中性粒细胞及血小板与淋巴细胞比值与2型糖尿病视网膜病变相关性

目的：探讨中性粒细胞与淋巴细胞比值(NLR)、血小板与淋巴细胞比值(PLR)与2型糖尿病视网膜病变(DR)的相关性。

方法：选择2型糖尿病(DM)患者200例, 按眼底检查结果分为眼底正常组(n=100)、非增殖期视网膜病变组(NPDR, n=62)和增殖期视网膜病变组(PDR, n=38)。同时选取100例健康体检者作为正常对照(n=100)组; 测定中性粒细胞、淋巴细胞及血小板计数等相关指标。

结果： PDR组患者NLR值(2.54)高于对照组(1.81)、DM组(1.76)及NPDR组(1.85),差异有统计学意义(P<0.05),PDR组患者PLR值(126.18)高于DM组(111.64),差异有统计学意义(P<0.05)。Logistic回归分析显示,年龄(β=-0.047)是糖尿病视网膜病变的保护因素(P<0.05),病程(β=0.071)和收缩压(β=0.024)是危险因素(P<0.05),而NLR、PLR在回归分析中无统计学意义。

结论：NLR、PLR值在PDR组升高,但并非糖尿病视网膜病变发生的独立危险因素。     

术前全血炎症标志物预测喉鳞状细胞癌患者预后的价值

目的 探讨全血炎症标志物与喉鳞状细胞癌(LSCC)临床特征和预后的相关性.方法 纳入116例LSCC患者,以受试者操作特征曲线(ROC曲线)上临界值定义血小板淋巴细胞比值(PLR)、中性粒细胞淋巴细胞比值(NLR)、淋巴细胞单核细胞比值(LMR)的高值组和低值组,并将PLR、NLR、LMR组合成PLR+LMR、PLR+...     

外周血炎症指标和血小板相关参数与不同OCT分型的视网膜静脉阻塞继发黄斑水肿的关系

目的　探索外周血炎症指标和血小板相关参数与不同OCT分型的视网膜静脉阻塞继发黄斑水肿（RVO-ME）的关系。方法　回顾性临床研究。纳入2018年6月至2021年6月于海南医学院第一附属医院眼科确诊的RVO-ME患者共100例（100眼）。根据视网膜静脉阻塞部位分为视网膜中央静脉阻塞（CRVO）组和视网膜分支静脉阻塞（BRVO）组；其次，根据RVO-ME患者的OCT形态分为视网膜神经上皮层脱离型（SRD）组、黄斑囊样水肿型（CME）组和混合型ME组。同时，选取已排除眼底疾病的白内障手术患者100例（100眼）作为正常对照组。对各组受试者外周血中性粒细胞/淋巴细胞比值（NLR）、血小板/淋巴细胞比值（PLR）、血小板计数（PLT）、平均血小板体积（MPV）和血小板分布宽度（PDW）进行组间比较。结果　CRVO组和BRVO组患者外周血NLR、PLR、MPV和PDW均较正常对照组明显升高，差异均有统计学意义（均为P＜0.05），而CRVO组、BRVO组和正常对照组患者的年龄、性别和PLT比较，差异均无统计学意义（均为P>0.05）。根据OCT不同形态分组结果发现，不同类型RVO-ME在不同RVO类型中占比不同(χ²=6.489,P<0.05),其中有15眼SRD由BRVO引起，占比78.9%。混合型ME组患者最佳矫正视力明显差于SRD组和CME组，差异均有统计学意义（均为P＜0.05），而三组间患者的年龄、性别和病程比较，差异均无统计学意义（均为P>0.05）。混合型ME组患者的MPV和PDW均高于SRD组和CME组，差异均有统计学意义（均为P＜0.05）；SRD组、CME组和混合型ME组患者的PLT、NLR和PLR比较，差异均无统计学意义（均为P>0.05）。结论　不同OCT分型的RVO-ME患者的MPV和PDW存在差异，血小板的活化和体积增大与混合型ME的发生发展可能相关。     

血糖控制达标2型糖尿病患者发生糖尿病视网膜病变的影响因素

目的：探究血糖控制达标2型糖尿病(T2DM)患者发生糖尿病视网膜病变(DR)后血清视黄醇结合蛋白4(RBP4)、炎症指标中性粒细胞与淋巴细胞比值(NLR)、血小板与淋巴细胞比值(PLR)水平及影响患者发生DR的因素。

方法：回顾性分析2017-02/2020-02我院收治的142例血糖控制达标的T2DM患者的临床资料,根据眼底造影检查结果将患者分为眼底正常组(N组,74例)、非增殖期糖尿病视网膜病变组(NPDR组,36例)和增殖期糖尿病视网膜病变组(PDR组,32例)。比较三组患者的一般资料和血液检查指标; 多因素Logistic回归分析影响患者发生DR的因素; 构建预测患者发生DR的列线图预测模型并评价其预测效能。

结果：PDR组患者的DM病程、血清生长激素(GH)、胰岛素样生长因子-Ⅰ(IGF-Ⅰ)、低密度脂蛋白胆固醇(LDL-C)、尿微量白蛋白(UA)、视黄醇结合蛋白4(RBP4)水平、NLR、PLR明显高于N组和NPDR组,C肽(C-P)、2h C-P明显低于N组和NPDR组(P<0.05); DM病程>12a、IGF-Ⅰ>145μg/L、C-P<0.75ng/mL、UA>245ng/mL、RBP4>54mg/L、NLR>1.8、PLR>110均是导致患者发生DR的危险因素; 列线图模型预测的区分度和校准度较高,具有良好的预测效能。

结论：除DM病程、IGF-Ⅰ、C-P、UA等常见的危险因素外,RBP4、NLR、PLR增加也是DR发生的危险因素,可能参与了DR的发生和发展。     

炎症及动脉硬化相关因子与视网膜静脉阻塞的相关性

目的：研究视网膜静脉阻塞(RVO)患者血清白介素6(IL-6)、脂联素(ADPN)、Apelin、超敏C反应蛋白(hs-CRP)、血管内皮生长因子(VEGF)水平变化情况,从分子角度探究其与RVO的相关性。

方法：收集中央型视网膜静脉阻塞(CRVO)35例,分支型视网膜静脉阻塞(BRVO)37例为试验组1、2,年龄相关性白内障患者32例为对照组,记录其发病时间、视力、心脑血管疾病病史及OCT示黄斑水肿高度,酶联免疫吸附法检测其外周血血清中与炎症及动脉硬化紧密相关因子—IL-6、ADPN、Apelin、hs-CRP、VEGF的表达情况。

结果：BRVO组、CRVO组Apelin值分别为6.69(4.25,10.52)、7.12(3.78,8.58)ng/mL,均高于对照组1.19(0.74,1.49)ng/mL(P<0.05)。BRVO组、CRVO组ADPN值分别为8.06(4.67,10.81)、9.74(4.10,11.67)μg/mL。BRVO组、CRVO组IL-6值分别为35.89(17.63,37.50)、37.16(11.52,42.80)pg/mL。BRVO组、CRVO组hs-CRP值分别为161.10(54.51,164.01)、206.93(51.47,331.29)μg/mL。BRVO组、CRVO组VEGF值分别为158.25(82.24,230.41)、174.14(76.04,243.98)pg/mL。该四项因子试验组与对照组比较均无差异(P>0.05)。RVO组视力及黄斑水肿高度与上述血清因子水平未见明显相关。

结论：RVO患者Apelin增高,且Apelin可能为RVO发生的相关危险因素。ADPN、IL-6、hs-CRP、VEGF在RVO急性期未见特异性表达。     

雷珠单抗治疗视网膜静脉阻塞继发黄斑水肿的疗效及其影响因素

目的：研究玻璃体腔注射雷珠单抗治疗视网膜静脉阻塞(RVO)继发黄斑水肿的疗效及其影响因素。

方法：回顾性病例研究。收集2020-04/2021-02于我院治疗的RVO继发黄斑水肿患者61例61眼,其中BRVO患者30例30眼,CRVO患者31例31眼。所有患者均完成了3次雷珠单抗(0.5mg)玻璃体腔注药治疗,部分患眼进行了视网膜激光治疗。治疗(首次玻璃体腔注药)后随访3mo,观察治疗后视力、眼压及黄斑中心凹厚度(CRT)情况,并记录眼部及全身并发症发生情况。

结果：纳入患者治疗后视力均较治疗前显著改善,CRT均较治疗前显著降低(P<0.01),且BRVO和CRVO患者中治疗前视力≤1(LogMAR)的患者3次玻璃体腔注药后视力均优于治疗前视力>1的患者(P<0.01),但CRT无差异(均P>0.05)。BRVO和CRVO患者中分别有12、8眼在3次玻璃体腔注药期间进行了病变区激光治疗,BRVO和CRVO患者中激光治疗和未激光治疗的患者3次玻璃体腔注药后视力和CRT均无差异(P>0.05)。随访期间未发现眼部及全身严重并发症的发生。

结论：雷珠单抗治疗RVO继发黄斑水肿具有良好的疗效和安全性,但基线视力可能对疗效具有一定影响。     

视网膜静脉阻塞激光光凝的时机选择

目的：观察激光光凝治疗不同病程的视网膜静脉阻塞(retinal vein occlusion,RVO)的临床疗效,探讨RVO激光光凝治疗的时机,为临床选择RVO光凝治疗时机提供依据。

方法：回顾性分析视网膜激光光凝治疗的RVO患者103例103眼,按发病时间将患者分为3组, A组46眼,病程≤1mo,其中视网膜分支静脉阻塞(branch retinal vein occlusion,BRVO)28眼,视网膜中央静脉阻塞(central retinal vein occlusion,CRVO)18眼; 缺血型RVO 30眼,非缺血型RVO 16眼。B组38眼,1mo<病程<3mo,其中BRVO 22眼,CRVO 16眼; 缺血型RVO 26眼,非缺血型RVO 12眼。C组19眼,病程≥3mo,其中BRVO 7眼,CRVO 12眼; 缺血型RVO 15眼,非缺血型RVO 4眼。随访3mo,观察光凝治疗后各组患者的视力变化差异、视网膜出血、眼部新生血管、黄斑中心凹厚度下降值。

结果：不同病程RVO光凝治疗后患者的最佳矫正视力提高率,视网膜出血、黄斑水肿吸收情况,黄斑中心凹厚度降低量,早期组优于晚期组,非缺血型RVO优于缺血型RVO,激光光凝治疗效果BRVO优于CRVO且差异具有统计学意义(P<0.05)。

结论：RVO早期激光光凝干预治疗,可以加速视网膜出血、黄斑水肿吸收,有效保护患者现有视力、促进远期视力提高,具有一定临床实用意义。     

视网膜静脉阻塞黄斑水肿患者的中性粒细胞/淋巴细胞比值和血小板平均体积的临床研究

目的研究外周血中性粒细胞/淋巴细胞比值(NLR)、平均血小板体积(MPV)与视网膜静脉阻塞-黄斑水肿(RVO-ME)的关系。方法研究对象:实验组:临床诊断为RVO-ME患者42例:20例视网膜中央静脉阻塞(CRVO)患者(CRVO-ME组)和22例视网膜分支静脉阻塞(BRVO)患者(BRVO-ME组)。对照组:体检健康人群43例,抽取各组患者空腹外周静脉血5 ml,统计分析各组NLR,MPV。结果RVO-ME组NLP(2.15±0.88)、MPV(10.65±1.68)fL较对照组NLP(1.60±0.24)、MPV(9.94±1.20)fL明显升高,且有统计学意义,而CRVO-ME组与BRVO-ME组间并无统计学差异。结论NLR、MPV升高与RVO-ME发病密切相关,有可能作为新的便捷易取的标记物监测RVO-ME的病情发展。     

中性粒细胞与淋巴细胞比值和急性视网膜坏死的相关性

目的　评估急性视网膜坏死（ARN）患者的临床特征以及中性粒细胞与淋巴细胞比值（NLR）在ARN发生发展过程中的作用。方法　回顾性分析2017年7月至2021年10月于北京朝阳医院就诊的ARN患者27例（27眼）为病例组,选择性别、年龄完全匹配的同时期健康体检者为对照组,分析两组受试者中性粒细胞计数、淋巴细胞计数、NLR和血小板平均体积的差异;评估病例组患者ARN的临床特征,并进行不同性别亚组间比较,分析NLR对视网膜脱离的预测价值。结果　ARN患者年龄中位数为50岁,男15例（55.6%）,女12例（44.4%）。所有患者中17例（63.0%）为水痘带状疱疹病毒感染,1例（3.7%）为巨细胞病毒感染,还有9例（33.3%）患者未行感染病毒类型检测。所有患者中9例（33.3%）发生视网膜脱离。男性亚组患者血小板平均体积明显高于女性（P=0.038）,男性亚组和女性亚组间其他基线资料差异均无统计学意义（均为P>0.05）。病例组和对照组受试者中性粒细胞计数（P=0.009）、淋巴细胞计数（P=0.025）和NLR（P=0.002）差异均有统计学意义。病例组和对照组受试者血小板平均体积差异无统计学意义（P=0.283）。Logistic回归分析发现中性粒细胞计数（P=0.523）、淋巴细胞计数（P=0.383）、NLR（P=0.765）、血小板平均体积（P=0.580）与ARN患者视网膜脱离均不相关。结论　NLR与ARN的发病有关,尚未发现NLR与ARN伴视网膜脱离有关。     

不同OCT分型的视网膜静脉阻塞性黄斑水肿与血小板参数的关系

目的：探究不同OCT分型的视网膜静脉阻塞(RVO)性黄斑水肿(ME)与血小板参数的关系。

方法：回顾性研究。收集2016-12/2021-02首诊于郑州大学第五附属医院眼科的RVO患者126例126眼,其中视网膜中央静脉阻塞(CRVO)患者51眼,视网膜分支静脉阻塞(BRVO)患者75眼,未合并ME(Non-ME)患者31眼,合并ME患者95眼。根据OCT形态将ME分为弥漫性视网膜增厚(DRT)组26眼、黄斑囊样水肿(CME)组30眼、浆液性视网膜脱离(SRD)组39眼,收集不同组别患者的血小板参数包括血小板计数(PLT)、血小板平均体积(MPV)、血小板压积(PCT)和血小板体积分布宽度(PDW)并进行统计学分析。

结果：ME组MPV及CMT高于Non-ME组(均P<0.001),SRD组患者的MPV高于DRT组及CME 组(均P<0.001),DRT组与CME组间 MPV比较无差异(P=0.526),SRD组CMT明显高于DRT组与CME 组(P<0.001),CMT在DRT组与CME组之间比较无差异(P=0.190)。

结论：MPV在不同OCT分型的RVO性ME患者中存在差异,活化的血小板与SRD发生和发展可能密切相关。     

Systemic immune-inflammation index,neutrophil-to-lymphocyte ratio,and platelet-to-lymphocyte ratio levels are associated with keratoconus

Purpose:The aim of this study was to assess the systemic immune-inflammation index (SII) levels, neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) in patients with keratoconus (KC).Methods:A total of 42 patients with KC (KC group) and 42 age- and sex-matched healthy subjects (control group) were included into this cross sectional study. Complete blood count parameters were assayed. SII, NLR, red cell distribution width (RDW), and PLR values were calculated. The SII value was calculated as follows: platelet count × (neutrophil/lymphocyte).Results:SII, NLR, RDW, and PLR values were significantly higher in KC group compared to control group [709 ± 236 vs. 418 ± 117 (P < 0.001), 2.5 ± 0.8 vs. 1.76 ± 0.3 (P < 0.001), 14.3 ± 1.6% vs. 12.9 ± 0.54% (P < 0.001), and 143 ± 36 vs. 106 ± 23 (P < 0.001), respectively]. Using the receiver operating characteristics (ROC) curve analysis to predict KC, the highest area under the curve (AUC) was determined SII (0.846 for SII, 0.778 for NLR, and 0.796 for PLR).Conclusion:SII, NLR, RDW, and PLR levels were significantly increased in patients with KC. This study supports the idea that several inflammatory pathways may play important role in the pathogenesis of this disorder. SII may be much better marker than NLR and PLR for predicting the inflammatory status of the disease.     

Assessment of Neutrophil-to-Lymphocyte Ratio and Platelet-to-Lymphocyte Ratio in Patients with Dry Eye Disease

Purpose: To evaluate the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) levels in patients with dry eye disease (DED).

Methods: The white blood cell, neutrophil, platelet, and lymphocyte counts were performed in 78 dry eye patients and 60 controls. The NLR was calculated by dividing neutrophil count by lymphocyte count and the PLR was calculated by dividing platelet count by lymphocyte count.

Results: The mean age was 53.4 ± 3.8 years in the DED group and 52.7 ± 3.4 years in the control group. The mean NLR was 2.6 ± 1.2 and the mean PLR was 138.4 ± 62.6 in the DED group and the mean NLR was 1.84 ± 0.5 and the mean PLR was 118.5 ± 64.7 in the control group. A significant difference was found in the NLR and PLR between the DED and the controls (p = 0.032 and p = 0.026, respectively).

Conclusion: The NLR and PLR values were found higher in patients with dry eye than in healthy subjects.     

Prediction of Pseudoexfoliation Syndrome and Pseudoexfoliation Glaucoma by Using Neutrophil to Lymphocyte Ratio and Platelet to Lymphocyte Ratio

Purpose: To assess the levels of neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) in patients with pseudoexfoliation syndrome (PEX) and to compare the NLR and PLR results of patients with PEX, PEX glaucoma (PXG), and healthy controls.

Methods: In total, 34 patients with PEX, 29 patients with PXG, and 42 healthy subjects were enrolled in this retrospective study. Complete ophthalmologic examination and complete blood count measurements were performed of all subjects. Complete blood counts were performed within 2 h of blood collection.

Results: There was a significant difference in NLR between PEX and control groups (p = 0.012) and PXG and control groups (p = 0.003). Also, a significant difference was found in PLR values between control and PXG groups (p = 0.024).

Conclusions: Our study for the first time provides evidence that PLR and NLR may be useful for predicting the prognosis of PEX patients and progression to PXG.     

Serum Inflammatory Biomarkers in Patients with Nonarteritic Anterior Ischemic Optic Neuropathy

PurposeTo evaluate the neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), platelet-to-lymphocyte ratio (PLR), and systemic immune-inflammation index (SII) in patients with non-arteritic anterior ischemic optic neuropathy (NAION).MethodsFifty-six patients with NAION and 60 age-sex matched healthy controls were included in the study. Demographic characteristics and laboratory findings of the patients and the controls were obtained from the electronic medical records. NLR, PLR, MLR, and SII were calculated and compared between the groups. Cutoff values were also determined.ResultsNeutrophil, monocyte and platelet counts were higher in the NAION group than in the control group, but the difference was not statistically significant (p > 0.05). The mean NLR and SII were higher in the NAION group than in the control group (p = 0.004 and p = 0.011, respectively). In the receiver operating characteristic curve analysis, the areas under the curve for NLR were 0.67, and NLR >1.79 predicted NAION with a sensitivity of 71% and specificity of 59%. The areas under the curve for SII was 0.66, and SII of >417 predicted NAION with a sensitivity of 71% and specificity of 49%. There was no significant difference in PLR and MLR between the groups (p = 0.105 and p = 0.347, respectively).ConclusionsThe current study demonstrated that NAION patients had increased NLR and SII levels compared with control subjects. Elevated NLR and SII might serve as readily available inflammatory predictors in NAION patients.     

Glucose-6-phosphate dehydrogenase deficiency in retinal vein occlusion

PURPOSE: Glucose-6-phosphate dehydrogenase (G6PD) deficiency is one of the most common human genetic abnormalities, with a high prevalence in Sardinia, Italy. Evidence indicates that G6PD-deficient patients are protected against ischemic heart and cerebrovascular disease. The purpose of this study was to assess the frequency of G6PD deficiency in Sardinian patients with retinal vein occlusion (RVO) and to ascertain whether the deficiency may offer protection against RVO. METHODS: Erythrocyte G6PD levels were measured in 448 consecutive RVO patients: 194 with central RVO (CRVO) and 254 with branch RVO (BRVO). Age- and sex-matched subjects (n = 896) who were undergoing cataract surgery and had no history of RVO served as the control. Multiple logistic regression models were used to investigate the association between G6PD deficiency and RVO, CRVO, or BRVO. RESULTS: G6PD deficiency was found in 21 (4.7%) patients with RVO, 7 (3.6%) with CRVO, 14 (5.5%) with BRVO, and 107 (11.9%) control subjects. Differences between cases and controls were statistically significant (P < 0.005). Multiple conditional logistic regression analysis, including as covariates G6PD deficiency, hypertension, diabetes, and hypercholesterolemia, revealed that G6PD deficiency was significantly associated with decreased risk of development of RVO, CRVO, or BRVO. After adjustment for hypertension, diabetes, and hypercholesterolemia, the association between G6PD deficiency and RVO, CRVO, or BRVO remained statistically significant. Similar results were obtained after adjustment for systolic or diastolic blood pressure, plasma glucose, and cholesterol levels. However, when the patients with CRVO or BRVO were categorized by gender, a significant association was found only in the women. CONCLUSIONS: The frequency of G6PD deficiency in patients with RVO was significantly lower than expected. The results suggest that G6PD-deficient patients have a significantly decreased risk of development of RVO in the Sardinian population.     

Aqueous levels of erythropoietin in acute retinal vein occlusion with macular edema

AIM: To investigate the aqueous erythropoietin (EPO) levels and associated factors in patients with acute retinal vein occlusion (RVO).METHODS:The aqueous EPO level was measured in patients with macular edema (ME) secondary to acute branched retinal vein occlusion (BRVO) or central retinal vein occlusion (CRVO). Aqueous fluid from cataract patients served as the control. We also evaluated whether aqueous level of EPO was associated with factors such as serum EPO level, non-perfusion area, central macular thickness (CMT), and arterio-venous (AV) transit timeRESULTS:Twenty-seven RVO patients (16 BRVO, 11 CRVO) and 9 control subjects were enrolled in the study. The aqueous EPO level (mU/mL) was higher in RVO (68.2±54.3) than that in the control subjects (12.9±5.9). More specifically, the aqueous EPO level was higher in CRVO (118.9±52.1) than that in BRVO (33.3±10.8). However, no differences were found in serum EPO levels among three groups. CMT in RVO patients had a positive correlation with the aqueous EPO level (r=0.66). Also, in terms of non-perfusion area, the aqueous EPO levels were more elevated in the ischemic subgroup than in the non-ischemic subgroup in both BRVO and CRVO.CONCLUSION:Aqueous EPO levels are elevated in patients with macular edema secondary to recent onset RVO. Patients with CRVO have higher EPO levels than those with BRVO. The aqueous EPO level in RVO has a positive correlation with CMT and is associated with non-perfusion area. These results suggest that the aqueous EPO level could be associated with retinal ischemia and may be involved in the pathogenesis of macular edema secondary to RVO.     

Is elevated level of soluble endothelial protein C receptor a new risk factor for retinal vein occlusion?

BACKGROUND: To evaluate the systemic and thrombophilic risk factors for retinal vein occlusion (RVO) and to determine whether the elevated level of soluble endothelial protein C receptor (sEPCR) is a risk factor for thrombosis. METHODS: In this case-control study, 56 patients with central RVO (CRVO), 26 patients with branch RVO (BRVO) and 78 healthy sex- and age-matched subjects were enrolled. Following ophthalmological examination, venous blood was analysed for glucose, lipid profile, lipoprotein (a), homocysteine, activated partial thromboplastin time, fibrinogen, factor VIII, protein C activity, protein S activity, activated protein C resistance, antithrombin III activity, lupus anticoagulant, anti-cardiolipin antibody, anti-phospholipid antibody, sEPCR, factor V Leiden mutation and prothrombin G20210A mutation. RESULTS: Apart from hypertension, glaucoma, lipoprotein (a), homocysteine and factor VIII, elevated levels of sEPCR were found to be a risk factor for CRVO (odds ratio, 1.02; 95% confidence interval, 1.007-1.028; P = 0.001). Patients with CRVO had significantly higher levels of sEPCR than those with BRVO and controls (respectively, 160.1 +/- 83.8, 116.8 +/- 65.2 and 111.3 +/- 60.5; P = 0.005). Moreover, 39% of patients with CRVO had levels of sEPCR more than 200 ng/mL, and only 5% of controls and 11% of patients with BRVO had similar high levels. CONCLUSIONS: Besides known classical risk factors, elevated levels of sEPCR seem to be an important candidate risk factor for especially CRVO.     

Correlation between systemic immune-inflammation index and routine hemogram-related inflammatory markers in the prognosis of retinopathy of prematurity

Purpose:To evaluate the prognostic potential of systemic inflammatory index in the course of retinopathy of prematurity (ROP).Methods:This is a retrospective case-control study. 303 infants with a gestational age of ≤35 weeks were screened with and without ROP at birth and 1 month after the birth of complete blood counts (CBC) were included in this study. Serum neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-monocyte ratio (LMR), platelet-to-lymphocyte (PLR), and systemic immune-inflammation index (SII) was calculated at birth and one month after. LMR was calculated by dividing the absolute lymphocyte count by the absolute monocyte count. NLR and PLR were determined by dividing the absolute neutrophil count or the absolute platelet count by the absolute lymphocyte count, respectively. The SII was calculated by the formula = neutrophilxplatelet/lymphocyte. All statistical analyses were performed using SPSS 22 (SPSS for Windows, version 22.0; SPSS, Inc. Chicago, IL, USA).Results:A total of 303 infants were included 145 with ROP and 158 without ROP. The NLR, LMR, PLR and SII values were 0.56 ± 1.17/0.51 ± 1.04 (P = 0.997), 13.7 ± 18/9.49 ± 13.1 (P = 0.014), 31.69 ± 68/24.1 ± 37.7 (P = 0.268), 131.42 ± 326/124.66 ± 267 (P = 0.935) in with ROP and without ROP infant at birth respectively. The NLR, LMR, PLR, and SII values were 0.68 ± 1.27/0.34 ± 0.99 (P = 0.001), 2.58 ± 6.01/2.46 ± 14.5 (P = 0.706), 47.5 ± 78.33/33.55 ± 42.4 (P = 0.035), and 253 ± 681/114 ± 345 (P = 0.001), respectively in with ROP and without ROP infant at 1 month after birth.Conclusion:The NLR, PLR, and SII seem an independent predictor of the development of ROP.     

视网膜静脉阻塞与血液中血小板相关参数及高密度脂蛋白胆固醇和低密度脂蛋白胆固醇水平之间的关系

目的　探讨视网膜静脉阻塞（retinal vein occlusion,RVO）与血液中血小板相关参数及高密度脂蛋白胆固醇（HDL-C)和低密度脂蛋白胆固醇（LDL-C)水平之间的关系。方法　选取我院2017年5月至2019年8月收治的113例113眼RVO患者作为研究对象。将研究对象中30例 30眼视网膜中央静脉阻塞(CRVO)患者作为CRVO组，将其余83例83眼视网膜分支静脉阻塞(BRVO)患者作为BRVO组。此外，将研究对象按年龄分为年轻组（≤50岁）和老年组（>50岁），分别为23例和90例；选取同期排除眼底病的患者112例112眼作为对照组。抽取各组患者空腹外周静脉血9 mL，采用Sysmex^@XN血液分析仪测定患者血液中血小板相关参数，包括:血小板计数(PLT）、血小板压积(PCT)、大型血小板比率（P-LCR)、血小板分布宽度（PDW)和血小板平均体积（MPV)等。采取终点法测量患者血液中HDL-C和LDL-C含量。结果　CRVO组、BRVO组及对照组患者血小板相关参数中PLT和PCT，差异均无统计学意义（均为P＞0.05）。BRVO组和CRVO组MPV均较对照组高，差异均有统计学意义(均为P<0.05)。CRVO组PDW较对照组高，差异有统计学意义（P<0.05）,但BRVO组与CRVO组和对照组比较，差异均无统计学意义（均为P＞0.05）。CRVO组和BRVO组P-LCR含量较对照组高，差异均有统计学意义（均为P<0.05）；BRVO组P-LCR与CRVO组比较，差异无统计学意义（P＞0.05）。BRVO组患者血液中HDL-C含量比对照组降低，差异有统计学意义（P<0.05），而CRVO组与对照组和BRVO组间差异均无统计学意义（均为P＞0.05）。三组间LDL-C含量比较，差异均无统计学意义（均为P＞0.05）。年轻组患者PLT较老年组高，差异有统计学意义（P<0.05）；年轻组和老年组患者PCT、MPV、PDW、P-LCR以及HDL-C、LDL-C含量比较，差异均无统计学意义（均为P＞0.05）。结论　人体血液中血小板相关参数及HDL-C水平与RVO的发病存在密切关系。