鼻唇沟皮瓣在鼻面部缺损修复中的应用

目的:探讨鼻面缺损修复的方法,评价鼻唇沟瓣在修复鼻面部缺损的临床应用。方法:22例应用鼻唇沟瓣修复其鼻面部组织缺损,缺损面积1.0 cm×1.5 cm~3.0 cm×4.0 cm。皮瓣沿鼻唇沟走行方向设计,蒂宽1.0~1.5 cm,长度根据缺损范围确定,长宽比例不超过5:1。结果:22例皮瓣全部成活,外形恢复满意,皮瓣质地、色泽与周围皮肤接近。结论:鼻唇沟瓣取材方便,供区瘢痕隐蔽,畸形不明显,是修复鼻部及小面积面部缺损的理想方法。     

腓肠神经营养血管逆行岛状皮瓣修复足踝部皮肤缺损

目的:观察腓肠神经营养血管逆行岛状皮瓣修复足踝部皮肤缺损临床疗效。方法:对20例足跟、踝关节和足背皮肤缺损的患者采用腓肠神经营养血管逆行岛状皮瓣修复,供区的切口直接缝合或游离植皮覆盖,皮瓣面积4cm×5cm~11cm×10cm。结果:术后18例皮瓣全部成活,供、受区创面均愈合;皮瓣远端坏死2例。术后12例获随访6~12个月,皮瓣外形满意,颜色与周围组织相同,未出现破溃。结论:腓肠神经营养血管逆行岛状皮瓣是修复足踝部皮肤缺损的一种理想皮瓣。     

食指背侧岛状皮瓣修复拇指皮扶缺损

目的 :进一步探讨食指背侧岛状皮瓣修复拇指皮肤缺损的临床意义。方法 :自 1993年 6月～ 1999年 10月 ,应用食指背侧岛状皮瓣修复拇指皮肤缺损 42例 ,皮瓣面积 2 0cm× 1 5cm～ 4 0cm× 2 0cm。结果 :皮瓣全部成活 ,效果满意。结论 :该皮瓣血供可靠 ,操作简单 ,特别适用于一期修复拇指皮肤缺损。     

足跟大面积皮肤缺损的显微外科治疗

目的 报道应用腓肠神经营养血管逆行岛状皮瓣及吻合血管的足背皮瓣修复足跟部较大面积皮肤缺损的临床效果.方法 临床治疗36例足跟及足踝部大面积皮肤缺损的病例,其中应用腓肠神经营养血管逆行岛状皮瓣修复足跟皮肤缺损25例,皮瓣面积最大30 cm×14 cm,最小11 cm×7 cm,应用吻合血管的足背皮瓣修复足跟皮肤缺损11例,皮瓣面积最大14 cm×11 cm,最小9 cm×6 cm.结果 皮瓣全部成活,术后有1例腓肠神经营养血管逆行岛状皮瓣远端少许皮肤坏死,经换药切痴后用中厚皮片植皮愈合.所有病例均经3个月～3 a随访,患肢正常步态行走,皮瓣耐磨,两点辨别觉4～7 cm.结论 腓肠神经营养血管逆行岛状皮瓣及足背皮瓣皮肤质量较好,不臃肿,供皮面积较大,适合修复足跟部较大面积皮肤缺损.     

岛状皮瓣在颊癌术后缺损修复的应用--附9例报告

目的推广岛状皮瓣在颊癌术后缺损修复中的应用.方法颊癌扩大切除术后,根据缺损的情况分别采用全额岛状皮瓣、胸三角皮瓣及全额岛状皮瓣结合皮片移植的方法修复.结果本组9例,皮肤缺损最大6cm×5cm,颊粘膜缺损最大,10cm×6cm.采用全额岛状瓣修复5例,全额岛状皮瓣与胸三角皮瓣瓦合修复2例,全额岛状皮瓣结合皮片移植2例,1例全额岛状皮瓣坏死,其余皮瓣均成活,功能及外形恢复满意.结论岛状皮瓣是修复颊部缺损的较好方法,以全额岛状皮瓣为佳.     

掌骨背动脉岛状皮瓣修复指掌面皮肤缺损21例

目的:探讨手指掌面皮肤缺损的修复方法。方法:在手背设计掌骨背动脉岛状皮瓣,逆行翻转修复2、3、4、5指中节以近掌面不同程度的皮肤缺损共21例(30指),皮瓣缺陷范围0.5cm×1.0cm￣2.5cm×3.0cm。结果:患者植皮区及供皮区均一期愈合,随访3个月￣2年,所有患者手指功能正常,无疤痕挛缩。结论:掌骨背动脉岛状皮瓣是指掌面皮肤缺损修复较理想的选择。     

指背动脉蒂逆行岛状皮瓣修复指端皮肤缺损的临床研究

目的 介绍一种修复手指末端皮肤缺损的新型逆行岛状皮辩.方法 应用指背动脉为蒂,设计成逆行岛状皮瓣,从2002年6月～2006年10月,临床应用掌背指背动脉蒂逆行岛状皮瓣修复手指末端皮肤缺损30例,皮瓣面积1.2 cm×1.4 cm～2.4cm×3.2 cm.结果 临床应用30例,皮瓣全部成活,效果满意.结论 以指背动脉为蒂设计成逆行岛状皮瓣,该皮瓣设计合理、血供可靠、操作简便,适用于手指末端软组织缺损的修复.     

改良拱顶石穿支岛状皮瓣在皮肤软组织缺损修复中的应用

目的:按照拱顶石穿支岛状皮瓣设计原则,修复皮肤软组织肿瘤切除后的继发创面。探讨该皮瓣的成活机制以及形成、移转方法的改良策略。方法:2015年1月—2016年8月,应用拱顶石穿支岛状皮瓣修复皮肤肿瘤切除后继发创面11例,其中缺损面积最小为5.0 cm×3.5 cm,最大为15.0 cm×10.0 cm,皮瓣切取面积最小为9.0 cm×4.0 cm,最大为20.0 cm×10.0 cm。创面旁设计拱顶石形状皮瓣,皮瓣与缺损同宽,与创缘相邻顶角成直角,皮瓣两端V-Y切口设计。改良策略：皮瓣长轴可垂直于人体纵轴;可减少皮瓣皮肤切口;皮瓣与基底面可适当分离,但须保证主要穿支血管勿损。结果:本组患者,皮瓣均成活良好。术后随访3~9个月,皮瓣色泽和形态恢复良好,瘢痕生长不明显,无明显功能活动障碍。结论：与传统的随意或轴型皮瓣相比,拱顶石穿支岛状皮瓣设计简单,安全可靠,能满足身体广泛区域的缺损修复需要。     

足底内侧岛状皮瓣转位修复足跟部皮肤缺损

目的 :探讨足底内侧岛状皮瓣转位修复足跟部皮肤缺损的疗效 ;方法 :1 986～ 1 997年采用足底内侧岛状皮瓣修复足跟部皮肤缺损 8例 ,其中外伤 5例 ,跟骨骨髓炎 2例 ,冻伤 1例。切取皮瓣面积 3 0cm× 3 0cm～ 5 0cm× 7 0cm ;结果 :皮瓣全部成活 ,治愈率 1 0 0 % ;结论 :足底非负重区组织修复足底负重区皮肤缺损不仅功能良好而且外形美观。除具有“同源性”外 ,更具有耐磨 ,耐压 ,承重 ,不滚动的特点 ,较其它转移组织有绝对优势。     

足跟部外露皮瓣修复

采用小腿前外侧逆行岛状皮瓣、胫后动脉岛状皮瓣转移或“桥式”交腿转位、足底内侧岛状皮瓣等形式,修复足跟部软组织缺损,跟骨外露14例。皮瓣切取范围5 cm×5 cm~16 cm×10 cm。探讨应用多种轴型岛状皮瓣修复足跟部皮肤缺损的疗效。结果:皮瓣全部成活,仅一例皮瓣周围发生静脉回流障碍,经间断拆线后缓解,皮肤质地达正常,负重后无溃疡发生。提示多种轴型岛状皮瓣修复足跟部皮肤缺损疗效可靠。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

APPLICATION OF LORNOXICAM TO PATIENT-CONTROLLED ANALGESIA IN PATIENTS UNDERGOING ABDOMINAL SURGERIES

FOR anesthesiologis s ,treatingpostoperativepainhas alwaysbeen a problem.Althoughopioidshave been provedtobe effective,theirsideeffectscouldnotbeignored.With thedevelopmentofscienceand pharmacology,many drugs with aspectsof satisfactoryanalgesicefficacyand couldbe welltoleratedby patientshave been developed.And lornoxicamisone of them, which isa non-steroidalanti-inflammatorydrug (NSAID ), with analgesic, anti-infl-ammatory,andantipyreticproperties.Itseliminationhalf-time(3 to 5 hours) isle…     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.     

Scientific principles and rigorous processes should be followed in developing clinical guidelines for therapeutic interventions of integrative medicine

A clinical guideline for the therapeutic interventions of integrative medicine may be defined as a written document which states a series of recommendations on therapeutic interventions of integrative medicine for a special disease or condition. The guideline may provide assistance to medical professionals in making clinical decisions aimed at improving the clinical outcome of patients and reducing the costs of medical care（~＇4~. Recommendations issued by a guideline should be based on the best available evidence in both Western and Chinese medicine. For fulfilling this purpose, the development of clinical guidelines for therapeutic interventions in the field of integrative medicine should follow scientific principles and undergo a rigorous processes.