205、-0.213、-0.207、-0.19,P0.05;r=-0.935、-0.933、-0.914、-0.929,P0.01);与a PL抗体阴性SLE组相比,a PL阳性SLE患者血清补体C3、C4水平显著降低,差异有统计学意义(P0.05),抗ds DNA抗体阳性率显著高于阴性组(P0.05)。结论 a PL抗体与SLE患者疾病活动度相关,且与补体C3、C4水平呈显著负相关,a PL抗体可能激活补体C3、C4共同参与SLE患者的疾病活动。     

自身抗体联合体液免疫检测在SLE中的应用价值

目的 探讨联合检测自身抗体、免疫球蛋白和补体在系统性红斑狼疮(SLE)诊断和病情判断中的应用价值.方法 选取SLE患者54例、其他自身免疫性疾病患者32例和正常对照30例,采用间接免疫荧光法测定抗核抗体(ANA)、免疫印迹法测定抗核提取物抗体(抗ENA抗体)、散射免疫比浊法测定免疫球蛋白和补体C3、C4.结果 SLE患者的ANA、抗dsDNA、抗Sm、抗核小体、抗U1-nRNP、抗核糖体P蛋白、抗组蛋白抗体的检测阳性率分别为87.04％、59.26％、27.78％、29.63％,37.04％、12.96％、27.78％;SLE活动组中抗dsDNA和抗核小体抗体的阳性率高于SLE非活动组,差异具有统计学意义(P＜0.05);SLE活动组IgG、IgA、IgM水平高于正常对照组,C3、C4水平低于正常对照组,差异具有统计学意义(P＜0.01).结论 自身抗体联合免疫球蛋白和补体检测对SLE患者的临床诊断和病情判断有良好的参考价值.     

妊高征患者胎盘组织中瘦素mRNA表达与NO含量的测定及临床研究

目的检测正常妊娠、妊高征妇女胎盘组织中瘦素mRNA的表达及与一氧化氮含量的关系,探讨瘦素在妊高征发病中的作用.方法用逆转录-聚合酶链技术(RT-PCR)测定38例正常妊娠妇女、62例妊高征妇女分娩时胎盘组织中瘦素mRNA表达水平;用硝酸还原酶法测定胎盘组织NO的含量.结果(1)正常晚孕及妊高征妇女胎盘瘦素mRNA表达水平分别为:0.139±0.12、0.603±0.287(其中轻、中、重度妊高征胎盘瘦素水平分别为:0.145±0.056、0.38±0.122、0.75±0.199).(2)妊高征组胎盘瘦素水平明显高于正常晚孕组,差异有显著性(P＜0.01),妊高征患者胎盘瘦素水平随病情加重而升高;重、中、轻度之间差异均有显著性(P＜0.01、P＜0.05).(3)妊高征胎盘组织中NO含量低于正常晚孕妇女,差异有显著性(P＜0.05);重度妊高征患者胎盘NO含量明显低于中度、中度低于轻度,差异有显著性(P＜0.01、P＜0.05),(4)妊高征胎盘瘦素mR-NA表达与NO含量呈负相关(r=-0.6294,P＜0.01),与收缩压、舒张压、平均动脉压、尿蛋白呈正相关(r=0.547,0.377,0.45,0.517;P=0.015,0.015,0.020,0.040),重度妊高征组与新生儿体重呈负相关(r=-0.447,P=0.018).结论胎盘瘦素mRNA表达水平在妊高征组中明显升高,随着妊高征病情加重,胎盘瘦素mRNA表达逐渐增加;同时,胎盘组织中NO含量在妊高征妇女中明显降低,胎盘瘦素mRNA表达与胎盘组织中NO含量呈负相关.因此,瘦素可能与妊高征发病有关,可望成为妊高征病情发展的检测指标之一.     

Prolactin and growth hormone secretion after thyrotrophin-releasing hormone infusion and dopaminergic (DA2) blockade in infertile patients with minimal/mild endometriosis

BACKGROUND: The origin of infertility in patients with endometriosis without tubal occlusion has not yet been clearly defined. Several reports show an abnormal pituitary-ovarian axis in this group of patients. Moreover, prolactin (PRL) and growth hormone (GH) secretion is closely related to reproductive status. This study aimed to evaluate PRL and GH secretion after metoclopramide and thyrotrophin-releasing hormone (TRH) infusion in infertile patients with minimal/mild endometriosis. METHODS: A total of 64 women participated in the study: 33 fertile patients without endometriosis; 10 fertile patients with minimal/mild endometriosis; and 21 infertile patients with minimal/mild endometriosis. TRH or metoclopramide was administered randomly in two sequential menstrual cycles (cycle days 3-5). Serum PRL and GH secretion before and after dopaminergic type 2 (DA2) receptor blockade and TRH were compared. RESULTS: Higher serum PRL levels were observed in patients with endometriosis at baseline and after 15 and 30 min of TRH administration. Also, infertile patients with endometriosis had lower serum estradiol levels than fertile patients. Moreover, the dopaminergic blockade did not result in abnormal PRL or GH secretion. CONCLUSIONS: Decreased serum estradiol levels and altered PRL secretion after TRH administration in infertile patients with minimal/mild endometriosis are related to ovulatory dysfunction and infertility in this group of patients without tubal occlusion.     

Vascular endothelial growth factor in systemic lupus erythematosus: relationship to disease activity,systemic organ manifestation,and nailfold capillaroscopic abnormalities

Introduction: The aim of the study was to evaluate whether vascular endothelial growth factor (VEGF) serum level is associated with systemic organ involvement, microvascular changes as determined by nailfold capillaroscopy, and disease activity of systemic lupus erythematosus (SLE). Materials and Methods: Serum levels of VEGF were determined by an enzyme-linked immunosorbent assay in 47 SLE patients and in 30 healthy controls. Nailfold capillaroscopy was performed in all patients and healthy subjects. Results: Morphological changes were observed by nailfold capillaroscopy in 45 of 47 (95.7%) SLE patients. Mild capillary changes were found in 16 (34%), moderate in 21 (44.7%), and severe in 8 (17%) SLE patients. All patients with systemic organ involvement showed severe or moderate changes in nailfold capillaroscopy. In comparison with the control group, a higher serum concentration of VEGF in SLE patients was demonstrated (p<0.05). Furthermore, significant differences in VEGF serum concentration between SLE patients with systemic involvement and controls were found (p<0.01). Comparison between patients with active and inactive SLE according to SLEDAI score showed a significantly higher concentration of VEGF in the sera of patients with active SLE (p<0.01). The SLE patients with severe and moderate changes in nailfold capillaroscopy showed significantly higher VEGF serum levels than SLE patients with mild changes (p<0.05) or healthy controls (p<0.01). Moreover, the VEGF serum level correlated significantly with ESR (r=0.580, p<0.0001) and CRP (r=0.512, p<0.005). Conclusions: Our data suggest that VEGF serum level may be a useful marker of disease activity and internal organ involvement in SLE patients. Abnormalities in nailfold capillaroscopy may reflect the extent of microvascular involvement and are associated with systemic manifestation in SLE.     

Selected acute phase proteins and interleukin-6 in systemic lupus erythematosus patients treated with low doses of quinagolide

The relationship between endocrine regulation and immune system has recently become the subject of intense investigations. The objective of this study was to determine the extent of selected serum acute phase proteins (APP), IL-6 and Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) involvement in systemic lupus erythematosus (SLE) patients during quinagolide therapy. A further aim of this study was to evaluate the relationships between the above mentioned parameters. In 25 SLE patients treated with a low dose of quinagolide (12.5-50 microg per day) and in 25 healthy persons who constituted the control group, serum concentration of C-creative protein (CRP), alpha-1-antitripsin (AAT), ceruloplasmin (CER), IL-6 and prolactin (PRL) were estimated at entry and in patients after 3 months of treatment. Moreover, SLEDAI score was calculated at entry and after 3 months of therapy with quinagolide. IL-6 and PRL levels were significantly higher in SLE group whereas the concentrations of CRP, AAT and CER were higher than in the controls, but without statistical significance. After 3 month therapy statistically significant decrease of serum level of IL-6 and PRL was revealed. Statistically significant lower serum concentration of CER was also obtained after 3 months of therapy whereas serum CRP and AAT concentration was lower compared with the mean pretreatment level but the results did not reach statistical significance. A raised SLEDAI score at entry was significantly reduced after 3 month therapy and positive correlation with PRL level in examined group of patients with SLE was noted at entry. The decreased serum concentration of IL-6, APP and SLEDAI score observed during applied therapy with small dose of quinagolide confirms the hypothesis that quinagolide may become a valuable and safe drug in the therapy of patients with mild SLE.     

胃癌患者性激素水平测定及临床意义

目的:探讨胃癌患者性激素水平变化及临床意义。方法:采用化学发光免疫分析法,测定134例胃癌患者血清睾酮(T)、雌二醇(E2)、催乳素(PRL)、黄体生成素(LH)及卵泡刺激素(FSH)水平,根据TNM分期对各期胃癌患者E2及T含量进行分析。结果:男性及女性胃癌患者E2、T含量明显低于对照组(P<0.05),女性患者E2水平较对照组下降更为明显(P<0.01);女性患者PLR水平显著性升高(P<0.01)、TNM各期胃癌患者E2、T水平变化为低分化者明显高于高分化者(P<0.01)。结论:了解胃癌患者血清性激素水平,对分析胃癌与性激素的关系有重要意义。     

Plasma levels of Th1/Th2 type cytokine are associated with change of prolactin and GH/IGF-I in hemodialysis patients

Patients undergoing chronic hemodialysis (HD) have an impaired immune system involving both B and T cell-mediated immune responses. Since T helper type 1 (Th1) and type 2 (Th2) cytokines are implicated in regulating the immune responses, while the pituitary hormones, prolactin (PRL) and growth hormone (GH) are known to be involved in the regulation of the immune response, all of them may, therefore, be involved in impaired status. The aims of the present study were to estimate the serum concentrations of Th1-Th2 cytokine, GH, insulin-like growth factor-I (IGF-I) and PRL, and to determine whether there are any correlations between the release of T-cell cytokines and disturbance of hormones in a group of patients on maintenance hemodialysis (MHD). The study included 35 HD patients (23 males and 12 females, mean age 56.8+/-12.8 years) and a control group of 20 age-matched healthy subjects. Baseline serum concentrations of GH/IGF-I, PRL, IL-2, sIL-2R, IFN-gamma, IL-4 and IL-10 were measured in all patients and control subjects. Our results demonstrate that the fasting serum concentration of IGF-I, PRL, sIL-2R and Th1-type cytokine, including IL-2 and IFN-gamma, were significantly higher in HD patients compared to the healthy subjects. GH and Th2-type cytokine including IL-4 and IL-10 levels were slightly reduced, but no significant differences were observed between HD patients and the control group. In the group of HD patients, PRL correlated directly with IFN-gamma and correlated inversely with IL-10; IFN-gamma correlated inversely with IL-4; and GH also correlated inversely with IGF-I and IL-4. However, IGF-I correlated directly with IL-2 and IL-10. These data suggest that the Th1/Th2 imbalance in HD patients with an increase of Th1 type cytokines, associated with the altered GH/IGF-I axis and prolactin and immuno-endocrine dysfunction, probably plays a role in an impaired immune system in HD patients.     

嗜酸粒细胞趋化因子、干扰素-γ和内皮素1在支气管哮喘中的临床意义

目的探讨血清嗜酸粒细胞趋化因子（eotaxin）、干扰素-γ（IFN-γ）和内皮素1（ET-1）在支气管哮喘中的临床价值。方法将120例支气管哮喘患者分为哮喘发作期83例、缓解期37例,另选35名健康者作为对照。并将83例哮喘发作期患者按病情程度分为轻度（20例）、中度（47例）和重度（16例）。应用ELISA法对发作期、缓解期哮喘患者以及健康对照者进行血清eotaxin、INF-γ和ET-1水平测定。结果哮喘发作组血清中eotaxin和ET-1高于哮喘缓解组及健康对照组（P〈0.05,P〈0.01）,缓解期血清eotaxin和ET-1水平与对照组比较差异无统计学意义（P〉0.05）,而血清水平INF-γ在发作期组低于哮喘缓解组及健康对照组（P〈0.01）。随着哮喘严重程度增加,哮喘患者的血清中eotaxin和ET-1浓度升高,INF-γ水平出现明显降低。重度哮喘与中、轻度哮喘比较,eotaxin、ET-1和INF-γ浓度差异有统计学意义（P〈0.05,P〈0.01）。结论 eotaxin、IFN-γ和ET-1参与了哮喘的发病过程,并与疾病的严重程度密切相关。     

颅脑损伤患者血浆NPY及CGRP检测的临床意义

目的探讨血浆神经肽Y（NPY）和降钙素基因相关肽（CGRP）水平在不同程度颅脑外伤患者中的临床意义。方法采用放射免疫方法（RIA）对91例依据GCS评分法分为轻度、中度和重度的颅脑损伤患者及35例正常对照组的NPY、CGRP和ET-1水平进行检测。结果轻、中、重三组颅脑损伤患者血浆NPY水平分别为（119.6±20.3）ng/L、（127.8±25.5）ng/L和（146.2±30.5）ng/L,显著高于正常对照组（65.2±13.2）ng/L,差异有统计学意义（P〈0.01）。轻、中度患者血浆CGRP含量分别为（54.3±5.6）ng/L、（57.5±7.4）ng/L,显著高于正常对照组（41.8±6.8）ng/L,差异有统计学意义（P〈0.01）;而重度患者组的CGRP水平（44.6±5.3）ng/L与对照组（41.8±6.8）ng/L间差异无统计学意义（P〉0.05）。结论血浆NPY及CGRP水平与不同程度颅脑损伤患者的病情密切相关,并对患者预后的判定具有一定的临床参考价值。     

食管癌患者胸段手术前后血清激素水平的变化及临床意义

目的：探讨食管癌患者胸段手术前后血清激素水平的变化及其测定的临床意义。方法：皮质醇（cortis01）、血清垂体泌乳素（pmlactin,PRL）、促甲状腺激素（thyroidstimulatinghormone,TSH）测定采用化学发光免疫分析;生长激素（growthhormone,GH）和血管紧张素-Ⅱ（angiotensin-Ⅱ,AT-Ⅱ）采用放射免疫分析;肾上腺髓质素（adrenomedullin,AM）采用酶联免疫分析。结果：表1可见,患者血清PRL、TSH和GH三项指标水平在术前24h组略高于正常对照组,但无统计学差异（P均〉0．05）;麻醉前组三项指标水平则均显著高于正常对照组（P均〈0．05）;术后24h组三项指标水平更显著高于上述三组（P〈0．05,P〈0．01）,且还显著高于麻醉前组（P均〈0．05）。表1中血清cortisol水平在术前24h已显著高于正常对照组（P〈0．05）;AM和AT—Ⅱ含量略高于正常对照组,但无统计学差异（P均〉0．05）;麻醉前组三项指标水平均显著高于正常对照组（P〈0．05,P〈0．01）;术后24h组三项指标水平更显著高于上述三组（P〈0．05,P〈0．01）,且还显著高于麻醉前组（P均〈0．05）。结论：本文患者血清六项血清指标的变化证实患者存在明显的应激反应;提醒临床应在手术前后对患者实施必要的药物和心理治疗。     

男性肝硬化患者血清性激素水平变化

目的：探讨男性肝硬化患者血清性激素水平的变化及其临床意义。方法：采用放射免疫分析测定118例肝硬化患者和108例正常健康人的血清卵泡刺激素（FSH）、黄体生成素（LH）、雌二醇（E2）、睾酮（T）及泌乳素（PRL）,以进行比较。结果：肝硬化患者血清T、E2水平较正常对照组显著降低（P〈0.01）,血清PRL含量则高于对照组（P〈0.01）,而FSH、LH变化不大。结论：男性肝硬化患者体内存在性激素水平的失衡和紊乱,联检血清T、E2、PRL含量对估测肝硬化的严重程度及预后具有实用价值。