心脏再同步治疗慢性心力衰竭的疗效评价及无反应原因分析

Objective To investigate the effect of cardiac resynchronization therapy (CRT) and the problem of non-response to CRT in patients with chronic heart failure. Methods Twenty patients[(64±10.9) yrs,5 women, 15men] underwent CRT. Conventional echocardiography was performed in each patient before implantation and at 6 months post implantation. Results The clinical response rate was 60% and echocardio-graphic response rate was 55% at 6 month follow-up. Average EF increased 10%. Three patients died and 1 pa-tient was found to have increased left electrode thresholds. One electrode dislocation occurred and recannulation was required. Four patients had no response to CRT. The response rate to CRT was lower in patients with a nar-row QRS or ischemic cardiomyopathy. Conclusion CRT is an effective treatment for chronic heart failure pa-tients. Non-response to CRT may berelated to the cause of heart failure and narrow QRS.     

心脏再同步治疗慢性心力衰竭的疗效评价及无反应原因分析

Objective To investigate the effect of cardiac resynchronization therapy (CRT) and the problem of non-response to CRT in patients with chronic heart failure. Methods Twenty patients[(64±10.9) yrs,5 women, 15men] underwent CRT. Conventional echocardiography was performed in each patient before implantation and at 6 months post implantation. Results The clinical response rate was 60% and echocardio-graphic response rate was 55% at 6 month follow-up. Average EF increased 10%. Three patients died and 1 pa-tient was found to have increased left electrode thresholds. One electrode dislocation occurred and recannulation was required. Four patients had no response to CRT. The response rate to CRT was lower in patients with a nar-row QRS or ischemic cardiomyopathy. Conclusion CRT is an effective treatment for chronic heart failure pa-tients. Non-response to CRT may berelated to the cause of heart failure and narrow QRS.     

心脏再同步治疗慢性心力衰竭的疗效评价及无反应原因分析

Objective To investigate the effect of cardiac resynchronization therapy (CRT) and the problem of non-response to CRT in patients with chronic heart failure. Methods Twenty patients[(64±10.9) yrs,5 women, 15men] underwent CRT. Conventional echocardiography was performed in each patient before implantation and at 6 months post implantation. Results The clinical response rate was 60% and echocardio-graphic response rate was 55% at 6 month follow-up. Average EF increased 10%. Three patients died and 1 pa-tient was found to have increased left electrode thresholds. One electrode dislocation occurred and recannulation was required. Four patients had no response to CRT. The response rate to CRT was lower in patients with a nar-row QRS or ischemic cardiomyopathy. Conclusion CRT is an effective treatment for chronic heart failure pa-tients. Non-response to CRT may berelated to the cause of heart failure and narrow QRS.     

心脏再同步治疗慢性心力衰竭的疗效评价及无反应原因分析

Objective To investigate the effect of cardiac resynchronization therapy (CRT) and the problem of non-response to CRT in patients with chronic heart failure. Methods Twenty patients[(64±10.9) yrs,5 women, 15men] underwent CRT. Conventional echocardiography was performed in each patient before implantation and at 6 months post implantation. Results The clinical response rate was 60% and echocardio-graphic response rate was 55% at 6 month follow-up. Average EF increased 10%. Three patients died and 1 pa-tient was found to have increased left electrode thresholds. One electrode dislocation occurred and recannulation was required. Four patients had no response to CRT. The response rate to CRT was lower in patients with a nar-row QRS or ischemic cardiomyopathy. Conclusion CRT is an effective treatment for chronic heart failure pa-tients. Non-response to CRT may berelated to the cause of heart failure and narrow QRS.     

心脏再同步治疗慢性心力衰竭的疗效评价及无反应原因分析

Objective To investigate the effect of cardiac resynchronization therapy (CRT) and the problem of non-response to CRT in patients with chronic heart failure. Methods Twenty patients[(64±10.9) yrs,5 women, 15men] underwent CRT. Conventional echocardiography was performed in each patient before implantation and at 6 months post implantation. Results The clinical response rate was 60% and echocardio-graphic response rate was 55% at 6 month follow-up. Average EF increased 10%. Three patients died and 1 pa-tient was found to have increased left electrode thresholds. One electrode dislocation occurred and recannulation was required. Four patients had no response to CRT. The response rate to CRT was lower in patients with a nar-row QRS or ischemic cardiomyopathy. Conclusion CRT is an effective treatment for chronic heart failure pa-tients. Non-response to CRT may berelated to the cause of heart failure and narrow QRS.     

心脏再同步治疗慢性心力衰竭的疗效评价及无反应原因分析

Objective To investigate the effect of cardiac resynchronization therapy (CRT) and the problem of non-response to CRT in patients with chronic heart failure. Methods Twenty patients[(64±10.9) yrs,5 women, 15men] underwent CRT. Conventional echocardiography was performed in each patient before implantation and at 6 months post implantation. Results The clinical response rate was 60% and echocardio-graphic response rate was 55% at 6 month follow-up. Average EF increased 10%. Three patients died and 1 pa-tient was found to have increased left electrode thresholds. One electrode dislocation occurred and recannulation was required. Four patients had no response to CRT. The response rate to CRT was lower in patients with a nar-row QRS or ischemic cardiomyopathy. Conclusion CRT is an effective treatment for chronic heart failure pa-tients. Non-response to CRT may berelated to the cause of heart failure and narrow QRS.     

心脏再同步治疗慢性心力衰竭的疗效评价及无反应原因分析

Objective To investigate the effect of cardiac resynchronization therapy (CRT) and the problem of non-response to CRT in patients with chronic heart failure. Methods Twenty patients[(64±10.9) yrs,5 women, 15men] underwent CRT. Conventional echocardiography was performed in each patient before implantation and at 6 months post implantation. Results The clinical response rate was 60% and echocardio-graphic response rate was 55% at 6 month follow-up. Average EF increased 10%. Three patients died and 1 pa-tient was found to have increased left electrode thresholds. One electrode dislocation occurred and recannulation was required. Four patients had no response to CRT. The response rate to CRT was lower in patients with a nar-row QRS or ischemic cardiomyopathy. Conclusion CRT is an effective treatment for chronic heart failure pa-tients. Non-response to CRT may berelated to the cause of heart failure and narrow QRS.     

心脏再同步治疗慢性心力衰竭的疗效评价及无反应原因分析

Objective To investigate the effect of cardiac resynchronization therapy (CRT) and the problem of non-response to CRT in patients with chronic heart failure. Methods Twenty patients[(64±10.9) yrs,5 women, 15men] underwent CRT. Conventional echocardiography was performed in each patient before implantation and at 6 months post implantation. Results The clinical response rate was 60% and echocardio-graphic response rate was 55% at 6 month follow-up. Average EF increased 10%. Three patients died and 1 pa-tient was found to have increased left electrode thresholds. One electrode dislocation occurred and recannulation was required. Four patients had no response to CRT. The response rate to CRT was lower in patients with a nar-row QRS or ischemic cardiomyopathy. Conclusion CRT is an effective treatment for chronic heart failure pa-tients. Non-response to CRT may berelated to the cause of heart failure and narrow QRS.     

心脏再同步治疗慢性心力衰竭的疗效评价及无反应原因分析

Objective To investigate the effect of cardiac resynchronization therapy (CRT) and the problem of non-response to CRT in patients with chronic heart failure. Methods Twenty patients[(64±10.9) yrs,5 women, 15men] underwent CRT. Conventional echocardiography was performed in each patient before implantation and at 6 months post implantation. Results The clinical response rate was 60% and echocardio-graphic response rate was 55% at 6 month follow-up. Average EF increased 10%. Three patients died and 1 pa-tient was found to have increased left electrode thresholds. One electrode dislocation occurred and recannulation was required. Four patients had no response to CRT. The response rate to CRT was lower in patients with a nar-row QRS or ischemic cardiomyopathy. Conclusion CRT is an effective treatment for chronic heart failure pa-tients. Non-response to CRT may berelated to the cause of heart failure and narrow QRS.     

重组人脑利钠肽治疗心力衰竭安全性和疗效的开放性随机对照多中心临床研究

Objective To explore the safety of intravenous recombinant human brain natriuretic peptide (rhBNP) in treating acute decompensated heart failure and acute exacerbation of chronic heart failure, and to compare the differences in efficacy with different dosage and administration time. Methods A total of 2160 patients characterized of acute decompensated heart failure and acute exacerbation of chronic heart failure were enrolled in this multicenter, randomized, open, dose-control study. The patients were randomly allocated to four groups with different doses and administration time on top of standard therapy. Results In the safety respect, the rate of hypotension is 1.44% at 5 -7 days after treatment, the serum creatinine level was reduced compared to baseline( P values were 0. 0437, 0. 0087 and 0. 0116)except in the group of 0. 015 μg at 24 h (P =0. 7054). The rate of 30-day readmission is 5.65%, mortality rate is 9. 44%. In terms of efficacy, dyspnea was significantly improved at 30 min after administration, and at 24 h after administration ( all P ＜ 0. 01 ). Urine output and LEVF were also significantly increased by 76. 59% (P ＜0. 01 ) and 12. 08% respectively ( all P ＜ 0. 01 ) compared to baseline. Plasma NT-proBNP decreased by 40. 29% at 5 - 7 days after administration ( P ＜ 0. 01 ). Conclusion The clinical application of intravenous rhBNP is safe and effective for treatment of acute decompensated heart failure and acute exacerbation of chronic heart failure in this large patient cohort.     

State of knowledge of helminth fauna of freshwater fishes of Poland

A total 89 fish and lamprey species has been recorded from Polish freshwater habitats. Twenty-seven of them (30.3%) have not been surveyed for parasitic helminthes. Some of the latter fishes are either rare or not easily accessible. Other live only in specific habitats in scattered localities. An important obstacle for studying parasite faunas of some fishes may be their status on an endangered species. Among the non-surveyed fishes, are those which have been relatively recently introduced to Poland or migrated there on their own. The present paper attempts to review all hitherto not studied helminthologically fish species, their habitats, localities and current protection status.     

高血压降压治疗目标的再认识

根据传统的高血压水平的定义,1993年WHO高血压治疗指南提出血压控制目标为<140/90mm Hg(1mm Hg=0.133kPa),但是并非所有患者都必须将血压降至同一水平,而应根据患者情况进行个体化治疗。Framingham进行的一项长达10～12年的心血管事件研究发现,第5年后,正常上限血压[收缩压(SBP